prolyl 4-hydroxylase, beta polypeptide (P4HB) - coding DNA reference sequence

(used for variant description)

(last modified February 23, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_000918.3 in the P4HB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_042033.1, covering P4HB transcript NM_000918.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5017
                                            gagcctcgaagtccgcc       c.-181

 .         .         .         .         .         .                g.5077
 ggccaatcgaaggcgggccccagcggcgcgtgcgcgccgcggccagcgcgcgcgggcggg       c.-121

 .         .         .         .         .         .                g.5137
 ggggcaggcgcgccccggacccaggatttataaaggcgaggccgggaccggcgcgcgctc       c.-61

 .         .         .         .         .         .                g.5197
 tcgtcgcccccgctgtcccggcggcgccaaccgaagcgccccgcctgatccgtgtccgac       c.-1

          .         .         .         .         .         .       g.5257
 ATGCTGCGCCGCGCTCTGCTGTGCCTGGCCGTGGCCGCCCTGGTGCGCGCCGACGCCCCC       c.60
 M  L  R  R  A  L  L  C  L  A  V  A  A  L  V  R  A  D  A  P         p.20

          .         .         .         .         .         .       g.5317
 GAGGAGGAGGACCACGTCCTGGTGCTGCGGAAAAGCAACTTCGCGGAGGCGCTGGCGGCC       c.120
 E  E  E  D  H  V  L  V  L  R  K  S  N  F  A  E  A  L  A  A         p.40

          .         .      | 02  .         .         .         .    g.6316
 CACAAGTACCTGCTGGTGGAGTTCT | ATGCCCCTTGGTGTGGCCACTGCAAGGCTCTGGCC    c.180
 H  K  Y  L  L  V  E  F  Y |   A  P  W  C  G  H  C  K  A  L  A      p.60

          .         .         .         .         .         .       g.6376
 CCTGAGTATGCCAAAGCCGCTGGGAAGCTGAAGGCAGAAGGTTCCGAGATCAGGTTGGCC       c.240
 P  E  Y  A  K  A  A  G  K  L  K  A  E  G  S  E  I  R  L  A         p.80

          .         .         .         .         .         .       g.6436
 AAGGTGGACGCCACGGAGGAGTCTGACCTGGCCCAGCAGTACGGCGTGCGCGGCTATCCC       c.300
 K  V  D  A  T  E  E  S  D  L  A  Q  Q  Y  G  V  R  G  Y  P         p.100

          .         .         .         .         .   | 03     .    g.10090
 ACCATCAAGTTCTTCAGGAATGGAGACACGGCTTCCCCCAAGGAATATACAG | CTGGCAGA    c.360
 T  I  K  F  F  R  N  G  D  T  A  S  P  K  E  Y  T  A |   G  R      p.120

          .         .         .         .         .         .       g.10150
 GAGGCTGATGACATCGTGAACTGGCTGAAGAAGCGCACGGGCCCGGCTGCCACCACCCTG       c.420
 E  A  D  D  I  V  N  W  L  K  K  R  T  G  P  A  A  T  T  L         p.140

          .         .         .         .         .         .       g.10210
 CCTGACGGCGCAGCTGCAGAGTCCTTGGTGGAGTCCAGCGAGGTGGCTGTCATCGGCTTC       c.480
 P  D  G  A  A  A  E  S  L  V  E  S  S  E  V  A  V  I  G  F         p.160

        | 04 .         .         .         .         .         .    g.10443
 TTCAAG | GACGTGGAGTCGGACTCTGCCAAGCAGTTTTTGCAGGCAGCAGAGGCCATCGAT    c.540
 F  K   | D  V  E  S  D  S  A  K  Q  F  L  Q  A  A  E  A  I  D      p.180

          .         .         .         .         .         .       g.10503
 GACATACCATTTGGGATCACTTCCAACAGTGACGTGTTCTCCAAATACCAGCTCGACAAA       c.600
 D  I  P  F  G  I  T  S  N  S  D  V  F  S  K  Y  Q  L  D  K         p.200

          .         .     | 05   .         .         .         .    g.18357
 GATGGGGTTGTCCTCTTTAAGAAG | TTTGATGAAGGCCGGAACAACTTTGAAGGGGAGGTC    c.660
 D  G  V  V  L  F  K  K   | F  D  E  G  R  N  N  F  E  G  E  V      p.220

          .         .         .         .         .         .       g.18417
 ACCAAGGAGAACCTGCTGGACTTTATCAAACACAACCAGCTGCCCCTTGTCATCGAGTTC       c.720
 T  K  E  N  L  L  D  F  I  K  H  N  Q  L  P  L  V  I  E  F         p.240

           | 06        .         .         .         .         .    g.18647
 ACCGAGCAG | ACAGCCCCGAAGATTTTTGGAGGTGAAATCAAGACTCACATCCTGCTGTTC    c.780
 T  E  Q   | T  A  P  K  I  F  G  G  E  I  K  T  H  I  L  L  F      p.260

          .         .         .         .         .         .       g.18707
 TTGCCCAAGAGTGTGTCTGACTATGACGGCAAACTGAGCAACTTCAAAACAGCAGCCGAG       c.840
 L  P  K  S  V  S  D  Y  D  G  K  L  S  N  F  K  T  A  A  E         p.280

          .      | 07  .         .         .         .         .    g.19084
 AGCTTCAAGGGCAAG | ATCCTGTTCATCTTCATCGACAGCGACCACACCGACAACCAGCGC    c.900
 S  F  K  G  K   | I  L  F  I  F  I  D  S  D  H  T  D  N  Q  R      p.300

