oral-facial-digital syndrome 1 (OFD1) - coding DNA reference sequence

(used for variant description)

(last modified January 17, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_003611.2 in the OFD1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008872.1, covering OFD1 transcript NM_003611.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5059
  aaggctatatttagcaggtttccggaagttgccggactggctgtgaggcggtcctgcct       c.-301

 .         .         .         .         .         .                g.5119
 cgctgccttcagtccctagtgtctgggtccccgccctccagccgcctttgagtcgtgcct       c.-241

 .         .         .         .         .         .                g.5179
 gggtcctcgcccttgcctcagaaccgcgaagaaaggaagctcgcgtgtttgctagaaaac       c.-181

 .         .         .         .         .         .                g.5239
 ctagttgggagtgcgaggcagagaacgttcagcacctttgttcctcccgaaccctcggga       c.-121

 .         .         .         .         .         .                g.5299
 cagaggcagggttctgagggcagggattccccctcgtcttggccccaccgcccgggctgg       c.-61

 .         .         .         .         .         .                g.5359
 gcactaaactcgggccgcggcggggcgagcgaggcgggctccggagggagctgacgcctg       c.-1

          .   | 02     .         .         .         .         .    g.5583
 ATGATGGCGCAG | TCCAACATGTTTACCGTGGCTGATGTGTTGAGTCAAGATGAACTGCGC    c.60
 M  M  A  Q   | S  N  M  F  T  V  A  D  V  L  S  Q  D  E  L  R      p.20

          .         .         .         .         .  | 03      .    g.6774
 AAAAAGCTATACCAGACGTTTAAGGATCGGGGTATACTGGATACACTCAAG | ACACAACTT    c.120
 K  K  L  Y  Q  T  F  K  D  R  G  I  L  D  T  L  K   | T  Q  L      p.40

          .         .         .         .         .         .       g.6834
 CGAAACCAGCTAATTCATGAGTTGATGCACCCTGTATTGAGTGGAGAACTGCAGCCTCGG       c.180
 R  N  Q  L  I  H  E  L  M  H  P  V  L  S  G  E  L  Q  P  R         p.60

          .         .         .         .         .         .       g.6894
 TCCATTTCAGTAGAAGGGAGCTCCCTCTTAATAGGCGCCTCTAACTCTTTAGTGGCAGAT       c.240
 S  I  S  V  E  G  S  S  L  L  I  G  A  S  N  S  L  V  A  D         p.80

          .         .         .         .         .         .       g.6954
 CACTTACAAAGATGTGGCTATGAATATTCACTTTCTGTTTTCTTTCCAGAAAGTGGTTTG       c.300
 H  L  Q  R  C  G  Y  E  Y  S  L  S  V  F  F  P  E  S  G  L         p.100

          .   | 04     .         .         .         .         .    g.9181
 GCAAAAGAAAAG | GTATTTACTATGCAGGATCTATTACAACTCATTAAAATCAACCCTACT    c.360
 A  K  E  K   | V  F  T  M  Q  D  L  L  Q  L  I  K  I  N  P  T      p.120

          .         .  | 05      .         .         .   | 06     . g.14710
 TCCAGTCTCTACAAATCACTG | GTTTCAGGATCTGATAAAGAAAATCAAAAAG | GTTTTCTT c.420
 S  S  L  Y  K  S  L   | V  S  G  S  D  K  E  N  Q  K  G |   F  L   p.140

          .         .         .         .         .         .       g.14770
 ATGCATTTTTTAAAAGAATTGGCAGAATATCATCAAGCTAAAGAGAGTTGTAATATGGAA       c.480
 M  H  F  L  K  E  L  A  E  Y  H  Q  A  K  E  S  C  N  M  E         p.160

          .         .         .        | 07.         .         .    g.16629
 ACTCAGACAAGTTCGACATTTAACAGAGATTCTCTGG | CTGAGAAGCTTCAGCTTATTGAT    c.540
 T  Q  T  S  S  T  F  N  R  D  S  L  A |   E  K  L  Q  L  I  D      p.180

          .         .         .         .         .         .       g.16689
 GATCAGTTTGCAGATGCTTACCCTCAGCGTATCAAGTTCGAATCTTTAGAAATAAAGCTA       c.600
 D  Q  F  A  D  A  Y  P  Q  R  I  K  F  E  S  L  E  I  K  L         p.200

          .         .         .         .         .     | 08   .    g.17073
 AATGAGTATAAGAGAGAAATAGAAGAGCAACTTCGGGCAGAAATGTGTCAAAAG | TTGAAG    c.660
 N  E  Y  K  R  E  I  E  E  Q  L  R  A  E  M  C  Q  K   | L  K      p.220

