phosphofurin acidic cluster sorting protein 1 (PACS1) - coding DNA reference sequence

(used for variant description)

(last modified June 4, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_018026.3 in the PACS1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033900.1, covering PACS1 transcript NM_018026.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               gcagctcgctggct       c.-121

 .         .         .         .         .         .                g.5074
 gctcgcgctcgggcaggcgggctgaggaggctgccgcgcccccgccgccgccgccgcggg       c.-61

 .         .         .         .         .         .                g.5134
 ggaagcctgggagccagatcggcgtcgcctcggcctccgtaacccccgcctagccgggcc       c.-1

          .         .         .         .         .         .       g.5194
 ATGGCGGAACGCGGAGGGGCGGGCGGTGGTCCCGGAGGCGCCGGGGGCGGCAGCGGCCAG       c.60
 M  A  E  R  G  G  A  G  G  G  P  G  G  A  G  G  G  S  G  Q         p.20

          .         .         .         .         .         .       g.5254
 CGGGGATCCGGGGTCGCCCAGTCCCCTCAGCAGCCGCCGCCGCAGCAGCAGCAGCAGCAG       c.120
 R  G  S  G  V  A  Q  S  P  Q  Q  P  P  P  Q  Q  Q  Q  Q  Q         p.40

          .         .         .         .         .         .       g.5314
 CCGCCGCAGCAGCCGACGCCCCCCAAGCTGGCCCAGGCCACCTCGTCGTCCTCGTCCACC       c.180
 P  P  Q  Q  P  T  P  P  K  L  A  Q  A  T  S  S  S  S  S  T         p.60

          .         .         .         .         .         .       g.5374
 TCGGCGGCGGCTGCCTCCTCCTCGTCCTCGTCTACCTCCACCTCCATGGCCGTGGCGGTG       c.240
 S  A  A  A  A  S  S  S  S  S  S  T  S  T  S  M  A  V  A  V         p.80

          .         .         .         .         .         .       g.5434
 GCCTCGGGCTCCGCGCCTCCCGGTGGCCCGGGGCCAGGCCGCACCCCCGCCCCGGTGCAG       c.300
 A  S  G  S  A  P  P  G  G  P  G  P  G  R  T  P  A  P  V  Q         p.100

          .         .         .         .         .       | 02 .    g.128137
 ATGAACCTGTACGCCACCTGGGAGGTGGACCGGAGCTCGTCCAGCTGCGTGCCTAG | GCTA    c.360
 M  N  L  Y  A  T  W  E  V  D  R  S  S  S  S  C  V  P  R  |  L      p.120

          .         .         .         .         .         .       g.128197
 TTCAGCTTGACCCTGAAGAAACTCGTCATGCTAAAAGAAATGGACAAAGATCTTAACTCA       c.420
 F  S  L  T  L  K  K  L  V  M  L  K  E  M  D  K  D  L  N  S         p.140

          .         .     | 03   .         .         .         .    g.145045
 GTGGTCATCGCTGTGAAGCTGCAG | GGTTCAAAAAGAATTCTTCGCTCCAACGAGATCGTC    c.480
 V  V  I  A  V  K  L  Q   | G  S  K  R  I  L  R  S  N  E  I  V      p.160

          .         .         .         .         .     | 04   .    g.145787
 CTTCCAGCTAGTGGACTGGTGGAAACAGAGCTCCAATTAACCTTCTCCCTTCAG | TACCCT    c.540
 L  P  A  S  G  L  V  E  T  E  L  Q  L  T  F  S  L  Q   | Y  P      p.180

          .         .         .         .         .         .       g.145847
 CATTTCCTTAAGCGAGATGCCAACAAGCTGCAGATCATGCTGCAAAGGAGAAAACGTTAC       c.600
 H  F  L  K  R  D  A  N  K  L  Q  I  M  L  Q  R  R  K  R  Y         p.200

