3-oxoacid CoA transferase 1 (OXCT1) - coding DNA reference sequence

(used for variant description)

(last modified March 9, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_000436.3 in the OXCT1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_011823.1, covering OXCT1 transcript NM_000436.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5031
                              atcgaagctaaagggctgacagaagggctgt       c.-301

 .         .         .         .         .         .                g.5091
 agcggcaagtgtgcgccaacacagctgcacacgcccagacacctgaggcgctgagaggaa       c.-241

 .         .         .         .         .         .                g.5151
 cttccccgcgatccgccccggctgcacagagcctcttctccccgccggggccccgcccag       c.-181

 .         .         .         .         .         .                g.5211
 cctcacttcttttaaaagcagcagccagcagcgcgccggtggcgtgcggctcgaaaggcc       c.-121

 .         .         .         .         .         .                g.5271
 gggaggacgtcatcgacgcgctgtcgagcctccagcccgcccgggtttccttcgcagtcg       c.-61

 .         .         .         .         .         .                g.5331
 cgcaccgacgctcaaacgcgcgctccaacccgcagcctcctcctgcctcaccgcccgaag       c.-1

          .         .         .         .         .         .       g.5391
 ATGGCGGCTCTCAAACTCCTCTCCTCCGGGCTTCGGCTCTGCGCCTCTGCCCGCGGATCT       c.60
 M  A  A  L  K  L  L  S  S  G  L  R  L  C  A  S  A  R  G  S         p.20

          .         | 02         .         .         .         .    g.12981
 GGGGCAACCTGGTACAAG | GGATGTGTTTGTTCCTTTTCCACCAGTGCTCATCGCCATACC    c.120
 G  A  T  W  Y  K   | G  C  V  C  S  F  S  T  S  A  H  R  H  T      p.40

          .         .         .         .         .         .       g.13041
 AAGTTTTATACAGATCCAGTAGAAGCTGTAAAAGACATCCCTGATGGTGCCACGGTTTTG       c.180
 K  F  Y  T  D  P  V  E  A  V  K  D  I  P  D  G  A  T  V  L         p.60

         | 03.         .         .         .         .         .    g.14338
 GTTGGTG | GTTTTGGGCTATGTGGAATTCCAGAGAATCTTATAGATGCTTTACTGAAAACT    c.240
 V  G  G |   F  G  L  C  G  I  P  E  N  L  I  D  A  L  L  K  T      p.80

          .         .         .         | 04         .         .    g.22157
 GGAGTAAAAGGACTAACTGCAGTCAGCAACAATGCAGG | GGTTGACAATTTTGGTTTGGGG    c.300
 G  V  K  G  L  T  A  V  S  N  N  A  G  |  V  D  N  F  G  L  G      p.100

          .         .         .         .         .         .       g.22217
 CTTTTGCTTCGGTCCAAGCAGATAAAACGCATGGTCTCTTCATATGTGGGAGAAAATGCA       c.360
 L  L  L  R  S  K  Q  I  K  R  M  V  S  S  Y  V  G  E  N  A         p.120

          .         .         .         .         .     | 05   .    g.25516
 GAATTTGAACGACAGTACTTATCTGGTGAATTAGAAGTGGAGCTGACACCACAG | GGCACA    c.420
 E  F  E  R  Q  Y  L  S  G  E  L  E  V  E  L  T  P  Q   | G  T      p.140

          .         .         .         .         .         .       g.25576
 CTTGCAGAGAGGATCCGTGCAGGCGGGGCTGGAGTTCCTGCATTTTACACCCCAACAGGG       c.480
 L  A  E  R  I  R  A  G  G  A  G  V  P  A  F  Y  T  P  T  G         p.160

          .         .         .         .         .         .       g.25636
 TATGGGACCCTGGTACAAGAAGGAGGATCGCCCATCAAATACAACAAAGATGGCAGTGTT       c.540
 Y  G  T  L  V  Q  E  G  G  S  P  I  K  Y  N  K  D  G  S  V         p.180

          .         .     | 06   .         .         .         .    g.32944
 GCCATTGCCAGTAAGCCAAGAGAG | GTGAGGGAGTTCAATGGTCAGCACTTTATTTTGGAG    c.600
 A  I  A  S  K  P  R  E   | V  R  E  F  N  G  Q  H  F  I  L  E      p.200

          .         .         .         .         .         .       g.33004
 GAAGCAATTACAGGGGATTTTGCTTTGGTGAAAGCCTGGAAGGCGGACCGAGCAGGAAAC       c.660
 E  A  I  T  G  D  F  A  L  V  K  A  W  K  A  D  R  A  G  N         p.220

