oxoglutarate dehydrogenase-like (OGDHL) - coding DNA reference sequence

(used for variant description)

(last modified October 20, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_018245.2 in the OGDHL gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000010.10, covering OGDHL transcript NM_018245.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       gagtctcaggggcgcgcgcccg       c.-121

 .         .         .         .         .         .                g.5082
 tgggcggctgcgtcacgtgacccaggtaattggcacggcgcgcgcgcaccccttccgcgc       c.-61

 .         .         .         .         .         .         | 02    g.8787
 agccccctgacctgcagcctccggacctcgctgcagcgcggacccggcccgcccgcccg | a    c.-1

          .         .         .         .         .         .       g.8847
 ATGAGTCAGCTGAGGCTGCTGCCGTCCCGTCTTGGGGTACAGGCTGCGAGGCTCCTGGCT       c.60
 M  S  Q  L  R  L  L  P  S  R  L  G  V  Q  A  A  R  L  L  A         p.20

          .         .         .         .         .         .       g.8907
 GCACATGACGTCCCGGTGTTTGGCTGGCGCAGCAGGTCCTCCGGGCCACCGGCCACCTTC       c.120
 A  H  D  V  P  V  F  G  W  R  S  R  S  S  G  P  P  A  T  F         p.40

          .         .         .         .         .         .       g.8967
 CCAAGCAGCAAAGGTGGAGGCGGCTCCAGTTACATGGAGGAGATGTACTTCGCCTGGTTG       c.180
 P  S  S  K  G  G  G  G  S  S  Y  M  E  E  M  Y  F  A  W  L         p.60

          .         .     | 03   .         .         .         .    g.10469
 GAAAACCCCCAGAGTGTCCACAAG | TCCTGGGACAGCTTCTTCAGGGAAGCCAGCGAGGAA    c.240
 E  N  P  Q  S  V  H  K   | S  W  D  S  F  F  R  E  A  S  E  E      p.80

          .         .         .         .         .         .       g.10529
 GCCTTTTCTGGCTCTGCTCAGCCACGGCCCCCTTCTGTTGTCCATGAGAGCAGGTCTGCA       c.300
 A  F  S  G  S  A  Q  P  R  P  P  S  V  V  H  E  S  R  S  A         p.100

          .         .         .         .         .         .       g.10589
 GTCTCAAGTCGGACCAAGACCAGCAAATTGGTGGAGGACCACCTGGCTGTGCAGTCCCTG       c.360
 V  S  S  R  T  K  T  S  K  L  V  E  D  H  L  A  V  Q  S  L         p.120

          .      | 04  .         .         .         .         .    g.14684
 ATCCGGGCCTACCAG | ATCCGGGGTCACCATGTGGCCCAGCTGGACCCCCTGGGCATTCTG    c.420
 I  R  A  Y  Q   | I  R  G  H  H  V  A  Q  L  D  P  L  G  I  L      p.140

          .         .         .         .         .         | 05    g.15133
 GATGCAGACCTGGACTCCTTTGTGCCCTCAGACTTGATCACAACCATTGATAAACTGG | CC    c.480
 D  A  D  L  D  S  F  V  P  S  D  L  I  T  T  I  D  K  L  A |       p.160

          .         .         .         .         .         .       g.15193
 TTCTATGACCTTCAGGAGGCTGACCTTGATAAGGAGTTCCAGCTGCCGACAACCACCTTC       c.540
 F  Y  D  L  Q  E  A  D  L  D  K  E  F  Q  L  P  T  T  T  F         p.180

          .         .         .         .         .     | 06   .    g.15404
 ATTGGGGGCTCTGAAAACACCCTCTCTCTGCGGGAGATCATTCGGCGCCTGGAG | AACACC    c.600
 I  G  G  S  E  N  T  L  S  L  R  E  I  I  R  R  L  E   | N  T      p.200

          .         .         .         .         .         .       g.15464
 TACTGCCAGCACATTGGCCTGGAGTTCATGTTCATCAACGATGTGGAGCAGTGCCAGTGG       c.660
 Y  C  Q  H  I  G  L  E  F  M  F  I  N  D  V  E  Q  C  Q  W         p.220

          .         .         .         .         .         .       g.15524
 ATCCGGCAGAAGTTTGAGACCCCTGGTGTGATGCAGTTCTCCAGCGAGGAGAAGCGGACC       c.720
 I  R  Q  K  F  E  T  P  G  V  M  Q  F  S  S  E  E  K  R  T         p.240

