pre-B-cell leukemia homeobox 1 (PBX1) - coding DNA reference sequence

(used for variant description)

(last modified October 25, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_002585.3 in the PBX1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_028246.2, covering PBX1 transcript NM_002585.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5043
                  aaagtttgcattgcaatccccctgccttcctctcctttctccc       c.-421

 .         .         .         .         .         .                g.5103
 gatcaatgcatatttgcaaaaggattaagccacagatttaagcgccgggagcccatttct       c.-361

 .         .         .         .         .         .                g.5163
 gccttgcaaaggagaccggactgaaaaacctaaagccagctctgatttcttttcgccaag       c.-301

 .         .         .         .         .         .                g.5223
 tgggaaggtggtttatttttcttgctttttggagtcaacacccttccccaccagccctta       c.-241

 .         .         .         .         .         .                g.5283
 tccccaccctcaccccgcaaccccttcacgccccctccccctccccctcctcatcctccc       c.-181

 .         .         .         .         .         .                g.5343
 accatcctctaaagaggcaaagggattttttttttcttttggtcttcttttttccccctt       c.-121

 .         .         .         .         .         .                g.5403
 ccctgtttatcctgaaaaggatttgaagacaagcttgaaggataaaaagccttggtgctt       c.-61

 .         .         .         .         .         .                g.5463
 cccaggagccgagccgaggagcagaagaggaagagccgggggctgccgtagcctttggag       c.-1

          .         .         .         .         .         .       g.5523
 ATGGACGAGCAGCCCAGGCTGATGCATTCCCATGCTGGGGTCGGGATGGCCGGACACCCC       c.60
 M  D  E  Q  P  R  L  M  H  S  H  A  G  V  G  M  A  G  H  P         p.20

          .         .         .         .         .         .       g.5583
 GGCCTGTCCCAGCACTTGCAGGATGGGGCCGGAGGGACCGAGGGGGAGGGCGGGAGGAAG       c.120
 G  L  S  Q  H  L  Q  D  G  A  G  G  T  E  G  E  G  G  R  K         p.40

          .         .         .         .         .         .       g.5643
 CAGGACATTGGAGACATTTTACAGCAAATTATGACCATCACAGACCAGAGTTTGGATGAG       c.180
 Q  D  I  G  D  I  L  Q  Q  I  M  T  I  T  D  Q  S  L  D  E         p.60

          .  | 02      .         .         .         .         .    g.8927
 GCGCAGGCCAG | AAAACATGCTTTAAACTGCCACAGAATGAAGCCTGCCTTGTTTAATGTG    c.240
 A  Q  A  R  |  K  H  A  L  N  C  H  R  M  K  P  A  L  F  N  V      p.80

          .         .      | 03  .         .         .         .    g.238169
 TTGTGTGAAATCAAAGAAAAAACAG | TTTTGAGTATCCGAGGAGCCCAGGAGGAGGAACCC    c.300
 L  C  E  I  K  E  K  T  V |   L  S  I  R  G  A  Q  E  E  E  P      p.100

          .         .         .         .         .         .       g.238229
 ACAGACCCCCAGCTGATGCGGCTGGACAACATGCTGTTAGCGGAAGGCGTGGCGGGGCCT       c.360
 T  D  P  Q  L  M  R  L  D  N  M  L  L  A  E  G  V  A  G  P         p.120

          .         .         .         .         .         .       g.238289
 GAGAAGGGCGGAGGGTCGGCGGCAGCGGCGGCAGCGGCGGCGGCTTCTGGAGGGGCAGGT       c.420
 E  K  G  G  G  S  A  A  A  A  A  A  A  A  A  S  G  G  A  G         p.140

          .         .         .         .         .         .       g.238349
 TCAGACAACTCAGTGGAGCATTCAGATTACAGAGCCAAACTCTCACAGATCAGACAAATC       c.480
 S  D  N  S  V  E  H  S  D  Y  R  A  K  L  S  Q  I  R  Q  I         p.160

          .         .         . | 04       .         .         .    g.245369
 TACCATACGGAGCTGGAGAAATACGAGCAG | GCCTGCAACGAGTTCACCACCCACGTGATG    c.540
 Y  H  T  E  L  E  K  Y  E  Q   | A  C  N  E  F  T  T  H  V  M      p.180

