peptidylglycine alpha-amidating monooxygenase (PAM) - coding DNA reference sequence

(used for variant description)

(last modified September 8, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_000919.3 in the PAM gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029444.2, covering PAM transcript NM_000919.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.116053
                                                gttctgaatgatg       c.-361

 .         .         .         .         .         .                g.116113
 actgacgcgggtttgggtgatacccctcacagcccctgtcattccggagtcataaggcac       c.-301

 .         .         .         .         .         .                g.116173
 ccgcgcgtctagccccagcgccagggcacgcgagcggcgctggagggaggaaagcttccg       c.-241

 .         .         .         .         .         .                g.116233
 cctgcgggccggacaaaagtcccgcctgcccacggctttttgcccgccgctcgtgaccga       c.-181

 .         .         .         .         .         .                g.116293
 gacgcctcgccgcggccagctcgctgctctcgctggcggatggtgtgtggccgccgcagg       c.-121

 .         .         .         .         .         .                g.116353
 acgcccgccgtgcccgggccatgaagtagcggctgctggcggcgccgctgcccaaccgcc       c.-61

 .         .         .         .         .         .                g.116413
 agccccagccccgcgctgcgctgcccggtcctctcccggcggggtcgtatcggcgtggac       c.-1

          .         .         .         .         .         .       g.116473
 ATGGCTGGCCGCGTCCCTAGCCTGCTAGTTCTCCTTGTTTTTCCAAGCAGCTGTTTGGCT       c.60
 M  A  G  R  V  P  S  L  L  V  L  L  V  F  P  S  S  C  L  A         p.20

          .         .          | 02        .         .         .    g.117521
 TTCCGAAGCCCACTTTCTGTCTTTAAGAG | GTTTAAAGAAACTACCAGACCATTTTCCAAT    c.120
 F  R  S  P  L  S  V  F  K  R  |  F  K  E  T  T  R  P  F  S  N      p.40

          .         .         .         .         .         .       g.117581
 GAATGTCTTGGTACCACCAGACCCGTAGTTCCTATTGATTCATCAGATTTTGCATTGGAT       c.180
 E  C  L  G  T  T  R  P  V  V  P  I  D  S  S  D  F  A  L  D         p.60

          .         .         . | 03       .         .         .    g.151603
 ATTCGCATGCCTGGGGTTACACCTAAACAG | TCCGATACATACTTCTGCATGTCTATGCGA    c.240
 I  R  M  P  G  V  T  P  K  Q   | S  D  T  Y  F  C  M  S  M  R      p.80

          .         .         | 04         .         .         .    g.164183
 ATACCAGTGGATGAGGAAGCCTTCGTGA | TTGACTTCAAGCCTCGAGCCAGCATGGATACT    c.300
 I  P  V  D  E  E  A  F  V  I |   D  F  K  P  R  A  S  M  D  T      p.100

          .         .         .         .         .       | 05 .    g.175178
 GTCCATCACATGTTACTTTTTGGATGCAATATGCCTTCATCCACTGGAAGTTACTG | GTTT    c.360
 V  H  H  M  L  L  F  G  C  N  M  P  S  S  T  G  S  Y  W  |  F      p.120

          .         .         .         .         .         .       g.175238
 TGTGATGAAGGAACCTGTACAGATAAAGCCAATATTCTGTATGCCTGGGCGAGAAATGCT       c.420
 C  D  E  G  T  C  T  D  K  A  N  I  L  Y  A  W  A  R  N  A         p.140

          .         .   | 06     .         .         .         .    g.176840
 CCCCCTACCCGGCTCCCCAAAG | GTGTTGGATTCAGAGTTGGAGGAGAGACTGGAAGTAAA    c.480
 P  P  T  R  L  P  K  G |   V  G  F  R  V  G  G  E  T  G  S  K      p.160

          .         .         .         .       | 07 .         .    g.197068
 TACTTTGTACTACAGGTACACTATGGGGATATTAGTGCTTTTAGAG | ATAATAACAAGGAC    c.540
 Y  F  V  L  Q  V  H  Y  G  D  I  S  A  F  R  D |   N  N  K  D      p.180

          .         .         .      | 08  .         .         .    g.198620
 TGTTCTGGTGTGTCCTTACACCTCACACGTCTGCC | ACAGCCTTTAATTGCTGGCATGTAC    c.600
 C  S  G  V  S  L  H  L  T  R  L  P  |  Q  P  L  I  A  G  M  Y      p.200

