nucleoporin 93kDa (NUP93) - coding DNA reference sequence

(used for variant description)

(last modified June 29, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_014669.4 in the NUP93 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_052904.1, covering NUP93 transcript NM_014669.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5001
                                                            g       c.-121

 .         .         .         .         .         .                g.5061
 ggagcggccagccttggccaatcaggaagcgggggagagcggcgcgagaagcggcggccg       c.-61

 .         .         .         .         .      | 02  .             g.23143
 cgtcctcaagccggcacctgagcggcggagacggctgtagcacaag | gatctgcatctcca    c.-1

          .         .         .         .         .         .       g.23203
 ATGGATACTGAGGGGTTTGGTGAGCTCCTTCAGCAAGCTGAACAGCTTGCTGCTGAGACT       c.60
 M  D  T  E  G  F  G  E  L  L  Q  Q  A  E  Q  L  A  A  E  T         p.20

          .         .         .         .         .         .       g.23263
 GAGGGCATCTCAGAGCTTCCCCATGTGGAACGGAACTTACAGGAGATCCAGCAGGCGGGA       c.120
 E  G  I  S  E  L  P  H  V  E  R  N  L  Q  E  I  Q  Q  A  G         p.40

          .         .         .         .         .          | 03    g.33434
 GAGCGCCTGCGTTCCCGTACCCTAACACGCACGTCCCAGGAGACGGCAGATGTCAAGGC | G    c.180
 E  R  L  R  S  R  T  L  T  R  T  S  Q  E  T  A  D  V  K  A  |      p.60

          .         .         .         .         .         .       g.33494
 TCAGTTCTCCTCGGGTCTCGGGGACTTGACATATCCCACATCTCCCAGCGATTGGAGAGT       c.240
 S  V  L  L  G  S  R  G  L  D  I  S  H  I  S  Q  R  L  E  S         p.80

          .         .         .         .         .        | 04.    g.73374
 CTGAGTGCAGCCACCACCTTTGAGCCTCTTGAGCCTGTGAAGGACACTGACATTCAG | GGC    c.300
 L  S  A  A  T  T  F  E  P  L  E  P  V  K  D  T  D  I  Q   | G      p.100

          .         .         .         .         .         .       g.73434
 TTCCTGAAGAATGAGAAGGACAATGCCCTGCTGTCTGCCATCGAAGAGTCCCGGAAGAGG       c.360
 F  L  K  N  E  K  D  N  A  L  L  S  A  I  E  E  S  R  K  R         p.120

  | 05       .         .         .         .         .         .    g.80459
  | ACCTTCGGCATGGCTGAGGAGTACCATCGGGAGTCAATGTTGGTTGAGTGGGAGCAAGTG    c.420
  | T  F  G  M  A  E  E  Y  H  R  E  S  M  L  V  E  W  E  Q  V      p.140

          .         .         .         .         .         .       g.80519
 AAACAGCGAATTCTGCACACACTGCTGGCATCAGGAGAAGACGCCCTTGACTTTACTCAA       c.480
 K  Q  R  I  L  H  T  L  L  A  S  G  E  D  A  L  D  F  T  Q         p.160

           | 06        .         .         .         .         .    g.93610
 GAAAGCGAG | CCAAGCTACATCAGTGATGTGGGACCCCCTGGTCGAAGCTCTCTGGATAAC    c.540
 E  S  E   | P  S  Y  I  S  D  V  G  P  P  G  R  S  S  L  D  N      p.180

          .         .     | 07   .         .         .         .    g.96435
 ATCGAGATGGCCTATGCGCGGCAA | ATTTATATCTATAATGAGAAAATTGTAAATGGACAC    c.600
 I  E  M  A  Y  A  R  Q   | I  Y  I  Y  N  E  K  I  V  N  G  H      p.200

          .         .         .         .         .     | 08   .    g.98608
 CTGCAGCCTAACCTGGTGGACCTTTGTGCTTCCGTCGCAGAGCTCGATGATAAG | AGCATT    c.660
 L  Q  P  N  L  V  D  L  C  A  S  V  A  E  L  D  D  K   | S  I      p.220

          .         .         .         .         .         .       g.98668
 TCCGACATGTGGACCATGGTAAAACAAATGACAGACGTGTTGTTGACACCGGCAACGGAT       c.720
 S  D  M  W  T  M  V  K  Q  M  T  D  V  L  L  T  P  A  T  D         p.240

          .         .         .         .         .         .       g.98728
 GCCCTGAAGAACCGCAGCAGCGTGGAAGTGCGCATGGAGTTTGTCAGGCAGGCCTTGGCG       c.780
 A  L  K  N  R  S  S  V  E  V  R  M  E  F  V  R  Q  A  L  A         p.260

          .     | 09   .         .         .         .         .    g.103918
 TACCTTGAGCAGAG | TTATAAGAATTACACCCTTGTGACTGTCTTTGGAAATTTGCATCAG    c.840
 Y  L  E  Q  S  |  Y  K  N  Y  T  L  V  T  V  F  G  N  L  H  Q      p.280

