propionyl CoA carboxylase, alpha polypeptide (PCCA) - coding DNA reference sequence

(used for variant description)

(last modified May 8, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000282.3 in the PCCA gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008768.1, covering PCCA transcript NM_000282.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.4978
               ggcatcgggtttctggctcgtgatttgccggagctcctgcgctccc       c.-61

 .         .         .         .         .         .                g.5038
 cttctccaccccctccggctgtgtgagaggtcagcagaggggcggtctgcggggacaaca       c.-1

          .         .         .         .         .         .       g.5098
 ATGGCGGGGTTCTGGGTCGGGACAGCACCGCTGGTCGCTGCCGGACGGCGTGGGCGGTGG       c.60
 M  A  G  F  W  V  G  T  A  P  L  V  A  A  G  R  R  G  R  W         p.20

          .         .         .         .      | 02  .         .    g.18815
 CCGCCGCAGCAGCTGATGCTGAGCGCGGCGCTGCGGACCCTGAAG | CATGTTCTGTACTAT    c.120
 P  P  Q  Q  L  M  L  S  A  A  L  R  T  L  K   | H  V  L  Y  Y      p.40

          .         .         .         .         .         .       g.18875
 TCAAGACAGTGCTTAATGGTGTCCCGTAATCTTGGTTCAGTGGGATATGATCCTAATGAA       c.180
 S  R  Q  C  L  M  V  S  R  N  L  G  S  V  G  Y  D  P  N  E         p.60

     | 03    .         .         .         .         .  | 04      . g.27919
 AAA | ACTTTTGATAAAATTCTTGTTGCTAATAGAGGAGAAATTGCATGTCGG | GTTATTAGA c.240
 K   | T  F  D  K  I  L  V  A  N  R  G  E  I  A  C  R   | V  I  R   p.80

          .         .         .         .         .         .       g.27979
 ACTTGCAAGAAGATGGGCATTAAGACAGTTGCCATCCACAGTGATGTTGATGCTAGTTCT       c.300
 T  C  K  K  M  G  I  K  T  V  A  I  H  S  D  V  D  A  S  S         p.100

  | 05       .         .         .         .         .         .    g.70956
  | GTTCATGTGAAAATGGCGGATGAGGCTGTCTGTGTTGGCCCAGCTCCCACCAGTAAAAGC    c.360
  | V  H  V  K  M  A  D  E  A  V  C  V  G  P  A  P  T  S  K  S      p.120

          .         .         .         .         .     | 06   .    g.73210
 TACCTCAACATGGATGCCATCATGGAAGCCATTAAGAAAACCAGGGCCCAAGCT | GTACAT    c.420
 Y  L  N  M  D  A  I  M  E  A  I  K  K  T  R  A  Q  A   | V  H      p.140

          .         .         .         .         | 07         .    g.125261
 CCAGGTTATGGATTCCTTTCAGAAAACAAAGAATTTGCCAGATGTTTG | GCAGCAGAAGAT    c.480
 P  G  Y  G  F  L  S  E  N  K  E  F  A  R  C  L   | A  A  E  D      p.160

          .         .         .         .         .         .       g.125321
 GTCGTTTTCATTGGACCTGACACACATGCTATTCAAGCCATGGGCGACAAGATTGAAAGC       c.540
 V  V  F  I  G  P  D  T  H  A  I  Q  A  M  G  D  K  I  E  S         p.180

          .         .         .         .         .         .       g.125381
 AAATTATTAGCTAAGAAAGCAGAGGTTAATACAATCCCTGGCTTTGATGGAGTAGTCAAG       c.600
 K  L  L  A  K  K  A  E  V  N  T  I  P  G  F  D  G  V  V  K         p.200

  | 08       .         .         .        | 09.         .         . g.173535
  | GATGCAGAAGAAGCTGTCAGAATTGCAAGGGAAATTG | GCTACCCTGTCATGATCAAGGCC c.660
  | D  A  E  E  A  V  R  I  A  R  E  I  G |   Y  P  V  M  I  K  A   p.220

          .         .         .         .         .       | 10 .    g.178650
 TCAGCAGGTGGTGGTGGGAAAGGCATGCGCATTGCTTGGGATGATGAAGAGACCAG | GGAT    c.720
 S  A  G  G  G  G  K  G  M  R  I  A  W  D  D  E  E  T  R  |  D      p.240

