phosphodiesterase 6A, cGMP-specific, rod, alpha (PDE6A) - coding DNA reference sequence

(used for variant description)

(last modified February 4, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000440.2 in the PDE6A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009102.1, covering PDE6A transcript NM_000440.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
 .         .         .         .         .         .                g.5060
 agtatgttttgcagacaagacccagagaagtccagactggacttgttgcagactgcaaaa       c.-61

 .         .         .         .         .         .                g.5120
 ctgccattggaaggcctccgtcccagtccttctacagagtagccagtgggattcccagcc       c.-1

          .         .         .         .         .         .       g.5180
 ATGGGCGAGGTGACAGCAGAGGAGGTGGAGAAGTTCCTGGACTCGAATATTGGCTTTGCC       c.60
 M  G  E  V  T  A  E  E  V  E  K  F  L  D  S  N  I  G  F  A         p.20

          .         .         .         .         .         .       g.5240
 AAACAGTACTACAACCTCCACTACCGGGCCAAGCTCATCTCCGACCTCCTTGGGGCCAAG       c.120
 K  Q  Y  Y  N  L  H  Y  R  A  K  L  I  S  D  L  L  G  A  K         p.40

          .         .         .         .         .         .       g.5300
 GAGGCTGCCGTGGACTTCAGCAACTACCACTCCCCGAGCAGCATGGAGGAGAGCGAAATC       c.180
 E  A  A  V  D  F  S  N  Y  H  S  P  S  S  M  E  E  S  E  I         p.60

          .         .         .         .         .         .       g.5360
 ATCTTTGATCTCCTGCGGGACTTTCAGGAGAATTTACAGACAGAGAAATGCATCTTCAAT       c.240
 I  F  D  L  L  R  D  F  Q  E  N  L  Q  T  E  K  C  I  F  N         p.80

          .         .         .         .         .         .       g.5420
 GTCATGAAGAAGCTGTGCTTCCTCCTGCAGGCAGACCGCATGAGCCTGTTCATGTACCGG       c.300
 V  M  K  K  L  C  F  L  L  Q  A  D  R  M  S  L  F  M  Y  R         p.100

          .         .         .         .         .         .       g.5480
 ACCCGCAATGGCATCGCAGAGCTGGCCACCAGGCTTTTCAATGTCCACAAGGATGCTGTC       c.360
 T  R  N  G  I  A  E  L  A  T  R  L  F  N  V  H  K  D  A  V         p.120

          .         .         .         .         .         .       g.5540
 CTCGAGGACTGCCTGGTGATGCCCGACCAAGAGATCGTCTTCCCTTTGGACATGGGCATC       c.420
 L  E  D  C  L  V  M  P  D  Q  E  I  V  F  P  L  D  M  G  I         p.140

          .         .         .         .         .     | 02   .    g.15081
 GTGGGCCATGTCGCACACTCTAAGAAGATTGCTAACGTCCCCAACACAGAGGAG | GATGAG    c.480
 V  G  H  V  A  H  S  K  K  I  A  N  V  P  N  T  E  E   | D  E      p.160

          .         .         .         .         .         .       g.15141
 CATTTCTGTGACTTTGTGGACATCCTCACAGAGTACAAGACCAAGAACATCTTGGCTTCC       c.540
 H  F  C  D  F  V  D  I  L  T  E  Y  K  T  K  N  I  L  A  S         p.180

          .         .         .         .         .         .       g.15201
 CCCATAATGAATGGGAAGGATGTGGTGGCCATAATCATGGCTGTGAATAAAGTGGATGGA       c.600
 P  I  M  N  G  K  D  V  V  A  I  I  M  A  V  N  K  V  D  G         p.200

          .         .        | 03.         .         .         .    g.15807
 TCCCACTTCACCAAGAGAGATGAAGAG | ATTCTTCTCAAGTACCTCAATTTTGCAAATCTA    c.660
 S  H  F  T  K  R  D  E  E   | I  L  L  K  Y  L  N  F  A  N  L      p.220

