purinergic receptor P2Y, G-protein coupled, 10 (P2RY10) - coding DNA reference sequence

(used for variant description)

(last modified July 20, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_014499.2 in the P2RY10 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_013276.1, covering P2RY10 transcript NM_014499.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5009
                                                    tttgtgcaa       c.-361

 .         .         .         .         .         .                g.5069
 ataaggtttctgtggtgagacaccagataaactcaacttcctctttcaacaacaaatgtg       c.-301

 .         .         .         .         .         .                g.5129
 tcagttatcagcaggatccatgccgccagagtaaagctttctaccctttactccctgcaa       c.-241

 .         .         .         .     | 02   .         .             g.7508
 agaaacaagagtgcttatcccagctaagctccagg | gtaatgttatcatgacagcttcaac    c.-181

 .         .         .    | 03    .         .         .             g.11897
 ttttagaccacaggcaaatgcttt | gttaaaactctatgctggtcattcccttcaggattt    c.-121

 .         .         .         .         .         .                g.11957
 ggcactcaccaacatacccttctttcaagtgaaaaggcatctcttttaatggtcctgacc       c.-61

 .         .         .         .         .       | 04 .             g.20189
 tttggaataggaagcatgtaccctggacagagcacttcaaactagag | gaaccataaatcc    c.-1

          .         .         .         .         .         .       g.20249
 ATGGCTAACCTTGACAAATACACTGAAACATTCAAGATGGGTAGCAACAGTACCAGCACT       c.60
 M  A  N  L  D  K  Y  T  E  T  F  K  M  G  S  N  S  T  S  T         p.20

          .         .         .         .         .         .       g.20309
 GCTGAGATTTACTGTAATGTCACTAATGTGAAATTTCAATACTCCCTCTATGCAACCACC       c.120
 A  E  I  Y  C  N  V  T  N  V  K  F  Q  Y  S  L  Y  A  T  T         p.40

          .         .         .         .         .         .       g.20369
 TATATCCTCATATTCATTCCTGGTCTTCTGGCTAACAGTGCAGCCTTGTGGGTTCTGTGC       c.180
 Y  I  L  I  F  I  P  G  L  L  A  N  S  A  A  L  W  V  L  C         p.60

          .         .         .         .         .         .       g.20429
 CGCTTCATCAGCAAGAAAAATAAAGCCATCATTTTCATGATCAACCTCTCTGTGGCTGAC       c.240
 R  F  I  S  K  K  N  K  A  I  I  F  M  I  N  L  S  V  A  D         p.80

          .         .         .         .         .         .       g.20489
 CTTGCTCATGTATTATCTTTACCCCTCCGGATTTACTATTACATCAGCCACCACTGGCCT       c.300
 L  A  H  V  L  S  L  P  L  R  I  Y  Y  Y  I  S  H  H  W  P         p.100

          .         .         .         .         .         .       g.20549
 TTCCAGAGAGCCCTTTGCCTGCTCTGCTTCTACCTGAAGTATCTCAACATGTATGCCAGC       c.360
 F  Q  R  A  L  C  L  L  C  F  Y  L  K  Y  L  N  M  Y  A  S         p.120

          .         .         .         .         .         .       g.20609
 ATTTGTTTCCTGACGTGCATCAGTCTTCAAAGGTGCTTTTTTCTCCTCAAGCCCTTCAGG       c.420
 I  C  F  L  T  C  I  S  L  Q  R  C  F  F  L  L  K  P  F  R         p.140

          .         .         .         .         .         .       g.20669
 GCCAGAGACTGGAAGCGTAGGTACGATGTGGGCATCAGTGCTGCCATCTGGATCGTTGTG       c.480
 A  R  D  W  K  R  R  Y  D  V  G  I  S  A  A  I  W  I  V  V         p.160