          .         .         .         .         .         .       g.178710
 GGTTTTAGATTGTCATCTCAAGAAGCTGCTTCTAGTTTTGGCGATGATAGACTACTAATA       c.780
 G  F  R  L  S  S  Q  E  A  A  S  S  F  G  D  D  R  L  L  I         p.260

          .         .         .          | 11        .         .    g.184627
 GAAAAATTTATTGATAATCCTCGTCATATAGAAATCCAG | GTTCTAGGTGATAAACATGGG    c.840
 E  K  F  I  D  N  P  R  H  I  E  I  Q   | V  L  G  D  K  H  G      p.280

          .         .         .         .         .         .       g.184687
 AATGCTTTATGGCTTAATGAAAGAGAGTGCTCAATTCAGAGAAGAAATCAGAAGGTGGTG       c.900
 N  A  L  W  L  N  E  R  E  C  S  I  Q  R  R  N  Q  K  V  V         p.300

          .     | 12   .         .         .         .         .    g.189159
 GAGGAAGCACCAAG | CATTTTTTTGGATGCGGAGACTCGAAGAGCGATGGGAGAACAAGCT    c.960
 E  E  A  P  S  |  I  F  L  D  A  E  T  R  R  A  M  G  E  Q  A      p.320

          .         .         .         .         .         .       g.189219
 GTAGCTCTTGCCAGAGCAGTAAAATATTCCTCTGCTGGGACCGTGGAGTTCCTTGTGGAC       c.1020
 V  A  L  A  R  A  V  K  Y  S  S  A  G  T  V  E  F  L  V  D         p.340

          .         .         .         .      | 13  .         .    g.217392
 TCTAAGAAGAATTTTTATTTCTTGGAAATGAATACAAGACTCCAG | GTTGAGCATCCTGTC    c.1080
 S  K  K  N  F  Y  F  L  E  M  N  T  R  L  Q   | V  E  H  P  V      p.360

          .         .         .         .         .         .       g.217452
 ACAGAATGCATTACTGGCCTGGACCTAGTCCAGGAAATGATCCGTGTTGCTAAGGGCTAC       c.1140
 T  E  C  I  T  G  L  D  L  V  Q  E  M  I  R  V  A  K  G  Y         p.380

          .         .         .         .         .         .       g.217512
 CCTCTCAGGCACAAACAAGCTGATATTCGCATCAACGGCTGGGCAGTTGAATGTCGGGTT       c.1200
 P  L  R  H  K  Q  A  D  I  R  I  N  G  W  A  V  E  C  R  V         p.400

           | 14        .         .         .         .         .    g.218892
 TATGCTGAG | GACCCCTACAAGTCTTTTGGTTTACCATCTATTGGGAGATTGTCTCAGTAC    c.1260
 Y  A  E   | D  P  Y  K  S  F  G  L  P  S  I  G  R  L  S  Q  Y      p.420

          .         .     | 15   .         .         .         .    g.223145
 CAAGAACCGTTACATCTACCTGGT | GTCCGAGTGGACAGTGGCATCCAACCAGGAAGTGAT    c.1320
 Q  E  P  L  H  L  P  G   | V  R  V  D  S  G  I  Q  P  G  S  D      p.440

          .         .         .    | 16    .         .         .    g.225777
 ATTAGCATTTATTATGATCCTATGATTTCAAAA | CTAATCACATATGGCTCTGATAGAACT    c.1380
 I  S  I  Y  Y  D  P  M  I  S  K   | L  I  T  Y  G  S  D  R  T      p.460

          .         .         .         .          | 17        .    g.246489
 GAGGCACTGAAGAGAATGGCAGATGCACTGGATAACTATGTTATTCGAG | GTGTTACACAT    c.1440
 E  A  L  K  R  M  A  D  A  L  D  N  Y  V  I  R  G |   V  T  H      p.480

          .         .         .         .         .         .       g.246549
 AATATTGCATTACTTCGAGAGGTGATAATCAACTCACGCTTTGTAAAAGGAGACATCAGC       c.1500
 N  I  A  L  L  R  E  V  I  I  N  S  R  F  V  K  G  D  I  S         p.500

          .         .         .         . | 18       .         .    g.256094
 ACTAAATTTCTCTCCGATGTGTATCCTGATGGCTTCAAAG | GACACATGCTAACCAAGAGT    c.1560
 T  K  F  L  S  D  V  Y  P  D  G  F  K  G |   H  M  L  T  K  S      p.520

