2'-5'-oligoadenylate synthetase 1, 40/46kDa (OAS1) - coding DNA reference sequence

(used for variant description)

(last modified March 24, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_016816.2 in the OAS1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011530.2, covering OAS1 transcript NM_016816.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5046
               tcccttctgaggaaacgaaaccaacagcagtccaagctcagtcagc       c.-61

 .         .         .         .         .         .                g.5106
 agaagagataaaagcaaacaggtctgggaggcagttctgttgccactctctctcctgtca       c.-1

          .         .         .         .         .         .       g.5166
 ATGATGGATCTCAGAAATACCCCAGCCAAATCTCTGGACAAGTTCATTGAAGACTATCTC       c.60
 M  M  D  L  R  N  T  P  A  K  S  L  D  K  F  I  E  D  Y  L         p.20

          .         .         .         .         .         .       g.5226
 TTGCCAGACACGTGTTTCCGCATGCAAATCAACCATGCCATTGACATCATCTGTGGGTTC       c.120
 L  P  D  T  C  F  R  M  Q  I  N  H  A  I  D  I  I  C  G  F         p.40

          .         .         .         .         .         .       g.5286
 CTGAAGGAAAGGTGCTTCCGAGGTAGCTCCTACCCTGTGTGTGTGTCCAAGGTGGTAAAG       c.180
 L  K  E  R  C  F  R  G  S  S  Y  P  V  C  V  S  K  V  V  K         p.60

  | 02       .         .         .         .         .         .    g.6662
  | GGTGGCTCCTCAGGCAAGGGCACCACCCTCAGAGGCCGATCTGACGCTGACCTGGTTGTC    c.240
  | G  G  S  S  G  K  G  T  T  L  R  G  R  S  D  A  D  L  V  V      p.80

          .         .         .         .         .         .       g.6722
 TTCCTCAGTCCTCTCACCACTTTTCAGGATCAGTTAAATCGCCGGGGAGAGTTCATCCAG       c.300
 F  L  S  P  L  T  T  F  Q  D  Q  L  N  R  R  G  E  F  I  Q         p.100

          .         .         .         .         .         .       g.6782
 GAAATTAGGAGACAGCTGGAAGCCTGTCAAAGAGAGAGAGCATTTTCCGTGAAGTTTGAG       c.360
 E  I  R  R  Q  L  E  A  C  Q  R  E  R  A  F  S  V  K  F  E         p.120

          .         .         .         .         .         .       g.6842
 GTCCAGGCTCCACGCTGGGGCAACCCCCGTGCGCTCAGCTTCGTACTGAGTTCGCTCCAG       c.420
 V  Q  A  P  R  W  G  N  P  R  A  L  S  F  V  L  S  S  L  Q         p.140

          .         .         .         .          | 03        .    g.9128
 CTCGGGGAGGGGGTGGAGTTCGATGTGCTGCCTGCCTTTGATGCCCTGG | GTCAGTTGACT    c.480
 L  G  E  G  V  E  F  D  V  L  P  A  F  D  A  L  G |   Q  L  T      p.160

          .         .         .         .         .         .       g.9188
 GGCGGCTATAAACCTAACCCCCAAATCTATGTCAAGCTCATCGAGGAGTGCACCGACCTG       c.540
 G  G  Y  K  P  N  P  Q  I  Y  V  K  L  I  E  E  C  T  D  L         p.180

          .         .         .         .         .         .       g.9248
 CAGAAAGAGGGCGAGTTCTCCACCTGCTTCACAGAACTACAGAGAGACTTCCTGAAGCAG       c.600
 Q  K  E  G  E  F  S  T  C  F  T  E  L  Q  R  D  F  L  K  Q         p.200

          .         .         .         .         .     | 04   .    g.14581
 CGCCCCACCAAGCTCAAGAGCCTCATCCGCCTAGTCAAGCACTGGTACCAAAAT | TGTAAG    c.660
 R  P  T  K  L  K  S  L  I  R  L  V  K  H  W  Y  Q  N   | C  K      p.220

