oculocerebrorenal syndrome of Lowe (OCRL) - coding DNA reference sequence

(used for variant description)

(last modified July 16, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_000276.3 in the OCRL gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008638.1, covering OCRL transcript NM_000276.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5045
                tctcagctcccagctccccgctcccggctcccggcgcccggcgcc       c.-121

 .         .         .         .         .         .                g.5105
 cggcgcggagctgttcctcaaacgacacgcagccgaggtgggtgggtgtggggacgcggg       c.-61

 .         .         .         .         .         .                g.5165
 agccagtgtcgtcggatcggcccgcagtccgctgtcctgctgagcccggaggccgcctgg       c.-1

          .         .         .          | 02        .         .    g.5490
 ATGGAGCCGCCGCTCCCGGTCGGAGCCCAGCCGCTTGCC | ACTGTCGAGGGTATGGAGATG    c.60
 M  E  P  P  L  P  V  G  A  Q  P  L  A   | T  V  E  G  M  E  M      p.20

          .         .         .         .         .          | 03    g.9684
 AAGGGTCCTCTCCGGGAGCCCTGCGCCCTGACCCTAGCCCAGAGGAACGGGCAATATGA | G    c.120
 K  G  P  L  R  E  P  C  A  L  T  L  A  Q  R  N  G  Q  Y  E  |      p.40

          .         .         .         .         .         .       g.9744
 TTAATAATCCAGTTGCATGAGAAGGAACAGCATGTTCAAGATATCATTCCTATAAATAGC       c.180
 L  I  I  Q  L  H  E  K  E  Q  H  V  Q  D  I  I  P  I  N  S         p.60

          .          | 04        .         .         .         | 05 g.22052
 CACTTCAGATGTGTTCAAG | AAGCAGAAGAAACTCTTTTGATTGACATAGCTTCTAACA | GT c.240
 H  F  R  C  V  Q  E |   A  E  E  T  L  L  I  D  I  A  S  N  S |    p.80

          .         .         .         .         .         .       g.22112
 GGCTGCAAAATTCGGGTTCAGGGGGACTGGATCAGAGAGCGCCGCTTTGAAATCCCTGAT       c.300
 G  C  K  I  R  V  Q  G  D  W  I  R  E  R  R  F  E  I  P  D         p.100

          .         .         .         .          | 06        .    g.22597
 GAGGAACACTGTTTGAAGTTCCTCTCAGCTGTCCTTGCTGCTCAGAAAG | CTCAGTCACAG    c.360
 E  E  H  C  L  K  F  L  S  A  V  L  A  A  Q  K  A |   Q  S  Q      p.120

          .         .         .         .         .         .       g.22657
 CTTCTTGTTCCAGAGCAAAAGGACTCATCTAGCTGGTACCAGAAATTAGACACTAAGGAC       c.420
 L  L  V  P  E  Q  K  D  S  S  S  W  Y  Q  K  L  D  T  K  D         p.140

          .          | 07        .         .         .         .    g.23399
 AAACCTTCTGTTTTTTCAG | GGCTTCTTGGATTTGAAGACAATTTTTCTTCTATGAATTTG    c.480
 K  P  S  V  F  S  G |   L  L  G  F  E  D  N  F  S  S  M  N  L      p.160

          .         .         .         .         .         .       g.23459
 GACAAGAAAATAAATTCACAAAATCAGCCTACTGGGATTCATCGGGAACCCCCACCTCCA       c.540
 D  K  K  I  N  S  Q  N  Q  P  T  G  I  H  R  E  P  P  P  P         p.180

          .         . | 08       .         .         .         .    g.23605
 CCCTTTTCAGTGAATAAAAT | GCTTCCACGTGAAAAAGAAGCTTCTAACAAGGAGCAGCCC    c.600
 P  F  S  V  N  K  M  |  L  P  R  E  K  E  A  S  N  K  E  Q  P      p.200

          .         .         .         .         .         .       g.23665
 AAAGTGACCAACACCATGCGGAAGCTCTTTGTACCAAATACCCAATCTGGGCAGCGGGAG       c.660
 K  V  T  N  T  M  R  K  L  F  V  P  N  T  Q  S  G  Q  R  E         p.220