          .         .         .         .         .         .       g.145907
 AAGAATCGGACCATCTTGGGCTATAAGACCTTGGCCGTGGGACTCATCAACATGGCAGAG       c.660
 K  N  R  T  I  L  G  Y  K  T  L  A  V  G  L  I  N  M  A  E         p.220

  | 05       .         .         .         .         .         .    g.150826
  | GTGATGCAGCATCCTAATGAAGGCGCACTGGTGCTTGGCCTACACAGCAACGTGAAGGAT    c.720
  | V  M  Q  H  P  N  E  G  A  L  V  L  G  L  H  S  N  V  K  D      p.240

          .         .         .         .         .         .       g.150886
 GTCTCTGTGCCTGTGGCAGAAATAAAGATCTACTCCCTGTCCAGCCAACCCATTGACCAT       c.780
 V  S  V  P  V  A  E  I  K  I  Y  S  L  S  S  Q  P  I  D  H         p.260

          .         .      | 06  .         .         .         .    g.151202
 GAAGGAATCAAATCCAAGCTTTCTG | ATCGTTCTCCTGATATTGACAATTATTCTGAGGAA    c.840
 E  G  I  K  S  K  L  S  D |   R  S  P  D  I  D  N  Y  S  E  E      p.280

          .         .         .         .         .        | 07.    g.151345
 GAGGAAGAGAGTTTCTCATCAGAACAGGAAGGCAGTGATGATCCATTGCATGGGCAG | GAC    c.900
 E  E  E  S  F  S  S  E  Q  E  G  S  D  D  P  L  H  G  Q   | D      p.300

          .         .         .         .         .         .       g.151405
 TTGTTCTACGAAGACGAAGATCTCCGGAAAGTGAAGAAGACCCGGAGGAAACTAACCTCA       c.960
 L  F  Y  E  D  E  D  L  R  K  V  K  K  T  R  R  K  L  T  S         p.320

          .         | 08         .         .         .         .    g.154435
 ACCTCTGCCATCACAAGG | CAACCTAACATCAAACAGAAGTTTGTGGCCCTCCTGAAGCGG    c.1020
 T  S  A  I  T  R   | Q  P  N  I  K  Q  K  F  V  A  L  L  K  R      p.340

          .         | 09         .         .         .         .    g.155320
 TTTAAAGTTTCAGATGAG | GTGGGCTTTGGGCTGGAGCATGTGTCCCGCGAGCAGATCCGG    c.1080
 F  K  V  S  D  E   | V  G  F  G  L  E  H  V  S  R  E  Q  I  R      p.360

          .         .         .         .         .         .       g.155380
 GAAGTGGAAGAGGACTTGGATGAATTGTATGACAGTCTGGAGATGTACAACCCCAGCGAC       c.1140
 E  V  E  E  D  L  D  E  L  Y  D  S  L  E  M  Y  N  P  S  D         p.380

          .         .         .         .         .          | 10    g.155802
 AGTGGCCCTGAGATGGAGGAGACAGAAAGCATCCTCAGCACGCCAAAGCCCAAGCTCAA | G    c.1200
 S  G  P  E  M  E  E  T  E  S  I  L  S  T  P  K  P  K  L  K  |      p.400

          .         .         .         .         .         .       g.155862
 CCTTTCTTTGAGGGGATGTCGCAGTCCAGCTCCCAGACGGAGATTGGCAGCCTCAACAGC       c.1260
 P  F  F  E  G  M  S  Q  S  S  S  Q  T  E  I  G  S  L  N  S         p.420

          .         .         .    | 11    .         .         .    g.162178
 AAAGGCAGCCTCGGAAAAGACACCACCAGCCCT | ATGGAATTGGCTGCTCTAGAAAAAATT    c.1320
 K  G  S  L  G  K  D  T  T  S  P   | M  E  L  A  A  L  E  K  I      p.440

          .         .         .         .         .     | 12   .    g.165201
 AAATCTACTTGGATTAAAAACCAAGATGACAGCTTGACTGAAACAGACACTCTG | GAAATC    c.1380
 K  S  T  W  I  K  N  Q  D  D  S  L  T  E  T  D  T  L   | E  I      p.460

