nucleoredoxin (NXN) - coding DNA reference sequence

(used for variant description)

(last modified September 29, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_022463.4 in the NXN gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering NXN transcript NM_022463.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5020
                                         cgccgacgccgccgcctcct       c.-61

 .         .         .         .         .         .                g.5080
 cccgccgcgcggaccgtggagcggggtcgcagccgcctgcccgccctgcggtgggccagg       c.-1

          .         .         .         .         .         .       g.5140
 ATGTCGGGCTTCCTGGAGGAGCTGCTCGGCGAGAAGCTGGTGACGGGCGGCGGCGAGGAG       c.60
 M  S  G  F  L  E  E  L  L  G  E  K  L  V  T  G  G  G  E  E         p.20

          .         .         .         .         .         .       g.5200
 GTGGACGTGCACTCGCTGGGCGCCCGCGGCATCTCGCTGCTGGGTCTCTACTTCGGCTGC       c.120
 V  D  V  H  S  L  G  A  R  G  I  S  L  L  G  L  Y  F  G  C         p.40

          .         .         .         .         .         .       g.5260
 AGCCTCAGCGCCCCCTGCGCGCAGCTCAGCGCCAGCCTGGCCGCCTTCTACGGGCGCCTG       c.180
 S  L  S  A  P  C  A  Q  L  S  A  S  L  A  A  F  Y  G  R  L         p.60

          .         .         .         .         .         .       g.5320
 CGGGGGGACGCGGCGGCCGGGCCGGGGCCGGGAGCGGGGGCCGGGGCGGCGGCGGAGCCC       c.240
 R  G  D  A  A  A  G  P  G  P  G  A  G  A  G  A  A  A  E  P         p.80

          .         .         .         .         .         .       g.5380
 GAGCCGCGGCGGCGCCTGGAGATCGTCTTCGTGTCCTCGGACCAGGACCAGCGGCAGTGG       c.300
 E  P  R  R  R  L  E  I  V  F  V  S  S  D  Q  D  Q  R  Q  W         p.100

          .         .         .         .         .         .       g.5440
 CAGGACTTCGTGCGGGACATGCCGTGGCTGGCGCTGCCCTACAAGGAGAAGCACAGGAAG       c.360
 Q  D  F  V  R  D  M  P  W  L  A  L  P  Y  K  E  K  H  R  K         p.120

  | 02       .         .         .         .         .         .    g.158740
  | CTCAAACTTTGGAACAAATACCGAATTTCCAACATTCCATCACTAATATTCCTCGACGCC    c.420
  | L  K  L  W  N  K  Y  R  I  S  N  I  P  S  L  I  F  L  D  A      p.140

          .         .         .         .         .         | 03    g.160995
 ACCACTGGGAAGGTTGTGTGCAGGAACGGGCTGCTGGTGATCCGAGATGACCCAGAAG | GT    c.480
 T  T  G  K  V  V  C  R  N  G  L  L  V  I  R  D  D  P  E  G |       p.160

          .         .         .         .         .         .       g.161055
 CTGGAGTTCCCCTGGGGACCGAAACCCTTCAGGGAAGTCATTGCAGGGCCCTTGCTTAGA       c.540
 L  E  F  P  W  G  P  K  P  F  R  E  V  I  A  G  P  L  L  R         p.180

          .         .         .         .         .         .       g.161115
 AACAATGGGCAGTCTCTGGAGAGCAGCAGCCTGGAGGGGTCTCACGTGGGCGTCTATTTC       c.600
 N  N  G  Q  S  L  E  S  S  S  L  E  G  S  H  V  G  V  Y  F         p.200

          .   | 04     .         .         .         .         .    g.162349
 TCCGCACATTGG | TGTCCGCCCTGCCGAAGCCTCACCCGGGTCCTGGTGGAATCCTACCGG    c.660
 S  A  H  W   | C  P  P  C  R  S  L  T  R  V  L  V  E  S  Y  R      p.220

