opioid receptor, mu 1 (OPRM1) - coding DNA reference sequence

(used for variant description)

(last modified March 31, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001008503.1 in the OPRM1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_021208.1, covering OPRM1 transcript NM_001008503.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.33869
    gatgagcctctgtgaactactaaggtgggagggggctatacgcagaggagaatgtca       c.-181

 .         .         .         .         .         .                g.33929
 gatgctcagctcggtcccctccgcctgacgctcctctctgtctcagccaggactggtttc       c.-121

 .         .         .         .         .         .                g.33989
 tgtaagaaacagcaggagctgtggcagcggcgaaaggaagcggctgaggcgcttggaacc       c.-61

 .         .         .         .         .         .                g.34049
 cgaaaagtctcggtgctcctggctacctcgcacagcggtgcccgcccggccgtcagtacc       c.-1

          .         .         .         .         .         .       g.34109
 ATGGACAGCAGCGCTGCCCCCACGAACGCCAGCAATTGCACTGATGCCTTGGCGTACTCA       c.60
 M  D  S  S  A  A  P  T  N  A  S  N  C  T  D  A  L  A  Y  S         p.20

          .         .         .         .         .         .       g.34169
 AGTTGCTCCCCAGCACCCAGCCCCGGTTCCTGGGTCAACTTGTCCCACTTAGATGGCAAC       c.120
 S  C  S  P  A  P  S  P  G  S  W  V  N  L  S  H  L  D  G  N         p.40

          .         .         .         .         .         .       g.34229
 CTGTCCGACCCATGCGGTCCGAACCGCACCGACCTGGGCGGGAGAGACAGCCTGTGCCCT       c.180
 L  S  D  P  C  G  P  N  R  T  D  L  G  G  R  D  S  L  C  P         p.60

          .         .         .         .         .         .       g.34289
 CCGACCGGCAGTCCCTCCATGATCACGGCCATCACGATCATGGCCCTCTACTCCATCGTG       c.240
 P  T  G  S  P  S  M  I  T  A  I  T  I  M  A  L  Y  S  I  V         p.80

          .         .         .         .         . | 02       .    g.84340
 TGCGTGGTGGGGCTCTTCGGAAACTTCCTGGTCATGTATGTGATTGTCAG | ATACACCAAG    c.300
 C  V  V  G  L  F  G  N  F  L  V  M  Y  V  I  V  R  |  Y  T  K      p.100

          .         .         .         .         .         .       g.84400
 ATGAAGACTGCCACCAACATCTACATTTTCAACCTTGCTCTGGCAGATGCCTTAGCCACC       c.360
 M  K  T  A  T  N  I  Y  I  F  N  L  A  L  A  D  A  L  A  T         p.120

          .         .         .         .         .         .       g.84460
 AGTACCCTGCCCTTCCAGAGTGTGAATTACCTAATGGGAACATGGCCATTTGGAACCATC       c.420
 S  T  L  P  F  Q  S  V  N  Y  L  M  G  T  W  P  F  G  T  I         p.140

          .         .         .         .         .         .       g.84520
 CTTTGCAAGATAGTGATCTCCATAGATTACTATAACATGTTCACCAGCATATTCACCCTC       c.480
 L  C  K  I  V  I  S  I  D  Y  Y  N  M  F  T  S  I  F  T  L         p.160

          .         .         .         .         .         .       g.84580
 TGCACCATGAGTGTTGATCGATACATTGCAGTCTGCCACCCTGTCAAGGCCTTAGATTTC       c.540
 C  T  M  S  V  D  R  Y  I  A  V  C  H  P  V  K  A  L  D  F         p.180

          .         .         .         .         .         .       g.84640
 CGTACTCCCCGAAATGCCAAAATTATCAATGTCTGCAACTGGATCCTCTCTTCAGCCATT       c.600
 R  T  P  R  N  A  K  I  I  N  V  C  N  W  I  L  S  S  A  I         p.200

          .         .         .         .    | 03    .         .    g.85473
 GGTCTTCCTGTAATGTTCATGGCTACAACAAAATACAGGCAAG | GTTCCATAGATTGTACA    c.660
 G  L  P  V  M  F  M  A  T  T  K  Y  R  Q  G |   S  I  D  C  T      p.220

          .         .         .         .         .         .       g.85533
 CTAACATTCTCTCATCCAACCTGGTACTGGGAAAACCTGCTGAAGATCTGTGTTTTCATC       c.720
 L  T  F  S  H  P  T  W  Y  W  E  N  L  L  K  I  C  V  F  I         p.240

          .         .         .         .         .         .       g.85593
 TTCGCCTTCATTATGCCAGTGCTCATCATTACCGTGTGCTATGGACTGATGATCTTGCGC       c.780
 F  A  F  I  M  P  V  L  I  I  T  V  C  Y  G  L  M  I  L  R         p.260

          .         .         .         .         .         .       g.85653
 CTCAAGAGTGTCCGCATGCTCTCTGGCTCCAAAGAAAAGGACAGGAATCTTCGAAGGATC       c.840
 L  K  S  V  R  M  L  S  G  S  K  E  K  D  R  N  L  R  R  I         p.280

          .         .         .         .         .         .       g.85713
 ACCAGGATGGTGCTGGTGGTGGTGGCTGTGTTCATCGTCTGCTGGACTCCCATTCACATT       c.900
 T  R  M  V  L  V  V  V  A  V  F  I  V  C  W  T  P  I  H  I         p.300

          .         .         .         .         .         .       g.85773
 TACGTCATCATTAAAGCCTTGGTTACAATCCCAGAAACTACGTTCCAGACTGTTTCTTGG       c.960
 Y  V  I  I  K  A  L  V  T  I  P  E  T  T  F  Q  T  V  S  W         p.320

          .         .         .         .         .         .       g.85833
 CACTTCTGCATTGCTCTAGGTTACACAAACAGCTGCCTCAACCCAGTCCTTTATGCATTT       c.1020
 H  F  C  I  A  L  G  Y  T  N  S  C  L  N  P  V  L  Y  A  F         p.340

          .         .         .         .         .         .       g.85893
 CTGGATGAAAACTTCAAACGATGCTTCAGAGAGTTCTGTATCCCAACCTCTTCCAACATT       c.1080
 L  D  E  N  F  K  R  C  F  R  E  F  C  I  P  T  S  S  N  I         p.360

          .         .         .         .         .         .       g.85953
 GAGCAACAAAACTCCACTCGAATTCGTCAGAACACTAGAGACCACCCCTCCACGGCCAAT       c.1140
 E  Q  Q  N  S  T  R  I  R  Q  N  T  R  D  H  P  S  T  A  N         p.380

          .         .     | 04   .         .         .         .    g.241232
 ACAGTGGATAGAACTAATCATCAG | CCACCCTTGGCAGTCAGCATGGCCCAGATCTTTACA    c.1200
 T  V  D  R  T  N  H  Q   | P  P  L  A  V  S  M  A  Q  I  F  T      p.400

          .         .         .         .         .                 g.241289
 CGATATCCTCCTCCGACTCATCGTGAGAAAACCTGCAATGATTACATGAAGAGGTAG          c.1257
 R  Y  P  P  P  T  H  R  E  K  T  C  N  D  Y  M  K  R  X            p.418

          .         .         .         .         .         .       g.241349
 ataatgtattaccctgatttggtaggtaaagtattatcctgatttatgtgacagagtgaa       c.*60

          .         .                                               g.241371
 aggcaacttttaattgttaacc                                             c.*82

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Opioid receptor, mu 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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