          .         .         .         .         .         .       g.165261
 ACTGACCAGGACATGTTTGGAGATGCCAGCACGAGTCTGGTTGTGCCGGAGAAAGTCAAA       c.1440
 T  D  Q  D  M  F  G  D  A  S  T  S  L  V  V  P  E  K  V  K         p.480

          .         .         .         .         . | 13       .    g.165462
 ACTCCCATGAAGTCCAGTAAAACGGATCTCCAGGGCTCTGCCTCCCCCAG | CAAAGTGGAG    c.1500
 T  P  M  K  S  S  K  T  D  L  Q  G  S  A  S  P  S  |  K  V  E      p.500

          .         .         .         .         .         .       g.165522
 GGGGTGCACACACCCCGGCAGAAGAGGAGCACGCCCCTGAAGGAGCGGCAGCTCTCCAAG       c.1560
 G  V  H  T  P  R  Q  K  R  S  T  P  L  K  E  R  Q  L  S  K         p.520

          .         .         .         .         .         .       g.165582
 CCCCTAAGTGAGAGGACCAACAGTTCCGACAGCGAGCGCTCCCCAGATCTGGGCCACAGC       c.1620
 P  L  S  E  R  T  N  S  S  D  S  E  R  S  P  D  L  G  H  S         p.540

        | 14 .         .         .         .         .         .    g.166873
 ACGCAG | ATTCCAAGAAAGGTGGTGTATGACCAGCTCAATCAGATCCTGGTGTCAGATGCA    c.1680
 T  Q   | I  P  R  K  V  V  Y  D  Q  L  N  Q  I  L  V  S  D  A      p.560

          .         .         .         .         .  | 15      .    g.167616
 GCCCTCCCAGAAAATGTCATTCTGGTGAACACCACTGACTGGCAGGGCCAG | TATGTGGCT    c.1740
 A  L  P  E  N  V  I  L  V  N  T  T  D  W  Q  G  Q   | Y  V  A      p.580

          .         .         .         .         .         .       g.167676
 GAGCTGCTCCAGGACCAGCGGAAGCCTGTGGTGTGCACCTGCTCCACCGTGGAGGTCCAG       c.1800
 E  L  L  Q  D  Q  R  K  P  V  V  C  T  C  S  T  V  E  V  Q         p.600

          .         .         .         | 16         .         .    g.168454
 GCCGTGCTGTCCGCCCTGCTCACCCGGATCCAGCGCTA | CTGCAACTGCAACTCTTCCATG    c.1860
 A  V  L  S  A  L  L  T  R  I  Q  R  Y  |  C  N  C  N  S  S  M      p.620

          .         .         .         .         .         .       g.168514
 CCGAGGCCAGTGAAGGTGGCTGCTGTGGGAGGCCAGAGCTACCTGAGCTCCATCCTCAGG       c.1920
 P  R  P  V  K  V  A  A  V  G  G  Q  S  Y  L  S  S  I  L  R         p.640

          .         .         .         .         .         .       g.168574
 TTCTTTGTCAAGTCCCTGGCCAACAAGACCTCCGACTGGCTTGGCTACATGCGCTTCCTC       c.1980
 F  F  V  K  S  L  A  N  K  T  S  D  W  L  G  Y  M  R  F  L         p.660

          .    | 17    .         .         .         .         .    g.168826
 ATCATCCCCCTCG | GTTCTCACCCTGTGGCCAAATACTTGGGGTCAGTCGACAGTAAATAC    c.2040
 I  I  P  L  G |   S  H  P  V  A  K  Y  L  G  S  V  D  S  K  Y      p.680

          .         .         .         .         .         .       g.168886
 AGTAGTTCCTTCCTGGATTCTGGTTGGAGAGATCTGTTCAGTCGCTCGGAGCCACCAGTG       c.2100
 S  S  S  F  L  D  S  G  W  R  D  L  F  S  R  S  E  P  P  V         p.700

      | 18   .         .         .         .         .         .    g.170004
 TCAG | AGCAACTGGACGTGGCAGGGCGGGTGATGCAGTACGTCAACGGGGCAGCCACGACA    c.2160
 S  E |   Q  L  D  V  A  G  R  V  M  Q  Y  V  N  G  A  A  T  T      p.720