          .         .         .         .         .    | 05    .    g.165220
 AAGATCAAGGAGGCAGGCCAGAACTTCGAGATCATCTTCGTTAGTGCAGACAG | GTCGGAG    c.720
 K  I  K  E  A  G  Q  N  F  E  I  I  F  V  S  A  D  R  |  S  E      p.240

          .         .         .         .         .         .       g.165280
 GAGTCCTTCAAACAGTACTTCAGTGAGATGCCCTGGCTCGCCGTCCCCTACACGGATGAG       c.780
 E  S  F  K  Q  Y  F  S  E  M  P  W  L  A  V  P  Y  T  D  E         p.260

          .         .         .         . | 06       .         .    g.179531
 GCCCGGCGGTCGCGCCTCAACCGGCTGTACGGAATCCAAG | GCATCCCCACGCTCATCATG    c.840
 A  R  R  S  R  L  N  R  L  Y  G  I  Q  G |   I  P  T  L  I  M      p.280

          .         .         .         .         .         .       g.179591
 CTGGACCCGCAGGGCGAGGTGATCACGCGGCAGGGGCGGGTGGAGGTGCTGAACGACGAG       c.900
 L  D  P  Q  G  E  V  I  T  R  Q  G  R  V  E  V  L  N  D  E         p.300

          .         .         .         .         .         .       g.179651
 GACTGCCGGGAGTTCCCCTGGCACCCCAAGCCCGTGCTGGAGCTCTCCGACTCCAACGCC       c.960
 D  C  R  E  F  P  W  H  P  K  P  V  L  E  L  S  D  S  N  A         p.320

          .         .         .         . | 07       .         .    g.180972
 GCGCAGCTTAACGAGGGCCCCTGCCTCGTCCTTTTTGTAG | ATTCTGAGGATGACGGAGAG    c.1020
 A  Q  L  N  E  G  P  C  L  V  L  F  V  D |   S  E  D  D  G  E      p.340

          .         .         .         .         .         .       g.181032
 TCCGAGGCGGCCAAGCAGCTGATTCAGCCGATAGCTGAGAAAATCATTGCCAAGTACAAA       c.1080
 S  E  A  A  K  Q  L  I  Q  P  I  A  E  K  I  I  A  K  Y  K         p.360

          .         .         .         .      | 08  .         .    g.183642
 GCCAAAGAGGAGGAGGCACCCCTTCTGTTCTTCGTAGCCGGGGAG | GATGACATGACTGAC    c.1140
 A  K  E  E  E  A  P  L  L  F  F  V  A  G  E   | D  D  M  T  D      p.380

          .         .         .         .         .         .       g.183702
 TCCCTGCGAGATTACACCAACCTGCCTGAGGCTGCCCCTTTGCTCACCATCCTGGACATG       c.1200
 S  L  R  D  Y  T  N  L  P  E  A  A  P  L  L  T  I  L  D  M         p.400

          .         .         .         .         .         .       g.183762
 TCAGCCCGGGCCAAGTACGTGATGGACGTGGAGGAGATCACCCCCGCCATCGTGGAGGCC       c.1260
 S  A  R  A  K  Y  V  M  D  V  E  E  I  T  P  A  I  V  E  A         p.420

          .         .         .         .                           g.183810
 TTTGTGAATGACTTCCTAGCAGAGAAGCTCAAACCGGAGCCCATCTAG                   c.1308
 F  V  N  D  F  L  A  E  K  L  K  P  E  P  I  X                     p.435

          .         .         .         .         .         .       g.183870
 cgtggctccggcctcctgagacgttatttaaaactcagccttctcctcctccccctcctt       c.*60

          .         .         .         .         .         .       g.183930
 ccttccgcccttggacttacccagcgtgccccgaatcccaccacccaagtgtccagcctc       c.*120

          .         .         .         .         .         .       g.183990
 tctgtggtgccttgtttctgcagtaaactcctcagccagcaccctggggtgtggaatcag       c.*180

