osteopetrosis associated transmembrane protein 1 (OSTM1) - coding DNA reference sequence

(used for variant description)

(last modified March 2, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_014028.3 in the OSTM1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007262.1, covering OSTM1 transcript NM_014028.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5026
                                   gcggaaaccggaagcggcggctgtcc       c.-61

 .         .         .         .         .         .                g.5086
 gcggtgccggctgggggcggagaggcggcggtgggctccctggggtgtgtgagcccggtg       c.-1

          .         .         .         .         .         .       g.5146
 ATGGAGCCGGGCCCGACAGCCGCGCAGCGGAGGTGTTCGTTGCCGCCGTGGCTGCCGCTG       c.60
 M  E  P  G  P  T  A  A  Q  R  R  C  S  L  P  P  W  L  P  L         p.20

          .         .         .         .         .         .       g.5206
 GGGCTGCTGCTGTGGTCGGGGCTGGCCCTGGGCGCGCTCCCCTTCGGCAGCAGTCCGCAC       c.120
 G  L  L  L  W  S  G  L  A  L  G  A  L  P  F  G  S  S  P  H         p.40

          .         .         .         .         .         .       g.5266
 AGGGTCTTCCACGACCTCCTGTCGGAGCAGCAGTTGCTGGAGGTGGAGGACTTGTCCCTG       c.180
 R  V  F  H  D  L  L  S  E  Q  Q  L  L  E  V  E  D  L  S  L         p.60

          .         .         .         .         .         .       g.5326
 TCCCTCCTGCAGGGTGGAGGGCTGGGGCCTCTGTCGCTGCCCCCGGACCTGCCGGATCTG       c.240
 S  L  L  Q  G  G  G  L  G  P  L  S  L  P  P  D  L  P  D  L         p.80

          .         .         .         .         .         .       g.5386
 GATCCTGAGTGCCGGGAGCTCCTGCTGGACTTCGCCAACAGCAGCGCAGAGCTGACAGGG       c.300
 D  P  E  C  R  E  L  L  L  D  F  A  N  S  S  A  E  L  T  G         p.100

          .         .         .         .         .         .       g.5446
 TGTCTGGTGCGCAGCGCCCGGCCCGTGCGCCTCTGTCAGACCTGCTACCCCCTCTTCCAA       c.360
 C  L  V  R  S  A  R  P  V  R  L  C  Q  T  C  Y  P  L  F  Q         p.120

          .         .         .         .   | 02     .         .    g.15456
 CAGGTCGTCAGCAAGATGGACAACATCAGCCGAGCCGCGGGG | AATACTTCAGAGAGTCAG    c.420
 Q  V  V  S  K  M  D  N  I  S  R  A  A  G   | N  T  S  E  S  Q      p.140

          .         .         .         .         .         .       g.15516
 AGTTGTGCCAGAAGTCTCTTAATGGCAGATAGAATGCAAATAGTTGTGATTCTCTCAGAA       c.480
 S  C  A  R  S  L  L  M  A  D  R  M  Q  I  V  V  I  L  S  E         p.160

          .         .         .        | 03.         .         .    g.25173
 TTTTTTAATACCACATGGCAGGAGGCAAATTGTGCAA | ATTGTTTAACAAACAACAGTGAA    c.540
 F  F  N  T  T  W  Q  E  A  N  C  A  N |   C  L  T  N  N  S  E      p.180

          .         .         .         .         .         .       g.25233
 GAATTATCAAACAGCACAGTATATTTCCTTAATCTATTTAATCACACCCTGACCTGCTTT       c.600
 E  L  S  N  S  T  V  Y  F  L  N  L  F  N  H  T  L  T  C  F         p.200

          .      | 04  .         .         .         .         .    g.28584
 GAACATAACCTTCAG | GGGAATGCACATAGTCTTTTACAGACAAAAAATTATTCAGAAGTA    c.660
 E  H  N  L  Q   | G  N  A  H  S  L  L  Q  T  K  N  Y  S  E  V      p.220

          .         .         .         .         .         .       g.28644
 TGCAAAAACTGCCGTGAAGCATACAAAACTCTGAGTAGTCTGTACAGTGAAATGCAAAAA       c.720
 C  K  N  C  R  E  A  Y  K  T  L  S  S  L  Y  S  E  M  Q  K         p.240

          .         .         .         .         .         .       g.28704
 ATGAATGAACTTGAGAATAAGGCTGAACCTGGAACACATTTATGCATTGATGTGGAAGAT       c.780
 M  N  E  L  E  N  K  A  E  P  G  T  H  L  C  I  D  V  E  D         p.260

     | 05    .         .         .         .         .         .    g.30376
 GCA | ATGAACATCACTCGAAAACTATGGAGTCGAACTTTCAACTGTTCAGTCCCTTGCAGT    c.840
 A   | M  N  I  T  R  K  L  W  S  R  T  F  N  C  S  V  P  C  S      p.280

