phosphodiesterase 2A, cGMP-stimulated (PDE2A) - coding DNA reference sequence

(used for variant description)

(last modified September 10, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_002599.4 in the PDE2A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering PDE2A transcript NM_002599.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5006
                                                       tgcatt       c.-241

 .         .         .         .         .         .                g.5066
 atcagacctgctccaacctcctcccagagccagccgagcagcagaggcagtggcagcggg       c.-181

 .         .         .         .         .         .                g.5126
 agaggcgggagcagcggggcagcagagctggattggggtgttgagtccaggctgagtagg       c.-121

 .         .         .         .         .         .                g.5186
 gggcagcccactgctcttggtccctgtgcctgctgggggtgccctgccctgaactccagg       c.-61

 .         .         .         .         .         .                g.5246
 cagcggggacagggcgaggtgccaccttagtctggctggggaggcggacgatgaggagtg       c.-1

          .         .         .         .         .         .       g.5306
 ATGGGGCAGGCATGCGGCCACTCCATCCTCTGCAGGAGCCAGCAGTACCCGGCAGCGCGA       c.60
 M  G  Q  A  C  G  H  S  I  L  C  R  S  Q  Q  Y  P  A  A  R         p.20

          .  | 02      .         .         .         .         .    g.37176
 CCGGCTGAGCC | GCGGGGCCAGCAGGTCTTCCTCAAGCCGGACGAGCCGCCGCCGCCGCCG    c.120
 P  A  E  P  |  R  G  Q  Q  V  F  L  K  P  D  E  P  P  P  P  P      p.40

          .         .     | 03   .         .         .         .    g.70738
 CAGCCATGCGCCGACAGCCTGCAG | GACGCCTTGCTGAGTCTGGGCTCTGTCATCGACATT    c.180
 Q  P  C  A  D  S  L  Q   | D  A  L  L  S  L  G  S  V  I  D  I      p.60

          .         .         .         .         .     | 04   .    g.74233
 TCAGGCCTGCAACGTGCTGTCAAGGAGGCCCTGTCAGCTGTGCTCCCCCGAGTG | GAAACT    c.240
 S  G  L  Q  R  A  V  K  E  A  L  S  A  V  L  P  R  V   | E  T      p.80

          .         .         .         .         .         .       g.74293
 GTCTACACCTACCTACTGGATGGTGAGTCCCAGCTGGTGTGTGAGGACCCCCCACATGAG       c.300
 V  Y  T  Y  L  L  D  G  E  S  Q  L  V  C  E  D  P  P  H  E         p.100

          .         .    | 05    .         .         .         .    g.81871
 CTGCCCCAGGAGGGGAAAGTCCG | GGAGGCTATCATCTCCCAGAAGCGGCTGGGCTGCAAT    c.360
 L  P  Q  E  G  K  V  R  |  E  A  I  I  S  Q  K  R  L  G  C  N      p.120

          .         .         .         .         .         .       g.81931
 GGGCTGGGCTTCTCAGACCTGCCAGGGAAGCCCTTGGCCAGGCTGGTGGCTCCACTGGCT       c.420
 G  L  G  F  S  D  L  P  G  K  P  L  A  R  L  V  A  P  L  A         p.140

          .    | 06    .         .         .         .         .    g.82852
 CCTGATACCCAAG | TGCTGGTCATGCCGCTAGCGGACAAGGAGGCTGGGGCCGTGGCAGCT    c.480
 P  D  T  Q  V |   L  V  M  P  L  A  D  K  E  A  G  A  V  A  A      p.160

           | 07        .         .         .         .         .    g.88148
 GTCATCTTG | GTGCACTGTGGCCAGCTGAGTGATAATGAGGAATGGAGCCTGCAGGCGGTG    c.540
 V  I  L   | V  H  C  G  Q  L  S  D  N  E  E  W  S  L  Q  A  V      p.180

           | 08        .         .         .         .         .    g.88924
 GAGAAGCAT | ACCCTGGTCGCCCTGCGGAGGGTGCAGGTCCTGCAGCAGCGCGGGCCCAGG    c.600
 E  K  H   | T  L  V  A  L  R  R  V  Q  V  L  Q  Q  R  G  P  R      p.200