          .         .         .         .         .         .       g.245429
 AATCTCCTGCGAGAGCAAAGCCGGACCAGGCCCATCTCCCCAAAGGAGATTGAGCGGATG       c.600
 N  L  L  R  E  Q  S  R  T  R  P  I  S  P  K  E  I  E  R  M         p.200

          .         .         .         .         .         .       g.245489
 GTCAGCATCATCCACCGCAAGTTCAGCTCCATCCAGATGCAGCTCAAGCAGAGCACGTGC       c.660
 V  S  I  I  H  R  K  F  S  S  I  Q  M  Q  L  K  Q  S  T  C         p.220

          .         .         .         .  | 05      .         .    g.253201
 GAGGCGGTGATGATCCTGCGTTCCCGATTTCTGGATGCGCG | GCGGAAGAGACGGAATTTC    c.720
 E  A  V  M  I  L  R  S  R  F  L  D  A  R  |  R  K  R  R  N  F      p.240

          .         .         .         .         .         .       g.253261
 AACAAGCAAGCGACAGAAATCCTGAATGAATATTTCTATTCCCATCTCAGCAACCCTTAC       c.780
 N  K  Q  A  T  E  I  L  N  E  Y  F  Y  S  H  L  S  N  P  Y         p.260

          .         .         .         .         .        | 06.    g.257633
 CCCAGTGAGGAAGCCAAAGAGGAGTTAGCCAAGAAGTGTGGCATCACAGTCTCCCAG | GTA    c.840
 P  S  E  E  A  K  E  E  L  A  K  K  C  G  I  T  V  S  Q   | V      p.280

          .         .         .         .         .         .       g.257693
 TCAAACTGGTTTGGAAATAAGCGAATCCGGTACAAGAAGAACATAGGTAAATTTCAAGAG       c.900
 S  N  W  F  G  N  K  R  I  R  Y  K  K  N  I  G  K  F  Q  E         p.300

          .         .         .         .         .         .       g.257753
 GAAGCCAATATTTATGCTGCCAAAACAGCTGTCACTGCTACCAATGTGTCAGCCCATGGA       c.960
 E  A  N  I  Y  A  A  K  T  A  V  T  A  T  N  V  S  A  H  G         p.320

          .         .         .        | 07.         .         .    g.265735
 AGCCAAGCTAACTCGCCCTCAACTCCCAACTCGGCTG | GTTCTTCCAGTTCTTTTAACATG    c.1020
 S  Q  A  N  S  P  S  T  P  N  S  A  G |   S  S  S  S  F  N  M      p.340

          .         .         .         .         .         .       g.265795
 TCAAACTCTGGAGATTTGTTCATGAGCGTGCAGTCACTCAATGGGGATTCTTACCAAGGG       c.1080
 S  N  S  G  D  L  F  M  S  V  Q  S  L  N  G  D  S  Y  Q  G         p.360

          .         .         . | 08       .         .         .    g.267207
 GCCCAGGTTGGAGCCAACGTGCAATCACAG | GTGGATACCCTTCGCCATGTTATCAGCCAG    c.1140
 A  Q  V  G  A  N  V  Q  S  Q   | V  D  T  L  R  H  V  I  S  Q      p.380

          .         .         .         .         .         .       g.267267
 ACAGGAGGATACAGTGATGGACTCGCAGCCAGTCAGATGTACAGTCCGCAGGGCATCAGT       c.1200
 T  G  G  Y  S  D  G  L  A  A  S  Q  M  Y  S  P  Q  G  I  S         p.400

  | 09       .         .         .         .         .         .    g.292284
  | GCTAATGGAGGTTGGCAGGATGCTACTACCCCTTCATCAGTGACCTCCCCTACAGAAGGC    c.1260
  | A  N  G  G  W  Q  D  A  T  T  P  S  S  V  T  S  P  T  E  G      p.420

          .         .         .                                     g.292317
 CCTGGCAGTGTTCACTCTGATACCTCCAACTGA                                  c.1293
 P  G  S  V  H  S  D  T  S  N  X                                    p.430

          .         .         .         .         .         .       g.292377
 tctcccagcaatcgcatcccggctgaccctgtgccccagttggggcaggggcaggaggga       c.*60

          .         .         .         .         .         .       g.292437
 gggtttctctcccaacgctgaagcggtcagactggaggtcgaagcaatcagcaaacacaa       c.*120

          .         .         .         .         .         .       g.292497
 taagagtctccttctcttctcttctttgggatgctatttcagccaatctggacacttctt       c.*180

