peptidyl arginine deiminase, type VI (PADI6) - coding DNA reference sequence

(used for variant description)

(last modified July 9, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_207421.3 in the PADI6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032943.2, covering PADI6 transcript NM_207421.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
          .         .         .         .         .         .       g.60
 ATGGTCAGCGTGGAGGGCCGAGCCATGTCCTTCCAGAGTATCATCCACCTGTCCCTGGAC       c.60
 M  V  S  V  E  G  R  A  M  S  F  Q  S  I  I  H  L  S  L  D         p.20

          .         .         .         .         .       | 02 .    g.814
 AGCCCTGTCCATGCCGTTTGTGTGTTGGGCACAGAAATCTGCTTGGATCTCAGCGG | GTGT    c.120
 S  P  V  H  A  V  C  V  L  G  T  E  I  C  L  D  L  S  G  |  C      p.40

          .         .         .         .         .         .       g.874
 GCCCCCCAGAAGTGCCAGTGCTTCACCATCCATGGCTCTGGGAGGGTCTTGATCGATGTG       c.180
 A  P  Q  K  C  Q  C  F  T  I  H  G  S  G  R  V  L  I  D  V         p.60

          .         .         .         .         .         .       g.934
 GCCAACACGGTGATTTCTGAGAAGGAGGACGCCACCATCTGGTGGCCCCTGTCTGATCCC       c.240
 A  N  T  V  I  S  E  K  E  D  A  T  I  W  W  P  L  S  D  P         p.80

          .         .         .         .         .     | 03   .    g.3187
 ACGTACGCCACAGTGAAGATGACATCGCCCAGCCCTTCCGTGGATGCGGATAAG | GTCTCG    c.300
 T  Y  A  T  V  K  M  T  S  P  S  P  S  V  D  A  D  K   | V  S      p.100

          .         .         .         .         .         .       g.3247
 GTCACATACTATGGGCCCAACGAGGATGCCCCCGTGGGCACAGCTGTGCTGTACCTCACT       c.360
 V  T  Y  Y  G  P  N  E  D  A  P  V  G  T  A  V  L  Y  L  T         p.120

         | 04.         .         .         .         .         .    g.7727
 GGCATTG | AGGTCTCTCTAGAGGTAGACATCTACCGCAATGGGCAAGTTGAGATGTCAAGT    c.420
 G  I  E |   V  S  L  E  V  D  I  Y  R  N  G  Q  V  E  M  S  S      p.140

          .      | 05  .         .         .         .         .    g.8846
 GACAAACAGGCTAAG | AAAAAATGGATCTGGGGTCCCAGCGGTTGGGGTGCCATCCTGCTT    c.480
 D  K  Q  A  K   | K  K  W  I  W  G  P  S  G  W  G  A  I  L  L      p.160

          .         .         .         .         .         .       g.8906
 GTGAATTGCAACCCTGCTGATGTGGGCCAGCAACTTGAGGACAAGAAAACCAAGAAAGTG       c.540
 V  N  C  N  P  A  D  V  G  Q  Q  L  E  D  K  K  T  K  K  V         p.180

          .    | 06    .         .         .         .         .    g.9768
 ATCTTTTCAGAGG | AAATAACGAATCTGTCCCAGATGACTCTGAATGTCCAAGGCCCCAGC    c.600
 I  F  S  E  E |   I  T  N  L  S  Q  M  T  L  N  V  Q  G  P  S      p.200

          .         .         .         .         .         .       g.9828
 TGTATCTTAAAGAAATATCGGCTAGTCCTCCATACCTCCAAGGAAGAGTCGAAGAAGGCG       c.660
 C  I  L  K  K  Y  R  L  V  L  H  T  S  K  E  E  S  K  K  A         p.220

          .          | 07        .         .         .         .    g.16176
 AGAGTCTACTGGCCCCAAA | AAGACAACTCCAGTACCTTTGAGTTGGTGCTGGGGCCCGAC    c.720
 R  V  Y  W  P  Q  K |   D  N  S  S  T  F  E  L  V  L  G  P  D      p.240

