parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2) - coding DNA reference sequence

(used for variant description)

(last modified September 18, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_004562.2 in the PARK2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering PARK2 transcript NM_004562.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5014
                                               attcctagggccgg       c.-121

 .         .         .         .         .         .                g.5074
 gcgcgggggcggggaggcctggaggatttaacccaggagagccgctggtgggaggcgcgg       c.-61

 .         .         .         .         .         .                g.5134
 ctggcgccgctgcgcgcatgggcctgttcctggcccgcagccgccacctacccagtgacc       c.-1

         | 02.         .         .         .         .         .    g.289382
 ATGATAG | TGTTTGTCAGGTTCAACTCCAGCCATGGTTTCCCAGTGGAGGTCGATTCTGAC    c.60
 M  I  V |   F  V  R  F  N  S  S  H  G  F  P  V  E  V  D  S  D      p.20

          .         .         .         .         .         .       g.289442
 ACCAGCATCTTCCAGCTCAAGGAGGTGGTTGCTAAGCGACAGGGGGTTCCGGCTGACCAG       c.120
 T  S  I  F  Q  L  K  E  V  V  A  K  R  Q  G  V  P  A  D  Q         p.40

          .         .         .         .         .  | 03      .    g.470046
 TTGCGTGTGATTTTCGCAGGGAAGGAGCTGAGGAATGACTGGACTGTGCAG | AATTGTGAC    c.180
 L  R  V  I  F  A  G  K  E  L  R  N  D  W  T  V  Q   | N  C  D      p.60

          .         .         .         .         .         .       g.470106
 CTGGATCAGCAGAGCATTGTTCACATTGTGCAGAGACCGTGGAGAAAAGGTCAAGAAATG       c.240
 L  D  Q  Q  S  I  V  H  I  V  Q  R  P  W  R  K  G  Q  E  M         p.80

          .         .         .         .         .         .       g.470166
 AATGCAACTGGAGGCGACGACCCCAGAAACGCGGCGGGAGGCTGTGAGCGGGAGCCCCAG       c.300
 N  A  T  G  G  D  D  P  R  N  A  A  G  G  C  E  R  E  P  Q         p.100

          .         .         .         .         .         .       g.470226
 AGCTTGACTCGGGTGGACCTCAGCAGCTCAGTCCTCCCAGGAGACTCTGTGGGGCTGGCT       c.360
 S  L  T  R  V  D  L  S  S  S  V  L  P  G  D  S  V  G  L  A         p.120

          .         .         .         .         .   | 04     .    g.531558
 GTCATTCTGCACACTGACAGCAGGAAGGACTCACCACCAGCTGGAAGTCCAG | CAGGTAGA    c.420
 V  I  L  H  T  D  S  R  K  D  S  P  P  A  G  S  P  A |   G  R      p.140

          .         .         .         .         .         .       g.531618
 TCAATCTACAACAGCTTTTATGTGTATTGCAAAGGCCCCTGTCAAAGAGTGCAGCCGGGA       c.480
 S  I  Y  N  S  F  Y  V  Y  C  K  G  P  C  Q  R  V  Q  P  G         p.160

          .         .         .         .         .     | 05   .    g.678634
 AAACTCAGGGTACAGTGCAGCACCTGCAGGCAGGCAACGCTCACCTTGACCCAG | GGTCCA    c.540
 K  L  R  V  Q  C  S  T  C  R  Q  A  T  L  T  L  T  Q   | G  P      p.180

          .         .         .         .         .         .       g.678694
 TCTTGCTGGGATGATGTTTTAATTCCAAACCGGATGAGTGGTGAATGCCAATCCCCACAC       c.600
 S  C  W  D  D  V  L  I  P  N  R  M  S  G  E  C  Q  S  P  H         p.200

          .         | 06         .         .         .         .    g.759427
 TGCCCTGGGACTAGTGCA | GAATTTTTCTTTAAATGTGGAGCACACCCCACCTCTGACAAG    c.660
 C  P  G  T  S  A   | E  F  F  F  K  C  G  A  H  P  T  S  D  K      p.220

          .         .         .         .         .         .       g.759487
 GAAACATCAGTAGCTTTGCACCTGATCGCAACAAATAGTCGGAACATCACTTGCATTACG       c.720
 E  T  S  V  A  L  H  L  I  A  T  N  S  R  N  I  T  C  I  T         p.240

          .     | 07   .         .         .         .         .    g.946940
 TGCACAGACGTCAG | GAGCCCCGTCCTGGTTTTCCAGTGCAACTCCCGCCACGTGATTTGC    c.780
 C  T  D  V  R  |  S  P  V  L  V  F  Q  C  N  S  R  H  V  I  C      p.260

          .         .         .         .         .         .       g.947000
 TTAGACTGTTTCCACTTATACTGTGTGACAAGACTCAATGATCGGCAGTTTGTTCACGAC       c.840
 L  D  C  F  H  L  Y  C  V  T  R  L  N  D  R  Q  F  V  H  D         p.280