          .         .         .         .        | 19.         .    g.170558
 CACCAGCTTCCCGTGGCCGAAGCCATGCTGACTTGCCGGCATAAGTT | CCCTGATGAAGAC    c.2220
 H  Q  L  P  V  A  E  A  M  L  T  C  R  H  K  F  |  P  D  E  D      p.740

          .         .         . | 20       .         .         .    g.173481
 TCCTATCAGAAGTTTATTCCCTTCATTGGC | GTGGTGAAGGTGGGTCTGGTTGAAGACTCT    c.2280
 S  Y  Q  K  F  I  P  F  I  G   | V  V  K  V  G  L  V  E  D  S      p.760

          .    | 21    .         .         .         .         .    g.173836
 CCCTCCACAGCAG | GCGATGGGGACGATTCTCCTGTGGTCAGCCTTACTGTGCCCTCCACA    c.2340
 P  S  T  A  G |   D  G  D  D  S  P  V  V  S  L  T  V  P  S  T      p.780

          .         .         .         .         .         .       g.173896
 TCACCACCCTCCAGCTCGGGCCTGAGCCGAGACGCCACGGCCACCCCTCCCTCCTCCCCA       c.2400
 S  P  P  S  S  S  G  L  S  R  D  A  T  A  T  P  P  S  S  P         p.800

          .         .          | 22        .         .         .    g.176105
 TCTATGAGCAGCGCCCTGGCCATCGTGGG | GAGCCCTAATAGCCCATATGGGGACGTGATT    c.2460
 S  M  S  S  A  L  A  I  V  G  |  S  P  N  S  P  Y  G  D  V  I      p.820

          .         .         .         .         .         .       g.176165
 GGCCTCCAGGTGGACTACTGGCTGGGCCACCCCGGGGAGCGGAGGAGGGAAGGCGACAAG       c.2520
 G  L  Q  V  D  Y  W  L  G  H  P  G  E  R  R  R  E  G  D  K         p.840

          .         .         .         .         .         .       g.176225
 AGGGACGCCAGCTCGAAGAACACCCTCAAGAGTGTCTTCCGCTCAGTGCAGGTGTCCCGC       c.2580
 R  D  A  S  S  K  N  T  L  K  S  V  F  R  S  V  Q  V  S  R         p.860

          .         .         .         .         .         .       g.176285
 CTGCCCCATAGTGGGGAGGCCCAGCTTTCTGGCACCATGGCCATGACTGTGGTCACCAAA       c.2640
 L  P  H  S  G  E  A  Q  L  S  G  T  M  A  M  T  V  V  T  K         p.880

          .       | 23 .         .         .         .         .    g.177603
 GAAAAGAACAAGAAAG | TTCCCACCATCTTCCTGAGCAAGAAACCCCGAGAAAAGGAGGTG    c.2700
 E  K  N  K  K  V |   P  T  I  F  L  S  K  K  P  R  E  K  E  V      p.900

          .         .         .         .         .         .       g.177663
 GATTCTAAGAGCCAGGTCATTGAAGGCATCAGCCGCCTCATCTGCTCAGCCAAGCAGCAG       c.2760
 D  S  K  S  Q  V  I  E  G  I  S  R  L  I  C  S  A  K  Q  Q         p.920

          .       | 24 .         .         .         .         .    g.177856
 CAGACTATGCTGAGAG | TGTCCATCGATGGGGTCGAGTGGAGTGACATCAAGTTCTTCCAG    c.2820
 Q  T  M  L  R  V |   S  I  D  G  V  E  W  S  D  I  K  F  F  Q      p.940

          .         .         .         .         .         .       g.177916
 CTGGCAGCCCAGTGGCCCACCCATGTCAAGCACTTTCCAGTGGGACTCTTCAGTGGCAGC       c.2880
 L  A  A  Q  W  P  T  H  V  K  H  F  P  V  G  L  F  S  G  S         p.960