          .         .         .         .         .         .       g.88984
 GAGGCTCCCCGAGCCGTCCAGAACCCCCCGGAGGGGACGGCGGAAGACCAGAAGGGCGGG       c.660
 E  A  P  R  A  V  Q  N  P  P  E  G  T  A  E  D  Q  K  G  G         p.220

          .         .         .         .    | 09    .         .    g.89226
 GCGGCGTACACCGACCGCGACCGCAAGATCCTCCAACTGTGCG | GGGAACTCTACGACCTG    c.720
 A  A  Y  T  D  R  D  R  K  I  L  Q  L  C  G |   E  L  Y  D  L      p.240

          .         .         .       | 10 .         .         .    g.89496
 GATGCCTCTTCCCTGCAGCTCAAAGTGCTCCAATAC | CTGCAGCAGGAGACCCGGGCATCC    c.780
 D  A  S  S  L  Q  L  K  V  L  Q  Y   | L  Q  Q  E  T  R  A  S      p.260

          .         .         .         .         .  | 11      .    g.89670
 CGCTGCTGCCTCCTGCTGGTGTCGGAGGACAATCTCCAGCTTTCTTGCAAG | GTCATCGGA    c.840
 R  C  C  L  L  L  V  S  E  D  N  L  Q  L  S  C  K   | V  I  G      p.280

          .         .         .    | 12    .         .         .    g.90240
 GACAAAGTGCTCGGGGAAGAGGTCAGCTTTCCC | TTGACAGGATGCCTGGGCCAGGTGGTG    c.900
 D  K  V  L  G  E  E  V  S  F  P   | L  T  G  C  L  G  Q  V  V      p.300

          .         .         .          | 13        .         .    g.90560
 GAAGACAAGAAGTCCATCCAGCTGAAGGACCTCACCTCC | GAGGATGTACAACAGCTGCAG    c.960
 E  D  K  K  S  I  Q  L  K  D  L  T  S   | E  D  V  Q  Q  L  Q      p.320

          .         .         .         .         .         .       g.90620
 AGCATGTTGGGCTGTGAGCTGCAGGCCATGCTCTGTGTCCCTGTCATCAGCCGGGCCACT       c.1020
 S  M  L  G  C  E  L  Q  A  M  L  C  V  P  V  I  S  R  A  T         p.340

          .         .         .         .         . | 14       .    g.93282
 GACCAGGTGGTGGCCTTGGCCTGCGCCTTCAACAAGCTAGAAGGAGACTT | GTTCACCGAC    c.1080
 D  Q  V  V  A  L  A  C  A  F  N  K  L  E  G  D  L  |  F  T  D      p.360

          .         .         .         .         .         .       g.93342
 GAGGACGAGCATGTGATCCAGCACTGCTTCCACTACACCAGCACCGTGCTCACCAGCACC       c.1140
 E  D  E  H  V  I  Q  H  C  F  H  Y  T  S  T  V  L  T  S  T         p.380

          .         .         .         .   | 15     .         .    g.93878
 CTGGCCTTCCAGAAGGAACAGAAACTCAAGTGTGAGTGCCAG | GCTCTTCTCCAAGTGGCA    c.1200
 L  A  F  Q  K  E  Q  K  L  K  C  E  C  Q   | A  L  L  Q  V  A      p.400

          .         .   | 16     .         .         .         .    g.94057
 AAGAACCTCTTCACCCACCTGG | ATGACGTCTCTGTCCTGCTCCAGGAGATCATCACGGAG    c.1260
 K  N  L  F  T  H  L  D |   D  V  S  V  L  L  Q  E  I  I  T  E      p.420

