nucleoporin 88kDa (NUP88) - coding DNA reference sequence

(used for variant description)

(last modified October 27, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_002532.4 in the NUP88 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering NUP88 transcript NM_002532.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                attggccgaaacagtgagtggacggccgc       c.-61

 .         .         .         .         .         .                g.5089
 ggattggctgtgctcagcggcgggctgagcaactggagtgaggggagcagttgggccaag       c.-1

          .         .         .         .         .         .       g.5149
 ATGGCGGCCGCCGAGGGACCGGTGGGCGACGGCGAGCTGTGGCAGACCTGGCTTCCTAAC       c.60
 M  A  A  A  E  G  P  V  G  D  G  E  L  W  Q  T  W  L  P  N         p.20

          .         .         .         .         .         .       g.5209
 CACGTCGTGTTCTTGCGGCTCCGGGAGGGACTGAAAAACCAGAGTCCAACCGAAGCTGAG       c.120
 H  V  V  F  L  R  L  R  E  G  L  K  N  Q  S  P  T  E  A  E         p.40

          .         .         .         .         .         .       g.5269
 AAACCAGCTTCTTCGTCGTTGCCTTCGTCGCCGCCGCCGCAGTTGCTGACGAGAAACGTG       c.180
 K  P  A  S  S  S  L  P  S  S  P  P  P  Q  L  L  T  R  N  V         p.60

          .         .         .         .         .         .       g.5329
 GTCTTTGGCCTCGGCGGAGAGCTTTTCCTGTGGGACGGAGAAGACAGCTCCTTCTTAGTC       c.240
 V  F  G  L  G  G  E  L  F  L  W  D  G  E  D  S  S  F  L  V         p.80

          .         .         .         .         .        | 02.    g.8060
 GTTCGCCTTCGGGGCCCCAGCGGCGGCGGCGAAGAGCCCGCCCTGTCCCAGTACCAG | AGA    c.300
 V  R  L  R  G  P  S  G  G  G  E  E  P  A  L  S  Q  Y  Q   | R      p.100

          .         .         .         .         .         .       g.8120
 TTGCTTTGCATAAATCCACCCCTGTTTGAAATCTATCAAGTCTTGTTAAGCCCAACACAA       c.360
 L  L  C  I  N  P  P  L  F  E  I  Y  Q  V  L  L  S  P  T  Q         p.120

          .         .         .         .         .         .       g.8180
 CATCATGTAGCACTTATAGGAATAAAAGGACTTATGGTATTAGAATTACCTAAAAGATGG       c.420
 H  H  V  A  L  I  G  I  K  G  L  M  V  L  E  L  P  K  R  W         p.140

          .         .         .         .        | 03.         .    g.10618
 GGGAAGAATTCTGAATTTGAAGGTGGAAAATCAACAGTGAATTGTAG | TACCACTCCAGTT    c.480
 G  K  N  S  E  F  E  G  G  K  S  T  V  N  C  S  |  T  T  P  V      p.160

          .         .         .         .         .         .       g.10678
 GCGGAGAGATTTTTCACCAGTTCCACCTCTCTGACTCTAAAGCATGCTGCATGGTATCCA       c.540
 A  E  R  F  F  T  S  S  T  S  L  T  L  K  H  A  A  W  Y  P         p.180

          .         .         .         .         .    | 04    .    g.13957
 AGTGAAATCCTGGATCCCCACGTAGTGCTGTTAACATCAGACAACGTAATCAG | AATTTAC    c.600
 S  E  I  L  D  P  H  V  V  L  L  T  S  D  N  V  I  R  |  I  Y      p.200

          .         .         .         .         .         .       g.14017
 TCACTACGTGAGCCGCAGACACCCACTAACGTGATAATACTTTCAGAAGCCGAAGAGGAA       c.660
 S  L  R  E  P  Q  T  P  T  N  V  I  I  L  S  E  A  E  E  E         p.220

          .         . | 05       .         .         .         .    g.15870
 AGTCTAGTACTCAATAAAGG | AAGGGCGTATACCGCATCTCTAGGAGAGACAGCAGTTGCA    c.720
 S  L  V  L  N  K  G  |  R  A  Y  T  A  S  L  G  E  T  A  V  A      p.240

