PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) (PAN2) - coding DNA reference sequence

(used for variant description)

(last modified June 24, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_001127460.2 in the PAN2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000012.11, covering PAN2 transcript NM_001127460.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5321
                                            agagaattctgggtaac       c.-361

 .         .         .         .         .         .                g.5381
 tagccgtttccgtcaccttcccctgcccccgccccaattgtgggtaactggccattattg       c.-301

 .         .         .         .         .         .                g.5441
 ttttcctctagagaatcctgggtagctattggagaggattctaggaaactgacttctcgt       c.-241

 .         .         .         .         .         .                g.5501
 tctccccaccgtccaatccacccgttttcacccccaattctgggagaaagcaccttaaat       c.-181

 .         .         .         .         .         .                g.5561
 ccctctacctaactccaacccccgcaattctcgctcccttcacctgatgattcagggctg       c.-121

 .      | 02  .         .         .         .         .             g.5899
 aacaag | gccaggatgtccattctaggcccatcggtgctgtcttgctgaaggttgggtcag    c.-61

 .         .         .         .         .         .                g.5959
 gcatctaaagggactgtggtaagggagggtgtgacacaggtgtaagctgccatcgtcatc       c.-1

          .         .         .         .         .         .       g.6019
 ATGAACTTTGAGGGTCTGGACCCTGGACTGGCAGAATATGCCCCAGCCATGCATTCTGCC       c.60
 M  N  F  E  G  L  D  P  G  L  A  E  Y  A  P  A  M  H  S  A         p.20

          .         .         .         .         .         .       g.6079
 CTGGACCCTGTCTTGGATGCCCACCTGAACCCAAGTCTGCTACAGAATGTGGAGCTGGAC       c.120
 L  D  P  V  L  D  A  H  L  N  P  S  L  L  Q  N  V  E  L  D         p.40

          .         .         .         .         .         .       g.6139
 CCAGAGGGAGTGGCCTTGGAGGCTCTTCCCGTCCAGGAATCAGTGCACATAATGGAAGGT       c.180
 P  E  G  V  A  L  E  A  L  P  V  Q  E  S  V  H  I  M  E  G         p.60

          .         .         .         .         .         .       g.6199
 GTCTACTCTGAATTGCACAGCGTGGTGGCTGAAGTGGGTGTACCTGTTTCCGTCTCCCAC       c.240
 V  Y  S  E  L  H  S  V  V  A  E  V  G  V  P  V  S  V  S  H         p.80

          .         .         .         .   | 03     .         .    g.10430
 TTTGACTTGCACGAGGAGATGCTGTGGGTGGGGAGCCACGGG | GGCCATGCCACTTCATTT    c.300
 F  D  L  H  E  E  M  L  W  V  G  S  H  G   | G  H  A  T  S  F      p.100

          .         .         .         .         .         .       g.10490
 TTTGGCCCAGCCTTGGAGCGCTACTCATCCTTTCAAGTCAATGGCAGTGATGATATTCGG       c.360
 F  G  P  A  L  E  R  Y  S  S  F  Q  V  N  G  S  D  D  I  R         p.120

          .         .         .         .         .         .       g.10550
 CAGATCCAGAGCCTGGAGAATGGTATCCTTTTTCTCACCAAGAACAACCTCAAGTATATG       c.420
 Q  I  Q  S  L  E  N  G  I  L  F  L  T  K  N  N  L  K  Y  M         p.140

          .         .         .   | 04     .         .         .    g.10723
 GCCCGTGGGGGCCTCATTATATTTGATTACCT | GCTGGATGAGAATGAGGATATGCACAGT    c.480
 A  R  G  G  L  I  I  F  D  Y  L  |  L  D  E  N  E  D  M  H  S      p.160

          .         .         .         .         .         .       g.10783
 CTCCTACTGACTGACAGCAGCACTCTACTCGTTGGTGGGCTGCAGAATCACATAATAGAG       c.540
 L  L  L  T  D  S  S  T  L  L  V  G  G  L  Q  N  H  I  I  E         p.180