          .         .       | 17 .         .         .         .    g.94543
 GCCAGAAACCTCAGCAACGCAGAGAT | CTGCTCTGTGTTCCTGCTGGATCAGAATGAGCTG    c.1320
 A  R  N  L  S  N  A  E  I  |  C  S  V  F  L  L  D  Q  N  E  L      p.440

          .         .         .          | 18        .         .    g.94746
 GTGGCCAAGGTGTTCGACGGGGGCGTGGTGGATGATGAG | AGCTATGAGATCCGCATCCCG    c.1380
 V  A  K  V  F  D  G  G  V  V  D  D  E   | S  Y  E  I  R  I  P      p.460

          .         .         .         .         .         .       g.94806
 GCCGATCAGGGCATCGCGGGACACGTGGCGACCACGGGCCAGATCCTGAACATCCCTGAC       c.1440
 A  D  Q  G  I  A  G  H  V  A  T  T  G  Q  I  L  N  I  P  D         p.480

          .         .         .         .         .         .       g.94866
 GCATATGCCCATCCGCTTTTCTACCGCGGCGTGGACGACAGCACCGGCTTCCGCACGCGC       c.1500
 A  Y  A  H  P  L  F  Y  R  G  V  D  D  S  T  G  F  R  T  R         p.500

          .         .         .        | 19.         .         .    g.95163
 AACATCCTCTGCTTCCCCATCAAGAACGAGAACCAGG | AGGTCATCGGTGTGGCCGAGCTG    c.1560
 N  I  L  C  F  P  I  K  N  E  N  Q  E |   V  I  G  V  A  E  L      p.520

          .         .         .         .         .         .       g.95223
 GTGAACAAGATCAATGGGCCATGGTTCAGCAAGTTCGACGAGGACCTGGCGACGGCCTTC       c.1620
 V  N  K  I  N  G  P  W  F  S  K  F  D  E  D  L  A  T  A  F         p.540

          .         .         . | 20       .         .         .    g.95968
 TCCATCTACTGCGGCATCAGCATCGCCCAT | TCTCTCCTATACAAAAAAGTGAATGAGGCT    c.1680
 S  I  Y  C  G  I  S  I  A  H   | S  L  L  Y  K  K  V  N  E  A      p.560

          .         .         .         .         | 21         .    g.96899
 CAGTATCGCAGCCACCTGGCCAATGAGATGATGATGTACCACATGAAG | GTCTCCGATGAT    c.1740
 Q  Y  R  S  H  L  A  N  E  M  M  M  Y  H  M  K   | V  S  D  D      p.580

          .         .         .         .         .         .       g.96959
 GAGTATACCAAACTTCTCCATGATGGGATCCAGCCTGTGGCTGCCATTGACTCCAATTTT       c.1800
 E  Y  T  K  L  L  H  D  G  I  Q  P  V  A  A  I  D  S  N  F         p.600

          .         .         .         .         .  | 22      .    g.97515
 GCAAGTTTCACCTATACCCCTCGTTCCCTGCCCGAGGATGACACGTCCATG | GCCATCCTG    c.1860
 A  S  F  T  Y  T  P  R  S  L  P  E  D  D  T  S  M   | A  I  L      p.620

          .         .         .         .         .         .       g.97575
 AGCATGCTGCAGGACATGAATTTCATCAACAACTACAAAATTGACTGCCCGACCCTGGCC       c.1920
 S  M  L  Q  D  M  N  F  I  N  N  Y  K  I  D  C  P  T  L  A         p.640

    | 23     .         .         .         .         .         .    g.98032
 CG | GTTCTGTTTGATGGTGAAGAAGGGCTACCGGGATCCCCCCTACCACAACTGGATGCAC    c.1980
 R  |  F  C  L  M  V  K  K  G  Y  R  D  P  P  Y  H  N  W  M  H      p.660

