pannexin 1 (PANX1) - coding DNA reference sequence

(used for variant description)

(last modified November 17, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_015368.3 in the PANX1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_027936.1, covering PANX1 transcript NM_015368.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5025
                                    gggcggcgcggaggggcagggccag       c.-361

 .         .         .         .         .         .                g.5085
 agggaagcgctttgttccgcgcgtggttcccgcgcctgggggtgcgcgggagaggcgcga       c.-301

 .         .         .         .         .         .                g.5145
 atccgagtgccgcgcgcggcccggggacttgcacgggcgtgcggggtggaaccgcaggaa       c.-241

 .         .         .         .         .         .                g.5205
 gcggagctctcgggttcccgccccgccccgccccgccggcggcggaggcagcgagcgcga       c.-181

 .         .         .         .         .         .                g.5265
 gagcccagcggagtcgctgggagcctgaggcaccgagacacaaaggcaggcgggatgcgg       c.-121

 .         .         .         .         .         .                g.5325
 gagcaggcaaagggaaagcgaaagccgcgcgcccggccggtgactgggtgaaggcgccgc       c.-61

 .         .         .         .         .         .                g.5385
 gcagctttcccgacgccggctgtacccggacctcctggtcgagcctggcgcgccgcagcc       c.-1

          .         .         .         .         .         .       g.5445
 ATGGCCATCGCTCAACTGGCCACGGAGTACGTGTTCTCGGATTTCTTGCTGAAGGAGCCC       c.60
 M  A  I  A  Q  L  A  T  E  Y  V  F  S  D  F  L  L  K  E  P         p.20

          .         .         .         .         .         .       g.5505
 ACGGAGCCCAAGTTCAAGGGGCTGCGACTGGAGCTGGCTGTGGACAAGATGGTCACGTGC       c.120
 T  E  P  K  F  K  G  L  R  L  E  L  A  V  D  K  M  V  T  C         p.40

          .         .         .         .         .         .       g.5565
 ATTGCGGTGGGGCTGCCCCTGCTGCTCATCTCGCTGGCCTTCGCGCAGGAGATCTCGATT       c.180
 I  A  V  G  L  P  L  L  L  I  S  L  A  F  A  Q  E  I  S  I         p.60

   | 02      .         .         .         .         .         .    g.29622
 G | GTACACAGATAAGCTGTTTCTCTCCAAGTTCTTTCTCCTGGCGTCAGGCTGCCTTTGTG    c.240
 G |   T  Q  I  S  C  F  S  P  S  S  F  S  W  R  Q  A  A  F  V      p.80

          .         .         .         .         .         .       g.29682
 GATTCATATTGCTGGGCGGCTGTTCAGCAGAAGAACTCACTGCAGAGCGAGTCTGGAAAC       c.300
 D  S  Y  C  W  A  A  V  Q  Q  K  N  S  L  Q  S  E  S  G  N         p.100

          .         .  | 03      .         .         .         .    g.54480
 CTCCCACTGTGGCTGCATAAG | TTTTTCCCCTACATCCTGCTGCTCTTTGCGATCCTCCTG    c.360
 L  P  L  W  L  H  K   | F  F  P  Y  I  L  L  L  F  A  I  L  L      p.120

          .         .         .         .         .         .       g.54540
 TACCTGCCCCCGCTGTTCTGGCGTTTCGCAGCTGCTCCTCATATTTGCTCAGACTTGAAG       c.420
 Y  L  P  P  L  F  W  R  F  A  A  A  P  H  I  C  S  D  L  K         p.140

          .         .         .         .         .         .       g.54600
 TTTATCATGGAAGAACTTGACAAAGTTTACAACCGTGCAATTAAGGCTGCAAAGAGTGCG       c.480
 F  I  M  E  E  L  D  K  V  Y  N  R  A  I  K  A  A  K  S  A         p.160

          .         .         .         .         .         .       g.54660
 CGTGACCTTGACATGAGAGATGGAGCCTGCTCAGTTCCAGGTGTTACCGAGAACTTAGGG       c.540
 R  D  L  D  M  R  D  G  A  C  S  V  P  G  V  T  E  N  L  G         p.180

       | 04  .         .         .         .         .         .    g.55729
 CAAAG | TTTGTGGGAGGTATCTGAAAGCCACTTCAAGTACCCAATTGTGGAGCAGTACTTG    c.600
 Q  S  |  L  W  E  V  S  E  S  H  F  K  Y  P  I  V  E  Q  Y  L      p.200

          .         .         .         .         .         .       g.55789
 AAGACAAAGAAAAATTCTAATAATTTAATCATCAAGTACATTAGCTGCCGCCTGCTGACA       c.660
 K  T  K  K  N  S  N  N  L  I  I  K  Y  I  S  C  R  L  L  T         p.220

          .         .         .         .         .         .       g.55849
 CTCATCATTATACTGTTAGCGTGTATCTACCTGGGCTATTACTTCAGCCTCTCCTCACTC       c.720
 L  I  I  I  L  L  A  C  I  Y  L  G  Y  Y  F  S  L  S  S  L         p.240

          .         .         .         .         .         .       g.55909
 TCAGACGAGTTTGTGTGCAGCATCAAATCAGGGATCCTGAGAAACGACAGCACCGTGCCC       c.780
 S  D  E  F  V  C  S  I  K  S  G  I  L  R  N  D  S  T  V  P         p.260

