3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2) - coding DNA reference sequence

(used for variant description)

(last modified February 7, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_001015880.1 in the PAPSS2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012150.1, covering PAPSS2 transcript NM_001015880.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5023
                                      ctaggcggcggcggccgggtccc       c.-241

 .         .         .         .         .         .                g.5083
 caaggctgggcgctgcttgcggaaccgacggggcggagaggagcgtggcgggaggaggag       c.-181

 .         .         .         .         .         .                g.5143
 taggagaagggggctggtcaagggaagtgcgacgtgtctgcggagcctttttatacctcc       c.-121

 .         .         .         .         .         .                g.5203
 ttcccgggagtccggcagccgctgctgctgctgctgctgctgctgccgccgccgccgccg       c.-61

 .         .         .         .         .         .                g.5263
 ccgtccctgcgtccttcggtctctgctcccgggacccgggctccgccgcagccagccagc       c.-1

          .         .        | 02.         .         .         .    g.54510
 ATGTCGGGGATCAAGAAGCAAAAGACG | GAGAACCAGCAGAAATCCACCAATGTAGTCTAT    c.60
 M  S  G  I  K  K  Q  K  T   | E  N  Q  Q  K  S  T  N  V  V  Y      p.20

          .         .         .         .         .         .       g.54570
 CAGGCCCACCATGTGAGCAGGAATAAGAGAGGGCAAGTGGTTGGAACAAGGGGTGGGTTC       c.120
 Q  A  H  H  V  S  R  N  K  R  G  Q  V  V  G  T  R  G  G  F         p.40

          .         .      | 03  .         .         .         .    g.58391
 CGAGGATGTACCGTGTGGCTAACAG | GTCTCTCTGGTGCTGGAAAAACAACGATAAGTTTT    c.180
 R  G  C  T  V  W  L  T  G |   L  S  G  A  G  K  T  T  I  S  F      p.60

          .         .         .         .         .         .       g.58451
 GCCCTGGAGGAGTACCTTGTCTCCCATGCCATCCCTTGTTACTCCCTGGATGGGGACAAT       c.240
 A  L  E  E  Y  L  V  S  H  A  I  P  C  Y  S  L  D  G  D  N         p.80

          .         .         .         .         .         .       g.58511
 GTCCGTCATGGCCTTAACAGAAATCTCGGATTCTCTCCTGGGGACAGAGAGGAAAATATC       c.300
 V  R  H  G  L  N  R  N  L  G  F  S  P  G  D  R  E  E  N  I         p.100

          .         .         .         .         .         .       g.58571
 CGCCGGATTGCTGAGGTGGCTAAGCTGTTTGCTGATGCTGGTCTGGTCTGCATTACCAGC       c.360
 R  R  I  A  E  V  A  K  L  F  A  D  A  G  L  V  C  I  T  S         p.120

          .         .  | 04      .         .         .         .    g.59364
 TTTATTTCTCCATTCGCAAAG | GATCGTGAGAATGCCCGCAAAATACATGAATCAGCAGGG    c.420
 F  I  S  P  F  A  K   | D  R  E  N  A  R  K  I  H  E  S  A  G      p.140

          .         .         .         .         .         .       g.59424
 CTGCCATTCTTTGAAATATTTGTAGATGCACCTCTAAATATTTGTGAAAGCAGAGACGTA       c.480
 L  P  F  F  E  I  F  V  D  A  P  L  N  I  C  E  S  R  D  V         p.160

          .         .         .         . | 05       .         .    g.60046
 AAAGGCCTCTATAAAAGGGCCAGAGCTGGGGAGATTAAAG | GATTTACAGGTATTGATTCT    c.540
 K  G  L  Y  K  R  A  R  A  G  E  I  K  G |   F  T  G  I  D  S      p.180

