prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) (P4HTM) - coding DNA reference sequence

(used for variant description)

(last modified February 1, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_177938.2 in the P4HTM gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering P4HTM transcript NM_177938.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5049
            agagggcgtcttcacgcaggcaccgagaagctcccactagtgtatgcct       c.-301

 .         .         .         .         .         .                g.5109
 taatggtgccgctcttgtccgcgtctacgcttgggaccttggcttctgacttggagagtg       c.-241

 .         .         .         .         .         .                g.5169
 tacagctctgcccgacggcaacccagcttgggaagagaagccccagcgtgggctggggct       c.-181

 .         .         .         .         .         .                g.5229
 caaggcgcaggaaggccgagcccggcgcggacgcaggcggctccgggcgggctcagcacc       c.-121

 .         .         .         .         .         .                g.5289
 cccaggcaccgtctcctagtgaccgcggcgctcgcgggcctggcggccgttgtccgggcg       c.-61

 .         .         .         .         .         .                g.5349
 actgcgcagcgcgggcacccccgcggcccctcccctgggcgcgcgcgcgacctgggtgcc       c.-1

          .         .         .         .         .         .       g.5409
 ATGGCGGCAGCGGCGGTGACAGGCCAGCGGCCTGAGACCGCGGCGGCCGAGGAGGCCTCG       c.60
 M  A  A  A  A  V  T  G  Q  R  P  E  T  A  A  A  E  E  A  S         p.20

          .         .         .         .         .         .       g.5469
 AGGCCGCAGTGGGCGCCGCCAGACCACTGCCAGGCTCAGGCGGCGGCCGGGCTGGGCGAC       c.120
 R  P  Q  W  A  P  P  D  H  C  Q  A  Q  A  A  A  G  L  G  D         p.40

          .         .         .         .         .         .       g.5529
 GGCGAGGACGCACCGGTGCGTCCGCTGTGCAAGCCCCGCGGCATCTGCTCGCGCGCCTAC       c.180
 G  E  D  A  P  V  R  P  L  C  K  P  R  G  I  C  S  R  A  Y         p.60

          .         .         .         .         .         .       g.5589
 TTCCTGGTGCTGATGGTGTTCGTGCACCTGTACCTGGGTAACGTGCTGGCGCTGCTGCTC       c.240
 F  L  V  L  M  V  F  V  H  L  Y  L  G  N  V  L  A  L  L  L         p.80

          .         .         .         .         .         .       g.5649
 TTCGTGCACTACAGCAACGGCGACGAAAGCAGCGATCCCGGGCCCCAACACCGTGCCCAG       c.300
 F  V  H  Y  S  N  G  D  E  S  S  D  P  G  P  Q  H  R  A  Q         p.100

          .         .         .         .         .     | 02   .    g.5931
 GGCCCCGGGCCCGAGCCCACCTTAGGTCCCCTCACCCGGCTGGAGGGCATCAAG | GTGGGG    c.360
 G  P  G  P  E  P  T  L  G  P  L  T  R  L  E  G  I  K   | V  G      p.120

          .         .         .         .         .         .       g.5991
 CACGAGCGTAAGGTCCAGCTGGTCACCGACAGGGATCACTTCATCCGAACCCTCAGCCTC       c.420
 H  E  R  K  V  Q  L  V  T  D  R  D  H  F  I  R  T  L  S  L         p.140

          .       | 03 .         .         .         .         .    g.16574
 AAGCCGCTGCTCTTCG | AAATCCCCGGCTTCCTGACTGATGAAGAGTGTCGGCTCATCATC    c.480
 K  P  L  L  F  E |   I  P  G  F  L  T  D  E  E  C  R  L  I  I      p.160

          .         .         .         .         .         .       g.16634
 CATCTGGCGCAGATGAAGGGGTTACAGCGCAGCCAGATCCTGCCTACTGAAGAGTATGAA       c.540
 H  L  A  Q  M  K  G  L  Q  R  S  Q  I  L  P  T  E  E  Y  E         p.180

          .         .         .         .         .         .       g.16694
 GAGGCAATGAGCACTATGCAGGTCAGCCAGCTGGACCTCTTCCGGCTGCTGGACCAGAAC       c.600
 E  A  M  S  T  M  Q  V  S  Q  L  D  L  F  R  L  L  D  Q  N         p.200

          .         .        | 04.         .         .         .    g.17625
 CGTGATGGGCACCTTCAGCTCCGTGAG | GTTCTGGCCCAGACTCGCCTGGGAAATGGATGG    c.660
 R  D  G  H  L  Q  L  R  E   | V  L  A  Q  T  R  L  G  N  G  W      p.220

          .         .         .         .         .         .       g.17685
 TGGATGACTCCAGAGAGCATTCAGGAGATGTACGCCGCGATCAAGGCTGACCCTGATGGT       c.720
 W  M  T  P  E  S  I  Q  E  M  Y  A  A  I  K  A  D  P  D  G         p.240

      | 05   .         .         .         .         .         .    g.19246
 GACG | GAGTGCTGAGTCTGCAGGAGTTCTCCAACATGGACCTTCGGGACTTCCACAAGTAC    c.780
 D  G |   V  L  S  L  Q  E  F  S  N  M  D  L  R  D  F  H  K  Y      p.260

          .         .         .         .         .         .       g.19306
 ATGAGGAGCCACAAGGCAGAGTCCAGTGAGCTGGTGCGGAACAGCCACCATACCTGGCTC       c.840
 M  R  S  H  K  A  E  S  S  E  L  V  R  N  S  H  H  T  W  L         p.280