          .         .         .         .         .         .       g.16236
 CAGCACGCCTATACCTTGGCCCTCCTCGGGAACCACTTGAAGGAGACTTTCTACGTTGAA       c.780
 Q  H  A  Y  T  L  A  L  L  G  N  H  L  K  E  T  F  Y  V  E         p.260

          .         .         .         .         .         .       g.16296
 GCTATAGCATTCCCATCTGCCGAATTCTCAGGCCTCATCTCCTACTCTGTGTCCCTGGTG       c.840
 A  I  A  F  P  S  A  E  F  S  G  L  I  S  Y  S  V  S  L  V         p.280

          .         | 08         .         .         .         .    g.16573
 GAGGAGTCTCAAGACCCG | TCAATTCCAGAGACTGTGCTGTACAAAGACACGGTGGTGTTC    c.900
 E  E  S  Q  D  P   | S  I  P  E  T  V  L  Y  K  D  T  V  V  F      p.300

          .         .         .         .         .         .       g.16633
 CGGGTGGCTCCCTGTGTCTTCATTCCCTGTACCCAGGTGCCTCTGGAGGTTTACCTGTGC       c.960
 R  V  A  P  C  V  F  I  P  C  T  Q  V  P  L  E  V  Y  L  C         p.320

    | 09     .         .         .         .         .         .    g.19926
 AG | GGAGCTGCAGCTGCAGGGTTTTGTGGACACAGTGACGAAGCTGAGTGAGAAGAGCAAC    c.1020
 R  |  E  L  Q  L  Q  G  F  V  D  T  V  T  K  L  S  E  K  S  N      p.340

          .         .         .         .         .     | 10   .    g.21735
 AGCCAGGTGGCATCTGTCTATGAGGACCCCAACCGCCTGGGCAGGTGGCTCCAG | GATGAG    c.1080
 S  Q  V  A  S  V  Y  E  D  P  N  R  L  G  R  W  L  Q   | D  E      p.360

          .         .         .         .         .         .       g.21795
 ATGGCCTTCTGCTACACCCAGGCTCCCCACAAGACAACGTCCTTGATCCTCGACACACCT       c.1140
 M  A  F  C  Y  T  Q  A  P  H  K  T  T  S  L  I  L  D  T  P         p.380

          .         .         .         .   | 11     .         .    g.22072
 CAGGCCGCCGATCTCGATGAGTTCCCCATGAAGTACTCACTG | AGCCCTGGTATTGGCTAC    c.1200
 Q  A  A  D  L  D  E  F  P  M  K  Y  S  L   | S  P  G  I  G  Y      p.400

          .         .         .         .         .         .       g.22132
 ATGATCCAGGACACTGAGGACCATAAAGTGGCCAGCATGGATTCCATTGGGAACCTGATG       c.1260
 M  I  Q  D  T  E  D  H  K  V  A  S  M  D  S  I  G  N  L  M         p.420

          .         .         .         .         .         .       g.22192
 GTGTCCCCACCTGTCAAGGTCCAAGGGAAAGAGTACCCGCTGGGCAGAGTCCTCATTGGC       c.1320
 V  S  P  P  V  K  V  Q  G  K  E  Y  P  L  G  R  V  L  I  G         p.440

          .        | 12.         .         .         .         .    g.22748
 AGCAGCTTTTACCCCAG | CGCAGAGGGCCGGGCCATGAGTAAGACCCTCCGAGACTTCCTC    c.1380
 S  S  F  Y  P  S  |  A  E  G  R  A  M  S  K  T  L  R  D  F  L      p.460

          .         .         .         .         .         .       g.22808
 TATGCCCAGCAGGTCCAAGCGCCGGTGGAGCTCTACTCAGATTGGCTAATGACTGGCCAC       c.1440
 Y  A  Q  Q  V  Q  A  P  V  E  L  Y  S  D  W  L  M  T  G  H         p.480

          .         .         .         .         .     | 13   .    g.23300
 GTGGATGAGTTCATGTGCTTCATCCCCACAGATGACAAGAATGAGGGCAAAAAG | GGCTTC    c.1500
 V  D  E  F  M  C  F  I  P  T  D  D  K  N  E  G  K  K   | G  F      p.500