          .         .         .         .         .        | 04.    g.18628
 ATCATGAAGGTGTACCACCTGAGTTACCTGCACAACTGTGAAACTCGACGTGGCCAG | ATA    c.720
 I  M  K  V  Y  H  L  S  Y  L  H  N  C  E  T  R  R  G  Q   | I      p.240

          .         .         .         .         .         .       g.18688
 CTGCTGTGGTCTGGGAGCAAAGTCTTTGAAGAACTTACGGACATCGAACGACAGTTCCAC       c.780
 L  L  W  S  G  S  K  V  F  E  E  L  T  D  I  E  R  Q  F  H         p.260

          .         .         .         .         .         .       g.18748
 AAAGCCCTGTACACAGTCCGTGCTTTCCTCAACTGTGACAGATACTCTGTGGGTCTCTTA       c.840
 K  A  L  Y  T  V  R  A  F  L  N  C  D  R  Y  S  V  G  L  L         p.280

          .         | 05         .         .         .         .    g.28126
 GACATGACCAAGCAGAAG | GAATTTTTTGATGTGTGGCCGGTTCTGATGGGTGAAGTTCCA    c.900
 D  M  T  K  Q  K   | E  F  F  D  V  W  P  V  L  M  G  E  V  P      p.300

          .         .         .    | 06    .         .         .    g.34813
 CCTTACTCTGGTCCCAGGACTCCGGATGGAAGA | GAAATTAACTTTTACAAGGTCATTGAC    c.960
 P  Y  S  G  P  R  T  P  D  G  R   | E  I  N  F  Y  K  V  I  D      p.320

          .         .         .         | 07         .         .    g.42437
 TACATCCTGCATGGCAAAGAGGACATCAAAGTCATCCC | GAATCCACCTCCTGACCATTGG    c.1020
 Y  I  L  H  G  K  E  D  I  K  V  I  P  |  N  P  P  P  D  H  W      p.340

          .         .         .         .      | 08  .         .    g.46113
 GCTTTAGTAAGCGGTCTCCCAGCTTATGTTGCCCAGAATGGCCTG | ATTTGCAACATCATG    c.1080
 A  L  V  S  G  L  P  A  Y  V  A  Q  N  G  L   | I  C  N  I  M      p.360

          .         .         .    | 09    .         .         .    g.50296
 AATGCGCCTGCGGAGGACTTTTTTGCATTTCAG | AAAGAACCTCTGGATGAGTCTGGATGG    c.1140
 N  A  P  A  E  D  F  F  A  F  Q   | K  E  P  L  D  E  S  G  W      p.380

          .         .         .         .         .         .       g.50356
 ATGATTAAAAATGTGCTTTCAATGCCGATTGTGAACAAGAAGGAAGAAATTGTTGGAGTG       c.1200
 M  I  K  N  V  L  S  M  P  I  V  N  K  K  E  E  I  V  G  V         p.400

          .         .         .         .         .         .       g.50416
 GCCACATTTTACAATCGTAAAGATGGGAAGCCCTTTGATGAAATGGATGAGACGCTCATG       c.1260
 A  T  F  Y  N  R  K  D  G  K  P  F  D  E  M  D  E  T  L  M         p.420

     | 10    .         .         .         .         .         .    g.51344
 GAG | TCTTTGACTCAATTTCTGGGCTGGTCTGTCTTAAATCCTGACACCTATGAGTCAATG    c.1320
 E   | S  L  T  Q  F  L  G  W  S  V  L  N  P  D  T  Y  E  S  M      p.440

          .         .         .         .         .         .       g.51404
 AATAAACTTGAAAATAGGAAGGATATTTTCCAGGACATAGTAAAATATCATGTGAAGTGT       c.1380
 N  K  L  E  N  R  K  D  I  F  Q  D  I  V  K  Y  H  V  K  C         p.460