          .                                                         g.177928
 AAGGCCACCTGA                                                       c.2892
 K  A  T  X                                                         p.963

          .         .         .         .         .         .       g.177988
 ggccctgtctcccagccactttccctcctggcactgccaccagcctcaccgcctgcgggc       c.*60

          .         .         .         .         .         .       g.178048
 agggggaggccagcaggcccgggcccagcaccccttccctggcaccagggtctgcctctc       c.*120

          .         .         .         .         .         .       g.178108
 actcgcccaggtcccgaaggacactgccacagggacgccttccctcccctcccctccagc       c.*180

          .         .         .         .         .         .       g.178168
 ccacccctgcacagcccctcctccttcccgcttttccccttctccctcctgctccaggcc       c.*240

          .         .         .         .         .         .       g.178228
 caaggcgtgttggttttgccttctggtgcccatagtcccctggactgagtcccccaggcc       c.*300

          .         .         .         .         .         .       g.178288
 ttccttcacccgacttccaaactcttccttgtggtatcagtttccttctcggaaatgaga       c.*360

          .         .         .         .         .         .       g.178348
 aagctggaatcctggtccccagcaggagagcctagtcctcccccagcccctccagccacc       c.*420

          .         .         .         .         .         .       g.178408
 agggtgtcctctaggatgcagctgccagatccactcactctgctgcctccagcaggaccc       c.*480

          .         .         .         .         .         .       g.178468
 aaggccactttcaactcttatggggttctccacctgccccagagcttctcaagggagggt       c.*540

          .         .         .         .         .         .       g.178528
 aagggggcaccctgagcccacaggacccctacttcacagctcacaggggcaggaggcagc       c.*600

          .         .         .         .         .         .       g.178588
 tcccctgcctccaggaccctgttgctatggtgacacagcgtttctaggacagaggggcct       c.*660

          .         .         .         .         .         .       g.178648
 cccagtctccccccaccacccgtgcacgacttcctcaccacccccaggttccctgcagat       c.*720

          .         .         .         .         .         .       g.178708
 gtcgtgtgtgtcctgagtgtttctttggttctttgcacgccaagtctcttggttgtacca       c.*780

          .         .         .         .         .         .       g.178768
 tgtgacacaccctgtgcactggtcgctgtcttcgtggcttccacccttgttaatgatgct       c.*840

          .         .         .         .         .         .       g.178828
 cctgcctctgcctcccagcccctcacccagcacagctctgcctggacttggagagatggg       c.*900

          .         .         .         .         .         .       g.178888
 aggcagacccccaccaccatacatgctgtctgtggcccctcagacattctgtttcatctc       c.*960

          .         .         .         .         .         .       g.178948
 ccattcatctccctcctcccaccgtgtcagtttttctgcctttccctgctctgttcttcc       c.*1020

          .         .         .         .         .         .       g.179008
 ccctccttaggccccagcctgggcccagacccatcctcccagccaggtttccctccagca       c.*1080

          .         .         .         .         .         .       g.179068
 ggctccttccctccctgtcacctccctctcaccaacccggggtctgagcccctcattcct       c.*1140

          .         .         .         .         .         .       g.179128
 gaccgtccgtgttctcaggagtggttgaggacacagggccccagcccagccctctgcacc       c.*1200

          .         .         .         .         .         .       g.179188
 ccccagcccggccatctgcgccccacagcccctttggagcttttctcttgtcctctcact       c.*1260

          .         .         .         .         .         .       g.179248
 ccttcccagaagtttttgcacagaacttcattttgaaagtgtttttctcattctccatac       c.*1320

          .         .         .         .         .         .       g.179308
 ctcccccaagctctcctccagcccttcccagggctcagccctgctgtcctgagcgtctcc       c.*1380

          .         .         .         .         .         .       g.179368
 tgggccagagagaggagatgggggtgggagggactgagttgatgttgggtttttcattca       c.*1440

          .         .                                               g.179395
 ataaattggtgatttcttaccgactgc                                        c.*1467

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phosphofurin acidic cluster sorting protein 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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