          .         .         .         .         .         .       g.292557
 tatactctcttcccttttttttctgggtagaagccacccttccctgcctccagctgtcag       c.*240

          .         .         .         .         .         .       g.292617
 cctggttttcgtcatcttccctgcccctgtgcctctgtcctagactcccggggtccccgc       c.*300

          .         .         .         .         .         .       g.292677
 cctctctcatatcactgaaggatattttcaacaattagaggaatttaaagaggaaaaaaa       c.*360

          .         .         .         .         .         .       g.292737
 ttacaaagaaaataataaaagtgtttgtacgttttcatgctggtggtttgaggagccaaa       c.*420

          .         .         .         .         .         .       g.292797
 tttacctcactcgaatccctcactccctatgttaacaggcaatccttctctgtttctctt       c.*480

          .         .         .         .         .         .       g.292857
 attactctcactacctcttagcaggaatactccacattgccctattcattccaggcctcc       c.*540

          .         .         .         .         .         .       g.292917
 ctgcttcctcttgctcttcctccctggggacagtactgattggaacactttcctcctctt       c.*600

          .         .         .         .         .         .       g.292977
 ccttcctagccccagctattcactggggactgtcatagctgggattctaaaggtgccaca       c.*660

          .         .         .         .         .         .       g.293037
 tttttcagtttcatctccactaggttggttcccgggcaggaagtcaggcagcagggaagg       c.*720

          .         .         .         .         .         .       g.293097
 acacgggaacagcaggtggagaattcctacagtctttcttaccctgctagcaatagctct       c.*780

          .         .         .         .         .         .       g.293157
 cagtttcagaggcacagtctttggagaccattcagcactgagaaagcaatatttagaacc       c.*840

          .         .         .         .         .         .       g.293217
 tattgcaaaactgggcctgagttaggcatggtgatgaatgcatcagcaaggaatagaaag       c.*900

          .         .         .         .         .         .       g.293277
 ttcttatcgtgaaacccttcaacctcaactatgccttcatagacacacacgttcatgcac       c.*960

          .         .         .         .         .         .       g.293337
 atgtaggcacatgtaccatctcacatcttcactttcccgagatgccatatacaattacct       c.*1020

          .         .         .         .         .         .       g.293397
 acattaataactgtagcactatgccttttgagcccgagagagggaattagtgactctaag       c.*1080

          .         .         .         .         .         .       g.293457
 tgaaggtcactgacacagagaagcagtatgtgtctggggcttccaggacctgcaggccca       c.*1140

          .         .         .         .         .         .       g.293517
 ctagcgtgcacttaccagaatggcatacacaggacctgatcatgaggaagaccaggtttc       c.*1200

          .         .         .         .         .         .       g.293577
 cagtgtaaactactcttgttcccaccacctctggagcactcagggagccccatacagtac       c.*1260

          .         .         .         .         .         .       g.293637
 ttacaatgtctttaatggacttgattctgtttaattttttgttttatattaggcacactg       c.*1320

          .         .         .         .         .         .       g.293697
 tattaattttccaaaatgttataccacactatgttcttggtcctgacctattgctctgga       c.*1380

          .         .         .         .         .         .       g.293757
 ggaaagagttgtataagaacgtggctcatgtgaacttttgctagcttcatttgaggacct       c.*1440

          .         .         .         .         .         .       g.293817
 gagaatcatggggaaagggaaggtaatgttttcattgaaatcatcacagtgatttttatt       c.*1500

          .         .         .         .         .         .       g.293877
 ccctgggaacacagcgtgtactaaaaatacatgagaaaatagcatgtatatgaaagctat       c.*1560

          .         .         .         .         .         .       g.293937
 tctcaaaagtcacctgagctcaccatcttcatagccaaccctaccagttataaagatggc       c.*1620

          .         .         .         .         .         .       g.293997
 agctctatcacttgattaagtgggaggtggtcaaatattttggtgcctcattttcttcat       c.*1680

          .         .         .         .         .         .       g.294057
 ctgtgagatgggaactgttatgcctggcttactaagagtcttgtgagagactgagaagtt       c.*1740

          .         .         .         .         .         .       g.294117
 gattttgttcatatccaatctgtaaatgcgaagtcaggggaagtaatgtccctgaaataa       c.*1800

          .         .         .         .         .         .       g.294177
 acgggttcatgccatctagggacaataaatggttttcttgttgtaacttctggttaatat       c.*1860

