ornithine carbamoyltransferase (OTC) - coding DNA reference sequence

(used for variant description)

(last modified August 5, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000531.5 in the OTC gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008471.1, covering OTC transcript NM_000531.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5034
                           agcggtggagcttggcataaagttcaaatgctcc       c.-181

 .         .         .         .         .         .                g.5094
 tacaccctgccctgcagtatctctaaccaggggactttgataaggaagctgaagggtgat       c.-121

 .         .         .         .         .         .                g.5154
 attacctttgctccctcactgcaactgaacacatttcttagtttttaggtggcccccgct       c.-61

 .         .         .         .         .         .                g.5214
 ggctaacttgctgtggagttttcaagggcatagaatcgtcctttacacaattaaaagaag       c.-1

          .         .         .         .         .         .       g.5274
 ATGCTGTTTAATCTGAGGATCCTGTTAAACAATGCAGCTTTTAGAAATGGTCACAACTTC       c.60
 M  L  F  N  L  R  I  L  L  N  N  A  A  F  R  N  G  H  N  F         p.20

          .        | 02.         .         .         .         .    g.19851
 ATGGTTCGAAATTTTCG | GTGTGGACAACCACTACAAAATAAAGTGCAGCTGAAGGGCCGT    c.120
 M  V  R  N  F  R  |  C  G  Q  P  L  Q  N  K  V  Q  L  K  G  R      p.40

          .         .         .         .         .         .       g.19911
 GACCTTCTCACTCTAAAAAACTTTACCGGAGAAGAAATTAAATATATGCTATGGCTATCA       c.180
 D  L  L  T  L  K  N  F  T  G  E  E  I  K  Y  M  L  W  L  S         p.60

          .         .         .       | 03 .         .         .    g.22337
 GCAGATCTGAAATTTAGGATAAAACAGAAAGGAGAG | TATTTGCCTTTATTGCAAGGGAAG    c.240
 A  D  L  K  F  R  I  K  Q  K  G  E   | Y  L  P  L  L  Q  G  K      p.80

          .         .         .         .         .         | 04    g.33861
 TCCTTAGGCATGATTTTTGAGAAAAGAAGTACTCGAACAAGATTGTCTACAGAAACAG | GC    c.300
 S  L  G  M  I  F  E  K  R  S  T  R  T  R  L  S  T  E  T  G |       p.100

          .         .         .         .         .         .       g.33921
 TTTGCACTTCTGGGAGGACATCCTTGTTTTCTTACCACACAAGATATTCATTTGGGTGTG       c.360
 F  A  L  L  G  G  H  P  C  F  L  T  T  Q  D  I  H  L  G  V         p.120

          .         .       | 05 .         .         .         .    g.53826
 AATGAAAGTCTCACGGACACGGCCCG | TGTATTGTCTAGCATGGCAGATGCAGTATTGGCT    c.420
 N  E  S  L  T  D  T  A  R  |  V  L  S  S  M  A  D  A  V  L  A      p.140

          .         .         .         .         .         .       g.53886
 CGAGTGTATAAACAATCAGATTTGGACACCCTGGCTAAAGAAGCATCCATCCCAATTATC       c.480
 R  V  Y  K  Q  S  D  L  D  T  L  A  K  E  A  S  I  P  I  I         p.160

          .         .         .         .         .         .       g.53946
 AATGGGCTGTCAGATTTGTACCATCCTATCCAGATCCTGGCTGATTACCTCACGCTCCAG       c.540
 N  G  L  S  D  L  Y  H  P  I  Q  I  L  A  D  Y  L  T  L  Q         p.180

  | 06       .         .         .         .         .         .    g.56195
  | GAACACTATAGCTCTCTGAAAGGTCTTACCCTCAGCTGGATCGGGGATGGGAACAATATC    c.600
  | E  H  Y  S  S  L  K  G  L  T  L  S  W  I  G  D  G  N  N  I      p.200

          .         .         .         .         .         .       g.56255
 CTGCACTCCATCATGATGAGCGCAGCGAAATTCGGAATGCACCTTCAGGCAGCTACTCCA       c.660
 L  H  S  I  M  M  S  A  A  K  F  G  M  H  L  Q  A  A  T  P         p.220

     | 07    .         .         .         .         .        | 08. g.61396
 AAG | GGTTATGAGCCGGATGCTAGTGTAACCAAGTTGGCAGAGCAGTATGCCAAAGAG | AAT c.720
 K   | G  Y  E  P  D  A  S  V  T  K  L  A  E  Q  Y  A  K  E   | N   p.240

          .         .         .         .         .         .       g.61456
 GGTACCAAGCTGTTGCTGACAAATGATCCATTGGAAGCAGCGCATGGAGGCAATGTATTA       c.780
 G  T  K  L  L  L  T  N  D  P  L  E  A  A  H  G  G  N  V  L         p.260

          .         .         .         .         .         .       g.61516
 ATTACAGACACTTGGATAAGCATGGGACAAGAAGAGGAGAAGAAAAAGCGGCTCCAGGCT       c.840
 I  T  D  T  W  I  S  M  G  Q  E  E  E  K  K  K  R  L  Q  A         p.280

          .         .        | 09.         .         .         .    g.64412
 TTCCAAGGTTACCAGGTTACAATGAAG | ACTGCTAAAGTTGCTGCCTCTGACTGGACATTT    c.900
 F  Q  G  Y  Q  V  T  M  K   | T  A  K  V  A  A  S  D  W  T  F      p.300

          .         .         .         .         .         .       g.64472
 TTACACTGCTTGCCCAGAAAGCCAGAAGAAGTGGATGATGAAGTCTTTTATTCTCCTCGA       c.960
 L  H  C  L  P  R  K  P  E  E  V  D  D  E  V  F  Y  S  P  R         p.320

          .         .         .         .      | 10  .         .    g.73555
 TCACTAGTGTTCCCAGAGGCAGAAAACAGAAAGTGGACAATCATG | GCTGTCATGGTGTCC    c.1020
 S  L  V  F  P  E  A  E  N  R  K  W  T  I  M   | A  V  M  V  S      p.340

          .         .         .         .                           g.73600
 CTGCTGACAGATTACTCACCTCAGCTCCAGAAGCCTAAATTTTGA                      c.1065
 L  L  T  D  Y  S  P  Q  L  Q  K  P  K  F  X                        p.354

          .         .         .         .         .         .       g.73660
 tgttgtgttacttgtcaagaaagaagcaatgttcttcagtaacagaatgagttggtttat       c.*60

          .         .         .         .         .         .       g.73720
 ggggaaaagagaagagaatctaaaaaataaacaaatccctaacacgtggtatgggtgaac       c.*120

          .         .         .         .         .         .       g.73780
 cgtatgatatgctttgccattgtgaaactttccttaagcctttaatttaagtgctgatgc       c.*180

          .         .         .         .         .         .       g.73840
 actgtaatacgtgcttaactttgcttaaactctctaattcccaatttctgagttacattt       c.*240

          .         .         .         .         .         .       g.73900
 agatatcatattaattatcatatacatttacttcaacataaaatactgtgttcataatgt       c.*300

          .         .         .         .         .         .       g.73960
 ataatgtctaagccattaagtgtaatctatgcttattacctaaataaattatcacccatg       c.*360

                                                                    g.73968
 ctaattta                                                           c.*368

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Ornithine carbamoyltransferase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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