pantothenate kinase 4 (PANK4) - coding DNA reference sequence

(used for variant description)

(last modified November 20, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_018216.1 in the PANK4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering PANK4 transcript NM_018216.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5009
                                                    actttcaaa       c.-1

          .         .         .         .         .         .       g.5069
 ATGGCGGAGTGTGGAGCGAGCGGCAGCGGGAGCAGCGGGGACAGTCTGGACAAGAGCATC       c.60
 M  A  E  C  G  A  S  G  S  G  S  S  G  D  S  L  D  K  S  I         p.20

          .         .         .         .         .         .       g.5129
 ACGCTGCCCCCCGACGAGATCTTCCGCAACCTGGAGAACGCCAAGCGCTTCGCCATCGAC       c.120
 T  L  P  P  D  E  I  F  R  N  L  E  N  A  K  R  F  A  I  D         p.40

      | 02   .         .         .         .         .         .    g.9852
 ATAG | GCGGGTCGTTAACCAAGCTGGCCTACTATTCAACGGTACAGCACAAAGTCGCCAAG    c.180
 I  G |   G  S  L  T  K  L  A  Y  Y  S  T  V  Q  H  K  V  A  K      p.60

          .         .        | 03.         .         .         .    g.10314
 GTGCGGTCTTTCGACCACTCCGGAAAG | GACACAGAACGTGAACATGAGCCGCCCTATGAG    c.240
 V  R  S  F  D  H  S  G  K   | D  T  E  R  E  H  E  P  P  Y  E      p.80

          .         .         .         .         .         .       g.10374
 ATTTCAGTTCAAGAAGAGATCACTGCTCGACTGCACTTCATTAAGTTTGAGAATACCTAC       c.300
 I  S  V  Q  E  E  I  T  A  R  L  H  F  I  K  F  E  N  T  Y         p.100

          .         .         .         .         .         .       g.10434
 ATCGAAGCCTGCCTGGACTTCATCAAAGACCATCTCGTCAACACAGAGACCAAGGTCATC       c.360
 I  E  A  C  L  D  F  I  K  D  H  L  V  N  T  E  T  K  V  I         p.120

          .         .         .         .         .         .       g.10494
 CAGGCGACCGGGGGCGGGGCCTACAAGTTCAAAGACCTCATCGAAGAGAAGCTGCGGCTG       c.420
 Q  A  T  G  G  G  A  Y  K  F  K  D  L  I  E  E  K  L  R  L         p.140

    | 04     .         .         .         .         .         .    g.10748
 AA | AGTCGACAAGGAGGACGTGATGACGTGCCTGATTAAGGGGTGCAACTTCGTGCTCAAG    c.480
 K  |  V  D  K  E  D  V  M  T  C  L  I  K  G  C  N  F  V  L  K      p.160

          .         .         .         .         .         .       g.10808
 AACATCCCCCATGAGGCCTTCGTGTACCAGAAGGATTCCGACCCTGAGTTCCGGTTCCAG       c.540
 N  I  P  H  E  A  F  V  Y  Q  K  D  S  D  P  E  F  R  F  Q         p.180

          .         .         .         .         .         .       g.10868
 ACCAACCACCCCCACATTTTCCCCTATCTTCTTGTCAATATCGGCTCTGGAGTCTCCATC       c.600
 T  N  H  P  H  I  F  P  Y  L  L  V  N  I  G  S  G  V  S  I         p.200

        | 05 .         .         .         .         .         .    g.11236
 GTGAAG | GTGGAGACGGAGGACAGGTTCGAGTGGGTCGGCGGCAGCTCCATTGGAGGCGGC    c.660
 V  K   | V  E  T  E  D  R  F  E  W  V  G  G  S  S  I  G  G  G      p.220

          .         .         .          | 06        .         .    g.11663
 ACCTTCTGGGGGCTTGGCGCTCTGCTCACCAAAACGAAG | AAGTTTGACGAGCTCCTGCAC    c.720
 T  F  W  G  L  G  A  L  L  T  K  T  K   | K  F  D  E  L  L  H      p.240

          .         .         .         .         .         .       g.11723
 CTGGCCTCGAGGGGCCAGCACAGCAATGTGGACATGCTGGTGCGGGACGTCTACGGCGGC       c.780
 L  A  S  R  G  Q  H  S  N  V  D  M  L  V  R  D  V  Y  G  G         p.260

          .         .         .         .         .         .       g.11783
 GCCCACCAGACTCTCGGGCTGAGCGGGAACCTCATCGCCAGCAGCTTCGGGAAGTCGGCC       c.840
 A  H  Q  T  L  G  L  S  G  N  L  I  A  S  S  F  G  K  S  A         p.280