          .         .         .         .         .         .       g.103978
 GCCCAGCTGGGCGGGGTGCCTGGGACTTACCAATTGGTTCGAAGTTTCCTGAACATTAAA       c.900
 A  Q  L  G  G  V  P  G  T  Y  Q  L  V  R  S  F  L  N  I  K         p.300

          .         .        | 10.         .         .         .    g.105456
 CTGCCAGCTCCCTTGCCTGGACTACAG | GATGGAGAGGTGGAAGGCCATCCTGTGTGGGCG    c.960
 L  P  A  P  L  P  G  L  Q   | D  G  E  V  E  G  H  P  V  W  A      p.320

          .         .         .         .         .         .       g.105516
 CTAATTTACTACTGCATGCGCTGTGGAGACCTGCTTGCCGCTTCACAGGTAGTTAATCGA       c.1020
 L  I  Y  Y  C  M  R  C  G  D  L  L  A  A  S  Q  V  V  N  R         p.340

          .         .         .         .         .         .       g.105576
 GCCCAGCACCAGCTGGGAGAGTTTAAAACCTGGTTCCAGGAGTACATGAACAGCAAGGAC       c.1080
 A  Q  H  Q  L  G  E  F  K  T  W  F  Q  E  Y  M  N  S  K  D         p.360

       | 11  .         .         .         .         .         .    g.106792
 AGAAG | ATTGTCCCCAGCTACGGAAAACAAGCTCCGGCTGCATTACCGTAGGGCCCTCAGG    c.1140
 R  R  |  L  S  P  A  T  E  N  K  L  R  L  H  Y  R  R  A  L  R      p.380

          .         .         .         .         .         .       g.106852
 AACAATACAGATCCCTACAAGCGGGCCGTGTACTGTATCATTGGCAGATGTGACGTCACC       c.1200
 N  N  T  D  P  Y  K  R  A  V  Y  C  I  I  G  R  C  D  V  T         p.400

          .         .         .         .         .  | 12      .    g.107199
 GACAACCAGAGTGAAGTGGCGGACAAAACTGAGGATTACCTGTGGCTGAAG | TTGAACCAA    c.1260
 D  N  Q  S  E  V  A  D  K  T  E  D  Y  L  W  L  K   | L  N  Q      p.420

          .         .         .         .         .         .       g.107259
 GTGTGTTTTGACGACGATGGCACCAGCTCCCCACAAGACAGGCTCACTCTCTCACAGTTC       c.1320
 V  C  F  D  D  D  G  T  S  S  P  Q  D  R  L  T  L  S  Q  F         p.440

          .         .      | 13  .         .         .         .    g.108145
 CAGAAGCAGTTGTTGGAAGACTATG | GCGAGTCCCACTTTACGGTGAACCAGCAACCCTTC    c.1380
 Q  K  Q  L  L  E  D  Y  G |   E  S  H  F  T  V  N  Q  Q  P  F      p.460

          .         .         .         .         .         .       g.108205
 CTCTACTTCCAAGTCCTGTTCCTGACAGCGCAGTTTGAAGCAGCAGTTGCCTTTCTTTTC       c.1440
 L  Y  F  Q  V  L  F  L  T  A  Q  F  E  A  A  V  A  F  L  F         p.480

          .         .         .         .         .         .       g.108265
 CGCATGGAGCGGCTGCGCTGCCATGCTGTCCATGTAGCACTGGTGCTGTTTGAGCTGAAG       c.1500
 R  M  E  R  L  R  C  H  A  V  H  V  A  L  V  L  F  E  L  K         p.500

          .         .         .        | 14.         .         .    g.109046
 CTGCTTTTAAAGTCCTCTGGACAGAGTGCTCAGCTCC | TCAGCCACGAGCCTGGTGACCCT    c.1560
 L  L  L  K  S  S  G  Q  S  A  Q  L  L |   S  H  E  P  G  D  P      p.520

          .         .         .         .         .         .       g.109106
 CCTTGCTTGCGGCGGCTGAACTTCGTGCGGCTCCTCATGCTGTACACCCGGAAGTTTGAG       c.1620
 P  C  L  R  R  L  N  F  V  R  L  L  M  L  Y  T  R  K  F  E         p.540

          .         .         .         .     | 15   .         .    g.109281
 TCCACGGACCCAAGGGAGGCCCTCCAGTACTTCTATTTCCTCAG | GGATGAGAAAGATAGT    c.1680
 S  T  D  P  R  E  A  L  Q  Y  F  Y  F  L  R  |  D  E  K  D  S      p.560

          .         .         .         .         .        | 16.    g.109632
 CAAGGAGAAAACATGTTTCTGCGCTGTGTGAGTGAGCTTGTGATTGAAAGCCGAGAG | TTC    c.1740
 Q  G  E  N  M  F  L  R  C  V  S  E  L  V  I  E  S  R  E   | F      p.580