          .         .         .         .         .         .       g.98092
 GCCTTTTCTGTCTCCCACTTCTGCTACCTGCTCTACAAGAACCTGGAGCTCACCAACTAC       c.2040
 A  F  S  V  S  H  F  C  Y  L  L  Y  K  N  L  E  L  T  N  Y         p.680

       | 24  .         .         .         .         .         .    g.98535
 CTCGA | GGACATCGAGATCTTTGCCTTGTTTATTTCCTGCATGTGTCATGACCTGGACCAC    c.2100
 L  E  |  D  I  E  I  F  A  L  F  I  S  C  M  C  H  D  L  D  H      p.700

          .         .         .    | 25    .         .         .    g.98856
 AGAGGCACAAACAACTCTTTCCAGGTGGCCTCG | AAATCTGTGCTGGCTGCGCTCTACAGC    c.2160
 R  G  T  N  N  S  F  Q  V  A  S   | K  S  V  L  A  A  L  Y  S      p.720

          .         .  | 26      .         .         .         .    g.99884
 TCTGAGGGCTCCGTCATGGAG | AGGCACCACTTTGCTCAGGCCATCGCCATCCTCAACACC    c.2220
 S  E  G  S  V  M  E   | R  H  H  F  A  Q  A  I  A  I  L  N  T      p.740

          .         .         .       | 27 .         .         .    g.100094
 CACGGCTGCAACATCTTTGATCATTTCTCCCGGAAG | GACTATCAGCGCATGCTGGATCTG    c.2280
 H  G  C  N  I  F  D  H  F  S  R  K   | D  Y  Q  R  M  L  D  L      p.760

          .         .         .         .         .         .       g.100154
 ATGCGGGACATCATCTTGGCCACAGACCTGGCCCACCATCTCCGCATCTTCAAGGACCTC       c.2340
 M  R  D  I  I  L  A  T  D  L  A  H  H  L  R  I  F  K  D  L         p.780

          .       | 28 .         .         .         .         .    g.100488
 CAGAAGATGGCTGAGG | TGGGCTACGACCGAAACAACAAGCAGCACCACAGACTTCTCCTC    c.2400
 Q  K  M  A  E  V |   G  Y  D  R  N  N  K  Q  H  H  R  L  L  L      p.800

          .         .         .         .         .         .       g.100548
 TGCCTCCTCATGACCTCCTGTGACCTCTCTGACCAGACCAAGGGCTGGAAGACTACGAGA       c.2460
 C  L  L  M  T  S  C  D  L  S  D  Q  T  K  G  W  K  T  T  R         p.820

           | 29        .         .         .         | 30         . g.101126
 AAGATCGCG | GAGCTGATCTACAAAGAATTCTTCTCCCAGGGAGACCTG | GAGAAGGCCATG c.2520
 K  I  A   | E  L  I  Y  K  E  F  F  S  Q  G  D  L   | E  K  A  M   p.840

          .         .         .         .         .         .       g.101186
 GGCAACAGGCCGATGGAGATGATGGACCGGGAGAAGGCCTATATCCCTGAGCTGCAAATC       c.2580
 G  N  R  P  M  E  M  M  D  R  E  K  A  Y  I  P  E  L  Q  I         p.860

          .         .         .      | 31  .         .         .    g.101884
 AGCTTCATGGAGCACATTGCAATGCCCATCTACAA | GCTGTTGCAGGACCTGTTCCCCAAA    c.2640
 S  F  M  E  H  I  A  M  P  I  Y  K  |  L  L  Q  D  L  F  P  K      p.880

          .         .         .         .         .         .       g.101944
 GCGGCAGAGCTGTACGAGCGCGTGGCCTCCAACCGTGAGCACTGGACCAAGGTGTCCCAC       c.2700
 A  A  E  L  Y  E  R  V  A  S  N  R  E  H  W  T  K  V  S  H         p.900