          .         .         .         .         .         .       g.294237
 cagtaccttgatgtcatcaccgtgatgacaaagagaagagttattgttgatcttcttggt       c.*1920

          .         .         .         .         .         .       g.294297
 tttggtctgtctcttttcttaggataaagaaaaacttccaaactagaaaaacaggccctg       c.*1980

          .         .         .         .         .         .       g.294357
 gttcccttagtttgcacttgaacccaatatgttgccttgtacatacttggtccctgtcac       c.*2040

          .         .         .         .         .         .       g.294417
 attgactgcttgggaggcttccagggagaagtatgagaccctgaggggtgagaatgggca       c.*2100

          .         .         .         .         .         .       g.294477
 gctagcaagaacatggaaattctgcttggcactacagtcataaatagaaaacactgtgtg       c.*2160

          .         .         .         .         .         .       g.294537
 tgctcaggggagcaggggatgccactgaagaaactcaagggaatgtgtatttgaaggaaa       c.*2220

          .         .         .         .         .         .       g.294597
 tgcaaaaactaagtatttagcaaaatgaaattatgccttgatgactaaaaggcactagaa       c.*2280

          .         .         .         .         .         .       g.294657
 aggttgtgtctactaacttcagccctaatcagaacagatgcctagaaggagcatttttgt       c.*2340

          .         .         .         .         .         .       g.294717
 gacaacttcatagtgattagaatcagtggagaactccatcttagtggcaggaatataatg       c.*2400

          .         .         .         .         .         .       g.294777
 aaactacccacgcaagaacatggttgaatcacatttgcttgacttagggcaaagtacgaa       c.*2460

          .         .         .         .         .         .       g.294837
 agagagacaaaagggttctcttggaaacaagaagagtgactccagatgtggcctgaataa       c.*2520

          .         .         .         .         .         .       g.294897
 ttgccatgttaagttaatgcaaaagatcagaacagggctacatttgcacaggcagtttct       c.*2580

          .         .         .         .         .         .       g.294957
 ctccgggccgtagttttcactgatgatcacctttcacagcattttccccaaccagcattt       c.*2640

          .         .         .         .         .         .       g.295017
 cacttagtcttctctatacccagcacctcccccggcacccccggcaagcccactatcact       c.*2700

          .         .         .         .         .         .       g.295077
 tccgacttccaacgtggcatccgtgagatctgtccacattaggcgaagcaggagaacact       c.*2760

          .         .         .         .         .         .       g.295137
 gagagcagcaggatgggtttggaaagagcatgcctctggaaacacagcttcctgggaatt       c.*2820

          .         .         .         .         .         .       g.295197
 cacatgaggccagtcctacagagagcaagatgcaccccaggatttcttcattttctaata       c.*2880

          .         .         .         .         .         .       g.295257
 gatgtgggagtgctccattttccccgacagcgaatttcccctgagaaacgatactagacc       c.*2940

          .         .         .         .         .         .       g.295317
 ctgggtttgcccaccttgtaactcttccttatctcctccttttcatccctaatccatcct       c.*3000

          .         .         .         .         .         .       g.295377
 ccctctggcatggaattgacgcccgtgcagtacatttgccaagtggcaccttctttcaat       c.*3060

          .         .         .         .         .         .       g.295437
 ttatgttttattttgctatggtggtgattctttatttgctggttgtcttttctcacacat       c.*3120

          .         .         .         .         .         .       g.295497
 ctttctctctgtctctctctttcctgctctttgtttttctgcccagaaaaacctgacttc       c.*3180

          .         .         .         .         .         .       g.295557
 gataccaaaaaagatgaaactacagaaactcaaatttaaaaaaaactttaaaagaaacaa       c.*3240

          .         .         .         .         .         .       g.295617
 aaaaatactcaacgattctttcagctttattaacattttccattgtttcttgcgacttgt       c.*3300

          .         .         .         .         .         .       g.295677
 gtctcgttctttgtagtattgatgatgaacatttgataatgaatgttcttgtatattcag       c.*3360

          .         .         .         .         .         .       g.295737
 ataaagaaaaaaaaaaccaaaaaagcggtctgaatttaatagtgtttataataaaaattt       c.*3420

          .         .         .         .         .         .       g.295797
 taaaaatgaccctcatagcacgcaaaacaggatggggaatttcccctcttctttctgtga       c.*3480

          .         .         .         .         .         .       g.295857
 caatgcgcatcattcctgcattagtttttaacaccagactacctacattcatcatttccc       c.*3540