          .         .         .         .         .         .       g.30436
 GACACAGTGCCTGTAATTGCTGTTTCTGTGTTCATTCTCTTTCTACCTGTTGTCTTCTAC       c.900
 D  T  V  P  V  I  A  V  S  V  F  I  L  F  L  P  V  V  F  Y         p.300

          .         .         .         .          | 06        .    g.34908
 CTTAGTAGCTTTCTTCACTCAGAGCAAAAGAAACGCAAACTCATTCTGC | CCAAACGTCTC    c.960
 L  S  S  F  L  H  S  E  Q  K  K  R  K  L  I  L  P |   K  R  L      p.320

          .         .         .         .                           g.34953
 AAGTCCAGTACCAGTTTTGCAAATATTCAGGAAAATTCAAACTGA                      c.1005
 K  S  S  T  S  F  A  N  I  Q  E  N  S  N  X                        p.334

          .         .         .         .         .         .       g.35013
 gacctacaaaatggagaattgacatatcacgtgaatgaatggtggaagacacaacttggt       c.*60

          .         .         .         .         .         .       g.35073
 ttcagaaagaagataaactgtgatttgacaagtcaagctcttaagaaatacaaggacttc       c.*120

          .         .         .         .         .         .       g.35133
 agatccatttttaaataagaattttcgatttttctttccttttccacttctttctaacag       c.*180

          .         .         .         .         .         .       g.35193
 atttggatatttttaatttccaggcatagcaatgttatctattttaatgtgtatttgtca       c.*240

          .         .         .         .         .         .       g.35253
 caataacagaacatgcaagaacaatcattattttattttataggcatttgattactattc       c.*300

          .         .         .         .         .         .       g.35313
 tagacttctggtatcttcttactaacataaatatctcaagtagaaaagtttttgaaaact       c.*360

          .         .         .         .         .         .       g.35373
 aacatttaaaaattaatcagttacagtaaagactttgaaaaagaaatgtacttgttagga       c.*420

          .         .         .         .         .         .       g.35433
 agtagcttaattaccccccattgcagtattattgttatatatatagttaatatgttgtac       c.*480

          .         .         .         .         .         .       g.35493
 atcacaataatatataattcagtctctagtttccctagagtcatttttgaaaccactgat       c.*540

          .         .         .         .         .         .       g.35553
 tgcaaacctccctgacaatttttaaaagtagtaagccacattacatttatctttgtaaaa       c.*600

          .         .         .         .         .         .       g.35613
 agatttatggtaactggtttcttacttgacttttataaatagtattttacatcttatttt       c.*660

          .         .         .         .         .         .       g.35673
 tgcctttatttcataagtaatttaaaaatcactggattgctttattatattcagggcaat       c.*720

          .         .         .         .         .         .       g.35733
 atggattatttttataccaaggatttgcatcgtgaattacattaagttatttggcaattt       c.*780

          .         .         .         .         .         .       g.35793
 ataatttattactactttaaatcaaatgtagcattatcacactgtatttaaattgtcatt       c.*840

          .         .         .         .         .         .       g.35853
 ttttaaaggaatattttcttcttaagatatatagaggattttggagaagagagacaggag       c.*900

          .         .         .         .         .         .       g.35913
 gggtaaaaccagcttaaggttcagcgagcagaaagggacctgagaggatgctcactgtaa       c.*960

          .         .         .         .         .         .       g.35973
 gactgttggacagtggtgtgtattgaggggatgaatcggaacgatagtctcatgcagaaa       c.*1020

          .         .         .         .         .         .       g.36033
 atagtgagattaagatcatccttattgtttctaaattatttcaatcagatgaaagtgata       c.*1080

          .         .         .         .         .         .       g.36093
 cgattgaaatgaaatcacatagttcgtgctcagaaattctattttggtatgtttgtatta       c.*1140

          .         .         .         .         .         .       g.36153
 gcctttagaaaaaacactccgtttcagaattgttcacagttttatttcttaggtttttag       c.*1200

          .         .         .         .         .         .       g.36213
 agttcaggatttcatttattaatttcttcttgcttttttggtggaaataggctttgttgt       c.*1260

          .         .         .         .         .         .       g.36273
 aaacattaagaatataaaatctcctctatatagaaacaagaattttgttaaaaagagaat       c.*1320

          .         .         .         .         .         .       g.36333
 ttgaatcccttcctatactataaaatgctctatagggagacaaagtgtttcttttttctt       c.*1380

          .         .         .         .         .         .       g.36393
 ttatgtttactgtttatgtggagtgaaatataaggctcttggatgtataacatactcaaa       c.*1440

          .         .         .         .         .         .       g.36453
 agctgttacactttctctgatctgctgtgatccactgaaaatgtgctggggtttgttctg       c.*1500

          .         .         .         .         .         .       g.36513
 ctgtcactgtttatgctgctggaacttagcactgtcttgatttgaagcatatgattgaga       c.*1560