          .         .         .         .    | 09    .         .    g.199771
 CTTATGATGTCTGTTGACACTGTTATCCCAGCAGGAGAAAAAG | TGGTGAATTCTGACATT    c.660
 L  M  M  S  V  D  T  V  I  P  A  G  E  K  V |   V  N  S  D  I      p.220

          .         .         .         .         .         .       g.199831
 TCATGCCATTATAAAAATTATCCAATGCATGTCTTTGCCTATAGAGTTCACACTCACCAT       c.720
 S  C  H  Y  K  N  Y  P  M  H  V  F  A  Y  R  V  H  T  H  H         p.240

      | 10   .         .         .         .         .         .    g.200175
 TTAG | GTAAGGTAGTAAGTGGATACAGAGTAAGAAATGGACAGTGGACACTGATTGGACGG    c.780
 L  G |   K  V  V  S  G  Y  R  V  R  N  G  Q  W  T  L  I  G  R      p.260

          .         .  | 11      .         .         .         .    g.200973
 CAGAGCCCTCAGCTGCCACAG | GCTTTCTACCCTGTGGGGCATCCAGTTGATGTAAGTTTT    c.840
 Q  S  P  Q  L  P  Q   | A  F  Y  P  V  G  H  P  V  D  V  S  F      p.280

          .         .         .         .         .         .       g.201033
 GGTGACCTACTGGCTGCAAGATGTGTATTCACTGGTGAAGGAAGGACAGAAGCCACACAC       c.900
 G  D  L  L  A  A  R  C  V  F  T  G  E  G  R  T  E  A  T  H         p.300

       | 12  .         .         .         .         .         .    g.210147
 ATTGG | TGGCACGTCTAGTGATGAAATGTGCAACTTATACATTATGTATTACATGGAAGCC    c.960
 I  G  |  G  T  S  S  D  E  M  C  N  L  Y  I  M  Y  Y  M  E  A      p.320

          .         .         .         .         .         .       g.210207
 AAGCATGCAGTTTCTTTCATGACCTGTACCCAGAATGTAGCTCCAGATATGTTCAGAACC       c.1020
 K  H  A  V  S  F  M  T  C  T  Q  N  V  A  P  D  M  F  R  T         p.340

          .         .         .         .         .         .       g.210267
 ATACCACCAGAGGCCAACATTCCAATTCCCGTGAAGTCTGATATGGTTATGATGCATGAA       c.1080
 I  P  P  E  A  N  I  P  I  P  V  K  S  D  M  V  M  M  H  E         p.360

          . | 13       .         .         .         .         .    g.211425
 CATCATAAAG | AAACAGAATATAAAGATAAGATTCCTTTACTACAGCAGCCAAAACGAGAA    c.1140
 H  H  K  E |   T  E  Y  K  D  K  I  P  L  L  Q  Q  P  K  R  E      p.380

          .         .   | 14     .         .         .         .    g.224371
 GAAGAAGAAGTGTTAGACCAGG | GTGATTTCTATTCACTACTTTCCAAGCTGCTAGGAGAA    c.1200
 E  E  E  V  L  D  Q  G |   D  F  Y  S  L  L  S  K  L  L  G  E      p.400

          .         .         .         .         .         .       g.224431
 AGGGAAGATGTTGTTCATGTGCACAAATATAATCCTACAGAAAAGGCAGAATCAGAGTCA       c.1260
 R  E  D  V  V  H  V  H  K  Y  N  P  T  E  K  A  E  S  E  S         p.420

          .         .         .         .         .         .       g.224491
 GACCTGGTAGCTGAGATTGCAAATGTAGTCCAAAAAAAGGATCTTGGTCGATCTGATGCC       c.1320
 D  L  V  A  E  I  A  N  V  V  Q  K  K  D  L  G  R  S  D  A         p.440

          .         .         .         .         .         .       g.224551
 AGAGAGGGTGCAGAACATGAGAGGGGTAATGCTATTCTTGTCAGAGACAGAATTCACAAA       c.1380
 R  E  G  A  E  H  E  R  G  N  A  I  L  V  R  D  R  I  H  K         p.460

          .         .         .         .         .         .       g.224611
 TTCCACAGACTAGTATCTACCTTGAGGCCACCAGAGAGCAGAGTTTTCTCATTACAGCAG       c.1440
 F  H  R  L  V  S  T  L  R  P  P  E  S  R  V  F  S  L  Q  Q         p.480

