phosphoenolpyruvate carboxykinase 1 (soluble) (PCK1) - coding DNA reference sequence

(used for variant description)

(last modified January 26, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_002591.3 in the PCK1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008205.1, covering PCK1 transcript NM_002591.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5043
                  tttaaagctgggaggttctgccaccaagcacggccttcccact       c.-121

 .         .         .         .         .         .                g.5103
 gggaacacaaacttgctggcgggaagagcccggaaagaaacctgtggatctcccttcgag       c.-61

 .         .          | 02        .         .         .             g.5331
 atcatccaaagagaagaaag | gtgacctcacattcgtgccccttagcagcactctgcagaa    c.-1

          .         .         .         .         .         .       g.5391
 ATGCCTCCTCAGCTGCAAAACGGCCTGAACCTCTCGGCCAAAGTTGTCCAGGGAAGCCTG       c.60
 M  P  P  Q  L  Q  N  G  L  N  L  S  A  K  V  V  Q  G  S  L         p.20

          .         .         .         .         .         .       g.5451
 GACAGCCTACCCCAGGCAGTGAGGGAGTTTCTCGAGAATAACGCTGAGCTGTGTCAGCCT       c.120
 D  S  L  P  Q  A  V  R  E  F  L  E  N  N  A  E  L  C  Q  P         p.40

          .         .         .         .         .         .       g.5511
 GATCACATCCACATCTGTGACGGCTCTGAGGAGGAGAATGGGCGGCTTCTGGGCCAGATG       c.180
 D  H  I  H  I  C  D  G  S  E  E  E  N  G  R  L  L  G  Q  M         p.60

          .         .         .         .     | 03   .         .    g.6006
 GAGGAAGAGGGCATCCTCAGGCGGCTGAAGAAGTATGACAACTG | CTGGTTGGCTCTCACT    c.240
 E  E  E  G  I  L  R  R  L  K  K  Y  D  N  C  |  W  L  A  L  T      p.80

          .         .         .         .         .         .       g.6066
 GACCCCAGGGATGTGGCCAGGATCGAAAGCAAGACGGTTATCGTCACCCAAGAGCAAAGA       c.300
 D  P  R  D  V  A  R  I  E  S  K  T  V  I  V  T  Q  E  Q  R         p.100

          .         .         .         .         .         .       g.6126
 GACACAGTGCCCATCCCCAAAACAGGCCTCAGCCAGCTCGGTCGCTGGATGTCAGAGGAG       c.360
 D  T  V  P  I  P  K  T  G  L  S  Q  L  G  R  W  M  S  E  E         p.120

          .         .         .         .       | 04 .         .    g.6629
 GATTTTGAGAAAGCGTTCAATGCCAGGTTCCCAGGGTGCATGAAAG | GTCGCACCATGTAC    c.420
 D  F  E  K  A  F  N  A  R  F  P  G  C  M  K  G |   R  T  M  Y      p.140

          .         .         .         .         .         .       g.6689
 GTCATCCCATTCAGCATGGGGCCGCTGGGCTCGCCTCTGTCAAAGATCGGCATCGAGCTG       c.480
 V  I  P  F  S  M  G  P  L  G  S  P  L  S  K  I  G  I  E  L         p.160

          .         .         .         .         .         .       g.6749
 ACGGATTCACCCTACGTGGTGGCCAGCATGCGGATCATGACGCGGATGGGCACGCCCGTC       c.540
 T  D  S  P  Y  V  V  A  S  M  R  I  M  T  R  M  G  T  P  V         p.180

          .         .         .         .         .         .       g.6809
 CTGGAAGCAGTGGGCGATGGGGAGTTTGTCAAATGCCTCCATTCTGTGGGGTGCCCTCTG       c.600
 L  E  A  V  G  D  G  E  F  V  K  C  L  H  S  V  G  C  P  L         p.200

          . | 05       .         .         .         .         .    g.6997
 CCTTTACAAA | AGCCTTTGGTCAACAACTGGCCCTGCAACCCGGAGCTGACGCTCATCGCC    c.660
 P  L  Q  K |   P  L  V  N  N  W  P  C  N  P  E  L  T  L  I  A      p.220