          .         .         .         .         .         .       g.17133
 TTTTTTAAAGATACCGAGATAGCAAAAATTAAAATGGAAGCAAAAAAAAAGTATGAAAAG       c.720
 F  F  K  D  T  E  I  A  K  I  K  M  E  A  K  K  K  Y  E  K         p.240

          .         .         .         .         .         .       g.17193
 GAGTTAACCATGTTCCAGAATGATTTTGAAAAAGCTTGTCAAGCAAAATCTGAAGCTCTC       c.780
 E  L  T  M  F  Q  N  D  F  E  K  A  C  Q  A  K  S  E  A  L         p.260

          .         .         .         .         | 09         .    g.19726
 GTTCTTCGGGAAAAGAGTACCCTTGAAAGAATTCACAAGCACCAAGAG | ATTGAAACAAAA    c.840
 V  L  R  E  K  S  T  L  E  R  I  H  K  H  Q  E   | I  E  T  K      p.280

          .         .         .         .         .         .       g.19786
 GAAATTTATGCTCAAAGGCAACTTTTACTAAAAGATATGGATTTGCTAAGAGGAAGAGAA       c.900
 E  I  Y  A  Q  R  Q  L  L  L  K  D  M  D  L  L  R  G  R  E         p.300

          .         .         .      | 10  .         .         .    g.21561
 GCAGAGCTGAAGCAAAGAGTTGAAGCTTTTGAATT | GAACCAGAAGCTCCAGGAAGAAAAA    c.960
 A  E  L  K  Q  R  V  E  A  F  E  L  |  N  Q  K  L  Q  E  E  K      p.320

          .         .         .         .         .         .       g.21621
 CATAAAAGCATAACTGAGGCACTTAGGAGACAGGAGCAGAATATAAAGAGTTTTGAGGAG       c.1020
 H  K  S  I  T  E  A  L  R  R  Q  E  Q  N  I  K  S  F  E  E         p.340

          .         .         .      | 11  .         .         .    g.23680
 ACCTATGACCGAAAGCTCAAGAATGAACTTCTAAA | GTATCAACTTGAACTGAAGGATGAC    c.1080
 T  Y  D  R  K  L  K  N  E  L  L  K  |  Y  Q  L  E  L  K  D  D      p.360

          .         .         .         .          | 12        .    g.25449
 TACATCATTAGAACTAATCGACTGATTGAAGATGAAAGGAAGAATAAAG | AAAAAGCTGTT    c.1140
 Y  I  I  R  T  N  R  L  I  E  D  E  R  K  N  K  E |   K  A  V      p.380

          .         .         .         .         .         .       g.25509
 CATTTGCAAGAGGAGCTCATAGCTATTAATTCAAAAAAGGAGGAACTCAATCAATCTGTA       c.1200
 H  L  Q  E  E  L  I  A  I  N  S  K  K  E  E  L  N  Q  S  V         p.400

          .         .  | 13      .         .         .         .    g.26904
 AATCGTGTGAAAGAACTTGAG | CTTGAATTAGAGTCTGTCAAAGCCCAGTCTTTGGCAATA    c.1260
 N  R  V  K  E  L  E   | L  E  L  E  S  V  K  A  Q  S  L  A  I      p.420

          .         .         .         .         .         .       g.26964
 ACAAAACAAAACCATATGCTGAATGAAAAGGTTAAAGAGATGAGTGATTATTCACTACTA       c.1320
 T  K  Q  N  H  M  L  N  E  K  V  K  E  M  S  D  Y  S  L  L         p.440

          .         .         .         .         .         .       g.27024
 AAAGAAGAGAAACTGGAGCTTCTGGCACAAAATAAATTACTTAAACAACAACTGGAAGAG       c.1380
 K  E  E  K  L  E  L  L  A  Q  N  K  L  L  K  Q  Q  L  E  E         p.460

          .         .         .  | 14      .         .         .    g.27976
 AGTAGAAATGAAAACCTGCGTCTCCTAAACC | GCCTAGCTCAGCCGGCTCCTGAACTTGCA    c.1440
 S  R  N  E  N  L  R  L  L  N  R |   L  A  Q  P  A  P  E  L  A      p.480

          .         .         .         .         .         .       g.28036
 GTCTTTCAGAAAGAACTACGGAAAGCCGAAAAGGCTATAGTGGTTGAGCATGAGGAGTTC       c.1500
 V  F  Q  K  E  L  R  K  A  E  K  A  I  V  V  E  H  E  E  F         p.500