          .         .         .         .    | 15    .         .    g.240506
 CCCCCACCTGGTGAAGGCACCTGGGAACCAGAACACACAGGAG | ATTTCCACATGGAAGAG    c.1500
 P  P  P  G  E  G  T  W  E  P  E  H  T  G  D |   F  H  M  E  E      p.500

          .         .         .         .         .         .       g.240566
 GCACTGGATTGGCCTGGAGTATACTTGTTACCAGGCCAGGTTTCTGGGGTGGCTCTAGAC       c.1560
 A  L  D  W  P  G  V  Y  L  L  P  G  Q  V  S  G  V  A  L  D         p.520

          .         .         .         .         .    | 16    .    g.253257
 CCTAAGAATAACCTGGTGATTTTCCACAGAGGTGACCATGTCTGGGATGGAAA | CTCGTTT    c.1620
 P  K  N  N  L  V  I  F  H  R  G  D  H  V  W  D  G  N  |  S  F      p.540

          .         .         .         .         .         .       g.253317
 GACAGCAAGTTTGTTTACCAGCAAATAGGACTCGGACCAATTGAAGAAGACACTATTCTT       c.1680
 D  S  K  F  V  Y  Q  Q  I  G  L  G  P  I  E  E  D  T  I  L         p.560

          .         .         .         .         . | 17       .    g.255381
 GTCATAGATCCAAATAATGCTGCAGTACTCCAGTCCAGTGGAAAAAATCT | GTTTTACTTG    c.1740
 V  I  D  P  N  N  A  A  V  L  Q  S  S  G  K  N  L  |  F  Y  L      p.580

          .         .         .         .         .         .       g.255441
 CCACATGGCTTGAGTATAGATAAAGATGGGAATTATTGGGTCACAGACGTGGCTCTCCAT       c.1800
 P  H  G  L  S  I  D  K  D  G  N  Y  W  V  T  D  V  A  L  H         p.600

     | 18    .         .         .         .         .         .    g.257075
 CAG | GTGTTCAAACTGGATCCAAACAATAAAGAAGGCCCTGTATTAATCCTGGGAAGGAGC    c.1860
 Q   | V  F  K  L  D  P  N  N  K  E  G  P  V  L  I  L  G  R  S      p.620

          .         .         .         .         .         .       g.257135
 ATGCAACCAGGCAGTGACCAGAATCACTTCTGTCAACCCACTGATGTGGCTGTGGATCCA       c.1920
 M  Q  P  G  S  D  Q  N  H  F  C  Q  P  T  D  V  A  V  D  P         p.640

          .         .         .         .         .         .       g.257195
 GGCACTGGAGCCATTTATGTATCAGATGGTTACTGCAACAGCAGGATTGTGCAGTTTTCA       c.1980
 G  T  G  A  I  Y  V  S  D  G  Y  C  N  S  R  I  V  Q  F  S         p.660

          .         .         .     | 19   .         .         .    g.257700
 CCAAGTGGAAAGTTCATCACACAGTGGGGAGAAG | AGTCTTCAGGGAGCAGTCCTCTGCCA    c.2040
 P  S  G  K  F  I  T  Q  W  G  E  E |   S  S  G  S  S  P  L  P      p.680

          .         .         .         .         .         .       g.257760
 GGCCAGTTCACTGTTCCTCACAGCTTGGCTCTTGTGCCTCTTTTGGGCCAATTATGTGTG       c.2100
 G  Q  F  T  V  P  H  S  L  A  L  V  P  L  L  G  Q  L  C  V         p.700

          .         .         .         .         .         .       g.257820
 GCAGACCGGGAAAATGGTCGGATCCAGTGTTTTAAAACTGACACCAAAGAATTTGTGAGA       c.2160
 A  D  R  E  N  G  R  I  Q  C  F  K  T  D  T  K  E  F  V  R         p.720

          .         .         .         .         .      | 20  .    g.259973
 GAGATTAAGCATTCATCATTTGGAAGAAATGTATTTGCAATTTCATATATACCAG | GCTTG    c.2220
 E  I  K  H  S  S  F  G  R  N  V  F  A  I  S  Y  I  P  G |   L      p.740

          .         .         .         .         .         .       g.260033
 CTCTTTGCAGTGAATGGGAAGCCTCATTTTGGGGACCAAGAACCTGTACAAGGATTTGTG       c.2280
 L  F  A  V  N  G  K  P  H  F  G  D  Q  E  P  V  Q  G  F  V         p.760