          .         .         .         .         .         .       g.15930
 TTTGACTTTGGGCCATTGGCAGCAGTCCCAAAGACTCTATTTGGACAAAACGGCAAAGAT       c.780
 F  D  F  G  P  L  A  A  V  P  K  T  L  F  G  Q  N  G  K  D         p.260

          .         .         .         .         .         .       g.15990
 GAAGTAGTGGCATACCCACTGTACATCTTATATGAAAATGGAGAGACTTTCCTGACATAC       c.840
 E  V  V  A  Y  P  L  Y  I  L  Y  E  N  G  E  T  F  L  T  Y         p.280

          .        | 06.         .         .         .         .    g.19539
 ATCAGTCTGTTACACAG | CCCTGGAAATATTGGAAAGCTGTTGGGTCCATTGCCCATGCAT    c.900
 I  S  L  L  H  S  |  P  G  N  I  G  K  L  L  G  P  L  P  M  H      p.300

          .         .         .         .         .         .       g.19599
 CCTGCGGCTGAAGATAACTATGGTTATGATGCGTGTGCTGTACTCTGCTTACCCTGTGTC       c.960
 P  A  A  E  D  N  Y  G  Y  D  A  C  A  V  L  C  L  P  C  V         p.320

          .         .         .         .         .         .       g.19659
 CCCAATATCTTAGTGATCGCTACTGAATCAGGAATGCTGTATCACTGTGTCGTGCTAGAA       c.1020
 P  N  I  L  V  I  A  T  E  S  G  M  L  Y  H  C  V  V  L  E         p.340

          .         .     | 07   .         .         .         .    g.20529
 GGGGAAGAAGAAGATGACCACACG | TCAGAAAAGTCCTGGGATTCCAGGATTGACCTCATT    c.1080
 G  E  E  E  D  D  H  T   | S  E  K  S  W  D  S  R  I  D  L  I      p.360

          .         .         .         .         .         .       g.20589
 CCTTCTCTGTATGTGTTTGAATGTGTTGAGTTGGAGCTTGCTTTGAAACTGGCATCTGGA       c.1140
 P  S  L  Y  V  F  E  C  V  E  L  E  L  A  L  K  L  A  S  G         p.380

          .         .         .         .         .   | 08     .    g.25097
 GAGGATGACCCTTTTGATTCTGACTTTTCTTGTCCAGTCAAACTTCATAGAG | ATCCCAAG    c.1200
 E  D  D  P  F  D  S  D  F  S  C  P  V  K  L  H  R  D |   P  K      p.400

          .         .         .         .         .         .       g.25157
 TGTCCTTCAAGATATCACTGTACTCATGAAGCTGGTGTACATAGTGTTGGGCTAACTTGG       c.1260
 C  P  S  R  Y  H  C  T  H  E  A  G  V  H  S  V  G  L  T  W         p.420

          .         .         .  | 09      .         .         .    g.29787
 ATTCATAAACTTCACAAATTTCTTGGATCAG | ATGAAGAAGATAAGGATAGTTTACAGGAA    c.1320
 I  H  K  L  H  K  F  L  G  S  D |   E  E  D  K  D  S  L  Q  E      p.440

          .         .         .         .         .         .       g.29847
 CTCTCTACAGAACAGAAATGCTTTGTTGAACACATCCTTTGTACGAAGCCATTGCCCTGC       c.1380
 L  S  T  E  Q  K  C  F  V  E  H  I  L  C  T  K  P  L  P  C         p.460

    | 10     .         .         .         .         .         .    g.33135
 AG | GCAGCCAGCTCCAATTCGAGGATTTTGGATTGTACCTGACATTCTGGGACCCACGATG    c.1440
 R  |  Q  P  A  P  I  R  G  F  W  I  V  P  D  I  L  G  P  T  M      p.480

          .         .         .         .     | 11   .         .    g.35795
 ATCTGCATCACCAGTACCTATGAATGCCTCATATGGCCGTTATT | AAGTACAGTCCATCCA    c.1500
 I  C  I  T  S  T  Y  E  C  L  I  W  P  L  L  |  S  T  V  H  P      p.500

          .         .         .         .         .         .       g.35855
 GCGTCTCCTCCCCTGCTTTGTACTCGAGAAGATGTTGAAGTGGCAGAGTCTCCCCTCCGT       c.1560
 A  S  P  P  L  L  C  T  R  E  D  V  E  V  A  E  S  P  L  R         p.520

