oxysterol binding protein-like 1A (OSBPL1A) - coding DNA reference sequence

(used for variant description)

(last modified January 25, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_080597.3 in the OSBPL1A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029432.1, covering OSBPL1A transcript NM_080597.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5037
                        caggggcgggctgcggggaggggcggcgccacctcgc       c.-181

 .         .         .         .         .         .                g.5097
 gctccgccgtggtcccggcgccgggtcccggagacagacgttacgcgggctcgagcgtcc       c.-121

 .         .         .         .         .         .                g.5157
 tcggggagtgccagccagagttggtgacgaccacttcctcgacgtggggcgggcggacgg       c.-61

 .         .         .         .         .         .        | 02    g.25336
 gaagcctggggtcgtggccaccgcctcgggagctctgggagcccgggtgaccgcgtag | aa    c.-1

          .         .         .         .         .         .       g.25396
 ATGAACACAGAAGCGGAGCAACAGCTTCTCCATCACGCCAGAAATGGCAATGCTGAAGAA       c.60
 M  N  T  E  A  E  Q  Q  L  L  H  H  A  R  N  G  N  A  E  E         p.20

          .         .         .         .         .         .       g.25456
 GTAAGACAACTATTAGAGACCATGGCGAGGAATGAAGTGATTGCTGACATTAATTGCAAA       c.120
 V  R  Q  L  L  E  T  M  A  R  N  E  V  I  A  D  I  N  C  K         p.40

   | 03      .         .         .         .         .         .    g.34556
 G | GAAGAAGTAAGTCTAACTTGGGCTGGACACCTCTACATCTGGCATGCTATTTTGGACAC    c.180
 G |   R  S  K  S  N  L  G  W  T  P  L  H  L  A  C  Y  F  G  H      p.60

          .         .        | 04.         .         .         .    g.35936
 AGACAAGTGGTCCAGGATCTGTTGAAG | GCTGGTGCAGAAGTGAATGTGTTGAATGACATG    c.240
 R  Q  V  V  Q  D  L  L  K   | A  G  A  E  V  N  V  L  N  D  M      p.80

          .         .         .         .   | 05     .         .    g.61229
 GGAGACACGCCGCTTCATCGAGCTGCCTTTACAGGACGAAAG | GAGTTGGTAATGCTTCTC    c.300
 G  D  T  P  L  H  R  A  A  F  T  G  R  K   | E  L  V  M  L  L      p.100

          .         .         .         .         .         .       g.61289
 TTAGAATATAATGCTGATACTACTATTGTTAATGGGAGTGGACAGACAGCAAAAGAAGTT       c.360
 L  E  Y  N  A  D  T  T  I  V  N  G  S  G  Q  T  A  K  E  V         p.120

          .         .         .     | 06   .         .         .    g.68565
 ACTCATGCTGAAGAAATCAGAAGCATGCTTGAAG | CTGTAGAAAGGACTCAACAAAGAAAG    c.420
 T  H  A  E  E  I  R  S  M  L  E  A |   V  E  R  T  Q  Q  R  K      p.140

          .         .         .         .         .         .       g.68625
 CTTGAAGAATTACTTTTAGCAGCAGCAAGAGAAGGCAAAACAACAGAACTCACAGCTCTG       c.480
 L  E  E  L  L  L  A  A  A  R  E  G  K  T  T  E  L  T  A  L         p.160

  | 07       .         .         .         .         .         .    g.69843
  | CTCAACAGGCCCAATCCTCCTGATGTTAACTGTTCGGATCAGTTAGGAAATACACCCTTG    c.540
  | L  N  R  P  N  P  P  D  V  N  C  S  D  Q  L  G  N  T  P  L      p.180

          .         .         .         .         .         .       g.69903
 CATTGTGCAGCTTACCGGGCCCATAAACAATGTGCCTTAAAGCTTCTAAGAAGTGGAGCA       c.600
 H  C  A  A  Y  R  A  H  K  Q  C  A  L  K  L  L  R  S  G  A         p.200

          .         .      | 08  .         .         .         .    g.84095
 GACCCTAATCTGAAGAACAAAAATG | ATCAGAAACCTCTTGACCTTGCCCAGGGTGCTGAA    c.660
 D  P  N  L  K  N  K  N  D |   Q  K  P  L  D  L  A  Q  G  A  E      p.220

          .         .        | 09.         .         .         .    g.84257
 ATGAAACACATTCTTGTTGGTAATAAG | GTCATCTACAAAGCATTGAAACGATATGAGGGC    c.720
 M  K  H  I  L  V  G  N  K   | V  I  Y  K  A  L  K  R  Y  E  G      p.240