          .         .         .         .         .  | 21      .    g.267560
 ATGAACTTTTCCAATGGGGAAATTATAGACATCTTCAAGCCAGTGCGCAAG | CACTTTGAT    c.2340
 M  N  F  S  N  G  E  I  I  D  I  F  K  P  V  R  K   | H  F  D      p.780

          .         .         .         .         .         .       g.267620
 ATGCCTCATGATATTGTTGCATCTGAAGATGGGACTGTGTACATTGGAGATGCTCATACC       c.2400
 M  P  H  D  I  V  A  S  E  D  G  T  V  Y  I  G  D  A  H  T         p.800

          .         .         .  | 22      .         .         .    g.270036
 AACACCGTGTGGAAGTTCACCTTGACTGAGA | AATTGGAACATCGATCAGTTAAAAAGGCT    c.2460
 N  T  V  W  K  F  T  L  T  E  K |   L  E  H  R  S  V  K  K  A      p.820

          .         .      | 23  .         .         .         .    g.275383
 GGCATTGAGGTCCAGGAAATCAAAG | AAGCCGAGGCAGTTGTTGAAACCAAAATGGAGAAC    c.2520
 G  I  E  V  Q  E  I  K  E |   A  E  A  V  V  E  T  K  M  E  N      p.840

          .         .         .         .         .         .       g.275443
 AAACCCACCTCCTCAGAATTGCAGAAGATGCAAGAGAAACAGAAACTGATCAAAGAGCCA       c.2580
 K  P  T  S  S  E  L  Q  K  M  Q  E  K  Q  K  L  I  K  E  P         p.860

          .         .         .         .         .         .       g.275503
 GGCTCGGGAGTGCCTGTTGTTCTCATTACAACCCTTCTGGTTATTCCGGTGGTTGTCCTG       c.2640
 G  S  G  V  P  V  V  L  I  T  T  L  L  V  I  P  V  V  V  L         p.880

          .         .         .         .          | 24        .    g.278410
 CTGGCCATTGCCATATTTATTCGGTGGAAAAAATCAAGGGCCTTTGGAG | CAGATTCTGAA    c.2700
 L  A  I  A  I  F  I  R  W  K  K  S  R  A  F  G  A |   D  S  E      p.900

          .         .         .         .       | 25 .         .    g.279118
 CACAAACTCGAGACGAGTTCAGGAAGAGTACTGGGAAGATTTAGAG | GAAAGGGAAGTGGA    c.2760
 H  K  L  E  T  S  S  G  R  V  L  G  R  F  R  G |   K  G  S  G      p.920

          .         .         .         .         .         .       g.279178
 GGCTTAAACCTTGGTAATTTCTTTGCAAGCCGTAAGGGCTACAGTCGAAAAGGGTTTGAC       c.2820
 G  L  N  L  G  N  F  F  A  S  R  K  G  Y  S  R  K  G  F  D         p.940

          .         .         .         .         .         .       g.279238
 CGGCTTAGCACTGAGGGCAGTGACCAAGAGAAAGAGGATGATGGAAGTGAATCAGAAGAG       c.2880
 R  L  S  T  E  G  S  D  Q  E  K  E  D  D  G  S  E  S  E  E         p.960

          .         .         .         .                           g.279283
 GAGTATTCAGCACCTCTGCCTGCGCTCGCACCTTCCTCCTCCTGA                      c.2925
 E  Y  S  A  P  L  P  A  L  A  P  S  S  S  X                        p.974

          .         .         .         .         .         .       g.279343
 aaaccaagctttgatttagattgagtaagatttacccagaatgtcagattcctttccctt       c.*60

          .         .         .         .         .         .       g.279403
 tagcacgtttaaagttctgtgtatttaattgtaaactgtactagtctgtgtgggactgta       c.*120

          .         .         .         .         .         .       g.279463
 cacactttatttacttcgttttggttaagttggcttctgtttctagttgaggagtttcct       c.*180

          .         .         .         .         .         .       g.279523
 aaaagttcataacagtgccattgtctttatatgaacatagactagagaaaccgtcctctt       c.*240

          .         .         .         .         .         .       g.279583
 tttccatcataattctaatctaacaatggaagatttgcccatttacacttttgagacttt       c.*300

          .         .         .         .         .         .       g.279643
 ttggtggatgtaaataaccccattctttgcttgaacacagtattttcccaatagcacttt       c.*360