          .         .         .         .         .         .       g.36573
 gccatttgaagcaatcttcattaatgcagataaaacaagtttacatgtgcagagttagaa       c.*1620

          .         .         .         .         .         .       g.36633
 aatgacatgttcaattctgtaagtggtgactttttgagcacctttcagtattatgtattt       c.*1680

          .         .         .         .         .         .       g.36693
 gtaaaaaccattgtttttggatataaagctaataagcactttaaaaaggaaaaggcagcc       c.*1740

          .         .         .         .         .         .       g.36753
 tttactattttttctggttgagtcattgctctttagacctagcatcagcaatagatttca       c.*1800

          .         .         .         .         .         .       g.36813
 aagataagtattaagcgctaccctaaagtgtgtaagtttttcattttgtcatattgaaaa       c.*1860

          .         .         .         .         .         .       g.36873
 atgatttgcatagtactgaatgttgacacacagcttatatgtatttacaagaatatcttt       c.*1920

          .         .         .         .         .         .       g.36933
 aagtgtttttttgacacattaaaataaaggaaataaggaaattgtaagctttatttggat       c.*1980

          .         .         .         .         .         .       g.36993
 ttttaaatacatttttaaaatttcagatgtaatttaacatcacatttgtttttcaggtat       c.*2040

          .         .         .         .         .         .       g.37053
 tgagtttagatgcctacttttatgagtaccatcagctggacacagtgtctcatacctgta       c.*2100

          .         .         .         .         .         .       g.37113
 tttgcagcactttgggaggctgaagcagatcgctggagcttatgagttcgagaccagcct       c.*2160

          .         .         .         .         .         .       g.37173
 ggacaacatagtgaaacactgtctctgcaaaaaatacaaaaattagctgggtatggtggt       c.*2220

          .         .         .         .         .         .       g.37233
 aagtgcctgtagtcctagctacttgggaggctgagatgggaggatgtcttgagcccggga       c.*2280

          .         .         .         .         .         .       g.37293
 ggtggaggttgcaatgagccaagattgtaccactgcattccaacctgggcgacagagcca       c.*2340

          .         .         .         .         .         .       g.37353
 gaccttgtctcaaaaaaaaaaaaaaaaaaagaaaaaagaaagtactgtctgtcttaaatt       c.*2400

          .         .         .         .         .         .       g.37413
 ttgctgcaaataaaaatgtactttggattatttattgttgaacttgagagatagaaataa       c.*2460

          .         .         .         .         .         .       g.37473
 catcagatatattttttcttttttttttataattaattttttttttttttttttttgtag       c.*2520

          .         .         .         .         .         .       g.37533
 agacagtgtctcactatgttgcccaagctggtcttgaactcctgagttcaagagatcctc       c.*2580

          .         .         .         .         .         .       g.37593
 ctgccttagcctcccaaagtgctgggattacaagcataagcaccacacctggctgaacat       c.*2640

          .         .         .         .         .         .       g.37653
 cagatattttaaagtgtagcccagagtctagttggtaaatgttacttatattgggactag       c.*2700

          .         .         .         .         .         .       g.37713
 tattttctaatgtttctgggatatgctccctataaaatgaaatgttttcctggaacaatg       c.*2760

          .         .         .         .         .         .       g.37773
 ctaattaggattgcattcctggccaaagacatgacatcaaataagtaatagacatcacca       c.*2820

          .         .         .         .         .         .       g.37833
 gcaatgaattttgaaaagcaaaaaatactattaacctatataaccatttaaaatttaaaa       c.*2880

          .         .         .         .         .         .       g.37893
 aattatgttccaagtacctctattttctgagctagaagaaaccttagaggccatctgatg       c.*2940

          .         .         .         .         .         .       g.37953
 atagattcccagagctggatggatccctagggactacctaatctgactttctgtccactg       c.*3000

          .         .         .         .         .         .       g.38013
 catggattcttctaaaaagtatgtcacttatttccctaccttattaagactaaataagtg       c.*3060

          .         .         .         .         .         .       g.38073
 gaacatcatagagctctttatttataacagtcattctttgatagtcaactcttaaatgga       c.*3120

          .         .         .         .         .         .       g.38133
 gacttgagatgcttaaatattgtactactgtgcttatcttgtaaagatttcataaaatga       c.*3180

          .         .         .         .         .         .       g.38193
 tagtattggttattttaaaaaggctttggcttatgctgaattatacatgtagcaccaaaa       c.*3240

          .         .         .         .         .         .       g.38253
 tgttacaactctactaaatttccttgttctaaactattatattagctataataaatatta       c.*3300

          .         .         .         .         .         .       g.38313
 gtcatacatgtaacatgtttaatgacaaataactttctttatctccttggaattaaagag       c.*3360

          .                                                         g.38329
 ggcttttaaaagataa                                                   c.*3376

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Osteopetrosis associated transmembrane protein 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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