p21 protein (Cdc42/Rac)-activated kinase 3 (PAK3) - coding DNA reference sequence

(used for variant description)

(last modified July 23, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_002578.3 in the PAK3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008288.1, covering PAK3 transcript NM_002578.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.156883
                                        aatagcagagaagggctaggg       c.-601

 .         .         .         .         .         .                g.156943
 agcggttgccgagcaggggctctaccgcgggcgggcagctgtgccagctaaccgtctggg       c.-541

 .         .         .         .         .         .                g.157003
 atctcgcactgggggctgcagcttttccccgcctcgagccagtgtgcgggggcgggagaa       c.-481

 .         .         .         .         .         .                g.157063
 gagccagggggagcgggctgggcccggggctgcggctgcggccgcggggctgcggctccc       c.-421

 .         .         .         .         .         .                g.157123
 cagccccgccagctggagcgctcggaggtagaggaaaggtcttgacggggtggctggatc       c.-361

 .        | 02.         .         .         .         .             g.158157
 cgtggcag | aatccagttccagattctagacttgagggttctgggctgttggtctgtagaa    c.-301

 .         .     | 03   .         .         .         .             g.158335
 gcgaaggagagaagg | actcaaatccaggccaagtgtatggctgtctgaggtattggaaca    c.-241

 .         .         .         .         .         .                g.158395
 gaaggaggtccattcctgttggtgacaacaccgtggccctgttctgggatgagcaaggtg       c.-181

 .     | 04   .         .         .         .         .             g.163929
 taaag | gtttcccccaagaaagagcagctgagtccttgcatcttgtggcagctggtgtgcc    c.-121

 .         .         .         .         .         .                g.163989
 cagcactgagtctgtaggagctgaagccagcccggacccttctcatgggcagtgcccacc       c.-61

 .         .         .         .   | 05     .         .             g.183819
 tgtgctgaagtcctgcagcggtggcggtgtgag | gagctgtgaaattagttgtaactgaaa    c.-1

          .         .         .         .         .         .       g.183879
 ATGTCTGACGGTCTGGATAATGAAGAGAAACCCCCGGCTCCTCCACTGAGGATGAATAGT       c.60
 M  S  D  G  L  D  N  E  E  K  P  P  A  P  P  L  R  M  N  S         p.20

          .         .         .         .         .         .       g.183939
 AACAACCGGGATTCTTCAGCACTCAACCACAGCTCCAAACCACTTCCCATGGCCCCTGAA       c.120
 N  N  R  D  S  S  A  L  N  H  S  S  K  P  L  P  M  A  P  E         p.40

          .         .         .         .         .      | 06  .    g.202816
 GAGAAGAATAAGAAAGCCAGGCTTCGCTCTATCTTCCCAGGAGGAGGGGATAAAA | CCAAT    c.180
 E  K  N  K  K  A  R  L  R  S  I  F  P  G  G  G  D  K  T |   N      p.60

          .         .         .         .         .         .       g.202876
 AAGAAGAAGGAGAAAGAGCGCCCAGAGATCTCTCTTCCTTCAGACTTTGAGCATACGATT       c.240
 K  K  K  E  K  E  R  P  E  I  S  L  P  S  D  F  E  H  T  I         p.80

          .         .         .       | 07 .         .         .    g.208476
 CATGTGGGGTTTGATGCAGTCACCGGGGAATTCACT | GGAATTCCAGAGCAATGGGCACGA    c.300
 H  V  G  F  D  A  V  T  G  E  F  T   | G  I  P  E  Q  W  A  R      p.100

          .         .         .         .         .         .       g.208536
 TTACTCCAAACTTCCAACATAACAAAATTGGAACAGAAGAAGAACCCACAAGCTGTTCTA       c.360
 L  L  Q  T  S  N  I  T  K  L  E  Q  K  K  N  P  Q  A  V  L         p.120

          .         .         .         .         .         .       g.208596
 GATGTTCTCAAATTCTATGATTCCAAAGAAACAGTCAACAACCAGAAATACATGAGCTTT       c.420
 D  V  L  K  F  Y  D  S  K  E  T  V  N  N  Q  K  Y  M  S  F         p.140