          .         .         .         .         .         .       g.279703
 cattgccagtgtctttctttggtgcctttcctgttcagcattcttagcctgtggcagtaa       c.*420

          .         .         .         .         .         .       g.279763
 agagaaactttgtgctacatgacgacaaagctgctaaatctcctatttttttaaaatcac       c.*480

          .         .         .         .         .         .       g.279823
 taacattatattgcaatgaaggaaataaaaaagtctctatttaaattcttttttaaattt       c.*540

          .         .         .         .         .         .       g.279883
 tcttcagttggtgtgtttttgggatgtcttatttttagatggttacactgttagaacact       c.*600

          .         .         .         .         .         .       g.279943
 attttcagaatctgaatgtaatttgtgtaataaagtgttttcagagcattagctgtcagt       c.*660

          .         .         .         .         .         .       g.280003
 gtattttccagtttttgcgtatttgcagattttacatacaacttttataataattacaca       c.*720

          .         .         .         .         .         .       g.280063
 aacccacaaatattagtgaaacttactcgatgtcttcaactaaaagaaatgtgtgtattg       c.*780

          .         .         .         .         .         .       g.280123
 tacaaaatttagaagatactttagccaatataaattaaaaaccagcctgagtttacataa       c.*840

          .         .         .         .         .         .       g.280183
 atttgtaaagtcaggctcttctaaaatccaaagagggtttttgcctatatatcaatcaga       c.*900

          .         .         .         .         .         .       g.280243
 ggataaatactttaataaaaggtaatcacagctaagtggatacctgtgtctcaaattaca       c.*960

          .         .         .         .         .         .       g.280303
 tatgcaaatgatccatcagtagggatcactaataatagttttccttttaaaaaataattt       c.*1020

          .         .         .         .         .         .       g.280363
 cagggcaggtacagtggctcaagcctatacttccaggactttgggaggccaagcagaagg       c.*1080

          .         .         .         .         .         .       g.280423
 attgtgggaggccaagcagaaggattgtttgagcccagaaattcaaggctgcagtgagct       c.*1140

          .         .         .         .         .         .       g.280483
 atgatcaatccactgtactccagcctaggctacagagtgagatcctttctctaaaataaa       c.*1200

          .         .         .         .         .         .       g.280543
 atacaatttccatgtatccataggaatatattcatcttttacagtgattgcagattagtt       c.*1260

          .         .         .         .         .         .       g.280603
 ttaaaacgtctttttcgtaattcgtcaatgcaagttagtaagaaccagataattttccat       c.*1320

          .         .         .         .         .         .       g.280663
 tttaaaatgataggaatctaaaactctttttcaaaaatgccaacctgtttttccggcatc       c.*1380

          .         .         .         .         .         .       g.280723
 atagtagttggaataatacagatataattgactaatcataaagtacatgagagtacagaa       c.*1440

          .         .         .         .         .         .       g.280783
 gggaaatttggaaacggtaagtctgctagggcattacaatcctgtcctagcactccacct       c.*1500

          .         .         .         .         .         .       g.280843
 ttattctgccaacctgggttaattaaagatggtagcctggaaagtaatgaatgacattga       c.*1560

          .         .         .         .         .         .       g.280903
 cttcaggcaatctttccactgattattcttggctgaacttcatttatcgagtcagagaat       c.*1620

          .         .         .         .         .         .       g.280963
 gcactgcctgagaaatgtcccagaggagtgaatcctaggcctggccacagtagaatcgcc       c.*1680

          .         .         .         .         .         .       g.281023
 tggagaatttaagaaaaaaattgttgggcactcactctttccagtgatctttatttagtt       c.*1740

          .         .         .         .         .         .       g.281083
 ggcttacaatggaatacaggtatggttcatgtttttaaatttgtccaggtgtttctattg       c.*1800

          .         .         .         .         .         .       g.281143
 tgcagtcacagttgaaaaccattgtcttcgagaatagctattctatcttgccagttacaa       c.*1860

          .         .         .         .         .         .       g.281203
 taagtggatagctatattttcacataaattatagtttacagatgtttggagggggaagac       c.*1920

          .         .         .         .         .         .       g.281263
 aggatctgaggtgttttgatatgactgttagcaccaaaatctgaatgccttaattgttga       c.*1980

          .         .         .         .         .         .       g.281323
 atgtgttaaattggataattaaaatgggcataaatgacttattaaaaaagcaaagggaaa       c.*2040

 

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Peptidylglycine alpha-amidating monooxygenase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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