          .         .         .    | 05    .         .         .    g.11008
 ATTGATCTTAACACTGTCCAGGAGACTCAGAAG | TATGCAGTAGAGACGCCTGGAGTCACC    c.600
 I  D  L  N  T  V  Q  E  T  Q  K   | Y  A  V  E  T  P  G  V  T      p.200

          .         .         .         .         .  | 06      .    g.11431
 ATCATGAGACAGACAAATCGCTTCTTCTTCTGCGGCCACACGTCTGGCAAG | GTTTCCCTG    c.660
 I  M  R  Q  T  N  R  F  F  F  C  G  H  T  S  G  K   | V  S  L      p.220

          .         .         .         .         .         .       g.11491
 AGAGACCTCCGTACTTTTAAGGTGGAACATGAGTTTGATGCCTTCTCAGGAAGTCTGTCA       c.720
 R  D  L  R  T  F  K  V  E  H  E  F  D  A  F  S  G  S  L  S         p.240

          .         .         .         .         .         .       g.11551
 GACTTTGATGTGCATGGCAACCTGCTAGCTGCCTGTGGCTTCTCCAGCCGCCTCACTGGC       c.780
 D  F  D  V  H  G  N  L  L  A  A  C  G  F  S  S  R  L  T  G         p.260

          .         .         .         .         .         .       g.11611
 CTGGCCTGCGACCGTTTCCTCAAGGTGTATGATTTGCGCATGATGCGTGCCATCACACCA       c.840
 L  A  C  D  R  F  L  K  V  Y  D  L  R  M  M  R  A  I  T  P         p.280

          .         .         .         .         .         .       g.11671
 CTTCAAGTACATGTGGATCCTGCCTTCTTGCGCTTCATTCCTACATATACTTCTCGTCTT       c.900
 L  Q  V  H  V  D  P  A  F  L  R  F  I  P  T  Y  T  S  R  L         p.300

          .          | 07        .         .         .         .    g.12135
 GCTATCATCTCTCAGTCAG | GGCAGTGCCAATTCTGTGAACCCACAGGCCTGGCCAACCCA    c.960
 A  I  I  S  Q  S  G |   Q  C  Q  F  C  E  P  T  G  L  A  N  P      p.320

          .         .         .         .         .         .       g.12195
 GCCGATATCTTTCATGTGAATCCTGTGGGGCCTCTGCTAATGACATTTGATGTGTCAGCC       c.1020
 A  D  I  F  H  V  N  P  V  G  P  L  L  M  T  F  D  V  S  A         p.340

          .         .         .         .         .         .       g.12255
 AGCAAGCAGGCTCTGGCCTTTGGGGATTCTGAGGGCTGTGTGCACCTCTGGACTGATTCC       c.1080
 S  K  Q  A  L  A  F  G  D  S  E  G  C  V  H  L  W  T  D  S         p.360

          .         .         .         .         .         .       g.12315
 CCGGAGCCTTCCTTCAACCCCTACTCCCGTGAGACTGAGTTTGCTTTGCCGTGTCTCGTG       c.1140
 P  E  P  S  F  N  P  Y  S  R  E  T  E  F  A  L  P  C  L  V         p.380

          .         .         .         .         .         .       g.12375
 GACTCACTGCCTCCTCTGGACTGGAGCCAGGACCTGCTGCCTCTTTCCCTCATCCCTGTC       c.1200
 D  S  L  P  P  L  D  W  S  Q  D  L  L  P  L  S  L  I  P  V         p.400

          .         .         .         .         .         .       g.12435
 CCACTCACCACTGACACACTTCTCTCTGATTGGCCTGCTGCCAACTCTGCTCCAGCTCCC       c.1260
 P  L  T  T  D  T  L  L  S  D  W  P  A  A  N  S  A  P  A  P         p.420

    | 08     .         .         .         .         .         .    g.12702
 AG | GCGAGCACCACCCGTGGATGCAGAGATTCTGCGCACCATGAAGAAGGTGGGCTTCATT    c.1320
 R  |  R  A  P  P  V  D  A  E  I  L  R  T  M  K  K  V  G  F  I      p.440