          .         .         .         .         .         .       g.35915
 GTTCTGGCTGAAACCCCAGATTCCTTTGAAAAGCATATTAGAAGCATTTTGCAACGTAGT       c.1620
 V  L  A  E  T  P  D  S  F  E  K  H  I  R  S  I  L  Q  R  S         p.540

          .         .    | 12    .         .         .         .    g.36872
 GTTGCCAATCCAGCATTTTTGAA | AGCTTCTGAAAAGGACATAGCCCCTCCTCCTGAAGAA    c.1680
 V  A  N  P  A  F  L  K  |  A  S  E  K  D  I  A  P  P  P  E  E      p.560

          .         .         .         .         .         .       g.36932
 TGCCTTCAGCTCCTCAGCAGAGCCACCCAGGTGTTCAGAGAGCAGTACATTCTCAAACAG       c.1740
 C  L  Q  L  L  S  R  A  T  Q  V  F  R  E  Q  Y  I  L  K  Q         p.580

          .         .          | 13        .         .         .    g.37100
 GACTTGGCAAAGGAGGAGATTCAGCGGAG | GGTCAAATTATTATGTGACCAAAAAAAGAAA    c.1800
 D  L  A  K  E  E  I  Q  R  R  |  V  K  L  L  C  D  Q  K  K  K      p.600

          .         .         .      | 14  .         .         .    g.37298
 CAACTAGAAGATCTCAGTTATTGTCGAGAAGAGAG | GAAAAGTCTGCGGGAAATGGCTGAG    c.1860
 Q  L  E  D  L  S  Y  C  R  E  E  R  |  K  S  L  R  E  M  A  E      p.620

          .         .         .         .         .       | 15 .    g.37633
 CGTTTAGCTGACAAATATGAGGAAGCTAAAGAAAAACAAGAGGATATCATGAACAG | GATG    c.1920
 R  L  A  D  K  Y  E  E  A  K  E  K  Q  E  D  I  M  N  R  |  M      p.640

          .         .         .         .         .         .       g.37693
 AAAAAACTACTTCACAGTTTTCACTCTGAGCTCCCAGTTCTCTCTGATAGTGAGCGAGAC       c.1980
 K  K  L  L  H  S  F  H  S  E  L  P  V  L  S  D  S  E  R  D         p.660

          .         .         .         .         .         .       g.37753
 ATGAAGAAAGAATTACAGCTGATACCTGATCAACTTCGACATTTGGGCAATGCCATCAAA       c.2040
 M  K  K  E  L  Q  L  I  P  D  Q  L  R  H  L  G  N  A  I  K         p.680

     | 16    .         .         .         .         .         .    g.37970
 CAG | GTTACTATGAAAAAGGATTATCAACAGCAAAAGATGGAGAAGGTGTTGAGTCTTCCA    c.2100
 Q   | V  T  M  K  K  D  Y  Q  Q  Q  K  M  E  K  V  L  S  L  P      p.700

          .         .         .         .         .         .       g.38030
 AAACCCACCATTATTCTCAGTGCCTACCAGCGAAAGTGCATTCAGTCCATCCTGAAAGAG       c.2160
 K  P  T  I  I  L  S  A  Y  Q  R  K  C  I  Q  S  I  L  K  E         p.720

    | 17     .         .         .         .         .         .    g.38528
 GA | GGGTGAACATATAAGGGAAATGGTGAAGCAAATCAATGATATCCGCAATCATGTAAAC    c.2220
 E  |  G  E  H  I  R  E  M  V  K  Q  I  N  D  I  R  N  H  V  N      p.740

                                                                    g.38534
 TTCTGA                                                             c.2226
 F  X                                                               p.741

          .         .         .         .         .         .       g.38594
 caccaccaggagctgactcacacctgaactgaacaccattgaaggcttaaacccatattg       c.*60

          .         .         .         .         .         .       g.38654
 taaaacaggtagaattatctaatttataaaaaggtgttttgatgacctttggtgtggttc       c.*120

          .         .         .         .         .         .       g.38714
 atctttttaaatatgttgttttataataattgagtaaatgcttttatttaaaatttggaa       c.*180

 

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Nucleoporin 88kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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