          .         .          | 07        .         .         .    g.16425
 CTGCTGGCCCGGCTAGTGCGCTCCATGAG | GTTTGAAGACTTCCTGGCCCGGAAATGGTCC    c.780
 L  L  A  R  L  V  R  S  M  R  |  F  E  D  F  L  A  R  K  W  S      p.260

          .         .         .         .         .         .       g.16485
 TCAGAGAAGCGGTTTGGCCTGGAGGGCTGTGAAGTGATGATTCCTGCCCTCAAGACCATC       c.840
 S  E  K  R  F  G  L  E  G  C  E  V  M  I  P  A  L  K  T  I         p.280

          .         .         .         .         .       | 08 .    g.17567
 ATCGACAAATCCAGCGAGATGGGGATTGAGAATGTCATCTTGGGGATGCCACACAG | GGGA    c.900
 I  D  K  S  S  E  M  G  I  E  N  V  I  L  G  M  P  H  R  |  G      p.300

          .         .         .         .         .         .       g.17627
 AGGCTGAACGTGCTGGCCAACGTGATCCGCAAGGACCTGGAGCAGATCTTCTGCCAGTTT       c.960
 R  L  N  V  L  A  N  V  I  R  K  D  L  E  Q  I  F  C  Q  F         p.320

          .         .        | 09.         .         .         .    g.20204
 GACCCCAAGCTGGAGGCGGCGGACGAG | GGCTCCGGGGATGTCAAGTACCACCTGGGCATG    c.1020
 D  P  K  L  E  A  A  D  E   | G  S  G  D  V  K  Y  H  L  G  M      p.340

          .         .         .         .         .         .       g.20264
 TACCATGAGAGGATCAACCGCGTCACCAACCGGAACATCACTCTGTCGCTGGTTGCCAAC       c.1080
 Y  H  E  R  I  N  R  V  T  N  R  N  I  T  L  S  L  V  A  N         p.360

          .         .         .         .         .         .       g.20324
 CCCTCCCACCTGGAGGCAGTGGACCCTGTGGTGCAGGGGAAGACAAAGGCAGAGCAGTTC       c.1140
 P  S  H  L  E  A  V  D  P  V  V  Q  G  K  T  K  A  E  Q  F         p.380

          .         .        | 10.         .         .         .    g.20534
 TACCGTGGAGATGCCCAGGGCAAGAAG | GTCATGTCCATCCTGGTTCATGGGGACGCCGCC    c.1200
 Y  R  G  D  A  Q  G  K  K   | V  M  S  I  L  V  H  G  D  A  A      p.400

          .         .         .         .         .         .       g.20594
 TTTGCTGGCCAGGGCGTGGTATATGAGACCTTCCACCTGAGCGACCTGCCCTCCTACACG       c.1260
 F  A  G  Q  G  V  V  Y  E  T  F  H  L  S  D  L  P  S  Y  T         p.420

          .         .         .       | 11 .         .         .    g.21426
 ACCAATGGTACCGTGCACGTCGTCGTCAACAACCAG | ATTGGATTCACCACAGACCCCCGA    c.1320
 T  N  G  T  V  H  V  V  V  N  N  Q   | I  G  F  T  T  D  P  R      p.440

          .         .         .         .         .         .       g.21486
 ATGGCCCGCTCCTCACCATACCCGACCGACGTGGCCCGGGTGGTCAATGCGCCTATCTTC       c.1380
 M  A  R  S  S  P  Y  P  T  D  V  A  R  V  V  N  A  P  I  F         p.460

          .         .         .         .         .         .       g.21546
 CATGTGAATGCCGATGACCCAGAGGCTGTGATATATGTGTGCAGTGTGGCAGCCGAATGG       c.1440
 H  V  N  A  D  D  P  E  A  V  I  Y  V  C  S  V  A  A  E  W         p.480

          .         .         .       | 12 .         .         .    g.21907
 AGAAACACTTTCAACAAAGATGTTGTCGTGGACCTG | GTCTGTTACCGCCGGCGTGGCCAC    c.1500
 R  N  T  F  N  K  D  V  V  V  D  L   | V  C  Y  R  R  R  G  H      p.500

          .         .         .         .         .         .       g.21967
 AATGAGATGGACGAGCCCATGTTCACCCAGCCGCTCATGTACAAGCAGATCCACAGACAG       c.1560
 N  E  M  D  E  P  M  F  T  Q  P  L  M  Y  K  Q  I  H  R  Q         p.520