          .         .         .         .         .         .       g.55969
 GATCAGTTTCAGTGCAAACTCATTGCCGTGGGCATCTTCCAGTTGCTCAGTGTCATTAAC       c.840
 D  Q  F  Q  C  K  L  I  A  V  G  I  F  Q  L  L  S  V  I  N         p.280

          .         .         .         .         .         .       g.56029
 CTTGTGGTTTATGTCCTGCTGGCTCCCGTGGTTGTCTACACGCTGTTTGTTCCATTCCGA       c.900
 L  V  V  Y  V  L  L  A  P  V  V  V  Y  T  L  F  V  P  F  R         p.300

          .         .         .         .         .         .       g.56089
 CAGAAGACAGATGTTCTCAAAGTGTACGAAATCCTCCCCACTTTTGATGTTCTGCATTTC       c.960
 Q  K  T  D  V  L  K  V  Y  E  I  L  P  T  F  D  V  L  H  F         p.320

          .         .         .         .         .         .       g.56149
 AAATCTGAAGGGTACAACGATTTGAGCCTCTACAATCTCTTCTTGGAGGAAAATATAAGT       c.1020
 K  S  E  G  Y  N  D  L  S  L  Y  N  L  F  L  E  E  N  I  S         p.340

          .         .         .         .         .         .       g.56209
 GAGGTCAAGTCATACAAGTGTCTTAAGGTACTGGAGAATATTAAGAGCAGTGGTCAGGGG       c.1080
 E  V  K  S  Y  K  C  L  K  V  L  E  N  I  K  S  S  G  Q  G         p.360

          .         .         .         .         .         .       g.56269
 ATCGACCCAATGCTACTCCTGACAAACCTTGGCATGATCAAGATGGATGTTGTTGATGGC       c.1140
 I  D  P  M  L  L  L  T  N  L  G  M  I  K  M  D  V  V  D  G         p.380

          .         .         .         .         .         .       g.56329
 AAAACTCCCATGTCTGCAGAGATGAGAGAGGAGCAGGGGAACCAGACGGCAGAGCTCCAA       c.1200
 K  T  P  M  S  A  E  M  R  E  E  Q  G  N  Q  T  A  E  L  Q         p.400

   | 05      .         .         .         .         .         .    g.56921
 G | GTATGAACATAGACAGTGAAACTAAAGCAAATAATGGAGAGAAGAATGCCCGACAGAGA    c.1260
 G |   M  N  I  D  S  E  T  K  A  N  N  G  E  K  N  A  R  Q  R      p.420

          .         .                                               g.56942
 CTTCTGGATTCTTCTTGCTGA                                              c.1281
 L  L  D  S  S  C  X                                                p.426

          .         .         .         .         .         .       g.57002
 tgatttttttccttgagctgtaaatctgtgacttctgcgacatgggatttaatttggcta       c.*60

          .         .         .         .         .         .       g.57062
 aagcacccctgttggtttcacagctggtttgcaataaatggttcttggtggagatactga       c.*120

          .         .         .         .         .         .       g.57122
 gcatgtcttattgagtccctaatggaaatggtgatcaacaaaaggttatggaagaatggt       c.*180

          .         .         .         .         .         .       g.57182
 ttatgaacttcccataggaagcacctgagagatagtaaactgcagcaagtaactatgtgt       c.*240

          .         .         .         .         .         .       g.57242
 aagtcctcatcaaatgaaaagcagaaagacaagaacaattagtcaagagcagtagccctg       c.*300

          .         .         .         .         .         .       g.57302
 tcagagcctcggagcaatacctttctgtacccgtggtgagacaagacccagagctactgg       c.*360

          .         .         .         .         .         .       g.57362
 aaaacaagcactttggaagatttgttttgttttcatggaataataatatgtcagggtata       c.*420

          .         .         .         .         .         .       g.57422
 atttaacgtgagtttcttatgtgcccttaaagactgttagacaagaaaagcattcactgg       c.*480

          .         .         .         .         .         .       g.57482
 ctaataatccataggtcgacctatgtcctaagttaggtgtaaggtccgatgccttggccc       c.*540

          .         .         .         .         .         .       g.57542
 acactcgagctctctttacattgttagttgtcaaccttggctgatggaaatcccgtaacc       c.*600

          .         .         .         .         .         .       g.57602
 actatttgttgcactgtgccttgaagggcagcaggcccaagtgctgctctgactgaaaac       c.*660

          .         .         .         .         .         .       g.57662
 tgagttaacaagatgaaatctaaaggatattcacagtgacttcaattcaggaagaatgct       c.*720

          .         .         .         .         .         .       g.57722
 tccaaaagagcccagtggggaaatctgacatcacagaagacattaattcagtcactttca       c.*780

          .         .         .         .         .         .       g.57782
 aagagtttgtctacaggcggtttctctgttatcaaaggcatttgaaataggattttactt       c.*840

          .         .         .         .         .         .       g.57842
 aaacaataatggaacacaggagtatttaaagtgaagaacactttgcctgaatgtgatcag       c.*900

          .         .         .         .         .         .       g.57902
 ggcacataagtgacattggcatgcttcatatggcgtgcttggagccagaaaaacttagcg       c.*960

          .         .         .         .         .         .       g.57962
 gtttattttgtttatatttaagcacagctttaaaaaattcattatcgtttattcagtgtc       c.*1020

          .         .         .         .         .         .       g.58022
 cgaattgaggccatttgggaagaaaattctagcactggtggagaattatagaataaagat       c.*1080

          .         .                                               g.58045
 tataaatggttggataagacaaa                                            c.*1103

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Pannexin 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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