          .         .         .          | 09        .         .    g.13620
 GGCTATGCGCCCAATCCCCGCACCAGGCTGCGCAATCAG | ATACCCTACAGACTCAAGGAG    c.1380
 G  Y  A  P  N  P  R  T  R  L  R  N  Q   | I  P  Y  R  L  K  E      p.460

          .         .         .         .         .         .       g.13680
 TCAGACAGTGAATTTGACAGCTTCAGCCAGGTCACTGAGTCACCAGTAGGACGAGAAGAG       c.1440
 S  D  S  E  F  D  S  F  S  Q  V  T  E  S  P  V  G  R  E  E         p.480

          .         .         .          | 10        .         .    g.13946
 GAACCACATCTCCACATGGTTTCTAAGAAATACCGCAAG | GTGACCATCAAATATTCCAAG    c.1500
 E  P  H  L  H  M  V  S  K  K  Y  R  K   | V  T  I  K  Y  S  K      p.500

          .         .         .         .         .         .       g.14006
 CTAGGGCTGGAGGACTTTGACTTCAAACACTACAATAAGACCTTGTTTGCTGGATTAGAG       c.1560
 L  G  L  E  D  F  D  F  K  H  Y  N  K  T  L  F  A  G  L  E         p.520

          .         .         .          | 11        .         .    g.14365
 CCCCACATTCCCAACGCCTACTGTAACTGCATGATCCAG | GTGCTCTATTTCCTGGAGCCT    c.1620
 P  H  I  P  N  A  Y  C  N  C  M  I  Q   | V  L  Y  F  L  E  P      p.540

          .         .         .         .         .         .       g.14425
 GTACGCTGTCTAATTCAAAACCACCTTTGCCAGAAGGAGTTCTGTCTGGCATGTGAGCTG       c.1680
 V  R  C  L  I  Q  N  H  L  C  Q  K  E  F  C  L  A  C  E  L         p.560

          .         .         .         .         | 12         .    g.14572
 GGCTTCCTGTTTCACATGTTGGACCTCTCTCGTGGTGACCCTTGCCAG | GGCAATAATTTT    c.1740
 G  F  L  F  H  M  L  D  L  S  R  G  D  P  C  Q   | G  N  N  F      p.580

          .         .         .         .         .         .       g.14632
 CTTCGGGCATTCCGTACTATTCCTGAGGCCTCAGCCCTCGGTCTAATCCTGGCTGACTCA       c.1800
 L  R  A  F  R  T  I  P  E  A  S  A  L  G  L  I  L  A  D  S         p.600

          .         .         .         .         .         .       g.14692
 GATGAGGCCTCAGGCAAGGGCAATCTGGCCAGGCTCATTCAGAGGTGGAATCGCTTCATT       c.1860
 D  E  A  S  G  K  G  N  L  A  R  L  I  Q  R  W  N  R  F  I         p.620

          .         .         .         .         .         .       g.14752
 CTCACTCAACTGCATCAAGATATGCAGGAGCTGGAAATACCACAGGCTTATCGAGGTGCT       c.1920
 L  T  Q  L  H  Q  D  M  Q  E  L  E  I  P  Q  A  Y  R  G  A         p.640

          | 13         .         .         .         .         .    g.14920
 GGAGGCAG | CAGCTTTTGCTCATCGGGGGACTCTGTTATTGGGCAGCTCTTCAGCTGTGAG    c.1980
 G  G  S  |  S  F  C  S  S  G  D  S  V  I  G  Q  L  F  S  C  E      p.660

          .         .         .         .         .         .       g.14980
 ATGGAGAACTGCAGCCTCTGCCGCTGTGGCAGTGAGACCGTGCGAGCCTCATCCACTCTG       c.2040
 M  E  N  C  S  L  C  R  C  G  S  E  T  V  R  A  S  S  T  L         p.680