          .         .         .         .         .         .       g.7057
 CACCTGCCTGACCGCAGAGAGATCATCTCCTTTGGCAGTGGGTACGGCGGGAACTCGCTG       c.720
 H  L  P  D  R  R  E  I  I  S  F  G  S  G  Y  G  G  N  S  L         p.240

          .         .         .         .         .         .       g.7117
 CTCGGGAAGAAGTGCTTTGCTCTCAGGATGGCCAGCCGGCTGGCCAAGGAGGAAGGGTGG       c.780
 L  G  K  K  C  F  A  L  R  M  A  S  R  L  A  K  E  E  G  W         p.260

          .         | 06         .         .         .         .    g.7526
 CTGGCAGAGCACATGCTG | ATTCTGGGTATAACCAACCCTGAGGGTGAGAAGAAGTACCTG    c.840
 L  A  E  H  M  L   | I  L  G  I  T  N  P  E  G  E  K  K  Y  L      p.280

          .         .         .         .         .         .       g.7586
 GCGGCCGCATTTCCCAGCGCCTGCGGGAAGACCAACCTGGCCATGATGAACCCCAGCCTC       c.900
 A  A  A  F  P  S  A  C  G  K  T  N  L  A  M  M  N  P  S  L         p.300

          .         .         .         .         .         .       g.7646
 CCCGGGTGGAAGGTTGAGTGCGTCGGGGATGACATTGCCTGGATGAAGTTTGACGCACAA       c.960
 P  G  W  K  V  E  C  V  G  D  D  I  A  W  M  K  F  D  A  Q         p.320

   | 07      .         .         .         .         .         .    g.8147
 G | GTCATTTAAGGGCCATCAACCCAGAAAATGGCTTTTTCGGTGTCGCTCCTGGGACTTCA    c.1020
 G |   H  L  R  A  I  N  P  E  N  G  F  F  G  V  A  P  G  T  S      p.340

          .         .         .         .         .         .       g.8207
 GTGAAGACCAACCCCAATGCCATCAAGACCATCCAGAAGAACACAATCTTTACCAATGTG       c.1080
 V  K  T  N  P  N  A  I  K  T  I  Q  K  N  T  I  F  T  N  V         p.360

          .         .         .         .         .         .       g.8267
 GCCGAGACCAGCGACGGGGGCGTTTACTGGGAAGGCATTGATGAGCCGCTAGCTTCAGGT       c.1140
 A  E  T  S  D  G  G  V  Y  W  E  G  I  D  E  P  L  A  S  G         p.380

          .         .         .         .       | 08 .         .    g.8415
 GTCACCATCACGTCCTGGAAGAATAAGGAGTGGAGCTCAGAGGATG | GGGAACCTTGTGCC    c.1200
 V  T  I  T  S  W  K  N  K  E  W  S  S  E  D  G |   E  P  C  A      p.400

          .         .         .         .         .         .       g.8475
 CACCCCAACTCGAGGTTCTGCACCCCTGCCAGCCAGTGCCCCATCATTGATGCTGCCTGG       c.1260
 H  P  N  S  R  F  C  T  P  A  S  Q  C  P  I  I  D  A  A  W         p.420

          .         .         .         .         .         | 09    g.8961
 GAGTCTCCGGAAGGTGTTCCCATTGAAGGCATTATCTTTGGAGGCCGTAGACCTGCTG | GT    c.1320
 E  S  P  E  G  V  P  I  E  G  I  I  F  G  G  R  R  P  A  G |       p.440

          .         .         .         .         .         .       g.9021
 GTCCCTCTAGTCTATGAAGCTCTCAGCTGGCAACATGGAGTCTTTGTGGGGGCGGCCATG       c.1380
 V  P  L  V  Y  E  A  L  S  W  Q  H  G  V  F  V  G  A  A  M         p.460

          .         .         .     | 10   .         .         .    g.9295
 AGATCAGAGGCCACAGCGGCTGCAGAACATAAAG | GCAAAATCATCATGCATGACCCCTTT    c.1440
 R  S  E  A  T  A  A  A  E  H  K  G |   K  I  I  M  H  D  P  F      p.480