          .   | 10     .         .         .         .         .    g.85517
 CCTCTCTGGAAG | AGTTCAAGATTTTTTGGCTGGAGATTATTCTGGGTAGTGTTAGAGCAT    c.780
 P  L  W  K   | S  S  R  F  F  G  W  R  L  F  W  V  V  L  E  H      p.260

          .         .       | 11 .         .         .         .    g.85691
 GGAGTCCTTTCATGGTATAGGAAACA | GCCTGATGCAGTTCATAATATTTATCGCCAGGGA    c.840
 G  V  L  S  W  Y  R  K  Q  |  P  D  A  V  H  N  I  Y  R  Q  G      p.280

          .         .         . | 12       .         .         .    g.88552
 TGCAAACACCTGACTCAAGCAGTATGCACG | GTAAAATCCACTGATAGCTGCCTCTTCTTT    c.900
 C  K  H  L  T  Q  A  V  C  T   | V  K  S  T  D  S  C  L  F  F      p.300

          .         .         .         .         .         .       g.88612
 ATTAAATGCTTTGATGACACCATTCATGGCTTCCGGGTTCCTAAGAATAGCCTTCAGCAG       c.960
 I  K  C  F  D  D  T  I  H  G  F  R  V  P  K  N  S  L  Q  Q         p.320

           | 13        .         .         .         .         .    g.90814
 TCAAGAGAG | GACTGGCTGGAAGCAATAGAAGAACATTCTGCTTACAGCACTCACTACTGT    c.1020
 S  R  E   | D  W  L  E  A  I  E  E  H  S  A  Y  S  T  H  Y  C      p.340

          .         .         .         .         .         .       g.90874
 TCCCAGGACCAGCTGACTGATGAGGAGGAGGAAGATACGGTTTCTGCTGCAGACCTGAAG       c.1080
 S  Q  D  Q  L  T  D  E  E  E  E  D  T  V  S  A  A  D  L  K         p.360

          .   | 14     .         .         .         .         .    g.99199
 AAATCATTAGAG | AAAGCACAGTCATGCCAACAGCGACTAGATAGGGAAATTTCCAACTTT    c.1140
 K  S  L  E   | K  A  Q  S  C  Q  Q  R  L  D  R  E  I  S  N  F      p.380

          .         .         .     | 15   .         .         .    g.121947
 CTCAAAATGATTAAGGAGTGTGACATGGCTAAAG | AAATGCTTCCATCATTTCTTCAGAAA    c.1200
 L  K  M  I  K  E  C  D  M  A  K  E |   M  L  P  S  F  L  Q  K      p.400

          .         .         .         .         .         .       g.122007
 GTTGAAGTTGTCTCAGAAGCTTCTAGAGAAACTTGTGTAGCTTTGACTGATTGCCTTAAT       c.1260
 V  E  V  V  S  E  A  S  R  E  T  C  V  A  L  T  D  C  L  N         p.420

          .         .  | 16      .         .         .         .    g.163526
 CTCTTCACCAAACAAGAAGGG | GTGAGGAATTTTAAATTGGAACAAGAGCAAGAAAAAAAC    c.1320
 L  F  T  K  Q  E  G   | V  R  N  F  K  L  E  Q  E  Q  E  K  N      p.440

          .         .         .         .         .         .       g.163586
 AAAATCTTGTCAGAAGCACTGGAGACGCTGGCCACTGAACATCATGAATTAGAGCAGTCT       c.1380
 K  I  L  S  E  A  L  E  T  L  A  T  E  H  H  E  L  E  Q  S         p.460

          .         .         .         .         .         .       g.163646
 CTGGTGAAAGGCTCTCCACCCGCCAGCATCCTTAGCGAGGACGAGTTCTATGATGCGCTG       c.1440
 L  V  K  G  S  P  P  A  S  I  L  S  E  D  E  F  Y  D  A  L         p.480

      | 17   .         .         .         .         .         .    g.177727
 TCAG | ATTCCGAGTCCGAAAGGTCCCTGAGTAGATTGGAAGCAGTGACAGCACGCTCCTTT    c.1500
 S  D |   S  E  S  E  R  S  L  S  R  L  E  A  V  T  A  R  S  F      p.500

          .         .         .         .         .         .       g.177787
 GAAGAGGAAGGAGAGCATTTGGGCAGTAGAAAACACAGAATGTCCGAAGAAAAAGACTGT       c.1560
 E  E  E  G  E  H  L  G  S  R  K  H  R  M  S  E  E  K  D  C         p.520

          .         .         .         .  | 18      .         .    g.206688
 GGTGGCGGAGATGCTCTCTCCAATGGCATCAAGAAACACAG | AACAAGTTTGCCTTCTCCT    c.1620
 G  G  G  D  A  L  S  N  G  I  K  K  H  R  |  T  S  L  P  S  P      p.540