          .         .         .         .         .         .       g.60106
 GATTATGAGAAACCTGAAACTCCTGAGCGTGTGCTTAAAACCAATTTGTCCACAGTGAGT       c.600
 D  Y  E  K  P  E  T  P  E  R  V  L  K  T  N  L  S  T  V  S         p.200

          .         .         .          | 06        .         .    g.60287
 GACTGTGTCCACCAGGTAGTGGAACTTCTGCAAGAGCAG | AACATTGTACCCTATACTATA    c.660
 D  C  V  H  Q  V  V  E  L  L  Q  E  Q   | N  I  V  P  Y  T  I      p.220

          .         .         .         .         .         .       g.60347
 ATCAAAGATATCCACGAACTCTTTGTGCCGGAAAACAAACTTGACCACGTCCGAGCTGAG       c.720
 I  K  D  I  H  E  L  F  V  P  E  N  K  L  D  H  V  R  A  E         p.240

          .         .         .    | 07    .         .         .    g.61040
 GCTGAAACTCTCCCTTCATTATCAATTACTAAG | CTGGATCTCCAGTGGGTCCAGGTTTTG    c.780
 A  E  T  L  P  S  L  S  I  T  K   | L  D  L  Q  W  V  Q  V  L      p.260

          .         .         .         .         .         .       g.61100
 AGCGAAGGCTGGGCCACTCCCCTCAAAGGTTTCATGCGGGAGAAGGAGTACTTACAGGTT       c.840
 S  E  G  W  A  T  P  L  K  G  F  M  R  E  K  E  Y  L  Q  V         p.280

          .         .      | 08  .         . | 09       .         . g.72585
 ATGCACTTTGACACCCTGCTAGATG | GCATGGCCCTTCCTG | ATGGCGTGATCAACATGAGC c.900
 M  H  F  D  T  L  L  D  G |   M  A  L  P  D |   G  V  I  N  M  S   p.300

          .         .         .         .         .         .       g.72645
 ATCCCCATTGTACTGCCCGTCTCTGCAGAGGATAAGACACGGCTGGAAGGGTGCAGCAAG       c.960
 I  P  I  V  L  P  V  S  A  E  D  K  T  R  L  E  G  C  S  K         p.320

          .         .         .         .         .         .       g.72705
 TTTGTCCTGGCACATGGTGGACGGAGGGTAGCTATCTTACGAGACGCTGAATTCTATGAA       c.1020
 F  V  L  A  H  G  G  R  R  V  A  I  L  R  D  A  E  F  Y  E         p.340

          .         .         .         .         .         .       g.72765
 CACAGAAAAGAGGAACGCTGTTCCCGTGTTTGGGGGACAACATGTACAAAACACCCCCAT       c.1080
 H  R  K  E  E  R  C  S  R  V  W  G  T  T  C  T  K  H  P  H         p.360

        | 10 .         .         .         .         .         .    g.86570
 ATCAAA | ATGGTGATGGAAAGTGGGGACTGGCTGGTTGGTGGAGACCTTCAGGTGCTGGAG    c.1140
 I  K   | M  V  M  E  S  G  D  W  L  V  G  G  D  L  Q  V  L  E      p.380

          .         .         .         .         .         .       g.86630
 AAAATAAGATGGAATGATGGGCTGGACCAATACCGTCTGACACCTCTGGAGCTCAAACAG       c.1200
 K  I  R  W  N  D  G  L  D  Q  Y  R  L  T  P  L  E  L  K  Q         p.400

          .         .   | 11     .         .         .         .    g.88692
 AAATGTAAAGAAATGAATGCTG | ATGCGGTGTTTGCATTCCAGTTGCGCAATCCTGTCCAC    c.1260
 K  C  K  E  M  N  A  D |   A  V  F  A  F  Q  L  R  N  P  V  H      p.420