          .         .         .         .         .         .       g.23360
 CTGCTGCTCCTGGCCAGCCCCAGTGCCTGCTATAAACTGTTCCGAGAGAAACAGAAGGAA       c.1560
 L  L  L  L  A  S  P  S  A  C  Y  K  L  F  R  E  K  Q  K  E         p.520

          .         .         .         .         .         | 14    g.24827
 GGCTATGGCGACGCTCTTCTGTTTGATGAGCTTAGAGCAGATCAGCTCCTGTCTAATG | GA    c.1620
 G  Y  G  D  A  L  L  F  D  E  L  R  A  D  Q  L  L  S  N  G |       p.540

          .         .         .         .         .         .       g.24887
 AGGGAAGCCAAAACCATCGACCAACTTCTGGCTGATGAAAGCCTGAAGAAGCAGAATGAA       c.1680
 R  E  A  K  T  I  D  Q  L  L  A  D  E  S  L  K  K  Q  N  E         p.560

           | 15        .         .         .         .         .    g.26491
 TACGTGGAG | AAGTGCATTCACCTGAACCGTGACATCCTGAAGACGGAGCTGGGCCTGGTG    c.1740
 Y  V  E   | K  C  I  H  L  N  R  D  I  L  K  T  E  L  G  L  V      p.580

          .         .         .         .         .         .       g.26551
 GAACAGGACATCATCGAGATTCCCCAGCTGTTCTGCTTGGAGAAGCTGACTAACATCCCC       c.1800
 E  Q  D  I  I  E  I  P  Q  L  F  C  L  E  K  L  T  N  I  P         p.600

          .         .         .         .         .  | 16      .    g.28968
 TCTGACCAGCAGCCCAAGAGGTCCTTTGCGAGGCCATACTTCCCTGACCTG | TTGCGGATG    c.1860
 S  D  Q  Q  P  K  R  S  F  A  R  P  Y  F  P  D  L   | L  R  M      p.620

          .         .         .         .         .         .       g.29028
 ATTGTGATGGGCAAGAACCTGGGGATCCCCAAGCCTTTTGGGCCCCAAATCAAGGGGACC       c.1920
 I  V  M  G  K  N  L  G  I  P  K  P  F  G  P  Q  I  K  G  T         p.640

          .         .         .         .         .         .       g.29088
 TGCTGCCTGGAAGAAAAGATTTGCTGCTTGCTGGAGCCCCTGGGCTTCAAGTGCACCTTC       c.1980
 C  C  L  E  E  K  I  C  C  L  L  E  P  L  G  F  K  C  T  F         p.660

          .         .         .         .         .         .       g.29148
 ATCAATGACTTTGACTGTTACCTGACAGAGGTCGGAGACATCTGTGCCTGTGCCAACATC       c.2040
 I  N  D  F  D  C  Y  L  T  E  V  G  D  I  C  A  C  A  N  I         p.680

          .         .         .         .                           g.29193
 CGCCGGGTGCCCTTTGCCTTCAAATGGTGGAAGATGGTACCTTAG                      c.2085
 R  R  V  P  F  A  F  K  W  W  K  M  V  P  X                        p.694

          .         .         .         .         .         .       g.29253
 acccaggccctggagctgccagctctgccccagcgtggatggcccactgtcaccatgcaa       c.*60

          .         .         .         .         .         .       g.29313
 cagcatgattctttgcccagtagaggaggctggagagtccaggcaacagaaccctttctt       c.*120

          .         .         .         .         .         .       g.29373
 ccctgtctgccccgaccgaccctcggacccagtaggatggcaaatgccgccagcttgaac       c.*180

          .         .         .         .         .         .       g.29433
 ccctatggggaaaagatgcaaaagtgttcagccaagtgacgtttactaaatagccaataa       c.*240

          .         .                                               g.29454
 agggctggtgggtgtgaatgc                                              c.*261

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Peptidyl arginine deiminase, type VI protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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