          .    | 07    .         .         .         .         .    g.12319
 ACCGCCGACCAAG | AGTTCTCCAAAGAAGACATGGCGAAGAGCCTGCTGCACATGATCAGC    c.900
 T  A  D  Q  E |   F  S  K  E  D  M  A  K  S  L  L  H  M  I  S      p.300

          .         .         .         .         .         .       g.12379
 AACGACATTGGGCAGCTGGCCTGCCTCCACGCACGGCTGCACAGCCTGGACCGCGTGTAC       c.960
 N  D  I  G  Q  L  A  C  L  H  A  R  L  H  S  L  D  R  V  Y         p.320

          .         .         .         .         .         .       g.12439
 TTTGGAGGCTTCTTTATCCGGGGCCACCCCGTGACCATGCGCACCATCACCTATAGCATC       c.1020
 F  G  G  F  F  I  R  G  H  P  V  T  M  R  T  I  T  Y  S  I         p.340

          .      | 08  .         .         .         .         .    g.13044
 AACTTCTTCTCCAAG | GGGGAAGTGCAGGCGCTGTTTCTGAGGCACGAAGGCTACCTGGGA    c.1080
 N  F  F  S  K   | G  E  V  Q  A  L  F  L  R  H  E  G  Y  L  G      p.360

          .         .         .        | 09.         .         .    g.13355
 GCCATCGGAGCGTTCCTGAAAGGAGCTGAGCAGGACA | ATCCTAACCAGTACAGCTGGGGA    c.1140
 A  I  G  A  F  L  K  G  A  E  Q  D  N |   P  N  Q  Y  S  W  G      p.380

          .         .         .         .         .         .       g.13415
 GAGAACTATGCAGGCAGCTCCGGGCTGATGAGTGCATCACCCGAGCTCGGCCCGGCGCAG       c.1200
 E  N  Y  A  G  S  S  G  L  M  S  A  S  P  E  L  G  P  A  Q         p.400

          .         | 10         .         .         .         .    g.15921
 CGGGCGCGGAGTGGCACT | TTTGACTTGCTGGAAATGGACCGGCTGGAGAGGCCACTGGTT    c.1260
 R  A  R  S  G  T   | F  D  L  L  E  M  D  R  L  E  R  P  L  V      p.420

          .         .         .         .         .         .       g.15981
 GACCTGCCGCTCCTCCTGGACCCGCCCTCCTACGTGCCCGACACGGTGGACCTCACCGAT       c.1320
 D  L  P  L  L  L  D  P  P  S  Y  V  P  D  T  V  D  L  T  D         p.440

          .         .         .         .         .     | 11   .    g.17136
 GACGCTCTGGCCCGAAAATACTGGCTCACCTGCTTTGAGGAGGCCCTGGACGGG | GTAGTG    c.1380
 D  A  L  A  R  K  Y  W  L  T  C  F  E  E  A  L  D  G   | V  V      p.460

          .         .         .         .         .         .       g.17196
 AAGCGCGCAGTGGCGAGCCAGCCAGACTCTGTGGATGCAGCCGAGAGGGCGGAGAAGTTC       c.1440
 K  R  A  V  A  S  Q  P  D  S  V  D  A  A  E  R  A  E  K  F         p.480

          .         .         .         .        | 12.         .    g.17520
 CGGCAGAAGTACTGGAACAAGCTTCAGACCCTGAGGCAGCAGCCCTT | CGCCTATGGGACC    c.1500
 R  Q  K  Y  W  N  K  L  Q  T  L  R  Q  Q  P  F  |  A  Y  G  T      p.500

          .         .         .         .         .         .       g.17580
 CTGACCGTGCGCAGCCTGCTGGACACCAGGGAGCACTGTCTGAACGAGTTCAACTTCCCG       c.1560
 L  T  V  R  S  L  L  D  T  R  E  H  C  L  N  E  F  N  F  P         p.520

          .      | 13  .         .         .         .         .    g.18602
 GATCCCTACTCCAAA | GTGAAGCAGCGGGAGAATGGCGTGGCGCTGAGGTGCTTCCCCGGG    c.1620
 D  P  Y  S  K   | V  K  Q  R  E  N  G  V  A  L  R  C  F  P  G      p.540

          .         .         .         .         .         .       g.18662
 GTCGTGCGCTCCCTGGACGCGCTGGGCTGGGAGGAACGGCAGCTGGCGCTGGTGAAAGGC       c.1680
 V  V  R  S  L  D  A  L  G  W  E  E  R  Q  L  A  L  V  K  G         p.560