          .         .         .  | 08      .         .         .    g.1163415
 CCTCAACTTGGCTACTCCCTGCCTTGTGTGG | CTGGCTGTCCCAACTCCTTGATTAAAGAG    c.900
 P  Q  L  G  Y  S  L  P  C  V  A |   G  C  P  N  S  L  I  K  E      p.300

          .         .         .    | 09    .         .         .    g.1183826
 CTCCATCACTTCAGGATTCTGGGAGAAGAGCAG | TACAACCGGTACCAGCAGTATGGTGCA    c.960
 L  H  H  F  R  I  L  G  E  E  Q   | Y  N  R  Y  Q  Q  Y  G  A      p.320

          .         .         .         .         .         .       g.1183886
 GAGGAGTGTGTCCTGCAGATGGGGGGCGTGTTATGCCCCCGCCCTGGCTGTGGAGCGGGG       c.1020
 E  E  C  V  L  Q  M  G  G  V  L  C  P  R  P  G  C  G  A  G         p.340

          .         .         .         .         .         .       g.1183946
 CTGCTGCCGGAGCCTGACCAGAGGAAAGTCACCTGCGAAGGGGGCAATGGCCTGGGCTGT       c.1080
 L  L  P  E  P  D  Q  R  K  V  T  C  E  G  G  N  G  L  G  C         p.360

     | 10    .         .         .         .         .         .    g.1345982
 GGG | TTTGCCTTCTGCCGGGAATGTAAAGAAGCGTACCATGAAGGGGAGTGCAGTGCCGTA    c.1140
 G   | F  A  F  C  R  E  C  K  E  A  Y  H  E  G  E  C  S  A  V      p.380

          .         .        | 11.         .         .         .    g.1372630
 TTTGAAGCCTCAGGAACAACTACTCAG | GCCTACAGAGTCGATGAAAGAGCCGCCGAGCAG    c.1200
 F  E  A  S  G  T  T  T  Q   | A  Y  R  V  D  E  R  A  A  E  Q      p.400

          .         .         .         .         .         .       g.1372690
 GCTCGTTGGGAAGCAGCCTCCAAAGAAACCATCAAGAAAACCACCAAGCCCTGTCCCCGC       c.1260
 A  R  W  E  A  A  S  K  E  T  I  K  K  T  T  K  P  C  P  R         p.420

          .         .      | 12  .         .         .         .    g.1382626
 TGCCATGTACCAGTGGAAAAAAATG | GAGGCTGCATGCACATGAAGTGTCCGCAGCCCCAG    c.1320
 C  H  V  P  V  E  K  N  G |   G  C  M  H  M  K  C  P  Q  P  Q      p.440

          .         .         .         .         .         .       g.1382686
 TGCAGGCTCGAGTGGTGCTGGAACTGTGGCTGCGAGTGGAACCGCGTCTGCATGGGGGAC       c.1380
 C  R  L  E  W  C  W  N  C  G  C  E  W  N  R  V  C  M  G  D         p.460

          .                                                         g.1382704
 CACTGGTTCGACGTGTAG                                                 c.1398
 H  W  F  D  V  X                                                   p.465

          .         .         .         .         .         .       g.1382764
 ccagggcggccgggcgccccatcgccacatcctgggggagcatacccagtgtctaccttc       c.*60

          .         .         .         .         .         .       g.1382824
 attttctaattctcttttcaaacacacacacacacgcgcgcgcgcgcacacacactcttc       c.*120

          .         .         .         .         .         .       g.1382884
 aagtttttttcaaagtccaactacagccaaattgcagaagaaactcctggatccctttca       c.*180

          .         .         .         .         .         .       g.1382944
 ctatgtccatgaaaaacagcagagtaaaattacagaagaagctcctgaatccctttcagt       c.*240

          .         .         .         .         .         .       g.1383004
 ttgtccacacaagacagcagagccatctgcgacaccaccaacaggcgttctcagcctccg       c.*300

          .         .         .         .         .         .       g.1383064
 gatgacacaaataccagagcacagattcaagtgcaatccatgtatctgtatgggtcattc       c.*360

          .         .         .         .         .         .       g.1383124
 tcacctgaattcgagacaggcagaatcagtagctggagagagagttctcacatttaatat       c.*420

          .         .         .         .         .         .       g.1383184
 cctgccttttaccttcagtaaacaccatgaagatgccattgacaaggtgtttctctgtaa       c.*480

          .         .         .         .         .         .       g.1383244
 aatgaactgcagtgggttctccaaactagattcatggctttaacagtaatgttcttattt       c.*540

          .         .         .         .         .         .       g.1383304
 aaattttcagaaagcatctattcccaaagaaccccaggcaatagtcaaaaacatttgttt       c.*600

          .         .         .         .         .         .       g.1383364
 atccttaagaattccatctatataaatcgcattaatgaaataccaactatgcgtaaatca       c.*660

          .         .         .         .         .         .       g.1383424
 acttgtcacaaagtgagaaattatgaaagttaatttgaatgttgaatgtttgaattacag       c.*720