          .         .         .         .         .         .       g.23725
 GGTCTCATCAAACATATCCTGGCAAAGCGAGAGAAAGAATATGTCAACATTCAGACTTTC       c.720
 G  L  I  K  H  I  L  A  K  R  E  K  E  Y  V  N  I  Q  T  F         p.240

    | 09     .         .         .         .         .         .    g.25333
 AG | ATTTTTTGTTGGAACTTGGAATGTGAATGGCCAGTCTCCAGATAGCGGGTTAGAACCT    c.780
 R  |  F  F  V  G  T  W  N  V  N  G  Q  S  P  D  S  G  L  E  P      p.260

          .         .         .         .     | 10   .         .    g.25920
 TGGCTGAACTGTGATCCCAATCCTCCTGATATCTACTGCATTGG | ATTCCAAGAACTGGAC    c.840
 W  L  N  C  D  P  N  P  P  D  I  Y  C  I  G  |  F  Q  E  L  D      p.280

          .         .         .         .         .         .       g.25980
 TTGAGCACAGAAGCCTTCTTCTACTTTGAATCTGTGAAGGAACAAGAATGGTCCATGGCT       c.900
 L  S  T  E  A  F  F  Y  F  E  S  V  K  E  Q  E  W  S  M  A         p.300

          .         .         .          | 11        .         .    g.27130
 GTAGAGAGAGGTTTGCATTCCAAAGCCAAGTATAAGAAA | GTTCAACTGGTGCGCCTTGTT    c.960
 V  E  R  G  L  H  S  K  A  K  Y  K  K   | V  Q  L  V  R  L  V      p.320

          .         .         .         .         .         .       g.27190
 GGGATGATGCTTCTTATATTTGCCAGAAAGGATCAGTGTCGATACATTCGTGATATTGCT       c.1020
 G  M  M  L  L  I  F  A  R  K  D  Q  C  R  Y  I  R  D  I  A         p.340

          .         .         .       | 12 .         .         .    g.27348
 ACAGAAACAGTTGGAACTGGAATCATGGGGAAAATG | GGAAACAAAGGTGGGGTAGCTGTG    c.1080
 T  E  T  V  G  T  G  I  M  G  K  M   | G  N  K  G  G  V  A  V      p.360

          .         .         .         .         .         .       g.27408
 AGATTTGTATTTCACAACACCACCTTTTGCATTGTCAATTCCCATCTGGCTGCACACGTG       c.1140
 R  F  V  F  H  N  T  T  F  C  I  V  N  S  H  L  A  A  H  V         p.380

          .         .         .         .         .         .       g.27468
 GAGGACTTTGAGAGAAGGAATCAAGATTATAAGGACATTTGTGCGAGAATGAGTTTTGTG       c.1200
 E  D  F  E  R  R  N  Q  D  Y  K  D  I  C  A  R  M  S  F  V         p.400

          .         .         .         .     | 13   .         .    g.30513
 GTCCCAAATCAGACCCTCCCGCAGTTGAACATCATGAAACATGA | GGTTGTCATTTGGTTG    c.1260
 V  P  N  Q  T  L  P  Q  L  N  I  M  K  H  E  |  V  V  I  W  L      p.420

          .         .         .         .         .         .       g.30573
 GGAGATTTGAATTATAGACTTTGCATGCCTGATGCCAATGAGGTGAAAAGTCTTATTAAT       c.1320
 G  D  L  N  Y  R  L  C  M  P  D  A  N  E  V  K  S  L  I  N         p.440

          .         .         .       | 14 .         .         .    g.32003
 AAGAAAGACCTTCAGAGACTCTTGAAATTCGACCAG | CTAAATATTCAGCGCACACAGAAA    c.1380
 K  K  D  L  Q  R  L  L  K  F  D  Q   | L  N  I  Q  R  T  Q  K      p.460

          .         .         .         .         .         .       g.32063
 AAAGCTTTTGTTGACTTCAATGAAGGGGAAATCAAGTTCATCCCCACTTATAAGTATGAC       c.1440
 K  A  F  V  D  F  N  E  G  E  I  K  F  I  P  T  Y  K  Y  D         p.480

          .         .       | 15 .         .         .         .    g.34023
 TCTAAAACAGACCGGTGGGATTCCAG | TGGGAAATGCCGGGTTCCAGCCTGGTGTGACCGA    c.1500
 S  K  T  D  R  W  D  S  S  |  G  K  C  R  V  P  A  W  C  D  R      p.500