          .         .        | 11.         .         .         .    g.53050
 GACAATGAAGAAATTCAGAAAATCTTG | AAAACCAGAGAGGTGTATGGGAAGGAGCCATGG    c.1440
 D  N  E  E  I  Q  K  I  L   | K  T  R  E  V  Y  G  K  E  P  W      p.480

          .         .         .    | 12    .         .         .    g.53318
 GAGTGTGAGGAAGAGGAGCTGGCTGAGATCCTG | CAAGCGGAGCTGCCAGATGCAGATAAA    c.1500
 E  C  E  E  E  E  L  A  E  I  L   | Q  A  E  L  P  D  A  D  K      p.500

          .         .         .         .         .         .       g.53378
 TACGAAATTAATAAATTTCACTTCAGTGACTTACCCCTAACAGAACTGGAGCTGGTAAAA       c.1560
 Y  E  I  N  K  F  H  F  S  D  L  P  L  T  E  L  E  L  V  K         p.520

          .         .         .         .         .         .       g.53438
 TGTGGAATACAGATGTATTATGAGCTCAAAGTGGTGGATAAATTTCACATTCCACAAGAG       c.1620
 C  G  I  Q  M  Y  Y  E  L  K  V  V  D  K  F  H  I  P  Q  E         p.540

  | 13       .         .         .         .         .         .    g.54563
  | GCCCTGGTGCGGTTCATGTACTCCCTGAGTAAGGGCTACCGCAAGATCACCTACCACAAC    c.1680
  | A  L  V  R  F  M  Y  S  L  S  K  G  Y  R  K  I  T  Y  H  N      p.560

          .         .         .         .         | 14         .    g.63431
 TGGCGGCACGGCTTCAACGTGGGGCAGACCATGTTCTCCCTGCTGGTG | ACGGGAAAGCTG    c.1740
 W  R  H  G  F  N  V  G  Q  T  M  F  S  L  L  V   | T  G  K  L      p.580

          .         .         .         .         .         .       g.63491
 AAGCGCTACTTCACGGACCTAGAGGCCTTGGCCATGGTCACTGCTGCTTTCTGCCATGAC       c.1800
 K  R  Y  F  T  D  L  E  A  L  A  M  V  T  A  A  F  C  H  D         p.600

          .         .         .         | 15         .         .    g.64948
 ATTGACCACAGAGGCACCAATAACCTCTACCAGATGAA | ATCCCAGAACCCACTGGCCAAG    c.1860
 I  D  H  R  G  T  N  N  L  Y  Q  M  K  |  S  Q  N  P  L  A  K      p.620

          .         .         .         .         .         .       g.65008
 CTCCATGGGTCCTCTATCTTGGAAAGACACCACTTGGAGTTTGGCAAAACACTGCTCAGA       c.1920
 L  H  G  S  S  I  L  E  R  H  H  L  E  F  G  K  T  L  L  R         p.640

        | 16 .         .         .         .         .         .    g.65268
 GACGAG | AGCCTGAATATCTTTCAAAACCTCAATCGTCGACAGCATGAGCATGCCATCCAC    c.1980
 D  E   | S  L  N  I  F  Q  N  L  N  R  R  Q  H  E  H  A  I  H      p.660

          .         .         .         .        | 17.         .    g.66270
 ATGATGGACATTGCAATCATTGCCACAGACCTCGCCCTGTATTTCAA | GAAGAGGACGATG    c.2040
 M  M  D  I  A  I  I  A  T  D  L  A  L  Y  F  K  |  K  R  T  M      p.680

          .         .         .         .         .         .       g.66330
 TTCCAAAAGATCGTGGATCAGTCTAAGACATATGAGAGTGAACAGGAGTGGACACAGTAC       c.2100
 F  Q  K  I  V  D  Q  S  K  T  Y  E  S  E  Q  E  W  T  Q  Y         p.700

          .         .         .      | 18  .         .         .    g.81660
 ATGATGCTGGAGCAGACACGGAAGGAAATCGTTAT | GGCCATGATGATGACCGCCTGTGAT    c.2160
 M  M  L  E  Q  T  R  K  E  I  V  M  |  A  M  M  M  T  A  C  D      p.720

