programmed cell death 10 (PDCD10) - coding DNA reference sequence

(used for variant description)

(last modified July 18, 2014)

This file was created to facilitate the description of sequence variants on transcript NM_007217.3 in the PDCD10 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008158.1, covering PDCD10 transcript NM_007217.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                               .         .         .                g.5095
                       ggtaaggtgtagctgttctgtcccagtccccgtagctc       c.-361

 .         .         .         .         .         .                g.5155
 tgcaccgagcagaagaggtctagggtcacgcaggggccatggctgaggcacttgggcttg       c.-301

 .         .         .         .         .       | 02 .             g.5526
 gttctggcaggcggagcggacggggctgagagcggggccctacgggc | ggaagaggagcac    c.-241

 .         .         .         .         .         .                g.5586
 tggaagaaggaagagacaaatgttggggtctacggattcagttccagtttaatgatgtgg       c.-181

 .         .         .         .         .         .                g.5646
 ccctctaaggagataattttgccttaaacagaaagacttgaccctcttaggtgtcatacc       c.-121

 .    | 03    .         .         .         .         .             g.19646
 taag | atcagtgtgttttttgtgtccaattcttttatcaccaaaaaagagaagaaatattg    c.-61

 .         .         .         .         .         .                g.19706
 cagtgaatgaagattcctctgcattttagcactgctttttcaactgtagttggcttttga       c.-1

          .         .         .         .         .         .       g.19766
 ATGAGGATGACAATGGAAGAGATGAAGAATGAAGCTGAGACCACATCCATGGTTTCTATG       c.60
 M  R  M  T  M  E  E  M  K  N  E  A  E  T  T  S  M  V  S  M         p.20

          .         .         .       | 04 .         .         .    g.34992
 CCCCTCTATGCAGTCATGTATCCTGTGTTTAATGAG | CTAGAACGAGTAAATCTGTCTGCA    c.120
 P  L  Y  A  V  M  Y  P  V  F  N  E   | L  E  R  V  N  L  S  A      p.40

          .         .         . | 05       .         .         .    g.42767
 GCCCAGACACTGAGAGCCGCTTTCATCAAG | GCTGAAAAAGAAAATCCAGGTCTCACACAA    c.180
 A  Q  T  L  R  A  A  F  I  K   | A  E  K  E  N  P  G  L  T  Q      p.60

          .         .         .         .         .         .       g.42827
 GACATCATTATGAAAATTTTAGAGAAAAAAAGCGTGGAAGTTAACTTCACGGAGTCCCTT       c.240
 D  I  I  M  K  I  L  E  K  K  S  V  E  V  N  F  T  E  S  L         p.80

          .         .         | 06         .         .         .    g.44173
 CTTCGTATGGCAGCTGATGATGTAGAAG | AGTATATGATTGAACGACCAGAGCCAGAATTC    c.300
 L  R  M  A  A  D  D  V  E  E |   Y  M  I  E  R  P  E  P  E  F      p.100

          .         .         .         .         .         .       g.44233
 CAAGACCTAAACGAAAAGGCACGAGCACTTAAACAAATTCTCAGTAAGATCCCAGATGAG       c.360
 Q  D  L  N  E  K  A  R  A  L  K  Q  I  L  S  K  I  P  D  E         p.120

          .         .         .      | 07  .         .         .    g.52195
 ATCAATGACAGAGTGAGGTTTCTGCAGACAATCAA | GGATATAGCTAGTGCAATAAAAGAA    c.420
 I  N  D  R  V  R  F  L  Q  T  I  K  |  D  I  A  S  A  I  K  E      p.140

          .         .         .         .         .     | 08   .    g.52553
 CTTCTTGATACAGTGAATAATGTCTTCAAGAAATATCAATACCAGAACCGCAGG | GCACTT    c.480
 L  L  D  T  V  N  N  V  F  K  K  Y  Q  Y  Q  N  R  R   | A  L      p.160

          .         .         .         .         .         .       g.52613
 GAACACCAAAAGAAAGAATTTGTAAAGTACTCCAAAAGTTTCAGTGATACTCTGAAAACG       c.540
 E  H  Q  K  K  E  F  V  K  Y  S  K  S  F  S  D  T  L  K  T         p.180

          .        | 09.         .         .         .         .    g.55517
 TATTTTAAAGATGGCAA | GGCAATAAATGTGTTCGTAAGTGCCAACCGACTAATTCATCAA    c.600
 Y  F  K  D  G  K  |  A  I  N  V  F  V  S  A  N  R  L  I  H  Q      p.200

          .         .         .                                     g.55556
 ACCAACTTAATACTTCAGACCTTCAAAACTGTGGCCTGA                            c.639
 T  N  L  I  L  Q  T  F  K  T  V  A  X                              p.212

          .         .         .         .         .         .       g.55616
 aagttgtatatgttaagagatgtacttctcagtggcagtattgaactgcctttatctgta       c.*60

          .         .         .         .         .         .       g.55676
 aattttaaagtttgactgtataaattatcagtccctcctgaagggatctaatccaggatg       c.*120

          .         .         .         .         .         .       g.55736
 ttgaatgggattattgccatcttacaccatatttttgtaaaatgtagcttaatcataatc       c.*180

          .         .         .         .         .         .       g.55796
 tcacactgaagattttgcatcacttttgctattatcattcttttaagaattataagccaa       c.*240

          .         .         .         .         .         .       g.55856
 aagaatttacgccttaatgtgtcattatataacattccttaaaagaattgtaaatattgg       c.*300

          .         .         .         .         .         .       g.55916
 tgtttgtttctgacattttaacttgaaagcgatatgctgcaagataatgtatttaacaat       c.*360

          .         .         .         .                           g.55958
 atttggtggcaaatattcaataaatagtttacatctgttaaa                         c.*402

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Programmed cell death 10 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.