          .         .         .         .         .         .       g.34083
 ATTCTTTGGAGAGGAACAAATGTTAATCAGCTTAATTATCGGAGTCACATGGAACTGAAA       c.1560
 I  L  W  R  G  T  N  V  N  Q  L  N  Y  R  S  H  M  E  L  K         p.520

          .         .         .         .   | 16     .         .    g.39883
 ACCAGCGACCACAAGCCTGTTAGCGCCCTCTTCCATATTGGG | GTGAAGGTTGTGGATGAA    c.1620
 T  S  D  H  K  P  V  S  A  L  F  H  I  G   | V  K  V  V  D  E      p.540

          .         .         .         .         .         .       g.39943
 CGAAGGTACCGGAAAGTCTTTGAAGATAGTGTACGCATCATGGACAGAATGGAAAATGAC       c.1680
 R  R  Y  R  K  V  F  E  D  S  V  R  I  M  D  R  M  E  N  D         p.560

          .         .         .    | 17    .         .         .    g.40649
 TTCCTTCCTTCCTTAGAACTCAGCAGGAGGGAG | TTTGTGTTTGAAAATGTGAAGTTTCGG    c.1740
 F  L  P  S  L  E  L  S  R  R  E   | F  V  F  E  N  V  K  F  R      p.580

          .         .         .         .         .         .       g.40709
 CAACTACAAAAGGAGAAGTTCCAGATCAGCAACAATGGACAGGTTCCCTGCCATTTTTCT       c.1800
 Q  L  Q  K  E  K  F  Q  I  S  N  N  G  Q  V  P  C  H  F  S         p.600

          .         .         .         .         .         .       g.40769
 TTCATCCCTAAACTTAATGACAGCCAGTACTGCAAGCCATGGCTTCGGGCTGAACCTTTT       c.1860
 F  I  P  K  L  N  D  S  Q  Y  C  K  P  W  L  R  A  E  P  F         p.620

          .          | 18        .         .         .         .    g.41083
 GAGGGCTACTTGGAGCCAA | ATGAGACAGTGGACATTTCTCTTGATGTGTATGTCAGCAAA    c.1920
 E  G  Y  L  E  P  N |   E  T  V  D  I  S  L  D  V  Y  V  S  K      p.640

          .         .         .         .         .         .       g.41143
 GACTCTGTAACCATCCTGAACTCGGGAGAAGATAAGATTGAAGATATTCTCGTCCTTCAC       c.1980
 D  S  V  T  I  L  N  S  G  E  D  K  I  E  D  I  L  V  L  H         p.660

          .         .         .         .         .         .       g.41203
 CTGGATCGAGGCAAAGATTACTTCTTGACTATCAGTGGAAATTACCTCCCAAGTTGTTTT       c.2040
 L  D  R  G  K  D  Y  F  L  T  I  S  G  N  Y  L  P  S  C  F         p.680

          .         .         .         .         .         .       g.41263
 GGCACATCCTTAGAGGCTCTGTGCCGTATGAAAAGACCAATCCGAGAAGTTCCTGTTACC       c.2100
 G  T  S  L  E  A  L  C  R  M  K  R  P  I  R  E  V  P  V  T         p.700

          .      | 19  .         .          | 20        .         . g.51748
 AAACTCATAGACTTG | GAAGAAGACAGCTTCCTAGAAAAG | GAGAAATCCCTTCTGCAAATG c.2160
 K  L  I  D  L   | E  E  D  S  F  L  E  K   | E  K  S  L  L  Q  M   p.720

          .         .         .         .         .         .       g.51808
 GTTCCTTTGGATGAAGGTGCCAGTGAGAGACCCCTTCAGGTTCCCAAGGAGATCTGGCTT       c.2220
 V  P  L  D  E  G  A  S  E  R  P  L  Q  V  P  K  E  I  W  L         p.740

          .         .         .       | 21 .         .         .    g.52928
 CTAGTAGATCACCTATTCAAATACGCCTGTCACCAG | GAGGACCTGTTCCAGACCCCTGGA    c.2280
 L  V  D  H  L  F  K  Y  A  C  H  Q   | E  D  L  F  Q  T  P  G      p.760

