8-oxoguanine DNA glycosylase (OGG1) - coding DNA reference sequence

(used for variant description)

(last modified December 10, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_016828.2 in the OGG1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012106.1, covering OGG1 transcript NM_016828.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5043
                  ctacttccggtggtgctgtggtctgcccctggagaacccagaa       c.-301

 .         .         .         .         .         .                g.5103
 gaacacagctgtgcgcgcccacaggctctgggggcgggagaagataagtcgcaaggaggg       c.-241

 .         .         .         .         .         .                g.5163
 ggcgggacctacacctcaggaaagccggagaattggggcacgaagcggggctttgatgac       c.-181

 .         .         .         .         .         .                g.5223
 ccgcaaagggcgaggcatgcaggaggtggaggaattaagtgaaacagggaaggttgttaa       c.-121

 .         .         .         .         .         .                g.5283
 acagcaccgtgtgggcgaggccttaagggtcgtggtccttgtctgggcggggtctttggg       c.-61

 .         .         .         .         .         .                g.5343
 cgtcgacgaggcctggttctgggtaggcggggctactacggggcggtgcctgctgtggaa       c.-1

          .         .         .         .         .         .       g.5403
 ATGCCTGCCCGCGCGCTTCTGCCCAGGCGCATGGGGCATCGTACTCTAGCCTCCACTCCT       c.60
 M  P  A  R  A  L  L  P  R  R  M  G  H  R  T  L  A  S  T  P         p.20

          .         .         .         .         .         .       g.5463
 GCCCTGTGGGCCTCCATCCCGTGCCCTCGCTCTGAGCTGCGCCTGGACCTGGTTCTGCCT       c.120
 A  L  W  A  S  I  P  C  P  R  S  E  L  R  L  D  L  V  L  P         p.40

          .        | 02.         .         .         .         .    g.6044
 TCTGGACAATCTTTCCG | GTGGAGGGAGCAAAGTCCTGCACACTGGAGTGGTGTACTAGCG    c.180
 S  G  Q  S  F  R  |  W  R  E  Q  S  P  A  H  W  S  G  V  L  A      p.60

          .         .         .         .         .         .       g.6104
 GATCAAGTATGGACACTGACTCAGACTGAGGAGCAGCTCCACTGCACTGTGTACCGAGGA       c.240
 D  Q  V  W  T  L  T  Q  T  E  E  Q  L  H  C  T  V  Y  R  G         p.80

          .         .         .         .         .         .       g.6164
 GACAAGAGCCAGGCTAGCAGGCCCACACCAGACGAGCTGGAGGCCGTGCGCAAGTACTTC       c.300
 D  K  S  Q  A  S  R  P  T  P  D  E  L  E  A  V  R  K  Y  F         p.100

          .         .         .         .         .         .       g.6224
 CAGCTAGATGTTACCCTGGCTCAACTGTATCACCACTGGGGTTCCGTGGACTCCCACTTC       c.360
 Q  L  D  V  T  L  A  Q  L  Y  H  H  W  G  S  V  D  S  H  F         p.120

          .         .      | 03  .         .         .         .    g.6861
 CAAGAGGTGGCTCAGAAATTCCAAG | GTGTGCGACTGCTGCGACAAGACCCCATCGAATGC    c.420
 Q  E  V  A  Q  K  F  Q  G |   V  R  L  L  R  Q  D  P  I  E  C      p.140

          .         .         .         .         .         .       g.6921
 CTTTTCTCTTTTATCTGTTCCTCCAACAACAACATCGCCCGCATCACTGGCATGGTGGAG       c.480
 L  F  S  F  I  C  S  S  N  N  N  I  A  R  I  T  G  M  V  E         p.160

          .         .         .         .         .         .       g.6981
 CGGCTGTGCCAGGCTTTTGGACCTCGGCTCATCCAGCTTGATGATGTCACCTACCATGGC       c.540
 R  L  C  Q  A  F  G  P  R  L  I  Q  L  D  D  V  T  Y  H  G         p.180

          .         .      | 04  .         .         .         .    g.9795
 TTCCCCAGCCTGCAGGCCCTGGCTG | GGCCAGAGGTGGAGGCTCATCTCAGGAAGCTGGGC    c.600
 F  P  S  L  Q  A  L  A  G |   P  E  V  E  A  H  L  R  K  L  G      p.200

          .         .         .         .         .         .       g.9855
 CTGGGCTATCGTGCCCGTTACGTGAGTGCCAGTGCCCGAGCCATCCTGGAAGAACAGGGC       c.660
 L  G  Y  R  A  R  Y  V  S  A  S  A  R  A  I  L  E  E  Q  G         p.220