          . | 08       .         .         .         | 09         . g.223642
 ACATCAGGAG | ATAAAAGTGCACATGGATACATAGCAGCCCATCCTTCG | AGTACAAAAACA c.480
 T  S  G  D |   K  S  A  H  G  Y  I  A  A  H  P  S   | S  T  K  T   p.160

          .         .         .         .         .         .       g.223702
 GCATCTGAGCCTCCATTGGCCCCTCCTGTGTCTGAAGAAGAAGATGAAGAGGAAGAAGAA       c.540
 A  S  E  P  P  L  A  P  P  V  S  E  E  E  D  E  E  E  E  E         p.180

          .         .         .         .         .         .       g.223762
 GAAGAAGATGAAAATGAGCCACCACCAGTTATCGCACCAAGACCAGAGCATACAAAATCA       c.600
 E  E  D  E  N  E  P  P  P  V  I  A  P  R  P  E  H  T  K  S         p.200

  | 10       .         .         .         .         .         .    g.224337
  | ATCTATACTCGTTCTGTGGTTGAATCCATTGCTTCACCAGCAGTACCAAATAAAGAGGTC    c.660
  | I  Y  T  R  S  V  V  E  S  I  A  S  P  A  V  P  N  K  E  V      p.220

          .         .         .         .         .         .       g.224397
 ACACCACCCTCTGCTGAAAATGCCAATTCCAGTACTTTGTACAGGAACACAGATCGGCAA       c.720
 T  P  P  S  A  E  N  A  N  S  S  T  L  Y  R  N  T  D  R  Q         p.240

          .         .         .         .       | 11 .         .    g.233747
 AGAAAAAAATCCAAGATGACAGATGAGGAGATCTTAGAGAAGCTAA | GAAGCATTGTGAGT    c.780
 R  K  K  S  K  M  T  D  E  E  I  L  E  K  L  R |   S  I  V  S      p.260

          .         .         .         .         . | 12       .    g.252852
 GTTGGGGACCCAAAGAAAAAATACACAAGATTTGAAAAAATTGGTCAAGG | GGCATCAGGT    c.840
 V  G  D  P  K  K  K  Y  T  R  F  E  K  I  G  Q  G  |  A  S  G      p.280

          .         .         .          | 13        .         .    g.253242
 ACTGTTTATACAGCACTAGACATTGCAACAGGACAAGAG | GTGGCCATAAAGCAGATGAAC    c.900
 T  V  Y  T  A  L  D  I  A  T  G  Q  E   | V  A  I  K  Q  M  N      p.300

          .         .         .         .         .         .       g.253302
 CTTCAACAGCAACCCAAGAAGGAATTAATTATTAATGAAATTCTGGTCATGAGGGAAAAT       c.960
 L  Q  Q  Q  P  K  K  E  L  I  I  N  E  I  L  V  M  R  E  N         p.320

          .         .         .   | 14     .         .         .    g.255044
 AAGAACCCTAATATTGTTAATTATTTAGATAG | CTACTTGGTGGGTGATGAACTATGGGTA    c.1020
 K  N  P  N  I  V  N  Y  L  D  S  |  Y  L  V  G  D  E  L  W  V      p.340

          .         .         .         .         .         .       g.255104
 GTCATGGAATACTTGGCTGGTGGCTCTCTGACTGATGTGGTCACAGAGACCTGTATGGAT       c.1080
 V  M  E  Y  L  A  G  G  S  L  T  D  V  V  T  E  T  C  M  D         p.360

          .         .         . | 15       .         .         .    g.256587
 GAAGGACAGATAGCAGCTGTCTGCAGAGAG | TGCCTGCAAGCTTTGGATTTCCTGCACTCA    c.1140
 E  G  Q  I  A  A  V  C  R  E   | C  L  Q  A  L  D  F  L  H  S      p.380