          .         .         .         .         .         .       g.1383484
 ggaagaaatcaagttaatgtactttcattccctttcatgatttgcaactttagaaagaaa       c.*780

          .         .         .         .         .         .       g.1383544
 ttgtttttctgaaagtatcaccaaaaaatctatagtttgattctgagtattcattttgca       c.*840

          .         .         .         .         .         .       g.1383604
 acttggagattttgctaatacatttggctccactgtaaatttaatagataaagtgcctat       c.*900

          .         .         .         .         .         .       g.1383664
 aaaggaaacacgtttagaaatgatttcaaaatgatattcaatcttaacaaaagtgaacat       c.*960

          .         .         .         .         .         .       g.1383724
 tattaaatcagaatctttaaagaggagcctttccagaactaccaaaatgaagacacgccc       c.*1020

          .         .         .         .         .         .       g.1383784
 gactctctccatcagaagggtttatacccctttggcacaccctctctgtccaatctgcaa       c.*1080

          .         .         .         .         .         .       g.1383844
 gtcccagggagctctgcataccaggggttccccaggagagaccttctcttaggacagtaa       c.*1140

          .         .         .         .         .         .       g.1383904
 actcactagaatattccttatgttgacatggattggatttcagttcaatcaaactttcag       c.*1200

          .         .         .         .         .         .       g.1383964
 cttttttttcagccattcacaacacaatcaaaagattaacaacactgcatgcggcaaacc       c.*1260

          .         .         .         .         .         .       g.1384024
 gcatgctcttacccacactacgcagaagagaaagtacaaccactatcttttgttctacct       c.*1320

          .         .         .         .         .         .       g.1384084
 gtattgtctgacttctcaggaagatcgtgaacataactgagggcatgagtctcactagca       c.*1380

          .         .         .         .         .         .       g.1384144
 catggaggcccttttggatttagagactgtaaattattaaatcggcaacagggcttctct       c.*1440

          .         .         .         .         .         .       g.1384204
 ttttagatgtagcactgaaatccttgctggagggaagagaggggatgaactcaagttttc       c.*1500

          .         .         .         .         .         .       g.1384264
 cacatcctgggacacctgtccctcttttcctaactgcctaagataacccatttcttccaa       c.*1560

          .         .         .         .         .         .       g.1384324
 ccatctgaggacagtcccgtcgtctcagaggccctgcaccggggagagactgggctctgc       c.*1620

          .         .         .         .         .         .       g.1384384
 agcagccacatcagcattcacagcttcatgtggcttcactgtctgaaaatctaccgactc       c.*1680

          .         .         .         .         .         .       g.1384444
 caacatggccccacggtgacaacagacctgtgacaggaagcccaaagctcacatagaaat       c.*1740

          .         .         .         .         .         .       g.1384504
 ggtggacagatcaaagtctctatagtaagggaaaaaaagagaggtggcaggcatgagccc       c.*1800

          .         .         .         .         .         .       g.1384564
 cctgcacccagtggctcgtgtccatactgagtccagaccctgatcaaggcctgacttagt       c.*1860

          .         .         .         .         .         .       g.1384624
 gtcactggcagtcccactaaattacacttccttacactggcccgatgcgacaaatcaggt       c.*1920

          .         .         .         .         .         .       g.1384684
 ggctcccttctgtcacgtggagcacacagtgttttccatcatccatagctttcttcctga       c.*1980

          .         .         .         .         .         .       g.1384744
 tggtgtttgcattattgcgccttcccaatctgcatgctgcgttgggcttgcggtgcctga       c.*2040

          .         .         .         .         .         .       g.1384804
 acaaggtttgctcccatgagctcaggcaccctaggatcccctgttagactattaggctgt       c.*2100

          .         .         .         .         .         .       g.1384864
 ccagcatggtctcctttcccttcttggtggtggtcttttccctttccagaatagaacagt       c.*2160

          .         .         .         .         .         .       g.1384924
 gattcttaaaataagttagagcaggccgggcgcggtggctcatgcctgtaatcccagcac       c.*2220

          .         .         .         .         .         .       g.1384984
 tttgggaggccgaggtgggtggatcacgaggtcaggagttcaagaccagcctggccaaga       c.*2280

          .         .         .         .         .         .       g.1385044
 tgatgaaaccccgtctctattaaaaatacaaaaattagctgggcgtggtggcaggcacct       c.*2340

          .         .         .         .         .         .       g.1385104
 gtaatcccagcttcctgggaggctgaggcaggagaatcacttgaacccggggggcagagg       c.*2400

          .         .         .         .         .         .       g.1385164
 ttgcagtgagccgagatcacgccactgaactccagcctgggcaacagagtgagactctgt       c.*2460

          .         .         .         .         .         .       g.1385224
 ctcaaaaaaaaaaaaaaaacaaaaacaaaaaagcaagatcatccactacacatgaacatg       c.*2520

          .         .                                               g.1385245
 aatcacagtattatttgcaca                                              c.*2541

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Parkinson protein 2, E3 ubiquitin protein ligase (parkin) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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