          .         .         .        | 14.         .         .    g.15163
 CTTTTCACACTCTCCTACCCTGATGGTAGCAAAAGTG | ATAAAACTGGGAAGAACTATGAC    c.2100
 L  F  T  L  S  Y  P  D  G  S  K  S  D |   K  T  G  K  N  Y  D      p.700

          .         .         .         .         .         .       g.15223
 TTTGCTCAGGTGCTGAAGCGAAGCATCTGCCTGGACCAGAATACACAGGCCTGGTGTGAC       c.2160
 F  A  Q  V  L  K  R  S  I  C  L  D  Q  N  T  Q  A  W  C  D         p.720

          .         .     | 15   .         .         .         .    g.15491
 ACCTGTGAAAAGTACCAGCCCACG | ATTCAGACCCGCAACATCCGCCATCTGCCAGATATT    c.2220
 T  C  E  K  Y  Q  P  T   | I  Q  T  R  N  I  R  H  L  P  D  I      p.740

          .         .         .         .         .         .       g.15551
 CTTGTCATCAATTGTGAGGTGAACAGCTCAAAAGAGGCTGATTTCTGGAGAATGCAGGCT       c.2280
 L  V  I  N  C  E  V  N  S  S  K  E  A  D  F  W  R  M  Q  A         p.760

     | 16    .         .         .         .         .         .    g.15726
 GAG | GTTGCCTTCAAGATGGCAGTAAAGAAACACGGTGGGGAAATCTCCAAGAACAAGGAA    c.2340
 E   | V  A  F  K  M  A  V  K  K  H  G  G  E  I  S  K  N  K  E      p.780

          .        | 17.         .         .         .         .    g.15887
 TTTGCTTTGGCTGATTG | GAAGGAACTAGGGAGTCCAGAGGGTGTGCTGGTGTGTCCCTCC    c.2400
 F  A  L  A  D  W  |  K  E  L  G  S  P  E  G  V  L  V  C  P  S      p.800

          .         .         .         .         .         .       g.15947
 ATTGAGGAGTTGAAGAACGTCTGGCTTCCTTTCTCCATTCGCATGAAGATGACCAAAAAC       c.2460
 I  E  E  L  K  N  V  W  L  P  F  S  I  R  M  K  M  T  K  N         p.820

          .         .         .         .      | 18  .         .    g.16310
 AAAGGGCTGGATGTTTGCAATTGGACTGATGGGGATGAGATGCAG | TGGGGCCCAGCCAGG    c.2520
 K  G  L  D  V  C  N  W  T  D  G  D  E  M  Q   | W  G  P  A  R      p.840

          .         .         .         .         .         .       g.16370
 GCAGAGGAGGAGCATGGTGTCTATGTGTATGACCTGATGGCTACTGTGGTACACATCCTG       c.2580
 A  E  E  E  H  G  V  Y  V  Y  D  L  M  A  T  V  V  H  I  L         p.860

          .         .         .         .         .         .       g.16430
 GACTCACGCACAGGGGGCAGCCTGGTGGCTCACATCAAAGTTGGAGAGACCTACCACCAG       c.2640
 D  S  R  T  G  G  S  L  V  A  H  I  K  V  G  E  T  Y  H  Q         p.880

           | 19        .         .         .         .         .    g.16622
 CGCAAGGAG | GGCGTTACTCACCAGCAGTGGTATCTGTTCAATGACTTTCTTATTGAACCT    c.2700
 R  K  E   | G  V  T  H  Q  Q  W  Y  L  F  N  D  F  L  I  E  P      p.900

           | 20        .         .         .         .         .    g.16936
 ATTGATAAG | CATGAAGCTGTGCAGTTTGACATGAATTGGAAAGTACCTGCAATCCTTTAT    c.2760
 I  D  K   | H  E  A  V  Q  F  D  M  N  W  K  V  P  A  I  L  Y      p.920

          .         .         .         . | 21       .         .    g.19052
 TATGTCAAACGGAATCTCAATTCCAGATACAACCTGAACA | TCAAGAACCCTATTGAGGCA    c.2820
 Y  V  K  R  N  L  N  S  R  Y  N  L  N  I |   K  N  P  I  E  A      p.940