          .         .         .         .         .        | 19.    g.221593
 ATGTTTTCCAGAAATGACTTCAGTATCTGGAGCATCCTCAGAAAATGTATTGGAATG | GAA    c.1680
 M  F  S  R  N  D  F  S  I  W  S  I  L  R  K  C  I  G  M   | E      p.560

          .         .         .         .         .         .       g.221653
 CTATCCAAGATCACGATGCCAGTTATATTTAATGAGCCTCTGAGCTTCCTACAGCGCCTA       c.1740
 L  S  K  I  T  M  P  V  I  F  N  E  P  L  S  F  L  Q  R  L         p.580

          .         .         .         .         .         .       g.221713
 ACTGAATACATGGAGCATACTTACCTCATCCACAAGGCCAGTTCACTCTCTGATCCTGTG       c.1800
 T  E  Y  M  E  H  T  Y  L  I  H  K  A  S  S  L  S  D  P  V         p.600

          .   | 20     .         .         .         .         .    g.223082
 GAAAGGATGCAG | TGTGTAGCTGCGTTTGCTGTATCTGCTGTTGCTTCTCAGTGGGAACGG    c.1860
 E  R  M  Q   | C  V  A  A  F  A  V  S  A  V  A  S  Q  W  E  R      p.620

          .         .         .         .         . | 21       .    g.224684
 ACTGGAAAACCTTTCAACCCACTGCTGGGAGAGACTTATGAATTAGTGCG | AGATGACCTT    c.1920
 T  G  K  P  F  N  P  L  L  G  E  T  Y  E  L  V  R  |  D  D  L      p.640

          .         .         .         .         .         .       g.224744
 GGATTTAGACTCATCTCCGAACAGGTCAGCCATCACCCACCAATCAGTGCATTTCATGCT       c.1980
 G  F  R  L  I  S  E  Q  V  S  H  H  P  P  I  S  A  F  H  A         p.660

          .         .         .         .         .         .       g.224804
 GAAGGATTAAACAATGACTTCATCTTTCATGGCTCTATCTATCCCAAACTGAAATTCTGG       c.2040
 E  G  L  N  N  D  F  I  F  H  G  S  I  Y  P  K  L  K  F  W         p.680

          .         .         .         .         .    | 22    .    g.230393
 GGGAAGAGTGTAGAAGCAGAACCCAAAGGAACCATCACCTTGGAGCTCCTTGA | ACACAAT    c.2100
 G  K  S  V  E  A  E  P  K  G  T  I  T  L  E  L  L  E  |  H  N      p.700

          .         .         .         .         .         .       g.230453
 GAGGCATATACATGGACAAATCCCACCTGCTGTGTGCATAATATCATTGTGGGTAAACTG       c.2160
 E  A  Y  T  W  T  N  P  T  C  C  V  H  N  I  I  V  G  K  L         p.720

          .         .         .         .  | 23      .         .    g.231390
 TGGATCGAACAGTATGGCAATGTGGAAATTATAAACCACAA | GACTGGGGACAAATGTGTG    c.2220
 W  I  E  Q  Y  G  N  V  E  I  I  N  H  K  |  T  G  D  K  C  V      p.740

          .         .         .         .         .         .       g.231450
 TTGAATTTTAAGCCATGTGGCCTTTTTGGTAAGGAATTACACAAAGTTGAAGGCTACATT       c.2280
 L  N  F  K  P  C  G  L  F  G  K  E  L  H  K  V  E  G  Y  I         p.760

          .  | 24      .         .         .         .         .    g.232465
 CAAGATAAAAG | CAAAAAGAAGCTCTGTGCCCTCTATGGGAAGTGGACTGAATGTTTATAC    c.2340
 Q  D  K  S  |  K  K  K  L  C  A  L  Y  G  K  W  T  E  C  L  Y      p.780

          .         .         .         .         .         .       g.232525
 AGTGTTGACCCTGCCACGTTTGACGCTTACAAAAAAAATGATAAGAAAAATACAGAAGAG       c.2400
 S  V  D  P  A  T  F  D  A  Y  K  K  N  D  K  K  N  T  E  E         p.800

          .         | 25         .         .         .         .    g.235466
 AAGAAGAACAGCAAACAG | ATGAGCACCTCTGAGGAGTTGGATGAAATGCCAGTGCCGGAT    c.2460
 K  K  N  S  K  Q   | M  S  T  S  E  E  L  D  E  M  P  V  P  D      p.820

          .         .         .         .         .         .       g.235526
 TCTGAAAGTGTATTCATTATCCCTGGAAGCGTTCTTCTATGGCGAATAGCCCCACGGCCT       c.2520
 S  E  S  V  F  I  I  P  G  S  V  L  L  W  R  I  A  P  R  P         p.840