          .         .         .         .        | 14.         .    g.19926
 CTCCTGGCGGGGAATGTCTTCGACTGGGGGGCCAAAGCCGTGTCTGC | TGTCCTTGAATCC    c.1740
 L  L  A  G  N  V  F  D  W  G  A  K  A  V  S  A  |  V  L  E  S      p.580

          .         .         .         .    | 15    .         .    g.20226
 GACCCCTACTTTGGGTTTGAAGAAGCAAAGAGGAAGTTACAAG | AAAGACCCTGGCTCGTG    c.1800
 D  P  Y  F  G  F  E  E  A  K  R  K  L  Q  E |   R  P  W  L  V      p.600

          .         .         .    | 16    .         .         .    g.20841
 GATTCCTACAGCGAGTGGCTTCAGAGATTAAAG | GGGCCCCCTCATAAATGTGCCTTAATT    c.1860
 D  S  Y  S  E  W  L  Q  R  L  K   | G  P  P  H  K  C  A  L  I      p.620

          .         .         .         .         .         .       g.20901
 TTCGCAGATAACAGTGGAATAGACATCATTTTGGGAGTCTTCCCCTTTGTCAGGGAGCTA       c.1920
 F  A  D  N  S  G  I  D  I  I  L  G  V  F  P  F  V  R  E  L         p.640

          .         | 17         .         .         .         .    g.21481
 CTCCTTAGAGGGACAGAG | GTCATCCTGGCGTGCAACTCAGGCCCCGCCCTGAACGACGTG    c.1980
 L  L  R  G  T  E   | V  I  L  A  C  N  S  G  P  A  L  N  D  V      p.660

          .         .         .         .         .          | 18    g.21667
 ACCCACAGCGAGTCCCTCATCGTGGCAGAGCGTATTGCGGGCATGGACCCTGTCGTGCA | C    c.2040
 T  H  S  E  S  L  I  V  A  E  R  I  A  G  M  D  P  V  V  H  |      p.680

          .         .         .         .         .         .       g.21727
 TCTGCGCTCCAGGAAGAGAGGCTGCTGCTGGTGCAGACGGGCTCCAGCTCCCCGTGCCTC       c.2100
 S  A  L  Q  E  E  R  L  L  L  V  Q  T  G  S  S  S  P  C  L         p.700

          | 19         .         .         .         .         .    g.22588
 GACCTCAG | CCGCCTGGATAAGGGGCTGGCCGCACTGGTGCGGGAGCGTGGCGCGGATCTG    c.2160
 D  L  S  |  R  L  D  K  G  L  A  A  L  V  R  E  R  G  A  D  L      p.720

          .         .         .         .         .         .       g.22648
 GTGGTCATCGAGGGCATGGGCCGTGCTGTCCACACAAACTACCACGCAGCCCTGCGCTGC       c.2220
 V  V  I  E  G  M  G  R  A  V  H  T  N  Y  H  A  A  L  R  C         p.740

          .         .         .         .         .         .       g.22708
 GAGAGCCTCAAGCTGGCCGTCATCAAGAACGCGTGGCTGGCCGAGCGGCTGGGCGGCCGG       c.2280
 E  S  L  K  L  A  V  I  K  N  A  W  L  A  E  R  L  G  G  R         p.760

          .         .         .         .                           g.22750
 CTCTTCAGCGTCATCTTCAAGTACGAGGTCCCAGCCGAGTGA                         c.2322
 L  F  S  V  I  F  K  Y  E  V  P  A  E  X                           p.773

          .         .         .         .         .         .       g.22810
 ggcgctgcagctgccggactcttctgcttgtcacttgtcaggaatgtgtttttaccacca       c.*60

          .         .         .         .         .         .       g.22870
 cagggaaactgcgttcaaatcaacgtatttatatggtactgctgtgacgcggcacataca       c.*120

          .         .         .         .         .         .       g.22930
 ccccagccgcacagatgcgtgtgacccagaggcgagacgcagctttgtcctgggagacgt       c.*180

          .         .         .         .         .         .       g.22990
 tcatattggaatctatttaactgctaaagaaccttttatatatatatatatataaataga       c.*240

          .         .         .         .         .         .       g.23050
 gagatctatacaggtatgtctgacgggacgcagcaccgtgggcacgcaccaaatagagtt       c.*300

          .                                                         g.23061
 tttaaaagagg                                                        c.*311

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Pantothenate kinase 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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