          .         .         .         .         .         .       g.19112
 AGTGTCTTGCTGGCTGAAGCCTCGCTGGCACGGAAGCAGCGGAAAACACATACTACCTTT       c.2880
 S  V  L  L  A  E  A  S  L  A  R  K  Q  R  K  T  H  T  T  F         p.960

          .         .         .         .         .         .       g.19172
 ATTCCACTGATGCTGAATGAGATGCCACAGATTGGGGACCTGGTGGGTCTGGATGCTGAG       c.2940
 I  P  L  M  L  N  E  M  P  Q  I  G  D  L  V  G  L  D  A  E         p.980

          .         | 22         .         .         .         .    g.19331
 TTTGTCACCCTTAATGAG | GAGGAAGCAGAGTTACGCAGTGATGGTACCAAGTCTACCATT    c.3000
 F  V  T  L  N  E   | E  E  A  E  L  R  S  D  G  T  K  S  T  I      p.1000

          .         .         .         .         .         .       g.19391
 AAACCAAGCCAGATGTCAGTAGCCAGGATTACCTGTGTTCGGGGCCAGGGACCCAATGAG       c.3060
 K  P  S  Q  M  S  V  A  R  I  T  C  V  R  G  Q  G  P  N  E         p.1020

          .         .         .         .   | 23     .         .    g.19584
 GGTATCCCCTTCATTGATGACTACATCTCTACCCAGGAGCAG | GTGGTGGATTACTTGACT    c.3120
 G  I  P  F  I  D  D  Y  I  S  T  Q  E  Q   | V  V  D  Y  L  T      p.1040

          .         .         .         .         .         .       g.19644
 CAATACTCGGGTATAAAGCCTGGTGACCTCGATGCCAAAATTTCCTCCAAGCACCTAACA       c.3180
 Q  Y  S  G  I  K  P  G  D  L  D  A  K  I  S  S  K  H  L  T         p.1060

          .         .         .         .         .         .       g.19704
 ACTCTCAAGTCTACCTACTTAAAGCTTCGTTTTCTCATTGACATTGGAGTCAAGTTTGTG       c.3240
 T  L  K  S  T  Y  L  K  L  R  F  L  I  D  I  G  V  K  F  V         p.1080

          .         .         .         .   | 24     .         .    g.19890
 GGTCATGGCCTGCAGAAGGACTTCCGGGTCATCAACCTGATG | GTGCCCAAGGACCAAGTC    c.3300
 G  H  G  L  Q  K  D  F  R  V  I  N  L  M   | V  P  K  D  Q  V      p.1100

          .         .         .         .         .         .       g.19950
 CTTGACACTGTCTACCTGTTCCATATGCCCCGAAAACGAATGATTTCCCTGCGATTCCTT       c.3360
 L  D  T  V  Y  L  F  H  M  P  R  K  R  M  I  S  L  R  F  L         p.1120

          .       | 25 .         .         .         .         .    g.20663
 GCTTGGTACTTTCTGG | ACCTGAAGATTCAAGGGGAAACCCATGACAGTATTGAGGATGCC    c.3420
 A  W  Y  F  L  D |   L  K  I  Q  G  E  T  H  D  S  I  E  D  A      p.1140

          .         .         .         .         .         .       g.20723
 CGCACAGCCCTTCAGCTGTACCGAAAGTATCTGGAGCTAAGCAAAAATGGCACTGAGCCT       c.3480
 R  T  A  L  Q  L  Y  R  K  Y  L  E  L  S  K  N  G  T  E  P         p.1160

          .         .         .         .         .         .       g.20783
 GAGTCTTTCCACAAGGTGCTCAAGGGTCTTTATGAGAAGGGCAGAAAGATGGACTGGAAG       c.3540
 E  S  F  H  K  V  L  K  G  L  Y  E  K  G  R  K  M  D  W  K         p.1180

