ornithine aminotransferase (OAT) - coding DNA reference sequence

(used for variant description)

(last modified August 28, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_000274.3 in the OAT gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008861.1, covering OAT transcript NM_000274.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.4987
                                                ttgggggcggggc       c.-121

 .         .         .         .         .         .                g.5047
 agaatcagcctttaagttgcagtgactctccggcgtcactgttgcgcttcatagacgccg       c.-61

 .         .         .         . | 02       .         .             g.11779
 cgtgtacccggttgtcctcaggcgctgtcag | atctgtggtttttctacttgaaggacaca    c.-1

          .         .         .         .         .         .       g.11839
 ATGTTTTCCAAACTAGCACATTTGCAGAGGTTTGCTGTACTTAGTCGCGGAGTTCATTCT       c.60
 M  F  S  K  L  A  H  L  Q  R  F  A  V  L  S  R  G  V  H  S         p.20

          .         .         .         .         .         .       g.11899
 TCAGTGGCTTCTGCTACATCTGTTGCAACTAAAAAAACAGTCCAAGGCCCTCCAACCTCT       c.120
 S  V  A  S  A  T  S  V  A  T  K  K  T  V  Q  G  P  P  T  S         p.40

          .         .         .         .         .         .       g.11959
 GATGACATTTTTGAAAGGGAATATAAGTATGGTGCACACAACTACCATCCTTTACCTGTA       c.180
 D  D  I  F  E  R  E  Y  K  Y  G  A  H  N  Y  H  P  L  P  V         p.60

          .          | 03        .         .         .         .    g.15026
 GCCCTGGAGAGAGGAAAAG | GTATTTACTTATGGGATGTAGAAGGCAGAAAATATTTTGAC    c.240
 A  L  E  R  G  K  G |   I  Y  L  W  D  V  E  G  R  K  Y  F  D      p.80

          .         .         .         .         .         .       g.15086
 TTCCTGAGTTCTTACAGTGCTGTCAACCAAGGGCATTGTCACCCCAAGATTGTGAATGCT       c.300
 F  L  S  S  Y  S  A  V  N  Q  G  H  C  H  P  K  I  V  N  A         p.100

          .         .         .         .         .         .       g.15146
 CTGAAGAGTCAAGTGGACAAATTGACCTTAACATCTAGAGCTTTCTATAATAACGTACTT       c.360
 L  K  S  Q  V  D  K  L  T  L  T  S  R  A  F  Y  N  N  V  L         p.120

          .         .         .         .         .         .       g.15206
 GGTGAATATGAGGAGTATATTACTAAACTTTTCAACTACCACAAAGTTCTTCCTATGAAT       c.420
 G  E  Y  E  E  Y  I  T  K  L  F  N  Y  H  K  V  L  P  M  N         p.140

      | 04   .         .         .         .         .         .    g.15369
 ACAG | GAGTGGAGGCTGGAGAGACTGCCTGTAAACTAGCTCGTAAGTGGGGCTATACCGTG    c.480
 T  G |   V  E  A  G  E  T  A  C  K  L  A  R  K  W  G  Y  T  V      p.160

          .         .         .         . | 05       .         .    g.18407
 AAGGGCATTCAGAAATACAAAGCAAAGATTGTTTTTGCAG | CTGGGAACTTCTGGGGTAGG    c.540
 K  G  I  Q  K  Y  K  A  K  I  V  F  A  A |   G  N  F  W  G  R      p.180

          .         .         .         .         .         .       g.18467
 ACGTTGTCTGCTATCTCCAGTTCCACAGACCCAACCAGTTACGATGGTTTTGGACCATTT       c.600
 T  L  S  A  I  S  S  S  T  D  P  T  S  Y  D  G  F  G  P  F         p.200

          .         .         .         .         | 06         .    g.20042
 ATGCCGGGATTCGACATCATTCCCTATAATGATCTGCCCGCACTGGAG | CGTGCTCTTCAG    c.660
 M  P  G  F  D  I  I  P  Y  N  D  L  P  A  L  E   | R  A  L  Q      p.220

          .         .         .         .         .         .       g.20102
 GATCCAAATGTGGCTGCGTTCATGGTAGAACCAATTCAGGGTGAAGCAGGCGTTGTTGTT       c.720
 D  P  N  V  A  A  F  M  V  E  P  I  Q  G  E  A  G  V  V  V         p.240

          .         .         .         .         .  | 07      .    g.20904
 CCGGATCCAGGTTACCTAATGGGAGTGCGAGAGCTCTGCACCAGGCACCAG | GTTCTCTTT    c.780
 P  D  P  G  Y  L  M  G  V  R  E  L  C  T  R  H  Q   | V  L  F      p.260