          .         .         .         .         .         .       g.52988
 ATGCAGGAAGAGCTCCAGCAGATCATTGATTGTCTGGATACCAGCATTCCTGAGACAATC       c.2340
 M  Q  E  E  L  Q  Q  I  I  D  C  L  D  T  S  I  P  E  T  I         p.780

   | 22      .         .         .         .         .         .    g.53670
 C | CTGGCAGCAACCACTCTGTGGCTGAAGCACTGCTCATTTTCTTGGAAGCCCTGCCAGAG    c.2400
 P |   G  S  N  H  S  V  A  E  A  L  L  I  F  L  E  A  L  P  E      p.800

          .         .         .         .         .         .       g.53730
 CCAGTCATCTGTTACGAGCTGTATCAGCGATGTCTTGACTCTGCTTATGATCCCCGGATC       c.2460
 P  V  I  C  Y  E  L  Y  Q  R  C  L  D  S  A  Y  D  P  R  I         p.820

           | 23        .         .         .         .         .    g.54621
 TGCCGACAG | GTGATCTCCCAGCTTCCGAGATGCCATAGAAATGTTTTCCGTTACTTGATG    c.2520
 C  R  Q   | V  I  S  Q  L  P  R  C  H  R  N  V  F  R  Y  L  M      p.840

          .         .         .         .         .         .       g.54681
 GCATTCCTTCGAGAACTCTTAAAATTCTCTGAATACAATAGCGTCAATGCCAACATGATC       c.2580
 A  F  L  R  E  L  L  K  F  S  E  Y  N  S  V  N  A  N  M  I         p.860

   | 24      .         .         .         .         .         .    g.54930
 G | CTACTCTCTTCACTAGTCTTCTCCTGAGGCCTCCACCCAACCTTATGGCAAGACAGACT    c.2640
 A |   T  L  F  T  S  L  L  L  R  P  P  P  N  L  M  A  R  Q  T      p.880

          .         .         .         .         .         .       g.54990
 CCAAGTGACCGCCAGCGTGCTATTCAGTTCCTTCTGGGCTTTCTGCTTGGGAGCGAAGAA       c.2700
 P  S  D  R  Q  R  A  I  Q  F  L  L  G  F  L  L  G  S  E  E         p.900

                                                                    g.54996
 GACTAA                                                             c.2706
 D  X                                                               p.901

          .         .         .         .         .         .       g.55056
 ggcttttactgttctctgatattctagaagcagacgatctcgggctccaagtatttcaga       c.*60

          .         .         .         .         .         .       g.55116
 atgatttaaaaagtcatgccacaggaagggtctattgcagaatttcaagttctgtttata       c.*120

          .         .         .         .         .         .       g.55176
 gtaaaaaggaagagcgtttcctaatccctcctttaccatatcctacacagaaaaatactt       c.*180

          .         .         .         .         .         .       g.55236
 ttagacttatattgccaagccaaagttaccatattttggtgtttttgtgttttctcttta       c.*240

          .         .         .         .         .         .       g.55296
 taaggcaaaaagatctgtatttacactccttcacctagggatgtgtttgttgccctccta       c.*300

          .         .         .         .         .         .       g.55356
 cccaattgtcatgattgtccttagtaccctaggcctagattctgagatcttcccattcta       c.*360

          .         .         .         .         .         .       g.55416
 ggcctacaagcactacttgctgtagctgagacttgtctagagtcctttgttttgcacttt       c.*420

          .         .         .         .         .         .       g.55476
 tgacccaccccttcctggatcactcctttgcactccactcccctcgttctgtcactttga       c.*480

          .         .         .         .         .         .       g.55536
 acgaagtctgagtgaggctagtgactccttgggtgtcctcaacagtgaattcactgtctg       c.*540

          .         .         .         .         .         .       g.55596
 cgtgcagttattacatgcatttgtgcatttctactacaatggcatctttatgtctctgta       c.*600

          .         .         .         .         .         .       g.55656
 acattggccttttcatggctccacactgggtggaaccatattctcttagatcacatttag       c.*660

          .         .         .         .         .         .       g.55716
 tagcataactgtagggactattagagatggcatctcatcgatgagagagaatcacaatca       c.*720