          .         .         .         .         .         .       g.184050
 cagcggcagagtccaccgtgtttggagactctgtttgggagcacgggatggccgggggcc       c.*240

          .         .         .         .         .         .       g.184110
 cggccagagcggggctgcatggctttcgcaaagtcactagcttttggtgaaggatctgcc       c.*300

          .         .         .         .         .         .       g.184170
 agggtgtcctgggcagagtgagcgtggagggccggtgggtcccgctcgggctctgactct       c.*360

          .         .         .         .         .         .       g.184230
 gacgtcggcacacacggccccggacggccagaggggaaccgccgggtgacacctgcgtgg       c.*420

          .         .         .         .         .         .       g.184290
 aggctgagctgagaaagggcctccgcttagagctgcgggtgaggacgtccttttctaagc       c.*480

          .         .         .         .         .         .       g.184350
 aacacagtcttcctcggtctgagagaaaagcagcccactcttgtgttctcaggcagggga       c.*540

          .         .         .         .         .         .       g.184410
 tctccaaatgcaaaaggaagcttgtagaggttttttgggtgagaagaaaaatgtagctaa       c.*600

          .         .         .         .         .         .       g.184470
 ggtaatggttcatatcatacaaacagctcccacgatcctgaaattctgttaacgaatcct       c.*660

          .         .         .         .         .         .       g.184530
 tctctttggacatcttcccaagaaacttagccctgagtcctaggaggagcacctctgcac       c.*720

          .         .         .         .         .         .       g.184590
 cagcacggacctctcgctccacccagctctgtgcccaaggcccctgatctctgctgaggt       c.*780

          .         .         .         .         .         .       g.184650
 gcccacacccacgttcgatcacccctgccattcccttttattttcttttttttgagatgg       c.*840

          .         .         .         .         .         .       g.184710
 agtcttgctctgtcgcccaggctggagtgcagtggcaccatcttggctcacttcaacctc       c.*900

          .         .         .         .         .         .       g.184770
 cgcccccaaggttcaagtgattctcctgcctcagcctcccgagtagctgggattacaggc       c.*960

          .         .         .         .         .         .       g.184830
 acccgccaccgtacctggctaatttttgtatttttagtagagatggggtttcaccatgtt       c.*1020

          .         .         .         .         .         .       g.184890
 ggccaggctggtctcgaactcctgacctcaggtgatccacccgcctcggcctcccaaagt       c.*1080

          .         .         .         .         .         .       g.184950
 gctgggattacaggcgtgagccgccgtgcccggcccccttttcttttcaaagcagaacta       c.*1140

          .         .         .         .         .         .       g.185010
 caaagatgagaaattaccagaagcctcgccttttcctaagcaccagcggaaggagctgtg       c.*1200

          .         .         .         .         .         .       g.185070
 ccccgggatggagtgagggtggagggcgcgtcagccacgggtgggccttgtgtcgccttg       c.*1260

          .         .         .         .         .         .       g.185130
 tatcggcccaggtaggttgttggcctcttacttgggctgacctgacccccgaaagagaaa       c.*1320

          .         .         .         .         .         .       g.185190
 cagacaactctgttctcaggattggggatggacggcttcggccaagcgttttagcctcat       c.*1380

          .         .         .         .         .         .       g.185250
 tcactcaggccccactcagcactctgccagccaagaccattgatttggaaaatccggtcc       c.*1440

          .         .         .         .         .         .       g.185310
 ccacccgctaatgagctgttgacactgttgttccttgctgaattggattgttgacttgta       c.*1500

          .         .         .         .         .         .       g.185370
 gttcagaggcgtacaactagttggcgattagacttgttatgtgatgttaccagcctgaaa       c.*1560

          .         .         .         .         .         .       g.185430
 tgcgatcaccccgtaggaaataaagcaggcatctctggacctcatccaccctgggcctct       c.*1620

          .                                                         g.185446
 gctgtccttgatcaca                                                   c.*1636

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Nucleoredoxin protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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