          .         .         .         .   | 15     .         .    g.28642
 GAAAGCTGCAGGCAAGCTCTGCACAAACAACTGCAAGACGAA | ATTGAGCATTCTGCACAG    c.1560
 E  S  C  R  Q  A  L  H  K  Q  L  Q  D  E   | I  E  H  S  A  Q      p.520

          .         .         .         .         .         .       g.28702
 CTGAAGGCCCAGATTCTAGGTTACAAAGCTTCTGTAAAGAGTTTAACTACTCAGGTTGCC       c.1620
 L  K  A  Q  I  L  G  Y  K  A  S  V  K  S  L  T  T  Q  V  A         p.540

          .         .         .     | 16   .         .         .    g.30428
 GATTTAAAATTGCAACTGAAGCAAACTCAGACAG | CCCTAGAGAATGAAGTGTACTGCAAT    c.1680
 D  L  K  L  Q  L  K  Q  T  Q  T  A |   L  E  N  E  V  Y  C  N      p.560

          .         .         .         .         .         .       g.30488
 CCAAAGCAGTCTGTGATCGATCGTTCTGTCAATGGATTAATAAATGGCAATGTGGTGCCT       c.1740
 P  K  Q  S  V  I  D  R  S  V  N  G  L  I  N  G  N  V  V  P         p.580

          .         .         .         .         .         .       g.30548
 TGCAATGGTGAGATAAGTGGGGATTTCTTGAACAATCCTTTTAAACAGGAAAACGTTCTA       c.1800
 C  N  G  E  I  S  G  D  F  L  N  N  P  F  K  Q  E  N  V  L         p.600

          .         .         .         .         .         .       g.30608
 GCACGTATGGTTGCATCAAGGATCACAAATTATCCAACTGCATGGGTGGAGGGTAGTTCC       c.1860
 A  R  M  V  A  S  R  I  T  N  Y  P  T  A  W  V  E  G  S  S         p.620

          .         .         .         .         .         .       g.30668
 CCTGATTCTGACCTTGAGTTTGTAGCCAATACTAAGGCAAGGGTCAAAGAGCTTCAGCAA       c.1920
 P  D  S  D  L  E  F  V  A  N  T  K  A  R  V  K  E  L  Q  Q         p.640

          .         .         .         .         .         .       g.30728
 GAGGCCGAACGCTTGGAAAAGGCTTTCAGAAGTTACCATCGGAGAGTCATTAAAAACTCT       c.1980
 E  A  E  R  L  E  K  A  F  R  S  Y  H  R  R  V  I  K  N  S         p.660

          .         .         .         .         .         .       g.30788
 GCCAAAAGCCCACTAGCAGCAAAGAGCCCACCATCTCTGCACTTGCTGGAAGCCTTCAAA       c.2040
 A  K  S  P  L  A  A  K  S  P  P  S  L  H  L  L  E  A  F  K         p.680

          .         .         .         .         .         .       g.30848
 AACATTACTTCCAGTTCCCCGGAAAGACATATTTTTGGAGAGGACAGAGTTGTCTCTGAG       c.2100
 N  I  T  S  S  S  P  E  R  H  I  F  G  E  D  R  V  V  S  E         p.700

          .         .         .         .         .         .       g.30908
 CAGCCTCAAGTGGGCACACTTGAAGAAAGGAATGACGTCGTGGAAGCACTGACAGGCAGT       c.2160
 Q  P  Q  V  G  T  L  E  E  R  N  D  V  V  E  A  L  T  G  S         p.720

          .         .         .         .         .         .       g.30968
 GCAGCCTCGAGGCTCCGCGGGGGCACTTCCTCCAGACGCCTCTCTTCCACACCCCTTCCA       c.2220
 A  A  S  R  L  R  G  G  T  S  S  R  R  L  S  S  T  P  L  P         p.740

          .         .         .         . | 17       .         .    g.31392
 AAAGCAAAAAGAAGCCTCGAAAGTGAAATGTATCTGGAAG | GTCTGGGCAGATCACACATT    c.2280
 K  A  K  R  S  L  E  S  E  M  Y  L  E  G |   L  G  R  S  H  I      p.760

          .         .         .         .         .         .       g.31452
 GCTTCCCCCAGTCCTTGTCCTGACAGAATGCCCCTACCATCACCCACTGAGTCTAGGCAC       c.2340
 A  S  P  S  P  C  P  D  R  M  P  L  P  S  P  T  E  S  R  H         p.780