          .         .         .         .        | 06.         .    g.19966
 TACCAGGGTGAGGGTGCCCACCACATCATGCGTGCCATCCGCCAGAG | GGTGCTGCGCCTC    c.900
 Y  Q  G  E  G  A  H  H  I  M  R  A  I  R  Q  R  |  V  L  R  L      p.300

          .         .         .         .         .         .       g.20026
 ACTCGCCTGTCGCCTGAGATCGTGGAGCTCAGCGAGCCGCTGCAGGTTGTTCGATATGGT       c.960
 T  R  L  S  P  E  I  V  E  L  S  E  P  L  Q  V  V  R  Y  G         p.320

          .         .         .         .         .         .       g.20086
 GAGGGGGGCCACTACCATGCCCACGTGGACAGTGGGCCTGTGTACCCAGAGACCATCTGC       c.1020
 E  G  G  H  Y  H  A  H  V  D  S  G  P  V  Y  P  E  T  I  C         p.340

          .         .         .         .         .         .       g.20146
 TCCCATACCAAGCTGGTAGCCAACGAGTCTGTACCCTTCGAGACCTCCTGCCGGCAAGTA       c.1080
 S  H  T  K  L  V  A  N  E  S  V  P  F  E  T  S  C  R  Q  V         p.360

          .         .         .         .         .         .       g.20206
 TCTCCCAACTGGGGGCTGCCTTCAATCCTCAGACCAGGAACACCCATGACACAGGCACAG       c.1140
 S  P  N  W  G  L  P  S  I  L  R  P  G  T  P  M  T  Q  A  Q         p.380

          .         .         .         .         .        | 07.    g.20813
 CCCTGCACTGTGGGCGTGCCCCTTGGCATGGGGCCAGGAGATCACTGGGTTATCCCG | GTA    c.1200
 P  C  T  V  G  V  P  L  G  M  G  P  G  D  H  W  V  I  P   | V      p.400

          .         .         .         .         .         .       g.20873
 AGCCCCTGGGAGCATCCACAACTGGGGACCTGCTCAGTGCCCCCCCTGCCTTACAGCTAC       c.1260
 S  P  W  E  H  P  Q  L  G  T  C  S  V  P  P  L  P  Y  S  Y         p.420

          .         .         .         .         .         .       g.20933
 ATGACAGTGCTGTTTTATTTGAACAACGTCACTGGTGGGGGCGAGACTGTTTTCCCTGTA       c.1320
 M  T  V  L  F  Y  L  N  N  V  T  G  G  G  E  T  V  F  P  V         p.440

          .         .        | 08.         .         .         .    g.21189
 GCAGATAACAGAACCTACGATGAAATG | AGTCTGATTCAGGATGACGTGGACCTCCGTGAC    c.1380
 A  D  N  R  T  Y  D  E  M   | S  L  I  Q  D  D  V  D  L  R  D      p.460

          .         .         .         .         .         .       g.21249
 ACACGGAGGCACTGTGACAAGGGAAACCTGCGTGTCAAGCCCCAACAGGGCACAGCAGTC       c.1440
 T  R  R  H  C  D  K  G  N  L  R  V  K  P  Q  Q  G  T  A  V         p.480

          .         .         .  | 09      .         .         .    g.21808
 TTCTGGTACAACTACCTGCCTGATGGGCAAG | GTTGGGTGGGTGACGTAGACGACTACTCG    c.1500
 F  W  Y  N  Y  L  P  D  G  Q  G |   W  V  G  D  V  D  D  Y  S      p.500

          .         .         .         .         .         .       g.21868
 CTGCACGGGGGCTGCCTGGTCACGCGCGGCACCAAGTGGATTGCCAACAACTGGATTAAT       c.1560
 L  H  G  G  C  L  V  T  R  G  T  K  W  I  A  N  N  W  I  N         p.520

          .         .         .         .         .         .       g.21928
 GTGGACCCCAGCCGAGCGCGGCAAGCGCTGTTCCAACAGGAGATGGCCCGCCTTGCCCGA       c.1620
 V  D  P  S  R  A  R  Q  A  L  F  Q  Q  E  M  A  R  L  A  R         p.540

          .         .         .         .         .         .       g.21988
 GAAGGGGGCACCGACTCACAGCCCGAGTGGGCTCTGGACCGGGCCTACCGCGATGCGCGC       c.1680
 E  G  G  T  D  S  Q  P  E  W  A  L  D  R  A  Y  R  D  A  R         p.560

          .                                                         g.22000
 GTGGAACTCTGA                                                       c.1692
 V  E  L  X                                                         p.563

          .         .         .         .         .         .       g.22060
 gggaagagttagccccggttcccagccgcgggtcgccagttgcccaagatcaggggtccg       c.*60

          .         .         .         .         .         .       g.22120
 gctgtccttctgtcctgctgcagactaaaggtctggccaatgtcttgccccaccccgcca       c.*120

          .         .         .         .         .         .       g.22180
 gccgcgatacggcgcagttcctatattcatgttatttattgtgtactgactccatctgcc       c.*180

          .         .         .         .         .         .       g.22240
 ccgtcaaataaaaaaccacaaggttcgagccgccgggcccgacaaactccgggtcggcga       c.*240

                                                                    g.22242
 aa                                                                 c.*242

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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