          .         .         .         .   | 17     .         .    g.111514
 GATATGATTCTTGGGAAACTAGAGAATGACGGAAGTAGAAAG | CCTGGAGTCATAGATAAG    c.1800
 D  M  I  L  G  K  L  E  N  D  G  S  R  K   | P  G  V  I  D  K      p.600

          .         .         .         .         .         .       g.111574
 TTTACTAGTGACACAAAGCCTATTATCAACAAAGTTGCTTCTGTGGCAGAAAATAAAGGA       c.1860
 F  T  S  D  T  K  P  I  I  N  K  V  A  S  V  A  E  N  K  G         p.620

          .         .         .          | 18        .         .    g.112524
 CTGTTTGAAGAGGCAGCAAAGCTGTATGACCTTGCCAAG | AATGCTGACAAGGTACTGGAG    c.1920
 L  F  E  E  A  A  K  L  Y  D  L  A  K   | N  A  D  K  V  L  E      p.640

          .         .         .         .         .         .       g.112584
 CTGATGAACAAACTGCTGAGCCCTGTCGTCCCCCAGATCAGTGCCCCGCAATCCAACAAG       c.1980
 L  M  N  K  L  L  S  P  V  V  P  Q  I  S  A  P  Q  S  N  K         p.660

          .         .         .         | 19         .         .    g.113869
 GAGAGGCTGAAGAACATGGCACTCTCCATTGCCGAACG | GTATAGGGCTCAAGGAATAAGC    c.2040
 E  R  L  K  N  M  A  L  S  I  A  E  R  |  Y  R  A  Q  G  I  S      p.680

          .         .         .         .         .         .       g.113929
 GCAAATAAATTTGTGGACTCCACGTTCTATCTTCTTTTGGACTTGATCACCTTTTTTGAC       c.2100
 A  N  K  F  V  D  S  T  F  Y  L  L  L  D  L  I  T  F  F  D         p.700

          .         .         .       | 20 .         .         .    g.114440
 GAGTATCATAGTGGTCATATTGATAGAGCTTTTGAT | ATCATTGAGCGCTTGAAGCTGGTG    c.2160
 E  Y  H  S  G  H  I  D  R  A  F  D   | I  I  E  R  L  K  L  V      p.720

          .         .         .         .         .         .       g.114500
 CCCCTGAATCAGGAAAGTGTGGAAGAGAGAGTGGCTGCCTTCAGAAATTTCAGTGATGAA       c.2220
 P  L  N  Q  E  S  V  E  E  R  V  A  A  F  R  N  F  S  D  E         p.740

  | 21       .         .         .         .         .         .    g.116660
  | ATCAGGCACAACCTCTCAGAAGTGCTTCTTGCCACCATGAACATCTTGTTCACACAGTTT    c.2280
  | I  R  H  N  L  S  E  V  L  L  A  T  M  N  I  L  F  T  Q  F      p.760

          .         .         .         .         .         .       g.116720
 AAGAGGCTCAAGGGGACAAGTCCATCCTCGTCATCCAGGCCCCAGCGAGTCATCGAGGAC       c.2340
 K  R  L  K  G  T  S  P  S  S  S  S  R  P  Q  R  V  I  E  D         p.780

           | 22        .         .         .         .         .    g.119445
 CGCGACTCT | CAACTCCGAAGTCAAGCCCGCACTCTGATTACCTTTGCTGGAATGATACCA    c.2400
 R  D  S   | Q  L  R  S  Q  A  R  T  L  I  T  F  A  G  M  I  P      p.800

          .         .         .         .         .         .       g.119505
 TACCGAACGTCTGGGGACACCAATGCGAGGCTGGTGCAGATGGAGGTCCTCATGAATTAA       c.2460
 Y  R  T  S  G  D  T  N  A  R  L  V  Q  M  E  V  L  M  N  X         p.819

          .         .         .         .         .         .       g.119565
 gtgccatgctttgtgggagtctgggtcggcacactgtcagtacatcaggcacatgggccc       c.*60

          .         .         .         .         .         .       g.119625
 actaggctggggtttctggttttgtttctgttgtgttttgttttggtttctgtattatgt       c.*120

          .         .         .         .         .         .       g.119685
 atttttgtcaacgccaataaatttctttgatttgtatttcttttcaacattcttttattt       c.*180

          .         .         .         .         .         .       g.119745
 tctttttttttttctttgaaattttgtttacatttttatttgtgtaatgggaaataccgt       c.*240

          .         .         .         .         .         .       g.119805
 cactagctcttgggccagggaatgagaggctatgtagatattcattatttggttaaattg       c.*300

          .         .         .         .                           g.119846
 accttaattaattaaaaatctacccaaaatgagccaggaaa                          c.*341

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Nucleoporin 93kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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