          .      | 26  .         .         .         .         .    g.236212
 CCAAATTCTGCCCAG | ATGTATAATTTTACTAGTTTTGCAATGGTTTTGAATGAAGTAGAC    c.2580
 P  N  S  A  Q   | M  Y  N  F  T  S  F  A  M  V  L  N  E  V  D      p.860

          .         .         .         .         .         .       g.236272
 AAAGACATGGAGAGTGTGATTCCCAAGACAGACTGCAGGTTACGGCCTGACATCAGAGCC       c.2640
 K  D  M  E  S  V  I  P  K  T  D  C  R  L  R  P  D  I  R  A         p.880

          .          | 27        .         .         .         .    g.237755
 ATGGAAAATGGAGAGATAG | ATCAAGCTAGTGAAGAAAAAAAACGACTTGAGGAAAAACAA    c.2700
 M  E  N  G  E  I  D |   Q  A  S  E  E  K  K  R  L  E  E  K  Q      p.900

          .         .         .         .         . | 28       .    g.239598
 AGAGCAGCCCGCAAAAACAGGTCCAAGTCAGAAGAGGACTGGAAGACGAG | GTGGTTCCAT    c.2760
 R  A  A  R  K  N  R  S  K  S  E  E  D  W  K  T  R  |  W  F  H      p.920

          .         .         .         .         .         .       g.239658
 CAAGGTCCTAATCCCTACAATGGAGCACAGGACTGGATTTACTCTGGCAGCTACTGGGAC       c.2820
 Q  G  P  N  P  Y  N  G  A  Q  D  W  I  Y  S  G  S  Y  W  D         p.940

          .         .         .                                     g.239691
 AGAAATTACTTCAATTTGCCTGACATTTATTAA                                  c.2853
 R  N  Y  F  N  L  P  D  I  Y  X                                    p.950

          .         .         .         .         .         .       g.239751
 aatgcatacaagtcagggtgtttggctaatctacaaataagtcttaaacctatgttttta       c.*60

          .         .         .         .         .         .       g.239811
 aatttttttcccttggtttctacttatcttttaaaaaaaaaaatgaaaaaacactcatga       c.*120

          .         .         .         .         .         .       g.239871
 gataactgcatttcacccaacaaaagcagggtataaggcgatattggtgatgaaagtctt       c.*180

          .         .         .         .         .         .       g.239931
 aggaaaaatgcataattttgctataaaatgtacttatttggaatactattttatatagag       c.*240

          .         .         .         .         .         .       g.239991
 gtaagagaacactgctggggaatatgctttttatggttgctgttgccatatttactgaag       c.*300

          .         .         .         .         .         .       g.240051
 gtttatacctaaatgtaactttagctttatggaactatatagtaatcccaaatcaagtta       c.*360

          .         .         .         .         .         .       g.240111
 ttttgaatatttttatgctgtcatgcttgaatgttttagatgtaacctttgacatattta       c.*420

          .         .         .         .         .         .       g.240171
 gaactctcctcctatacaatgtttattctcagatatagaggttatgtcattttataaaga       c.*480

          .         .         .         .         .         .       g.240231
 cttcattgataagatggcttttattcatactaatcctcccaatgttaccccttccatctt       c.*540

          .         .         .         .         .         .       g.240291
 ccaagaagaaaaaaaatgcctgaatattcagaatagatatttctgatttgaaaattctaa       c.*600

          .         .         .         .         .         .       g.240351
 agaattaaactggaaaagtatttcatttacttagtgctctgaatttacttttacagtttt       c.*660

          .         .         .         .         .         .       g.240411
 ctgcagtcagtatcattaaaatggttaagtttacatttgaactgaaaatatgtataaaat       c.*720

          .         .         .         .         .         .       g.240471
 ctagcaattcacaaaaatgccctagaaatatagattttaatcaccattacataatgacaa       c.*780

          .         .         .         .         .         .       g.240531
 accttgttaaatgcttccacttccagtggcaaatgccactagggaaagtaagttgcactc       c.*840

          .         .         .         .         .         .       g.240591
 atgtaagtatcaaactatataaaaggaggccttgtgcatttcaagtttgcaaagtacctg       c.*900

          .         .         .         .         .         .       g.240651
 tgtacttaaaatatgtgtggagacctactgtacagtagttttgcccctttaattggggca       c.*960

          .         .         .         .         .         .       g.240711
 cattcatcttaaatcttatagtatttatccacccaaaccccagactgagatactgctccc       c.*1020

          .         .         .         .         .         .       g.240771
 aggggcctaggtagctgccagtccgtgattttaattgctgtcttgaagttaacaagtgtt       c.*1080

          .         .         .         .         .                 g.240825
 ataatgaaataatctacctgatgctaaataaaggctttagaatgttccccaaaa             c.*1134

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Oxysterol binding protein-like 1A protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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