          .         .         .         .        | 18.         .    g.32644
 AGCCTCTCCATCCCTCCTGTCTCCAGCCCTCCGGAGCAGAAAGTGGG | TCTTTATCGAAGA    c.2400
 S  L  S  I  P  P  V  S  S  P  P  E  Q  K  V  G  |  L  Y  R  R      p.800

          .         .         .         .         .         .       g.32704
 CAAACTGAACTTCAAGACAAAAGTGAATTTTCAGATGTGGACAAGCTAGCTTTTAAGGAT       c.2460
 Q  T  E  L  Q  D  K  S  E  F  S  D  V  D  K  L  A  F  K  D         p.820

          .         .         | 19         .         .         .    g.34064
 AATGAGGAGTTTGAATCATCTTTTGAAT | CTGCAGGGAACATGCCAAGGCAGTTGGAAATG    c.2520
 N  E  E  F  E  S  S  F  E  S |   A  G  N  M  P  R  Q  L  E  M      p.840

          .         .         .         .         .         .       g.34124
 GGCGGGCTTTCTCCTGCCGGGGATATGTCTCATGTGGACGCTGCTGCAGCTGCTGTGCCC       c.2580
 G  G  L  S  P  A  G  D  M  S  H  V  D  A  A  A  A  A  V  P         p.860

          .          | 20        .         .         .         .    g.37455
 CTCTCATATCAGCACCCAA | GTGTAGATCAGAAACAAATTGAAGAACAAAAGGAAGAAGAA    c.2640
 L  S  Y  Q  H  P  S |   V  D  Q  K  Q  I  E  E  Q  K  E  E  E      p.880

          .         .         .         .         .         .       g.37515
 AAAATACGGGAACAGCAAGTGAAAGAACGAAGGCAGAGAGAAGAAAGAAGGCAGAGTAAC       c.2700
 K  I  R  E  Q  Q  V  K  E  R  R  Q  R  E  E  R  R  Q  S  N         p.900

          .         .         .         .         .        | 21.    g.38344
 CTACAAGAAGTTTTAGAAAGGGAACGAAGAGAACTAGAAAAACTGTATCAGGAAAGG | AAG    c.2760
 L  Q  E  V  L  E  R  E  R  R  E  L  E  K  L  Y  Q  E  R   | K      p.920

          .         .         .         .         .         .       g.38404
 ATGATTGAAGAATCACTGAAGATTAAAATAAAAAAGGAATTAGAAATGGAAAATGAATTA       c.2820
 M  I  E  E  S  L  K  I  K  I  K  K  E  L  E  M  E  N  E  L         p.940

          .         .         .         .         .         .       g.38464
 GAAATGAGTAATCAAGAAATAAAAGACAAATCTGCTCACAGTGAAAATCCTTTAGAGAAA       c.2880
 E  M  S  N  Q  E  I  K  D  K  S  A  H  S  E  N  P  L  E  K         p.960

          .         .         .         .         | 22         .    g.39017
 TACATGAAAATCATCCAGCAGGAGCAAGACCAGGAGTCGGCAGATAAG | AGCTCAAAAAAG    c.2940
 Y  M  K  I  I  Q  Q  E  Q  D  Q  E  S  A  D  K   | S  S  K  K      p.980

          .         .         .         .         .       | 23 .    g.39357
 ATGGTCCAAGAAGGCTCCCTAGTGGACACGCTGCAATCTAGTGACAAAGTCGAAAG | TTTA    c.3000
 M  V  Q  E  G  S  L  V  D  T  L  Q  S  S  D  K  V  E  S  |  L      p.1000

          .         .         .                                     g.39396
 ACAGGCTTTTCTCATGAAGAACTAGACGACTCTTGGTAA                            c.3039
 T  G  F  S  H  E  E  L  D  D  S  W  X                              p.1012

          .         .         .         .         .         .       g.39456
 ccatgtttgctgcccagcttctaacttacataccgtgagaagttacgtaacatttactcc       c.*60

          .         .         .         .         .         .       g.39516
 tttgtaaatgtttccctatcatcagacaaaactcaataaaaatgtgtgtaatccaatgtg       c.*120

          .         .         .         .         .         .       g.39576
 ggtttttttttccataattaattttgataccatagtgtgtgaaccaagaataatctagtc       c.*180

          .         .         .         .         .         .       g.39636
 acgtgaaacctcttctccagtcatagtatttctcattcattataataaaagtaactggct       c.*240

          .                                                         g.39649
 tttaacctcctta                                                      c.*253

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Oral-facial-digital syndrome 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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