          .         .         .         .         .         .       g.14641
 AAGAAGCTTGGGAAGCTGCCACCTCAGTATGCCCTGGAGCTCCTGACGGTCTATGCTTGG       c.720
 K  K  L  G  K  L  P  P  Q  Y  A  L  E  L  L  T  V  Y  A  W         p.240

          .         .         .         .         .         .       g.14701
 GAGCGAGGGAGCATGAAAACACATTTCAACACAGCCCAGGGATTTCGGACGGTCTTGGAA       c.780
 E  R  G  S  M  K  T  H  F  N  T  A  Q  G  F  R  T  V  L  E         p.260

          .         .         .         .         .         .       g.14761
 TTAGTCATAAACTACCAGCAACTCTGCATCTACTGGACAAAGTATTATGACTTTAAAAAC       c.840
 L  V  I  N  Y  Q  Q  L  C  I  Y  W  T  K  Y  Y  D  F  K  N         p.280

          .         .         .         .     | 05   .         .    g.15629
 CCCATTATTGAAAAGTACCTGAGAAGGCAGCTCACGAAACCCAG | GCCTGTGATCCTGGAC    c.900
 P  I  I  E  K  Y  L  R  R  Q  L  T  K  P  R  |  P  V  I  L  D      p.300

          .         .         .         .         .         .       g.15689
 CCGGCGGACCCTACAGGAAACTTGGGTGGTGGAGACCCAAAGGGTTGGAGGCAGCTGGCA       c.960
 P  A  D  P  T  G  N  L  G  G  G  D  P  K  G  W  R  Q  L  A         p.320

          .         .         .         .         .         .       g.15749
 CAAGAGGCTGAGGCCTGGCTGAATTACCCATGCTTTAAGAATTGGGATGGGTCCCCAGTG       c.1020
 Q  E  A  E  A  W  L  N  Y  P  C  F  K  N  W  D  G  S  P  V         p.340

          .         | 06         .         .         .         .    g.17497
 AGCTCCTGGATTCTGCTG | GCTGAAAGCAACAGTGCAGACGATGAGACCGACGATCCCAGG    c.1080
 S  S  W  I  L  L   | A  E  S  N  S  A  D  D  E  T  D  D  P  R      p.360

          .         .         .         .         .         .       g.17557
 AGGTATCAGAAATATGGTTACATTGGAACACATGAGTACCCTCATTTCTCTCATAGACCC       c.1140
 R  Y  Q  K  Y  G  Y  I  G  T  H  E  Y  P  H  F  S  H  R  P         p.380

          .         .         .         .         .         .       g.17617
 AGCACACTCCAGGCAGCATCCACCCCACAGGCAGAAGAGGACTGGACCTGCACCATCCTC       c.1200
 S  T  L  Q  A  A  S  T  P  Q  A  E  E  D  W  T  C  T  I  L         p.400

                                                                    g.17620
 TGA                                                                c.1203
 X                                                                  p.400

          .         .         .         .         .         .       g.17680
 atgccagtgcatcttgggggaaagggctccagtgttatctggaccagttccttcattttc       c.*60

          .         .         .         .         .         .       g.17740
 aggtgggactcttgatccagagaggacaaagctcctcagtgagctggtgtataatccagg       c.*120

          .         .         .         .         .         .       g.17800
 acagaacccaggtctcctgactcctggccttctatgccctctatcctatcatagataaca       c.*180

          .         .         .         .         .         .       g.17860
 ttctccacagcctcacttcattccacctattctctgaaaatattccctgagagagaacag       c.*240

          .         .         .         .         .         .       g.17920
 agagatttagataagagaatgaaattccagccttgactttcttctgtgcacctgatggga       c.*300

          .         .         .         .         .                 g.17974
 gggtaatgtctaatgtattatcaataacaataaaaataaagcaaataccattta             c.*354

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The 2'-5'-oligoadenylate synthetase 1, 40/46kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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