          .         .         .         .         .         .       g.20964
 ATTGCTGATGAAATACAGACAGGATTGGCCAGAACTGGTAGATGGCTGGCTGTTGATTAT       c.840
 I  A  D  E  I  Q  T  G  L  A  R  T  G  R  W  L  A  V  D  Y         p.280

          .         .         .         .         .         .       g.21024
 GAAAATGTCAGACCTGATATAGTCCTCCTTGGAAAGGCCCTTTCTGGGGGCTTATACCCT       c.900
 E  N  V  R  P  D  I  V  L  L  G  K  A  L  S  G  G  L  Y  P         p.300

  | 08       .         .         .         .         .         .    g.22171
  | GTGTCTGCAGTGCTGTGTGATGATGACATCATGCTGACCATTAAGCCAGGGGAGCATGGG    c.960
  | V  S  A  V  L  C  D  D  D  I  M  L  T  I  K  P  G  E  H  G      p.320

          .         .         .         .         .     | 09   .    g.22972
 TCCACATACGGTGGCAATCCACTAGGCTGCCGAGTGGCCATCGCAGCCCTTGAG | GTTTTA    c.1020
 S  T  Y  G  G  N  P  L  G  C  R  V  A  I  A  A  L  E   | V  L      p.340

          .         .         .         .         .         .       g.23032
 GAAGAAGAAAACCTTGCTGAAAATGCAGACAAATTGGGCATTATCTTGAGAAATGAACTC       c.1080
 E  E  E  N  L  A  E  N  A  D  K  L  G  I  I  L  R  N  E  L         p.360

          .         .         .         .         .         .       g.23092
 ATGAAGCTACCTTCTGATGTTGTAACTGCCGTAAGAGGAAAAGGATTATTAAACGCTATT       c.1140
 M  K  L  P  S  D  V  V  T  A  V  R  G  K  G  L  L  N  A  I         p.380

          .          | 10        .         .         .         .    g.25889
 GTCATTAAAGAAACCAAAG | ATTGGGATGCTTGGAAGGTGTGTCTACGACTTCGAGATAAT    c.1200
 V  I  K  E  T  K  D |   W  D  A  W  K  V  C  L  R  L  R  D  N      p.400

          .         .         .         .         .         .       g.25949
 GGACTTCTGGCCAAGCCAACCCATGGCGACATTATCAGGTTTGCGCCTCCGCTGGTGATC       c.1260
 G  L  L  A  K  P  T  H  G  D  I  I  R  F  A  P  P  L  V  I         p.420

          .         .         .         .         .         .       g.26009
 AAGGAGGATGAGCTTCGAGAGTCCATTGAAATTATTAACAAGACCATCTTGTCTTTCTGA       c.1320
 K  E  D  E  L  R  E  S  I  E  I  I  N  K  T  I  L  S  F  X         p.439

          .         .         .         .         .         .       g.26069
 gggtagccagctgttttcagtggtccctgggagccagctggagacaggtggtcctgtaaa       c.*60

          .         .         .         .         .         .       g.26129
 agctttattcctaatgtgggcacattccactcccatgagtcttcaaaaactttttttttg       c.*120

          .         .         .         .         .         .       g.26189
 aatatatttttttcagttgatacataatagaacaacgtttatgaacctgccgtttgcttt       c.*180

          .         .         .         .         .         .       g.26249
 gtaacgtaactaaataatgtaatggcatctatattcagttgaagtgttttgatgtgcatg       c.*240

          .         .         .         .         .         .       g.26309
 tgtacttcctaaggtgaaatgcatctatatacagacagcctctaaatcaagtccttcagt       c.*300

          .         .         .         .         .         .       g.26369
 ataattgatatatgtttttataatttcctcactggtataagtgtttcatatttgaaaaag       c.*360

          .         .         .         .         .         .       g.26429
 ttatctctgggtattgcataaaaggcttcatcttataaagtgaaatcattgttattgaat       c.*420

          .         .         .         .         .         .       g.26489
 tttaggaaggattaatggttaagtgtatataaaatactaatattaagtaaacttcatatt       c.*480

          .         .         .         .         .         .       g.26549
 ggccaacaccagggttgtattctatggatgtcattattttgaattaagaattagtgttta       c.*540

          .         .         .         .         .         .       g.26609
 acattcctaaattgttttgagtgcttgattataatttgtaaaaaatgtttattttcaata       c.*600

          .         .         .                                     g.26648
 cttctttaaatttaaaataaagcttatatttcaaatgtc                            c.*639

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Ornithine aminotransferase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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