          .         .         .         .         .         .       g.295917
 tcatttttcttttattttcttgcatttgtgaattagttcaagaatgctagaaaagtgtcg       c.*3600

          .         .         .         .         .         .       g.295977
 agttgtgcacatccatttcttgtttcacaatgtttaaaagtgacagtaattcattttgta       c.*3660

          .         .         .         .         .         .       g.296037
 aactaaaaaaaaaaaaaaaaaggttggaatagtgagcataataggtacaacctaacacat       c.*3720

          .         .         .         .         .         .       g.296097
 tattatgtttattaactttgagacccagaaataaattcttttcttttcttgattcttgct       c.*3780

          .         .         .         .         .         .       g.296157
 cttaaaaatacaaaaaaaaaaatgttttgttttgtgttatttttggtttgtttattgggg       c.*3840

          .         .         .         .         .         .       g.296217
 ggctttttttaattgtcaggattatgatcttgctgtttttcttcaatatgtatacaaggt       c.*3900

          .         .         .         .         .         .       g.296277
 gatgtgaaaagatgacttgggcagaggagtaagaacaagtaggcttgttcttctactttg       c.*3960

          .         .         .         .         .         .       g.296337
 cttcagaattcagttaatgccaaaagcgaagatcaagcccatgttgatgtctcgttgctc       c.*4020

          .         .         .         .         .         .       g.296397
 acctgcatttccagagagtgtgacactcatgcagtccctgagaaaaataaaatcagggac       c.*4080

          .         .         .         .         .         .       g.296457
 atacttctccttttagccttttaaaaattcaaaaacgtttagtccaagggaactttttat       c.*4140

          .         .         .         .         .         .       g.296517
 gctatcaggaaaggtttttgctgtttttgattctgattatcacagccaagtactttgttt       c.*4200

          .         .         .         .         .         .       g.296577
 tatttctccctaattaataactacattccatgaggcctcttccaaccaaagaggcctttt       c.*4260

          .         .         .         .         .         .       g.296637
 cttccaggagagtcccgcaggagatgctggtatgatgggcaccattggttaagtaaacta       c.*4320

          .         .         .         .         .         .       g.296697
 catgcaggaagaagtccttggggccagtctgccagctgagtcctggttttggatgaagag       c.*4380

          .         .         .         .         .         .       g.296757
 ttaatgagatattgggccaggctcaatgctgtagttttaatgctaagaggttacgtttac       c.*4440

          .         .         .         .         .         .       g.296817
 ttcacagagtacacctcttagtaacctctgacttaggcagctgcttaaagcaaattgcaa       c.*4500

          .         .         .         .         .         .       g.296877
 aactggcttgatttggaatgtttttattagaggaaaaaagaaagccatattatctggaaa       c.*4560

          .         .         .         .         .         .       g.296937
 aaaattcattttaaataccatcattcaacaaattatgttcagaaagtggtcagaacttaa       c.*4620

          .         .         .         .         .         .       g.296997
 gcaagaaaagtaaagaaagaatgcagaattgtggagcaatgctttaggaaatatttctac       c.*4680

          .         .         .         .         .         .       g.297057
 ctgaacacttgtactcttgaagtcacaacaaaataatgatgagcttttcacatcaccttt       c.*4740

          .         .         .         .         .         .       g.297117
 atggtttcaatccctagctcaaagcttcctggaatcttttattttttgtaaacttttttt       c.*4800

          .         .         .         .         .         .       g.297177
 tcttttgttaaaataaataaaacattcaatgtttttctccttttctctcttattacttct       c.*4860

          .         .         .         .         .         .       g.297237
 ttcctttggcattttcaatttgaaatgctttcctttggttgttggttttattctccccct       c.*4920

          .         .         .         .         .         .       g.297297
 acccctccccttttcttattattcagaatataaacctgcaaagctctgctctgttttggt       c.*4980

          .         .         .         .         .         .       g.297357
 tttgaaagtttaagcttttctgcttctgtgagagcacaggcttctgtcccttttgattcc       c.*5040

          .         .         .         .         .         .       g.297417
 aactgaacttttgtgttctctaatgatactaacacggtgtaggttttacagtctcctaat       c.*5100

          .         .         .         .         .                 g.297471
 ttgtactggtaatgcatattccaaataaatagtttcttttgttgcaaaaaaaaa             c.*5154

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Pre-B-cell leukemia homeobox 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 25
©2004-2020 Leiden University Medical Center