paired box 7 (PAX7) - coding DNA reference sequence

(used for variant description)

(last modified October 5, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_002584.2 in the PAX7 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_023262.1, covering PAX7 transcript NM_002584.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5058
   gaaagctggtgtggagggagaagcgagtgtggtccggagaaagaaggcgtggagaaga       c.-541

 .         .         .         .         .         .                g.5118
 gggagggagcgagagcgagagaataaatatataaataaatacgagaacgaaatccactcc       c.-481

 .         .         .         .         .         .                g.5178
 gcagtctccgggctcggaaactttggccccgagcgccagagcgccagagcgcgagagcgc       c.-421

 .         .         .         .         .         .                g.5238
 ggcgctcgccactctgaggctggcggcctcgattccggccgcgttcccccggcccccctc       c.-361

 .         .         .         .         .         .                g.5298
 cgccgcggggcctggtctccgggttctgccaggcgcatcagcccgcacaacttctggccg       c.-301

 .         .         .         .         .         .                g.5358
 aggccagccggcagaggcggacttggggttggagtgtttgtttgtttgaacttcctcgtc       c.-241

 .         .         .         .         .         .                g.5418
 gtcgccaccttccctccccccaacctccaccccacctcacccccctccccagcttctgga       c.-181

 .         .         .         .         .         .                g.5478
 cgcgtttgactgcagccaggggtggggggtgggggtagggagtgtgtgtggaggggaggg       c.-121

 .         .         .         .         .         .                g.5538
 agaagaggttaaaaaaaagaagacgaagaagacggaaagaaagagatcgcagcaggggtg       c.-61

 .         .         .         .         .         .                g.5598
 aagggagcggacgggaagcgatttttgccgactttggattcgtccccggcgtgcgcaaga       c.-1

          .         .         .         .         .         .       g.5658
 ATGGCGGCCCTTCCCGGCACGGTACCGAGAATGATGCGGCCGGCTCCGGGGCAGAACTAC       c.60
 M  A  A  L  P  G  T  V  P  R  M  M  R  P  A  P  G  Q  N  Y         p.20

          .         .      | 02  .         .         .         .    g.8332
 CCCCGCACGGGATTCCCTTTGGAAG | TGTCCACCCCGCTTGGCCAAGGCCGGGTCAATCAG    c.120
 P  R  T  G  F  P  L  E  V |   S  T  P  L  G  Q  G  R  V  N  Q      p.40

          .         .         .         .         .         .       g.8392
 CTGGGAGGGGTCTTCATCAATGGGCGACCCCTGCCTAACCACATCCGCCACAAGATAGTG       c.180
 L  G  G  V  F  I  N  G  R  P  L  P  N  H  I  R  H  K  I  V         p.60

          .         .         .         .         .         .       g.8452
 GAGATGGCCCACCATGGCATCCGGCCCTGTGTCATCTCCCGACAGCTGCGTGTCTCCCAC       c.240
 E  M  A  H  H  G  I  R  P  C  V  I  S  R  Q  L  R  V  S  H         p.80

          .         .         .         .         .         .       g.8512
 GGCTGCGTCTCCAAGATTCTTTGCCGCTACCAGGAGACCGGGTCCATCCGGCCTGGGGCC       c.300
 G  C  V  S  K  I  L  C  R  Y  Q  E  T  G  S  I  R  P  G  A         p.100

          .         .  | 03      .         .         .         .    g.9144
 ATCGGCGGCAGCAAGCCCAGA | CAGGTGGCGACTCCGGATGTAGAGAAAAAGATTGAGGAG    c.360
 I  G  G  S  K  P  R   | Q  V  A  T  P  D  V  E  K  K  I  E  E      p.120

          .         .         .         .         .         .       g.9204
 TACAAGAGGGAAAACCCAGGCATGTTCAGCTGGGAGATCCGGGACAGGCTGCTGAAGGAT       c.420
 Y  K  R  E  N  P  G  M  F  S  W  E  I  R  D  R  L  L  K  D         p.140

          .         .         .  | 04      .         .         .    g.10260
 GGGCACTGTGACCGAAGCACTGTGCCCTCAG | GTTTAGTGAGTTCGATTAGCCGCGTGCTC    c.480
 G  H  C  D  R  S  T  V  P  S  G |   L  V  S  S  I  S  R  V  L      p.160

          .         .         .         .         .         .       g.10320
 AGAATCAAGTTCGGGAAGAAAGAGGAGGAGGATGAAGCGGACAAGAAGGAGGACGACGGC       c.540
 R  I  K  F  G  K  K  E  E  E  D  E  A  D  K  K  E  D  D  G         p.180

          .         .         .         .       | 05 .         .    g.65762
 GAAAAGAAGGCCAAACACAGCATCGACGGCATCCTGGGCGACAAAG | GGAACCGGCTGGAC    c.600
 E  K  K  A  K  H  S  I  D  G  I  L  G  D  K  G |   N  R  L  D      p.200

          .         .         .         .         .         .       g.65822
 GAGGGCTCGGATGTGGAGTCGGAACCTGACCTCCCACTGAAGCGCAAGCAGCGACGCAGT       c.660
 E  G  S  D  V  E  S  E  P  D  L  P  L  K  R  K  Q  R  R  S         p.220