          .         .         .     | 26   .         .         .    g.21436
 GTGCCTGAGCCTGAGGGCCAAACAAGTCCCAAGA | ATGCAGCTGTCTTCTCCTCAGTGCTG    c.3600
 V  P  E  P  E  G  Q  T  S  P  K  N |   A  A  V  F  S  S  V  L      p.1200

                                                                    g.21445
 GCGCTCTGA                                                          c.3609
 A  L  X                                                            p.1202

          .         .         .         .         .         .       g.21505
 ctacccttcccaaagaaccacggccctctccctttactgttctatagccccagaactggg       c.*60

          .         .         .         .         .         .       g.21565
 agatggcttcctaagttggctataccttgtccacttccagtactggacgtgctcagggtc       c.*120

          .         .         .         .         .         .       g.21625
 tagggtcacagatggtgctattaattgaactggaacacagcagaattgttgcaaaggttc       c.*180

          .         .         .         .         .         .       g.21685
 taggagccagattcattccttcttcattctttgcaaaacagtggtacagacatggagtct       c.*240

          .         .         .         .         .         .       g.21745
 agaattgacccagatggaaagtaattggtattcttaatatcctgggtgactaatatccag       c.*300

          .         .         .         .         .         .       g.21805
 gcagagaagctcctggaaccataactgtaagttcctagctggctagggattgaagtcctg       c.*360

          .         .         .         .         .         .       g.21865
 gacagtgacagaggataccacagtagttcaagacttagcacaagtcaccaactgcttcag       c.*420

          .         .         .         .         .         .       g.21925
 ggatacctggaggggccagcaagtagagtgttggtggcccaagcaaaccagtgttgccaa       c.*480

          .         .         .         .         .         .       g.21985
 taccattgccaaaagggcctttggatcctggacaaagcttggctgccggcttcatttatt       c.*540

          .         .         .         .         .         .       g.22045
 cctgctgatggctgagaagcatctgtcttccatcccacttgcctgtcccaagttttgttc       c.*600

          .         .         .         .         .         .       g.22105
 cattttttaaaaatttgttgtaaactgcatgttttataaaataaaaataaaatatcgttt       c.*660

          .         .         .         .         .         .       g.22165
 gttatttatctcattagagaactgctagtgtgggttctctggcttcagtcttcctctcct       c.*720

          .         .         .         .         .         .       g.22225
 tcctttgaaggtaaaggtccggaatccaaagttatggatatgaaagggtataattaggcc       c.*780

          .         .         .         .         .         .       g.22285
 gggcgcggtggctcacttctgtaatcctagcactttgggaggcagaggtgggtggaacac       c.*840

          .         .         .         .         .         .       g.22345
 gaggtcaggagttaaagaccagcctgaccaagatggtgaaaccccgtctctactaaaaat       c.*900

          .         .         .         .         .         .       g.22405
 acaaaaattagctgggagtggtggatggcgactgtaaccctagctgaggcagaaaattgc       c.*960

          .         .         .         .         .         .       g.22465
 ttcaacccgggaggcggaggttgcagtgagccgagatcacgccactgtatgccagcctgg       c.*1020

          .         .         .         .         .         .       g.22525
 gcgatagggcgagactccgtctcaaaaaaaggggaaaaaggtataatttatgccttttct       c.*1080

          .         .         .         .         .         .       g.22585
 gggcaatgctgggtctttgctatagctgcccagtaccctaagtcagactgaagatgtaca       c.*1140

          .         .         .         .         .         .       g.22645
 gtatggtttccgttaattgtgtaagccgacaaactacaggtcccaggatagcttgagact       c.*1200

          .         .         .         .         .         .       g.22705
 tgtagttgctcacaaagatgggtccggtgctgcggtgcttcctgggagatgtagtttcct       c.*1260

          .         .         .         .         .         .       g.22765
 gtgtattgaaacctggactgctcgctggccggcagcgcaccgttttgaaggtcctagccc       c.*1320

          .         .         .         .         .         .       g.22825
 acctgggctggctcacgcgcacgactagccgctcccatacagcacgcccggactctgtcg       c.*1380

                                                                    g.22831
 tcgctt                                                             c.*1386

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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