          .         .         .         .         .         .       g.9355
 GCCATGCGGCCCTTCTTTGGCTACAACTTCGGCAAATACCTGGCCCACTGGCTTAGCATG       c.1500
 A  M  R  P  F  F  G  Y  N  F  G  K  Y  L  A  H  W  L  S  M         p.500

          .         .         .         .         .         .       g.9415
 GCCCAGCACCCAGCAGCCAAACTGCCCAAGATCTTCCATGTCAACTGGTTCCGGAAGGAC       c.1560
 A  Q  H  P  A  A  K  L  P  K  I  F  H  V  N  W  F  R  K  D         p.520

          .         .         .         .         .         .       g.9475
 AAGGAAGGCAAATTCCTCTGGCCAGGCTTTGGAGAGAACTCCAGGGTGCTGGAGTGGATG       c.1620
 K  E  G  K  F  L  W  P  G  F  G  E  N  S  R  V  L  E  W  M         p.540

          .         .         .         .         .         .       g.9535
 TTCAACCGGATCGATGGAAAAGCCAGCACCAAGCTCACGCCCATAGGCTACATCCCCAAG       c.1680
 F  N  R  I  D  G  K  A  S  T  K  L  T  P  I  G  Y  I  P  K         p.560

          .         .         .         .         .         .       g.9595
 GAGGATGCCCTGAACCTGAAAGGCCTGGGGCACATCAACATGATGGAGCTTTTCAGCATC       c.1740
 E  D  A  L  N  L  K  G  L  G  H  I  N  M  M  E  L  F  S  I         p.580

          .         .         .         .         .         .       g.9655
 TCCAAGGAATTCTGGGAGAAGGAGGTGGAAGACATCGAGAAGTATCTGGAGGATCAAGTC       c.1800
 S  K  E  F  W  E  K  E  V  E  D  I  E  K  Y  L  E  D  Q  V         p.600

          .         .         .         .         .         .       g.9715
 AATGCCGACCTCCCCTGTGAAATCGAGAGAGAGATCCTTGCCTTGAAGCAAAGAATAAGC       c.1860
 N  A  D  L  P  C  E  I  E  R  E  I  L  A  L  K  Q  R  I  S         p.620

                                                                    g.9724
 CAGATGTAA                                                          c.1869
 Q  M  X                                                            p.622

          .         .         .         .         .         .       g.9784
 tcagggcctgagtgctttacctttaaaatcattccctttcccatccataaggtgcagtag       c.*60

          .         .         .         .         .         .       g.9844
 gagcaagagagggcaagtgttcccaaattgacgccaccataataatcatcaccacaccgt       c.*120

          .         .         .         .         .         .       g.9904
 gagcagatctgaaaggcacactttgatttttttaaggataagaaccacagaacactgggt       c.*180

          .         .         .         .         .         .       g.9964
 agtagctaatgaaattgagaagggaaatcttagcatgcctccaaaaattcacatccaatg       c.*240

          .         .         .         .         .         .       g.10024
 catagtttgttcaaatttaaggttactcaggcattgatcttttcagtgttttttcacttt       c.*300

          .         .         .         .         .         .       g.10084
 agctatgtggattagctagaatgcacaccaaaaaaatacttgagctgtatatatatatgt       c.*360

          .         .         .         .         .         .       g.10144
 gtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgcatgtatgtgcacatgtgtctgtgtgg       c.*420

          .         .         .         .         .         .       g.10204
 tatatttgtgtatgtgtatttgtatgtactgttattgaaaatatatttaatacctttgga       c.*480

          .         .         .         .         .         .       g.10264
 aaaatcttgggcaagatgacctactagttttccttgaaaaaaagttgctttgttattaat       c.*540

          .         .         .         .         .         .       g.10324
 attgtgcttaaattatttttatacaccattgttccttacctttacataattgcaatattt       c.*600

          .         .         .         .         .                 g.10377
 cccccttactacttcttggaaaaaaattacaaaatgaagttttatagaaaaga              c.*653

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phosphoenolpyruvate carboxykinase 1 (soluble) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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