          .         .         .         .         .         .       g.22027
 GTGCCTGTGCTGAAGAAGTACGCAGACAAGCTGATTGCCGAGGGCACAGTCACCCTGCAG       c.1620
 V  P  V  L  K  K  Y  A  D  K  L  I  A  E  G  T  V  T  L  Q         p.540

           | 13        .         .         .         .         .    g.22678
 GAGTTTGAG | GAAGAAATTGCCAAATACGACCGGATCTGTGAGGAGGCTTATGGCAGGTCC    c.1680
 E  F  E   | E  E  I  A  K  Y  D  R  I  C  E  E  A  Y  G  R  S      p.560

          .         .         .         .         .   | 14     .    g.23265
 AAGGATAAAAAGATTCTGCATATAAAGCACTGGTTGGACTCCCCCTGGCCTG | GCTTCTTC    c.1740
 K  D  K  K  I  L  H  I  K  H  W  L  D  S  P  W  P  G |   F  F      p.580

          .         .         .         .         .         .       g.23325
 AACGTAGATGGGGAGCCCAAGAGCATGACATGCCCAGCCACGGGGATCCCTGAGGACATG       c.1800
 N  V  D  G  E  P  K  S  M  T  C  P  A  T  G  I  P  E  D  M         p.600

          .         .         .         .         .         .       g.23385
 CTCACCCACATCGGCAGTGTGGCCAGCTCTGTGCCCCTGGAGGACTTTAAGATCCACACT       c.1860
 L  T  H  I  G  S  V  A  S  S  V  P  L  E  D  F  K  I  H  T         p.620

   | 15      .         .         .         .         .         .    g.24460
 G | GCCTCTCTCGCATTCTGCGGGGCCGTGCGGACATGACCAAGAACCGGACGGTGGACTGG    c.1920
 G |   L  S  R  I  L  R  G  R  A  D  M  T  K  N  R  T  V  D  W      p.640

          .         .         .         .         .         .       g.24520
 GCGTTGGCAGAGTACATGGCCTTTGGCTCCCTGCTGAAGGAAGGCATCCACGTGCGGCTC       c.1980
 A  L  A  E  Y  M  A  F  G  S  L  L  K  E  G  I  H  V  R  L         p.660

          .         .         .   | 16     .         .         .    g.26570
 AGCGGGCAGGATGTGGAGAGGGGCACATTCAG | TCACCGGCACCATGTTCTCCATGACCAG    c.2040
 S  G  Q  D  V  E  R  G  T  F  S  |  H  R  H  H  V  L  H  D  Q      p.680

          .         .         .         .         .         .       g.26630
 GAGGTTGACCGCAGGACGTGTGTGCCTATGAATCATCTCTGGCCTGACCAGGCCCCGTAC       c.2100
 E  V  D  R  R  T  C  V  P  M  N  H  L  W  P  D  Q  A  P  Y         p.700

          .         .         .         . | 17       .         .    g.27560
 ACCGTGTGCAACAGCTCCCTCTCGGAGTACGGAGTCCTGG | GCTTTGAGCTGGGCTATGCC    c.2160
 T  V  C  N  S  S  L  S  E  Y  G  V  L  G |   F  E  L  G  Y  A      p.720

          .         .         .         .         .         .       g.27620
 ATGGCCAGCCCCAATGCCCTGGTCCTCTGGGAGGCCCAGTTTGGGGACTTCCACAACACG       c.2220
 M  A  S  P  N  A  L  V  L  W  E  A  Q  F  G  D  F  H  N  T         p.740

          .         .         .         .         .         .       g.27680
 GCCCAGTGCATCATCGACCAGTTCATCAGCACCGGCCAGGCCAAGTGGGTGCGGCATAAT       c.2280
 A  Q  C  I  I  D  Q  F  I  S  T  G  Q  A  K  W  V  R  H  N         p.760

          .         .         .          | 18        .         .    g.29138
 GGCATTGTGCTGCTGCTGCCCCATGGCATGGAAGGCATG | GGCCCAGAGCACTCGTCAGCG    c.2340
 G  I  V  L  L  L  P  H  G  M  E  G  M   | G  P  E  H  S  S  A      p.780

          .         .         .         .         .  | 19      .    g.29316
 AGGCCCGAAAGGTTCCTGCAGATGAGCAATGATGACTCGGATGCCTACCCT | GCATTCACC    c.2400
 R  P  E  R  F  L  Q  M  S  N  D  D  S  D  A  Y  P   | A  F  T      p.800

          .         .         .         .         .         .       g.29376
 AAGGACTTCGAGGTGAGCCAGCTCTATGACTGCAACTGGATCGTGGTCAACTGCTCCACA       c.2460
 K  D  F  E  V  S  Q  L  Y  D  C  N  W  I  V  V  N  C  S  T         p.820