          .  | 07      .         .         .         .         .    g.35227
 GTGATTTTCAG | GAAAAGTGCAAGGAATTTCAACTTGCCAATGTGCAAAGCTGCAGAAACC    c.720
 V  I  F  R  |  K  S  A  R  N  F  N  L  P  M  C  K  A  A  E  T      p.240

          .   | 08     .         .         .         .         .    g.68299
 ACAGTGGTAGAG | GTTGAAGAAATTGTGGATATTGGAGCATTTGCTCCAGAAGACATCCAT    c.780
 T  V  V  E   | V  E  E  I  V  D  I  G  A  F  A  P  E  D  I  H      p.260

          .         .         .         .         .         .       g.68359
 ATTCCTCAGATTTATGTACATCGCCTTATAAAGGGAGAAAAATATGAGAAAAGAATTGAG       c.840
 I  P  Q  I  Y  V  H  R  L  I  K  G  E  K  Y  E  K  R  I  E         p.280

  | 09       .         .         .         .         .         .    g.70068
  | CGTTTATCAATCCGGAAAGAGGGAGATGGGGAAGCCAAATCTGCTAAACCTGGAGATGAC    c.900
  | R  L  S  I  R  K  E  G  D  G  E  A  K  S  A  K  P  G  D  D      p.300

          .         .         .         .         .      | 10  .    g.72531
 GTAAGGGAACGAATCATCAAGAGGGCCGCTCTTGAGTTTGAGGATGGCATGTATG | CTAAT    c.960
 V  R  E  R  I  I  K  R  A  A  L  E  F  E  D  G  M  Y  A |   N      p.320

          .         .         .         .         .         .       g.72591
 TTGGGCATAGGAATCCCTCTCCTGGCCAGCAATTTTATCAGCCCAAATATAACTGTTCAT       c.1020
 L  G  I  G  I  P  L  L  A  S  N  F  I  S  P  N  I  T  V  H         p.340

          .         .         . | 11       .         .         .    g.74649
 CTTCAAAGTGAAAATGGAGTTCTGGGTTTG | GGTCCATATCCACGACAACATGAAGCTGAT    c.1080
 L  Q  S  E  N  G  V  L  G  L   | G  P  Y  P  R  Q  H  E  A  D      p.360

          .          | 12        .         .         .         .    g.80981
 GCAGATCTCATCAATGCAG | GCAAGGAAACAGTTACTATTCTTCCAGGAGCCTCTTTTTTC    c.1140
 A  D  L  I  N  A  G |   K  E  T  V  T  I  L  P  G  A  S  F  F      p.380

          .         .         .   | 13     .         .         .    g.81639
 TCCAGCGATGAATCATTTGCAATGATTAGAGG | TGGACACGTCGATCTGACAATGCTAGGA    c.1200
 S  S  D  E  S  F  A  M  I  R  G  |  G  H  V  D  L  T  M  L  G      p.400

          .         .         .         .         | 14         .    g.113501
 GCGATGCAGGTTTCCAAATATGGTGACCTGGCTAACTGGATGATACCT | GGGAAGATGGTG    c.1260
 A  M  Q  V  S  K  Y  G  D  L  A  N  W  M  I  P   | G  K  M  V      p.420

          .         .         .         .         .         .       g.113561
 AAAGGAATGGGAGGTGCTATGGATTTAGTGTCCAGTGCGAAAACCAAAGTGGTGGTCACC       c.1320
 K  G  M  G  G  A  M  D  L  V  S  S  A  K  T  K  V  V  V  T         p.440

          .         | 15         .         .         .         .    g.126124
 ATGGAGCATTCTGCAAAG | GGAAATGCACATAAAATCATGGAGAAATGTACATTACCATTG    c.1380
 M  E  H  S  A  K   | G  N  A  H  K  I  M  E  K  C  T  L  P  L      p.460

          .         .         .          | 16        .         .    g.136219
 ACTGGAAAGCAATGTGTCAACCGCATTATTACTGAAAAG | GCTGTGTTTGATGTGGACAAG    c.1440
 T  G  K  Q  C  V  N  R  I  I  T  E  K   | A  V  F  D  V  D  K      p.480

          .         .         .         .         .         .       g.136279
 AAGAAAGGGTTGACTCTGATTGAGCTCTGGGAAGGCCTGACAGTGGATGACGTACAGAAG       c.1500
 K  K  G  L  T  L  I  E  L  W  E  G  L  T  V  D  D  V  Q  K         p.500

          .         .  | 17      .         .         .         .    g.143958
 AGTACTGGGTGTGATTTTGCA | GTTTCACCAAAACTCATGCCAATGCAGCAGATCGCAAAT    c.1560
 S  T  G  C  D  F  A   | V  S  P  K  L  M  P  M  Q  Q  I  A  N      p.520

