nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) (NUS1) - coding DNA reference sequence

(used for variant description)

(last modified November 1, 2017)

This file was created to facilitate the description of sequence variants on transcript NM_138459.3 in the NUS1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_054913.1, covering NUS1 transcript NM_138459.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                               .         .         .                g.5037
                        atcggaactgtccatgtactactgggggcggggctgc       c.-181

 .         .         .         .         .         .                g.5097
 caagggaggaggaagatggcggcgggggcgaggtgaggtgttggcagtggaaaggggttc       c.-121

 .         .         .         .         .         .                g.5157
 gggctcggggggcggggggacgcggagcgatggcccgcgccggccgcaggggcggataaa       c.-61

 .         .         .         .         .         .                g.5217
 aagccgtcgcgctgcgggagtgggcgggagggagagggggtgtctgagggccacaagagt       c.-1

          .         .         .         .         .         .       g.5277
 ATGACGGGGCTGTACGAGCTGGTGTGGCGGGTGCTGCACGCGCTGCTCTGTCTGCACCGC       c.60
 M  T  G  L  Y  E  L  V  W  R  V  L  H  A  L  L  C  L  H  R         p.20

          .         .         .         .         .         .       g.5337
 ACGCTCACCTCCTGGCTCCGCGTTCGGTTCGGCACCTGGAACTGGATCTGGCGGCGCTGC       c.120
 T  L  T  S  W  L  R  V  R  F  G  T  W  N  W  I  W  R  R  C         p.40

          .         .         .         .         .         .       g.5397
 TGCCGCGCCGCCTCTGCCGCGGTCCTAGCGCCGCTCGGCTTCACGCTCCGCAAGCCCCCG       c.180
 C  R  A  A  S  A  A  V  L  A  P  L  G  F  T  L  R  K  P  P         p.60

          .         .         .         .         .         .       g.5457
 GCAGTCGGCAGGAACCGCCGTCACCACCGGCACCCGCGCGGGGGGTCGTGCCTGGCAGCC       c.240
 A  V  G  R  N  R  R  H  H  R  H  P  R  G  G  S  C  L  A  A         p.80

          .         .         .         .         .         .       g.5517
 GCACACCACCGGATGCGCTGGCGCGCGGACGGTCGTTCCTTGGAGAAGCTGCCTGTGCAT       c.300
 A  H  H  R  M  R  W  R  A  D  G  R  S  L  E  K  L  P  V  H         p.100

          .         .         .         .         .         .       g.5577
 ATGGGCCTGGTGATCACCGAGGTGGAGCAGGAACCCAGCTTCTCGGACATCGCGAGCCTC       c.360
 M  G  L  V  I  T  E  V  E  Q  E  P  S  F  S  D  I  A  S  L         p.120

          .         .         .         .         .      | 02  .    g.22593
 GTGGTGTGGTGTATGGCCGTGGGCATCTCCTACATTAGCGTCTACGACCACCAAG | GTATT    c.420
 V  V  W  C  M  A  V  G  I  S  Y  I  S  V  Y  D  H  Q  G |   I      p.140

          .         .         .         .         .         .       g.22653
 TTCAAAAGAAATAATTCCAGATTGATGGATGAAATTTTAAAACAACAGCAAGAACTTCTG       c.480
 F  K  R  N  N  S  R  L  M  D  E  I  L  K  Q  Q  Q  E  L  L         p.160

          .         .         .         .         .         .       g.22713
 GGCCTAGATTGTTCAAAATACTCACCAGAATTTGCAAATAGTAATGACAAAGATGATCAA       c.540
 G  L  D  C  S  K  Y  S  P  E  F  A  N  S  N  D  K  D  D  Q         p.180

   | 03      .         .         .         .         .         .    g.23636
 G | TTTTAAATTGCCATTTGGCAGTGAAGGTGCTGTCTCCGGAAGATGGAAAAGCAGATATT    c.600
 V |   L  N  C  H  L  A  V  K  V  L  S  P  E  D  G  K  A  D  I      p.200

          .         .         .         .         .         .       g.23696
 GTAAGAGCTGCTCAGGACTTTTGCCAGTTAGTAGCCCAGAAGCAAAAGAGACCCACAGAT       c.660
 V  R  A  A  Q  D  F  C  Q  L  V  A  Q  K  Q  K  R  P  T  D         p.220

          .         .         .  | 04      .         .         .    g.33180
 TTGGATGTAGATACGTTAGCCAGTTTACTTA | GTTCAAATGGTTGTCCTGATCCTGATTTA    c.720
 L  D  V  D  T  L  A  S  L  L  S |   S  N  G  C  P  D  P  D  L      p.240

          .         .         .         .         .         .       g.33240
 GTATTGAAGTTCGGTCCTGTGGACAGCACATTAGGCTTTCTTCCCTGGCACATCAGATTG       c.780
 V  L  K  F  G  P  V  D  S  T  L  G  F  L  P  W  H  I  R  L         p.260

          .  | 05      .         .         .         .         .    g.36520
 ACTGAGATTGT | CTCTTTGCCTTCCCACCTAAACATCAGTTATGAGGACTTTTTCTCTGCC    c.840
 T  E  I  V  |  S  L  P  S  H  L  N  I  S  Y  E  D  F  F  S  A      p.280