          .         .         .         .         .         .       g.102004
 AAGTTCACCATCCGCGGCCTCCCAAGTAACAACTCGCTGGACTTCCTGGATGAGGAGTAC       c.2760
 K  F  T  I  R  G  L  P  S  N  N  S  L  D  F  L  D  E  E  Y         p.920

          .         .         .         .         .         .       g.102064
 GAGGTGCCTGATCTGGATGGCACTAGGGCCCCCATCAATGGCTGCTGCAGCCTTGATGCT       c.2820
 E  V  P  D  L  D  G  T  R  A  P  I  N  G  C  C  S  L  D  A         p.940

                                                                    g.102070
 GAGTGA                                                             c.2826
 E  X                                                               p.941

          .         .         .         .         .         .       g.102130
 tcccctccagggacacttccctgcccaggccacctcccacagccctccactggtctggcc       c.*60

          .         .         .         .         .         .       g.102190
 agatgcactgggaacagagccacgggtcctgggtcctagaccaggacttcctgtgtgacc       c.*120

          .         .         .         .         .         .       g.102250
 ctggacaagtactaccttcctgggcctcagctttctcgtctgtataatggaagcaagact       c.*180

          .         .         .         .         .         .       g.102310
 tccaacctcacggagactttgtaatttgttttctgagagcacaggggtgaccaatgagca       c.*240

          .         .         .         .         .         .       g.102370
 gtgggccctactctgcacctctgaccacaccttggcaagtctttcccaagccattctttg       c.*300

          .         .         .         .         .         .       g.102430
 tctgagcagcttgatggtttctccttgccccatttctgccccaccagatctttgctcctt       c.*360

          .         .         .         .         .         .       g.102490
 tccctttgaggactcccaccctttggggtctccaggatcctcatggaaggggaaggtgag       c.*420

          .         .         .         .         .         .       g.102550
 acatctgagtgagcagagtgtggcatcttggaaacagtccttagttctgtgggaggacta       c.*480

          .         .         .         .         .         .       g.102610
 gaaacagccgcggggcgaaggccccctgaggaccactactatactgatggtgggattggg       c.*540

          .         .         .         .         .         .       g.102670
 acctgggggatacaggggccccaggaagaagctgccagaggggcagctcagtgctctgca       c.*600

          .         .         .         .         .         .       g.102730
 gagaggggccctggggagaagcaggatgggattgatgggcaggagggatccccgcactgg       c.*660

          .         .         .         .         .         .       g.102790
 gagacaggcccaggtatgaatgagccagccatgcttcctcctgcctgtgtgacgctgggc       c.*720

          .         .         .         .         .         .       g.102850
 gagtctcttcccctgtctgggccaaacagggagcgggtaagacaatccatgctctaagat       c.*780

          .         .         .         .         .         .       g.102910
 ccattttagatcaatgtctaaaatagctctatcgctctgcggagtcccagcagaggctat       c.*840

          .         .         .         .         .         .       g.102970
 ggaatgtttctgcaaccctaaggcacagagagcccaaccctgagtgtctcagaggccccc       c.*900

          .         .         .         .         .         .       g.103030
 tgagtgttccccttggcctgagccccttacccattcctgcagccagtgagagacctggcc       c.*960

          .         .         .         .         .         .       g.103090
 tcagccctggcagggctctctcttcaaggccatatccacctgtgccctggggcttgggag       c.*1020

          .         .         .         .         .         .       g.103150
 accccatagggccgggactcttgggtcagcccggccactggcttctctctttttctctgt       c.*1080

          .         .         .         .         .         .       g.103210
 ttcattctgtgtgcgttgtggggtgggggagggggtccacctgccttacctttctgagtt       c.*1140

          .         .         .         .         .         .       g.103270
 gcctttagagagatgcgtttttctaggactctgtgcaactgtcgtatatggtcccgtggg       c.*1200

          .         .         .         .                           g.103314
 ctgaccgctttgtacatgagaataaatctatttctttctaccag                       c.*1244

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phosphodiesterase 2A, cGMP-stimulated protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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