          .         .         .         .         .         .       g.88752
 AATGGCCATGCCCTGTTGATGCAGGACACTCGCCGCAGGCTCCTAGAGAGGGGCTACAAG       c.1320
 N  G  H  A  L  L  M  Q  D  T  R  R  R  L  L  E  R  G  Y  K         p.440

          .         .         .         .         .         .       g.88812
 CACCCGGTCCTCCTACTACACCCTCTGGGCGGCTGGACCAAGGATGACGATGTGCCTCTA       c.1380
 H  P  V  L  L  L  H  P  L  G  G  W  T  K  D  D  D  V  P  L         p.460

          .         .         .         .         .         .       g.88872
 GACTGGCGGATGAAGCAGCACGCGGCTGTGCTCGAGGAAGGGGTCCTGGATCCCAAGTCA       c.1440
 D  W  R  M  K  Q  H  A  A  V  L  E  E  G  V  L  D  P  K  S         p.480

          .         .         .         .         .  | 12      .    g.90292
 ACCATTGTTGCCATCTTTCCGTCTCCCATGTTATATGCTGGCCCCACAGAG | GTCCAGTGG    c.1500
 T  I  V  A  I  F  P  S  P  M  L  Y  A  G  P  T  E   | V  Q  W      p.500

          .         .         .         .         .         .       g.90352
 CACTGCAGGTCCCGGATGATTGCGGGTGCCAATTTCTACATTGTGGGGAGGGACCCTGCA       c.1560
 H  C  R  S  R  M  I  A  G  A  N  F  Y  I  V  G  R  D  P  A         p.520

          .         .         .         .         .         .       g.90412
 GGAATGCCCCATCCTGAAACCAAGAAGGATCTGTATGAACCCACTCATGGGGGCAAGGTC       c.1620
 G  M  P  H  P  E  T  K  K  D  L  Y  E  P  T  H  G  G  K  V         p.540

          .         .         .         .         .         .       g.90472
 TTGAGCATGGCCCCTGGCCTCACCTCTGTGGAAATCATTCCATTCCGAGTGGCTGCCTAC       c.1680
 L  S  M  A  P  G  L  T  S  V  E  I  I  P  F  R  V  A  A  Y         p.560

          .         .         .         .  | 13      .         .    g.91132
 AACAAAGCCAAAAAAGCCATGGACTTCTATGATCCAGCAAG | GCACAATGAGTTTGACTTC    c.1740
 N  K  A  K  K  A  M  D  F  Y  D  P  A  R  |  H  N  E  F  D  F      p.580

          .         .         .         .         .         .       g.91192
 ATCTCAGGAACTCGAATGAGGAAGCTCGCCCGGGAAGGAGAGAATCCCCCAGATGGCTTC       c.1800
 I  S  G  T  R  M  R  K  L  A  R  E  G  E  N  P  P  D  G  F         p.600

          .         .         .         .         .         .       g.91252
 ATGGCCCCCAAAGCATGGAAGGTCCTGACAGATTATTACAGGTCCCTGGAGAAGAACTAA       c.1860
 M  A  P  K  A  W  K  V  L  T  D  Y  Y  R  S  L  E  K  N  X         p.619

          .         .         .         .         .         .       g.91312
 gcctttggctccagagtttctttctgaagtgctctttgattaccttttctatttttatga       c.*60

          .         .         .         .         .         .       g.91372
 ttagatgctttgtattaaattgcttctcaatgatgcattttaatcttttataatgaagta       c.*120

          .         .         .         .         .         .       g.91432
 aaagttgtgtctataattaaaaaaaaatatatatatatacacacacacatatacatacaa       c.*180

          .         .         .         .         .         .       g.91492
 agtcaaactgaagaccaaatcttagcaggtaaaagcaatattcttatacatttcataata       c.*240

          .         .         .         .         .         .       g.91552
 aaattagctctatgtattttctactgcacctgagcaggcaggtcccagatttcttaaggc       c.*300