          .         .         .         .                           g.36562
 CTTCGTCAATATGCAGCCTGTGAACAGCGTCTGGGAAAGTAG                         c.882
 L  R  Q  Y  A  A  C  E  Q  R  L  G  K  X                           p.293

          .         .         .         .         .         .       g.36622
 tggtcattggttgcataatttgatttgaggcttgtggaggaaaggaaccaagtgactctg       c.*60

          .         .         .         .         .         .       g.36682
 atgtttacaaagcacctatgaaaccctgtacacacctagttcataatcctcataatttat       c.*120

          .         .         .         .         .         .       g.36742
 caacaaacacaaaaaagtgtcttacttgagagtgagtgtgtgtgtgtgcgtgtgcacgtg       c.*180

          .         .         .         .         .         .       g.36802
 cacacatgtgcacgtttgtatgtatggaaataaacttataaatggggacgtattggagaa       c.*240

          .         .         .         .         .         .       g.36862
 ggaaatacatagacctacaactttgagcaaatagcagtgatgttttaggaactgaaatgt       c.*300

          .         .         .         .         .         .       g.36922
 cacacttaaagtcttcagcccagctacttccctatttttgtggggagaagagggcctgat       c.*360

          .         .         .         .         .         .       g.36982
 tagaactgttctggttgtgtttggcgggaggggaataatttttgttcagtccttcttagt       c.*420

          .         .         .         .         .         .       g.37042
 gaccaaactttaatttttaagaataatatattgacttactgaactgaagcattctgagtt       c.*480

          .         .         .         .         .         .       g.37102
 gaaaggagctccagaggagtggagttctgtgttgctcacatgttaaaatcttgctcacct       c.*540

          .         .         .         .         .         .       g.37162
 tcagagcagagggaatacctatcttcagatatccgtccattttcatctcttaattgtagt       c.*600

          .         .         .         .         .         .       g.37222
 caaaagtatgacttgagagtgttgctctggtattctgggttctgaagtctggtattctgg       c.*660

          .         .         .         .         .         .       g.37282
 tattctgggttcaaaagtatgacttgagagtgttgctctggtattctgagagttgctctg       c.*720

          .         .         .         .         .         .       g.37342
 tattctgggttctgaagattatttgaaaaataactcctactacattgaaatgcagactta       c.*780

          .         .         .         .         .         .       g.37402
 aaaatttaaacattggattaggcagtcaaaaaaaccaagcaagcataaaaggtcaataag       c.*840

          .         .         .         .         .         .       g.37462
 ttgtaatcttgatagtaaaggtggaaaacttattataaatggaaagaaagttttatttcc       c.*900

          .         .         .         .         .         .       g.37522
 ttttttgtttgatgggcagtatgccatattatacccaaagttcttttaaaaaatatttcc       c.*960

          .         .         .         .         .         .       g.37582
 atcaaccatttttatttaaaataaacatttgagggaagttaccaaggcagcttttttcct       c.*1020

          .         .         .         .         .         .       g.37642
 caaaagtaacctgttcctctttggaatagcacattttaggggcatggttaatacctgaga       c.*1080

          .         .         .         .         .         .       g.37702
 tttttactcagtaaatcctgatggttactgtgtgtaaaatatctttaagtaggattgaag       c.*1140

          .         .         .         .         .         .       g.37762
 gcctctgtgggggaataaaatattaccaaagtctataaaaataaattttacatgttctct       c.*1200

          .         .         .         .         .         .       g.37822
 tttatgacagagagcagcactggttctgttatttttaaaatgaataattgatttcttgat       c.*1260

          .         .         .         .         .         .       g.37882
 aggtgtttaatatttcttccctcactgctgattcttagatagaaaccattctttatattt       c.*1320

          .         .         .         .         .         .       g.37942
 gatagactgctttcagaaaacccttatcaacaagtgtacaatacttatctaaaactatac       c.*1380

          .         .         .         .         .         .       g.38002
 atttagaatggagcagtttaatactagatctcagaagttttgaaaaatagcaaagaagac       c.*1440

          .         .         .         .         .         .       g.38062
 tggatttggaaagcatggtctacaattggttgttaaattctgaagctatgaagaataaat       c.*1500

          .         .         .         .         .         .       g.38122
 gtttcaactttggattatgaaaccccatttatgattttttaaatacacttgaaataaaaa       c.*1560

          .         .         .         .         .         .       g.38182
 tgattaaactaaattttggtccagtgacattactttgcactgcataatccattatacgtt       c.*1620

          .         .         .         .         .         .       g.38242
 gtacgactttttttttttgttttaatttattactgagagttttgtgtgaagctacagcat       c.*1680

          .         .         .         .         .         .       g.38302
 atctaaccagagaatttctgattccttatactgtgattatattatattgaggcatttgta       c.*1740

          .         .         .         .         .         .       g.38362
 gtgcagctgaagactgaatttatgccttttgtaaacatgataggtataaatgtcttataa       c.*1800