          .         .         .         .         .         .       g.55776
 gaatggaagcactttgagtatctgaagagtgagagcattcatgtttgacaggtcctgctt       c.*780

          .         .         .         .         .         .       g.55836
 cccactatccttttcctgttattattcaaattttacacaaggactaatcctgggtgtctc       c.*840

          .         .         .         .         .         .       g.55896
 tgagacccatctcctgcctagacatccacctccagagcaacactggccccacagtaaaag       c.*900

          .         .         .         .         .         .       g.55956
 aggaagtcttgtacctcaggcaggcccatctagagctattgctccttcccacagcaaagg       c.*960

          .         .         .         .         .         .       g.56016
 tattgtggatgacccttagaatccattctctggtcttctgaaataccaagggcagatgtc       c.*1020

          .         .         .         .         .         .       g.56076
 acctccttcctcagcaggactgactctgggctctacaaccagctccttcacataaagggt       c.*1080

          .         .         .         .         .         .       g.56136
 ttagagactccccttggctcccagtcaccatatccagtgttgtgtaaagagactggccaa       c.*1140

          .         .         .         .         .         .       g.56196
 caggaccaaccaagcaccttacctctcccatacaagatgaccctctgagcttttcattta       c.*1200

          .         .         .         .         .         .       g.56256
 ttcaagctctgtggtacagcctttttttaaaataaattaatctatattggttgacaaaca       c.*1260

          .         .         .         .         .         .       g.56316
 agccaccaaccactgactgcaaaactgcctgatgcagttgggttcctcctggttttcttt       c.*1320

          .         .         .         .         .         .       g.56376
 tgttacaaccacccttgcctgtttacattaattgcaaggagcataacgtacaggctgtat       c.*1380

          .         .         .         .         .         .       g.56436
 gtacaatcctgggcattgactctgtgacatttctagcatatccaaggcaccaccagtgat       c.*1440

          .         .         .         .         .         .       g.56496
 ttctcctgtttcttggtgggggtgggggggaaggtacgtattctgcaatatggctaaacc       c.*1500

          .         .         .         .         .         .       g.56556
 ctttcctgattgagagttaaagcaataggagtcaagttactggtgccacagatctggagg       c.*1560

          .         .         .         .         .         .       g.56616
 tatgataggtcaggggctaggtgttgaacttagttaatggaagactgagagcagaacagg       c.*1620

          .         .         .         .         .         .       g.56676
 tttgtcatctccgcaaggccagaaagtgatcacaaaaagaggcagatgatagacactggg       c.*1680

          .         .         .         .         .         .       g.56736
 gtagggtcataccacagggaaatacctttcctgggcttgttttctagcatatcactgacc       c.*1740

          .         .         .         .         .         .       g.56796
 tgggatctttgggtgatcaagggtgtggttagtggaggctctgtgctgcacgtatgcagt       c.*1800

          .         .         .         .         .         .       g.56856
 atcctatctctttctacatcagatcaaaacactaagttggtgtactgcctcgaccttttt       c.*1860

          .         .         .         .         .         .       g.56916
 tcagctcatcctggaacatatacagagttgagagttttagacaatctctaggtagaggag       c.*1920

          .         .         .         .         .         .       g.56976
 acaagatgtagacccagacagaagaaatctgcttccctaccatggctattccagcacccc       c.*1980

          .         .         .         .         .         .       g.57036
 aacctgtaattgccaagtcctctaaggtactaatttgtagctgctctgaagtaaggattt       c.*2040

          .         .         .         .         .         .       g.57096
 cggattcagctggtagggaaagactctgcacctgctgtcttagggaagaaatggttcaaa       c.*2100

          .         .         .         .         .         .       g.57156
 tccatgtggtgacattgcattagtctccctttcactgttttcttattctgtaattgtttg       c.*2160

          .         .         .         .         .         .       g.57216
 ttatatttcccaaaaacgtcttgatcactaagcaaagctgctagtgggattctatatttc       c.*2220

          .         .         .         .         .         .       g.57276
 gtgtcatcttttttattataatttattgcaaatttttttctgaataaatatatgttgtgt       c.*2280

                                                                    g.57282
 gaaaaa                                                             c.*2286

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Oculocerebrorenal syndrome of Lowe protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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