                                                                    g.143961
 TGA                                                                c.1563
 X                                                                  p.520

          .         .         .         .         .         .       g.144021
 aatatggatatttgtaccaggctgcgtgtttttcattttaaacacacaagatttaattga       c.*60

          .         .         .         .         .         .       g.144081
 aaggacatcaataatcataattgtgtatttaacaggtggttttttattagttttcttgtg       c.*120

          .         .         .         .         .         .       g.144141
 tttcagactttatgcagccatataaactgttctctaggcatgctgtgacattttaataaa       c.*180

          .         .         .         .         .         .       g.144201
 aagcaaaaggagcatttataattatctcatttgttaaggctgagaaggttgtttttataa       c.*240

          .         .         .         .         .         .       g.144261
 taggtaattatattgaatgcattttcactgaatatggtatgtatgctaaattatatgaac       c.*300

          .         .         .         .         .         .       g.144321
 ctttccccaagaagggccctagaaattgatgtggctttcctcttaaatattaattattag       c.*360

          .         .         .         .         .         .       g.144381
 tcctgaaagaaagataacatatgtgatttttgtggttaggagagttgctgtcatgattgt       c.*420

          .         .         .         .         .         .       g.144441
 tttttcttcagcctcctctgacttttcttttggggcttcagattttatgattacatcttg       c.*480

          .         .         .         .         .         .       g.144501
 tccccctagaacatcccccttcctcccatactgcttttaaacagatgcccaagaaggcaa       c.*540

          .         .         .         .         .         .       g.144561
 gcaggaatgcctcttgtgggggagggcagggagaaataactagttcaaaccaactatcta       c.*600

          .         .         .         .         .         .       g.144621
 tctatgctttgcaaagactaaggcgtattataggaagagggctagaaacctaactgattc       c.*660

          .         .         .         .         .         .       g.144681
 ttctcagttttctcattttaaaacagcccagtattcctttgtatcctcaagggtccttga       c.*720

          .         .         .         .         .         .       g.144741
 gaatacttctgttattgagaccctgtgggctacttgtactgtacctcctctcaagccaag       c.*780

          .         .         .         .         .         .       g.144801
 aagggctgtgggataatttaccatgaatccttagtagcaatgacagcagagttaaaaaat       c.*840

          .         .         .         .         .         .       g.144861
 aaaaggtgttttactttcaggctcttgttttggttcagaggagattttaaatattgaatg       c.*900

          .         .         .         .         .         .       g.144921
 acacttctacagaacaacggtttttcttctgccaaggctacttcctttaacgaagtgcct       c.*960

          .         .         .         .         .         .       g.144981
 ttaattcagccttatccaactagggaaaataatgttggacaagtctaggatttgaagagt       c.*1020

          .         .         .         .         .         .       g.145041
 cagtgaacttttagtgtcagggaataaacatggtgggtagattaggtttgaaaaaaactt       c.*1080

          .         .         .         .         .         .       g.145101
 ccttagaggtatttattctcaatacctgacaggggcccatgggaatgacttcagaagcat       c.*1140

          .         .         .         .         .         .       g.145161
 cccggataatagatgggtaaaaagtctaggcaccctgaagaacaggtgagacagctggcc       c.*1200

          .         .         .         .         .         .       g.145221
 tctggacagaggtaggcatagtacagtacgatatatcattcctctggtcctaaatataca       c.*1260

          .         .         .         .         .         .       g.145281
 aacttattcatgtttttaggtgatgatggtcattgaaactcacttcttttcaggtgtagc       c.*1320

          .         .         .         .         .         .       g.145341
 tacaattgtgtaatgtacaatattagagaaaggacaggctttttatgagtaacacacacc       c.*1380

          .         .         .         .         .         .       g.145401
 atatataaaacagcctttctggctgaccacatggttaaatgcataccttcccagtactgg       c.*1440

          .         .         .         .         .         .       g.145461
 ggggaaaaaatgacccttcttagaatgtgcaagttccatgagagtaatatattgatatga       c.*1500

          .         .         .         .         .         .       g.145521
 ttttgaaaagaattgttgatagttacatcttcaaacttatcattccagtatgcatcttta       c.*1560

          .         .         .         .         .         .       g.145581
 agataatgtgattctaagtagatgactttatattcttgattaaagagtgctatacatgtt       c.*1620

          .         .         .         .                           g.145625
 aagaaatgcattaaggaatacaataaatattctaaagtgatgta                       c.*1664

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The 3-oxoacid CoA transferase 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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