          .         .         .         .         .         .       g.38422
 acattctggagtatgtatagctttaatgaatgaaatttaatggacctgattaaaatgaag       c.*1860

          .         .         .         .         .         .       g.38482
 ggatttaatcgttgttaaagttaagttagtcaaataaattacctactggaatatagccca       c.*1920

          .         .         .         .         .         .       g.38542
 agccagtaaaggtttaatatttgcattttcgtgcttttattttctccttccattcataag       c.*1980

          .         .         .         .         .         .       g.38602
 tatatacttgaaagtacatctgtagcctatgatttgagtctcttgaagttctaggaagag       c.*2040

          .         .         .         .         .         .       g.38662
 gcaaactacaaactactaggattctgatttcagatgtagtcattccagaaccttctcttt       c.*2100

          .         .         .         .         .         .       g.38722
 atgagttcacctgctagtacaatctccacaacttgaatggcattggttgttctgtaattc       c.*2160

          .         .         .         .         .         .       g.38782
 ctgccaaaagcatcacaagttgtacatcatcaaggctccctttgcactcccaagaagaac       c.*2220

          .         .         .         .         .         .       g.38842
 tggtaattttaaacaaaagtatgtgtctttatttgtattggaaaatactgtctttaaatt       c.*2280

          .         .         .         .         .         .       g.38902
 gtttcttgttgacactccccacaatggaaaaattaccgaattaaacctgttttatggatg       c.*2340

          .         .         .         .         .         .       g.38962
 gcagcttggagcatagcaagaagttggaggatttgaattccattcccagttctcattgtg       c.*2400

          .         .         .         .         .         .       g.39022
 ttttgtttcttaaaactataataatcggttactgttataaagtttaaaaggtggttttaa       c.*2460

          .         .         .         .         .         .       g.39082
 tgtgaatagcaaattctggtatatcgtgactaacgcttaagaatgcctgtctttgagagg       c.*2520

          .         .         .         .         .         .       g.39142
 aaggtgttataatattaatgaacagtgccaaatacactgtgcatatctgcaatttaatct       c.*2580

          .         .         .         .         .         .       g.39202
 ttgaatgtatgttactggattagctccctcctcctgtgtgatggtaccatgcatagagtc       c.*2640

          .         .         .         .         .         .       g.39262
 aatcaaatccttgtgatgttttgtatggactttgacaatatgtaaataatgtgtaaagcc       c.*2700

          .         .         .         .         .         .       g.39322
 agtttttatgattaaggaatcaaatttattgaattttattattgaaagttgaaacttaac       c.*2760

          .         .         .         .         .         .       g.39382
 atgtatgaacaaaaaccaataaaagaatatactcttttcattgactatagtattatgtga       c.*2820

          .         .         .         .         .         .       g.39442
 atgctacatttgttctgaacacttaggggctgcaaaaatgtaataagaaatgcatatgac       c.*2880

          .         .         .         .         .         .       g.39502
 tagatagcaatagtgttttttttagatggtatgctcttgattgaaatatattctcacttt       c.*2940

          .         .         .         .         .         .       g.39562
 taccaggttaaacatttggaatcttataatgttacttgctttttgatagataatagtgaa       c.*3000

          .         .         .         .         .         .       g.39622
 ataaattcagctttgccattgctggagttgtcaaaattccacagtaattaaaatttgaat       c.*3060

          .         .         .         .         .         .       g.39682
 ttttaccgaatatgaaatttccaaattaaaaacgtatatgtgtactcttttaaaaaggaa       c.*3120

          .         .         .         .         .         .       g.39742
 tttgatagttcttgtcaaatgagaaaatttaaaggtaagagttatggtttgtcttatgct       c.*3180

          .         .         .         .         .         .       g.39802
 gcatagactattcacctcctaacttgaaggtctaatcataagacaattgtttttttgtgc       c.*3240

          .         .         .         .         .         .       g.39862
 atagttttcatctaaaattaagtttaccaaaggcaaataactgcttactaggaacttcct       c.*3300

          .         .         .         .         .         .       g.39922
 ttagcaaaaattactataaagttcaggacagtttgaaataaaacccaggaaacaagatta       c.*3360

          .         .         .         .         .         .       g.39982
 atgtgagcagttctccaagatcctaactggtgggacataaactatgatgcaatggatagg       c.*3420

          .         .         .         .         .         .       g.40042
 aaaaggtagtgcaaaaagaatttcttaaggtttaaaaaatacacttttcattataggaaa       c.*3480

          .         .         .         .         .         .       g.40102
 aagaagattcagagaaacaaaggaatgtaaccttattgattacatttttggtgatcaccg       c.*3540

          .         .         .         .         .         .       g.40162
 agaattttttgtactatattttaaaaaatgtattctactgtaacaagttaataaagagat       c.*3600

          .         .         .         .         .         .       g.40222
 tttttaaaaaactataaactagaaattgagagtcttgcattctcttttgtatttgattat       c.*3660

          .         .         .         .         .                 g.40274
 tgtgtctggatataaattacaatagcacatgaaaataaaatgttttaaaaaa               c.*3712

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.