          .         .         .         .         .         .       g.19144
 ATCCTCGAGTTCTTTGGCCTGAAGAAGGAAGAGTGCCCGGCCGTGCGCCTCATCACCCTG       c.960
 I  L  E  F  F  G  L  K  K  E  E  C  P  A  V  R  L  I  T  L         p.320

          .         .         .         .         .         .       g.19204
 GAGGAGGAGATGACCAAGTACAAGCCCGAATCGGAGGAGCTGACGGCAGAGAGGATCACA       c.1020
 E  E  E  M  T  K  Y  K  P  E  S  E  E  L  T  A  E  R  I  T         p.340

          .         .         .       | 08 .         .         .    g.19701
 GAGTTCTGCCACCGCTTCCTGGAGGGCAAAATCAAG | CCCCACCTGATGAGCCAGGAGCTG    c.1080
 E  F  C  H  R  F  L  E  G  K  I  K   | P  H  L  M  S  Q  E  L      p.360

          .         .         .         .         .         .       g.19761
 CCGGAGGACTGGGACAAGCAGCCTGTCAAGGTGCTTGTTGGGAAGAACTTTGAAGACGTG       c.1140
 P  E  D  W  D  K  Q  P  V  K  V  L  V  G  K  N  F  E  D  V         p.380

          .         .         .        | 09.         .         .    g.19949
 GCTTTTGATGAGAAAAAAAACGTCTTTGTGGAGTTCT | ATGCCCCATGGTGTGGTCACTGC    c.1200
 A  F  D  E  K  K  N  V  F  V  E  F  Y |   A  P  W  C  G  H  C      p.400

          .         .         .         .         .         .       g.20009
 AAACAGTTGGCTCCCATTTGGGATAAACTGGGAGAGACGTACAAGGACCATGAGAACATC       c.1260
 K  Q  L  A  P  I  W  D  K  L  G  E  T  Y  K  D  H  E  N  I         p.420

          .         .         .         .         .         .       g.20069
 GTCATCGCCAAGATGGACTCGACTGCCAACGAGGTGGAGGCCGTCAAAGTGCACAGCTTC       c.1320
 V  I  A  K  M  D  S  T  A  N  E  V  E  A  V  K  V  H  S  F         p.440

          .         .         .          | 10        .         .    g.20459
 CCCACACTCAAGTTCTTTCCTGCCAGTGCCGACAGGACG | GTCATTGATTACAACGGGGAA    c.1380
 P  T  L  K  F  F  P  A  S  A  D  R  T   | V  I  D  Y  N  G  E      p.460

          .         .         .         .         .         .       g.20519
 CGCACGCTGGATGGTTTTAAGAAATTCCTGGAGAGCGGTGGCCAGGATGGGGCAGGGGAT       c.1440
 R  T  L  D  G  F  K  K  F  L  E  S  G  G  Q  D  G  A  G  D         p.480

        | 11 .         .         .         .         .         .    g.21630
 GATGAC | GATCTCGAGGACCTGGAAGAAGCAGAGGAGCCAGACATGGAGGAAGACGATGAT    c.1500
 D  D   | D  L  E  D  L  E  E  A  E  E  P  D  M  E  E  D  D  D      p.500

          .         .                                               g.21657
 CAGAAAGCTGTGAAAGATGAACTGTAA                                        c.1527
 Q  K  A  V  K  D  E  L  X                                          p.508

          .         .         .         .         .         .       g.21717
 tacgcaaagccagacccgggcgctgccgagacccctcgggggctgcacacccagcagcag       c.*60

          .         .         .         .         .         .       g.21777
 cgcacgcctccgaagcctgcggcctcgcttgaaggagggcgtcgccggaaacccagggaa       c.*120

          .         .         .         .         .         .       g.21837
 cctctctgaagtgacacctcacccctacacaccgtccgttcacccccgtctcttccttct       c.*180

          .         .         .         .         .         .       g.21897
 gcttttcggtttttggaaagggatccatctccaggcagcccaccctggtggggcttgttt       c.*240

          .         .         .         .         .         .       g.21957
 cctgaaaccatgatgtactttttcatacatgagtctgtccagagtgcttgctaccgtgtt       c.*300

          .         .         .         .         .         .       g.22017
 cggagtctcgctgcctccctcccgcgggaggtttctcctctttttgaaaattccgtctgt       c.*360

          .         .         .         .         .         .       g.22077
 gggatttttagacatttttcgacatcagggtatttgttccaccttggccaggcctcctcg       c.*420

          .         .         .         .         .         .       g.22137
 gagaagcttgtcccccgtgtgggagggacggagccggactggacatggtcactcagtacc       c.*480

          .         .         .         .         .         .       g.22197
 gcctgcagtgtcgccatgactgatcatggctcttgcatttttgggtaaatggagacttcc       c.*540

          .         .         .         .         .         .       g.22257
 ggatcctgtcagggtgtcccccatgcctggaagaggagctggtggctgccagccctgggg       c.*600

          .         .         .         .         .         .       g.22317
 cccggcacaggcctgggccttccccttccctcaagccagggctcctcctcctgtcgtggg       c.*660

          .         .         .         .         .         .       g.22377
 ctcattgtgaccactggcctctctacagcacggcctgtggcctgttcaaggcagaaccac       c.*720

          .         .         .         .         .         .       g.22437
 gacccttgactcccgggtggggaggtggccaaggatgctggagctgaatcagacgctgac       c.*780

          .         .         .         .         .         .       g.22497
 agttcttcaggcatttctatttcacaatcgaattgaacacattggccaaataaagttgaa       c.*840

          .                                                         g.22511
 attttaccacctgt                                                     c.*854

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Prolyl 4-hydroxylase, beta polypeptide protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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