          .         .         .         .         .         .       g.256647
 AACCAGGTGATCCATAGAGATATAAAGAGTGACAATATTCTTCTCGGGATGGATGGCTCT       c.1200
 N  Q  V  I  H  R  D  I  K  S  D  N  I  L  L  G  M  D  G  S         p.400

          . | 16       .         .         .         .         .    g.257209
 GTTAAATTGA | CTGACTTTGGGTTCTGTGCCCAGATCACTCCTGAGCAAAGTAAACGAAGC    c.1260
 V  K  L  T |   D  F  G  F  C  A  Q  I  T  P  E  Q  S  K  R  S      p.420

          .         .         .         .         .         .       g.257269
 ACTATGGTGGGAACCCCATATTGGATGGCACCTGAGGTGGTGACTCGAAAAGCTTATGGT       c.1320
 T  M  V  G  T  P  Y  W  M  A  P  E  V  V  T  R  K  A  Y  G         p.440

          .         .         .         .         .         .       g.257329
 CCGAAAGTTGATATCTGGTCTCTTGGAATTATGGCAATTGAAATGGTGGAAGGTGAACCC       c.1380
 P  K  V  D  I  W  S  L  G  I  M  A  I  E  M  V  E  G  E  P         p.460

          .         .        | 17.         .         .         .    g.277169
 CCTTACCTTAATGAAAATCCACTCAGG | GCATTGTATCTGATAGCCACTAATGGAACTCCA    c.1440
 P  Y  L  N  E  N  P  L  R   | A  L  Y  L  I  A  T  N  G  T  P      p.480

          .         .         .         .         .         .       g.277229
 GAGCTCCAGAATCCTGAGAGACTGTCAGCTGTATTCCGTGACTTTTTAAATCGCTGTCTT       c.1500
 E  L  Q  N  P  E  R  L  S  A  V  F  R  D  F  L  N  R  C  L         p.500

          .         .         .         .      | 18  .         .    g.281088
 GAGATGGATGTGGATAGGCGAGGATCTGCCAAGGAGCTTTTGCAG | CATCCATTTTTAAAA    c.1560
 E  M  D  V  D  R  R  G  S  A  K  E  L  L  Q   | H  P  F  L  K      p.520

          .         .         .         .         .         .       g.281148
 TTAGCCAAGCCTCTCTCCAGCCTGACTCCTCTGATTATCGCTGCAAAGGAAGCAATTAAG       c.1620
 L  A  K  P  L  S  S  L  T  P  L  I  I  A  A  K  E  A  I  K         p.540

          .                                                         g.281163
 AACAGCAGCCGCTAA                                                    c.1635
 N  S  S  R  X                                                      p.544

          .         .         .         .         .         .       g.281223
 gactgcaagccttacacctcaccatctccctcatgagtaagactgaaataaaactctgct       c.*60

          .         .         .         .         .         .       g.281283
 gcaggaaagatggaagaaaagacagtcaaatggggtgggggttctttacctttcaaatga       c.*120

          .         .         .         .         .         .       g.281343
 atagaaacttcttataagcctttttcctactccctcagattatgtaatttatttgtaagc       c.*180

          .         .         .         .         .         .       g.281403
 ctgaatcgcagcccaaacagggcagcaatgttgaagtgaccataaagtggtcacttccac       c.*240

          .         .         .         .         .         .       g.281463
 cgtgaagcgaaagagccagtagtgaatcccctcattttgtgcattcactttgaagaaaaa       c.*300

          .         .         .         .         .         .       g.281523
 ggtttctcaaagatgcacactccctcttcatagtgttgtgtttgtttttaagttagagag       c.*360

          .         .         .         .         .         .       g.281583
 tagtccctcttgcattcaaacctccttcaaaactccttacccaatgtgatgtttttcact       c.*420

          .         .         .         .         .         .       g.281643
 tgcattgtcattagatgtccagaaaaaaaaaagatgtcaaaatgtttttctaaaaaaaga       c.*480

          .                                                         g.281661
 aagcaaaaaaagcaaggc                                                 c.*498

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The P21 protein (Cdc42/Rac)-activated kinase 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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