          .         .         .         .         .        | 20.    g.29524
 CCGGCCAACTACTTCCACGTGCTGCGCCGGCAGATCCTGCTGCCCTTCCGCAAGCCG | CTG    c.2520
 P  A  N  Y  F  H  V  L  R  R  Q  I  L  L  P  F  R  K  P   | L      p.840

          .         .         .         .         .         .       g.29584
 ATTATCTTCACACCTAAATCTCTGCTGAGGCACCCAGAGGCCAAGTCCAGCTTTGACCAA       c.2580
 I  I  F  T  P  K  S  L  L  R  H  P  E  A  K  S  S  F  D  Q         p.860

          . | 21       .         .         .         .         .    g.30909
 ATGGTATCCG | GGACCAGCTTCCAGCGGGTGATTCCTGAAGATGGGGCCGCAGCACGGGCC    c.2640
 M  V  S  G |   T  S  F  Q  R  V  I  P  E  D  G  A  A  A  R  A      p.880

          .         .         .         .         .         .       g.30969
 CCTGAGCAGGTGCAGCGGCTCATCTTCTGCACGGGAAAGGTGTACTATGACCTGGTGAAG       c.2700
 P  E  Q  V  Q  R  L  I  F  C  T  G  K  V  Y  Y  D  L  V  K         p.900

          .         .         .         .         .     | 22   .    g.31208
 GAGCGGAGCAGCCAGGACCTGGAGGAGAAAGTGGCCATCACGCGCCTGGAGCAG | ATCTCT    c.2760
 E  R  S  S  Q  D  L  E  E  K  V  A  I  T  R  L  E  Q   | I  S      p.920

          .         .         .         .         .         .       g.31268
 CCATTCCCCTTCGACCTGATCAAGCAGGAGGCAGAGAAGTACCCAGGTGCGGAGCTGGCC       c.2820
 P  F  P  F  D  L  I  K  Q  E  A  E  K  Y  P  G  A  E  L  A         p.940

          .         .         .         .         .         .       g.31328
 TGGTGTCAGGAGGAGCACAAGAACATGGGCTACTATGACTACATCAGCCCACGCTTCATG       c.2880
 W  C  Q  E  E  H  K  N  M  G  Y  Y  D  Y  I  S  P  R  F  M         p.960

          .         .          | 23        .         .         .    g.32059
 ACCATCCTGAGGCGCGCACGGCCCATATG | GTATGTTGGCCGGGACCCAGCGGCTGCACCA    c.2940
 T  I  L  R  R  A  R  P  I  W  |  Y  V  G  R  D  P  A  A  A  P      p.980

          .         .         .         .         .         .       g.32119
 GCCACAGGAAACAGGAACACTCACCTGGTGTCACTGAAGAAGTTTCTGGATACTGCCTTC       c.3000
 A  T  G  N  R  N  T  H  L  V  S  L  K  K  F  L  D  T  A  F         p.1000

          .         .         .                                     g.32152
 AATCTCCAGGCCTTTGAGGGCAAGACATTTTAG                                  c.3033
 N  L  Q  A  F  E  G  K  T  F  X                                    p.1010

          .         .         .         .         .         .       g.32212
 agctgggcaaaacctgtgtaggtctcgctgtgggtttgctggggaccaagggggtgatga       c.*60

          .         .         .         .         .         .       g.32272
 aaaggggaggggcggagctcctgcccaggagaggggctgtggggccccaggataaaacag       c.*120

          .         .         .         .         .         .       g.32332
 acacagtgacagggccaagagccagcactgctggccttggtgtcatgccagaatctacca       c.*180

          .         .         .         .         .         .       g.32392
 ggactgagggagccagaggagtcctataggcaggctactgtgctggagcatcccccagct       c.*240

          .         .         .         .         .         .       g.32452
 gctcccatcttgctggaatttcttgggcggcttctccacctgtatctcaagacagacacc       c.*300

          .         .         .         .         .         .       g.32512
 cgggggcctgtgtctgtggccgctcccatcccggcagccctggctgctgctcgccccacc       c.*360

          .         .         .         .         .         .       g.32572
 ctcgcttatctgtagattcaaagcgatgttctcttctgtgctcttagaagtagggagttc       c.*420

          .         .         .         .         .         .       g.32632
 agcagtaacagccaggtgaagcgaacctgctgggtgatttgtttgcgctctgttttatgg       c.*480

          .         .         .         .         .         .       g.32692
 ggcattcctgcgagatgtgtcagcttctgtgtgaaatgcagccacagctcatgtgtacca       c.*540

          .         .         .         .                           g.32739
 aagtagaaaaccaaatcacagagaaataaaaacatgcttcagagaga                    c.*587

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Oxoglutarate dehydrogenase-like protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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