          .         .         .         .         .         .       g.9915
 GGGCTAGCCTGGCTGCAGCAGCTACGAGAGTCCTCATATGAGGAGGCCCACAAGGCCCTC       c.720
 G  L  A  W  L  Q  Q  L  R  E  S  S  Y  E  E  A  H  K  A  L         p.240

          .         .        | 05.         .         .         .    g.11560
 TGCATCCTGCCTGGAGTGGGCACCAAG | GTGGCTGACTGCATCTGCCTGATGGCCCTAGAC    c.780
 C  I  L  P  G  V  G  T  K   | V  A  D  C  I  C  L  M  A  L  D      p.260

          .         .         .         .         .         .       g.11620
 AAGCCCCAGGCTGTGCCCGTGGATGTCCATATGTGGCACATTGCCCAACGTGACTACAGC       c.840
 K  P  Q  A  V  P  V  D  V  H  M  W  H  I  A  Q  R  D  Y  S         p.280

          .         .         .         .         .         | 06    g.11825
 TGGCACCCTACCACGTCCCAGGCGAAGGGACCGAGCCCCCAGACCAACAAGGAACTGG | GA    c.900
 W  H  P  T  T  S  Q  A  K  G  P  S  P  Q  T  N  K  E  L  G |       p.300

          .         .         .         .         | 07         .    g.14255
 AACTTTTTCCGGAGCCTGTGGGGACCTTATGCTGGCTGGGCCCAAGCG | CTCTGTCAGGTC    c.960
 N  F  F  R  S  L  W  G  P  Y  A  G  W  A  Q  A   | L  C  Q  V      p.320

          .         .         .         .         .         .       g.14315
 ATCACCACTTTTATGACCTTTCTCGGACCCCATAGGCTGGATCAGATGCCTCCTGAAGAA       c.1020
 I  T  T  F  M  T  F  L  G  P  H  R  L  D  Q  M  P  P  E  E         p.340

          .         .         | 08         .         .              g.20897
 TTACAGACTTCTTCCTCTAGACTTGGAG | GGCCTCCTTGGCAATGCATTTGA             c.1071
 L  Q  T  S  S  S  R  L  G  G |   P  P  W  Q  C  I  X               p.356

          .         .         .         .         .         .       g.20957
 tggccaccagcttctgcgtcctcttatcttctgccaggatcacctccgagaaggcccccc       c.*60

          .         .         .         .         .         .       g.21017
 tatcgggagaggggattcacaaggtgaagaactggaaccccagcttccctccagcctctc       c.*120

          .         .         .         .         .         .       g.21077
 ctccattccctatgggttctgtgaccactgctggaccaaggacgtggatgaccctcccct       c.*180

          .         .         .         .         .         .       g.21137
 agtcactcatccatcccctggctccagagatggtcacatgacccaggcctggccagtcaa       c.*240

          .         .         .         .         .         .       g.21197
 agtagtctctcccctggccacagtaattggtcatgtgatgcaagccagcttactagcact       c.*300

          .         .         .         .         .         .       g.21257
 ttgagaatgagtctcctgttgagctggtaggatgtaagcctggagctaatggcgatcatc       c.*360

          .         .         .         .         .         .       g.21317
 tttgccaccacctggggagagcctgcttgggaatgaaattaacacaaaggaagtccaacc       c.*420

          .         .         .         .         .         .       g.21377
 tgagaaatggccaaatatatttcctgataacattatgtggccctctggatccagccatgc       c.*480

          .         .         .         .         .         .       g.21437
 ctgaggtctacccctgggcttttggattatgtgtacagttggttcatccctttttctgct       c.*540

          .         .         .         .         .         .       g.21497
 aattcgagtcatggctaatttaacaccctttagaaccttaaagaaccatcagcatcaccc       c.*600

          .         .         .         .         .         .       g.21557
 gggaacttttttagaaatgcaaaatctctactgctttggatcctgggtcaaaaaaaagaa       c.*660

          .         .         .         .         .         .       g.21617
 aaaaaaaagaaatgcaaaactttaggccctgccccagatttactaaatcaatctgcagtt       c.*720

          .         .         .         .         .         .       g.21677
 taacaaaatcctcaggtgatttgtatgctcattgaactttaagaagcagtgttttagaac       c.*780

          .         .         .         .         .                 g.21735
 aggttcttaaaaaggaacaaataaactcatttaactaaagttaactgattaaagagga         c.*838

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The 8-oxoguanine DNA glycosylase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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