          .         .         .         .         .         .       g.20729
 GGGACTGCCTGTTTGCCATTTCCCATCCTGAGAAGCACAGACTTAAACAACAACAAGTCC       c.540
 G  T  A  C  L  P  F  P  I  L  R  S  T  D  L  N  N  N  K  S         p.180

          .         .         .         .         .         .       g.20789
 TGCTTTGCTGATCTTGGATACAAGCAAATGAATGCAGTTGCGTTGGTCGGGATGATTACA       c.600
 C  F  A  D  L  G  Y  K  Q  M  N  A  V  A  L  V  G  M  I  T         p.200

          .         .         .         .         .         .       g.20849
 GTTGCTGAGCTTGCAGGATTTGTGATCCCAGTGATCATCATCGCATGGTGTACCTGGAAA       c.660
 V  A  E  L  A  G  F  V  I  P  V  I  I  I  A  W  C  T  W  K         p.220

          .         .         .         .         .         .       g.20909
 ACTACTATATCCTTGAGACAGCCACCAATGGCTTTCCAAGGGATCAGTGAGAGGCAGAAA       c.720
 T  T  I  S  L  R  Q  P  P  M  A  F  Q  G  I  S  E  R  Q  K         p.240

          .         .         .         .         .         .       g.20969
 GCACTGCGGATGGTGTTCATGTGTGCTGCAGTCTTCTTCATCTGCTTCACTCCCTATCAT       c.780
 A  L  R  M  V  F  M  C  A  A  V  F  F  I  C  F  T  P  Y  H         p.260

          .         .         .         .         .         .       g.21029
 ATTAACTTTATTTTTTACACCATGGTAAAGGAAACCATCATTAGCAGTTGTCCCGTTGTC       c.840
 I  N  F  I  F  Y  T  M  V  K  E  T  I  I  S  S  C  P  V  V         p.280

          .         .         .         .         .         .       g.21089
 CGAATCGCACTGTATTTCCACCCTTTTTGCCTGTGCCTTGCAAGTCTCTGCTGCCTTTTG       c.900
 R  I  A  L  Y  F  H  P  F  C  L  C  L  A  S  L  C  C  L  L         p.300

          .         .         .         .         .         .       g.21149
 GATCCAATTCTTTATTACTTTATGGCTTCAGAGTTTCGTGACCAACTATCCCGCCATGGC       c.960
 D  P  I  L  Y  Y  F  M  A  S  E  F  R  D  Q  L  S  R  H  G         p.320

          .         .         .         .         .         .       g.21209
 AGTTCTGTGACCCGCTCCCGCCTCATGAGCAAGGAGAGTGGTTCATCAATGATTGGCTAA       c.1020
 S  S  V  T  R  S  R  L  M  S  K  E  S  G  S  S  M  I  G  X         p.339

          .         .         .         .         .         .       g.21269
 aattaagatatctctttaattacgcctttgtttacctacgttccttgtctttttccaaag       c.*60

          .         .         .         .         .         .       g.21329
 gccagaattgtcaaccaatttctttaattgaacattgtaaaaaacaggaataagtacttt       c.*120

          .         .         .         .         .         .       g.21389
 tgtgtaatattcacagtcaacaggggtgtgatggtgaaggcagagtgtgaaaaacgtgag       c.*180

          .         .         .         .         .         .       g.21449
 agaggaagagaaaatagatttacctgattcctctttaaaattcaagccactttcttattt       c.*240

          .         .         .         .         .         .       g.21509
 aagaaacctagatcaagtttttacagatgtaaataaaagttgaatagtttaccttaaatt       c.*300

          .         .         .         .         .         .       g.21569
 tttttcaataagtaagttattgttaataatgcacagtaaatatgtgaatttttcctagat       c.*360

          .         .         .         .                           g.21610
 gtaaaaaaaaaaatctttcatataaagaccttaaattctga                          c.*401

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Purinergic receptor P2Y, G-protein coupled, 10 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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