          .         .         .         .         .         .       g.91612
 tttgtttgaccatgtgtctagttacttgctgaaaagtgaatatattttccagcatgtctt       c.*360

          .         .         .         .         .         .       g.91672
 gacaacctgtactcttccaatgtcatttatcagttgtaaaatatatcagattgtgtcctc       c.*420

          .         .         .         .         .         .       g.91732
 ttctgtacaattgacaaaaaaaaaaatttttttttctcactctaaaagaggtgtggctca       c.*480

          .         .         .         .         .         .       g.91792
 catcaagattcttcctgatattttacctcatgctgtacaaagccttaatgttgtaatcat       c.*540

          .         .         .         .         .         .       g.91852
 atcttacgtgttgaagacctgactggagaaacaaaatgtgcaataacgtgaattttatct       c.*600

          .         .         .         .         .         .       g.91912
 tagagatctgtgcagcctatttctgtcacaaaagttatattgtctaataagagaagtctt       c.*660

          .         .         .         .         .         .       g.91972
 aatggcctctgtgaataatgtaactccagttacacggtgacttttaatagcatacagtga       c.*720

          .         .         .         .         .         .       g.92032
 tttgatgaaaggacgtcaaacaatgtggcgatgtcgtggaaagttatctttcccgctctt       c.*780

          .         .         .         .         .         .       g.92092
 tgctgtggtcattgtgtcttgcagaaaggatggccctgatgcagcagcagcgccagctgt       c.*840

          .         .         .         .         .         .       g.92152
 aataaaaaataattcacactatcagactagcaaggcactagaactggaaaagaccacaga       c.*900

          .         .         .         .         .         .       g.92212
 aaacaaagaatccaaccctttcatcttacaggtgaacaaactgtgatgatgcacatgtat       c.*960

          .         .         .         .         .         .       g.92272
 gtgttttgtaagctgtgagcaccgtaacaaaatgtaaatttgccattattaggaagtgct       c.*1020

          .         .         .         .         .         .       g.92332
 ggtggcagtgaagaagcacccaggccacttgactcccagtctggtgccctgtctacacca       c.*1080

          .         .         .         .         .         .       g.92392
 gacaacacaggagctgggtcagattcccctcagctgcttaacaaagttcctcgaacagaa       c.*1140

          .         .         .         .         .         .       g.92452
 agtgcttacaaagctgccttctcggatactgaaaggtcgagttttctgaactgcactgat       c.*1200

          .         .         .         .         .         .       g.92512
 tttattgcagttgaaaaaaaaaaaaagctattccaaagatttcaagctgttctgagacat       c.*1260

          .         .         .         .         .         .       g.92572
 cttctgatggctttacttcctgagaggcaatgtttttactttatgcataattcattgttg       c.*1320

          .         .         .         .         .         .       g.92632
 ccaaggaataaagtgaagaaacagcaccttttaatatataggtctctctggaagagacct       c.*1380

          .         .         .         .         .         .       g.92692
 aaattagaaagagaaaactgtgacaattttcatattctcattcttaaaaaacactaatct       c.*1440

          .         .         .         .         .         .       g.92752
 taactaacaaaagttcttttgagaataagttacacacaatggccacagcagtttgtcttt       c.*1500

          .         .         .         .         .         .       g.92812
 aatagtatagtgcctatactcatgtaatcggttactcactactgcctttaaaaaaaaaaa       c.*1560

          .         .         .         .         .         .       g.92872
 ccagcatatttattgaaaacatgagacaggattatagtgccttaaccgatatattttgtg       c.*1620

          .         .         .         .         .         .       g.92932
 acttaaaaaatacatttaaaactgctcttctgctctagtaccatgcttagtgcaaatgat       c.*1680

          .         .         .         .         .                 g.92987
 tatttctatgtacaactgatgcttgttcttattttaataaatttatcagagtgaa            c.*1735

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The 3'-phosphoadenosine 5'-phosphosulfate synthase 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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