          .         .         .         .         .         .       g.256154
 GAGAAGAACCAGTTATTGGCAATAGCATCATCATTGTTTGTGGCATTCCAGTTAAGAGCA       c.1620
 E  K  N  Q  L  L  A  I  A  S  S  L  F  V  A  F  Q  L  R  A         p.540

          .         .    | 19    .         .         .         .    g.284426
 CAACATTTTCAAGAAAATTCAAG | AATGCCTGTTATTAAACCAGACATAGCCAACTGGGAG    c.1680
 Q  H  F  Q  E  N  S  R  |  M  P  V  I  K  P  D  I  A  N  W  E      p.560

          .         .         .         .         .         .       g.284486
 CTCTCAGTAAAATTGCATGATAAAGTTCATACCGTAGTAGCATCAAACAATGGGTCAGTG       c.1740
 L  S  V  K  L  H  D  K  V  H  T  V  V  A  S  N  N  G  S  V         p.580

        | 20 .         .         .         .         .         .    g.341604
 TTCTCG | GTGGAAGTTGATGGGTCGAAACTAAATGTGACCAGCACGTGGAACCTGGCTTCG    c.1800
 F  S   | V  E  V  D  G  S  K  L  N  V  T  S  T  W  N  L  A  S      p.600

          .         .         .         .      | 21  .         .    g.365184
 CCCTTATTGTCTGTCAGCGTTGATGGCACTCAGAGGACTGTCCAG | TGTCTTTCTCGAGAA    c.1860
 P  L  L  S  V  S  V  D  G  T  Q  R  T  V  Q   | C  L  S  R  E      p.620

          .         .         .          | 22        .         .    g.431365
 GCAGGTGGAAACATGAGCATTCAGTTTCTTGGTACAGTG | TACAAGGTGAATATCTTAACC    c.1920
 A  G  G  N  M  S  I  Q  F  L  G  T  V   | Y  K  V  N  I  L  T      p.640

          .         .         .         .         .         .       g.431425
 AGACTTGCCGCAGAATTGAACAAATTTATGCTGGAAAAAGTGACTGAGGACACAAGCAGT       c.1980
 R  L  A  A  E  L  N  K  F  M  L  E  K  V  T  E  D  T  S  S         p.660

          .         .         .         .         .         .       g.431485
 GTTCTGCGTTCCCCGATGCCCGGAGTGGTGGTGGCCGTCTCTGTCAAGCCTGGAGACGCG       c.2040
 V  L  R  S  P  M  P  G  V  V  V  A  V  S  V  K  P  G  D  A         p.680

  | 23       .         .         .         .         .         .    g.443652
  | GTAGCAGAAGGTCAAGAAATTTGTGTGATTGAAGCCATGAAAATGCAGAATAGTATGACA    c.2100
  | V  A  E  G  Q  E  I  C  V  I  E  A  M  K  M  Q  N  S  M  T      p.700

          .         | 24         .         .         .         .    g.446057
 GCTGGGAAAACTGGCACG | GTGAAATCTGTGCACTGTCAAGCTGGAGACACAGTTGGAGAA    c.2160
 A  G  K  T  G  T   | V  K  S  V  H  C  Q  A  G  D  T  V  G  E      p.720

          .         .                                               g.446084
 GGGGATCTGCTCGTGGAGCTGGAATGA                                        c.2187
 G  D  L  L  V  E  L  E  X                                          p.728

          .         .         .         .         .         .       g.446144
 aggatttataacctttcagtcatcacccaatttaattagccatttgcatgatgctttcac       c.*60

          .         .         .         .         .         .       g.446204
 acacaattgattcaagcattatacaggaacacccctgtgcagctacgtttacgtcgtcat       c.*120

          .         .         .         .         .         .       g.446264
 ttattccacagagtcaagaccaatattctgccaaaaaatcaccaatggaaattttcattg       c.*180

          .         .         .         .         .         .       g.446324
 atataaatacttgtacatatgatttgtacttctgctgtgagattccctagtgtcaaaatt       c.*240

          .         .         .                                     g.446355
 aaatcaataaaactgagcatttgtctaaata                                    c.*271

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Propionyl CoA carboxylase, alpha polypeptide protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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