          .         .         .         .         .         .       g.65882
 CGGACCACATTCACGGCCGAGCAGCTGGAGGAGCTGGAGAAGGCCTTTGAGAGGACCCAC       c.720
 R  T  T  F  T  A  E  Q  L  E  E  L  E  K  A  F  E  R  T  H         p.240

          .         .         .         .         .         .       g.65942
 TACCCAGACATATACACCCGCGAGGAGCTGGCGCAGAGGACCAAGCTGACAGAGGCGCGT       c.780
 Y  P  D  I  Y  T  R  E  E  L  A  Q  R  T  K  L  T  E  A  R         p.260

        | 06 .         .         .         .         .         .    g.74701
 GTGCAG | GTCTGGTTCAGTAACCGCCGCGCCCGTTGGCGTAAGCAGGCAGGAGCCAACCAG    c.840
 V  Q   | V  W  F  S  N  R  R  A  R  W  R  K  Q  A  G  A  N  Q      p.280

          .         .         .         .         .         .       g.74761
 CTGGCGGCGTTCAACCACCTTCTGCCAGGAGGCTTCCCACCCACCGGCATGCCCACGCTG       c.900
 L  A  A  F  N  H  L  L  P  G  G  F  P  P  T  G  M  P  T  L         p.300

          .         .         .         .         .   | 07     .    g.77096
 CCCCCCTACCAGCTGCCGGACTCCACCTACCCCACCACCACCATCTCCCAAG | ATGGGGGC    c.960
 P  P  Y  Q  L  P  D  S  T  Y  P  T  T  T  I  S  Q  D |   G  G      p.320

          .         .         .         .         .         .       g.77156
 AGCACTGTGCACCGGCCTCAGCCCCTGCCACCGTCCACCATGCACCAGGGCGGGCTGGCT       c.1020
 S  T  V  H  R  P  Q  P  L  P  P  S  T  M  H  Q  G  G  L  A         p.340

          .         .         .         .         .         .       g.77216
 GCAGCGGCTGCAGCCGCCGACACCAGCTCTGCCTACGGAGCCCGCCACAGCTTCTCCAGC       c.1080
 A  A  A  A  A  A  D  T  S  S  A  Y  G  A  R  H  S  F  S  S         p.360

          .         .         .         .         .         .       g.77276
 TACTCTGACAGCTTCATGAATCCGGCGGCGCCCTCCAACCACATGAACCCGGTCAGCAAC       c.1140
 Y  S  D  S  F  M  N  P  A  A  P  S  N  H  M  N  P  V  S  N         p.380

          .      | 08  .         .         .         .         .    g.109671
 GGCCTGTCTCCTCAG | GTGATGAGCATCTTGGGCAACCCCAGTGCGGTGCCCCCGCAGCCA    c.1200
 G  L  S  P  Q   | V  M  S  I  L  G  N  P  S  A  V  P  P  Q  P      p.400

          .         .         .         .         .         .       g.109731
 CAGGCTGACTTCTCCATCTCCCCGCTGCATGGCGGCCTGGACTCGGCCACCTCCATCTCA       c.1260
 Q  A  D  F  S  I  S  P  L  H  G  G  L  D  S  A  T  S  I  S         p.420

          .         .         .         .         .         .       g.109791
 GCCAGCTGCAGCCAGCGGGCCGACTCCATCAAGCCAGGAGACAGCCTGCCCACCTCCCAG       c.1320
 A  S  C  S  Q  R  A  D  S  I  K  P  G  D  S  L  P  T  S  Q         p.440

          .         .         .         .         .         .       g.109851
 GCCTACTGCCCACCCACCTACAGCACCACCGGCTACAGCGTGGACCCCGTGGCCGGCTAT       c.1380
 A  Y  C  P  P  T  Y  S  T  T  G  Y  S  V  D  P  V  A  G  Y         p.460

          .         .         .         .         .         .       g.109911
 CAGTACGGCCAGTACGGCCAGAGTGAGTGCCTGGTGCCCTGGGCGTCCCCCGTCCCCATT       c.1440
 Q  Y  G  Q  Y  G  Q  S  E  C  L  V  P  W  A  S  P  V  P  I         p.480

          .         .         .         .         .         .       g.109971
 CCTTCTCCCACCCCCAGGGCCTCCTGCTTGTTTATGGAGAGCTACAAGGTGGTGTCAGGG       c.1500
 P  S  P  T  P  R  A  S  C  L  F  M  E  S  Y  K  V  V  S  G         p.500

          .         .         .         .         .         .       g.110031
 TGGGGAATGTCCATTTCACAGATGGAAAAATTGAAGTCCAGCCAGATGGAACAGTTCACC       c.1560
 W  G  M  S  I  S  Q  M  E  K  L  K  S  S  Q  M  E  Q  F  T         p.520

                                                                    g.110034
 TAA                                                                c.1563
 X                                                                  p.520

          .         .         .         .         .         .       g.110094
 aatgacactgagttgggcaaaacccaggacatctcctggctaagcctctgcttccgtact       c.*60

          .         .         .                                     g.110133
 atggctccaacagaaataaaatacacaacacaaatatca                            c.*99

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Paired box 7 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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