          .         .         .          | 19        .         .    g.82015
 CTCTCAGCCATCACCAAACCCTGGGAGGTGCAGAGCCAG | GTAGCTCTGCTGGTGGCTGCT    c.2220
 L  S  A  I  T  K  P  W  E  V  Q  S  Q   | V  A  L  L  V  A  A      p.740

          .         .         .         .         .     | 20   .    g.83546
 GAATTCTGGGAACAAGGTGACCTGGAGCGCACGGTGCTGCAACAGAATCCCATT | CCCATG    c.2280
 E  F  W  E  Q  G  D  L  E  R  T  V  L  Q  Q  N  P  I   | P  M      p.760

          .         .         .         .         .         .       g.83606
 ATGGACAGAAACAAAGCAGATGAACTCCCTAAGCTTCAAGTCGGCTTCATTGACTTTGTT       c.2340
 M  D  R  N  K  A  D  E  L  P  K  L  Q  V  G  F  I  D  F  V         p.780

          .         | 21         .         .         .         .    g.86569
 TGCACCTTCGTCTACAAG | GAATTCTCCCGTTTCCACGAGGAGATCACCCCAATGTTGGAC    c.2400
 C  T  F  V  Y  K   | E  F  S  R  F  H  E  E  I  T  P  M  L  D      p.800

          .         .         .         .         .         .       g.86629
 GGGATCACCAACAATCGCAAGGAGTGGAAGGCGCTTGCTGATGAGTACGATGCCAAGATG       c.2460
 G  I  T  N  N  R  K  E  W  K  A  L  A  D  E  Y  D  A  K  M         p.820

          .         .         .         .       | 22 .         .    g.88836
 AAGGTGCAGGAGGAGAAGAAGCAGAAACAGCAGTCGGCCAAGTCAG | CAGCCGCAGGAAAT    c.2520
 K  V  Q  E  E  K  K  Q  K  Q  Q  S  A  K  S  A |   A  A  G  N      p.840

          .         .         .         .         .         .       g.88896
 CAGCCGGGGGGAAACCCCAGCCCAGGGGGTGCAACTACATCCAAGTCCTGCTGCATCCAG       c.2580
 Q  P  G  G  N  P  S  P  G  G  A  T  T  S  K  S  C  C  I  Q         p.860

                                                                    g.88899
 TAA                                                                c.2583
 X                                                                  p.860

          .         .         .         .         .         .       g.88959
 caccactggggatgtgctggctggacggcaccaccctttcctgggaagagatgactcaag       c.*60

          .         .         .         .         .         .       g.89019
 ccagtggaagaccacacaccttgagaagtagaagagtcataggatttgaaagctgttaga       c.*120

          .         .         .         .         .         .       g.89079
 gaatttagcttccaggactgttcaatcttttggcttccctgggccacattggaagaattg       c.*180

          .         .         .         .         .         .       g.89139
 tcttgggtcacacataaaatacagtaacactaatgatagctgttgaacttaaaaaaaaaa       c.*240

          .         .         .         .         .         .       g.89199
 atcgccaaaaaaaaaaatttcataatgttttaagaaagtttatgaatttgtgttgggccg       c.*300

          .         .         .         .         .         .       g.89259
 cattcaaagccgtcctgggctgcatgtggcccacgggccgtgggttgaacaagcttggct       c.*360

          .         .         .         .         .         .       g.89319
 tataccttatccagtggcttttaaacattcttttagtcttgagaactgcctattgagcta       c.*420

          .         .         .         .         .         .       g.89379
 aaaccaatattctagctttcatagacatcagttaaacatttaattacatttaattaatgc       c.*480

          .         .         .         .         .         .       g.89439
 cagattcactggcttgcttagaatcatttttgttcttatactttcagttaatgtattgta       c.*540

          .         .         .         .         .         .       g.89499
 aaaattttcaatcattttcaaaagtagagaattgtacgttgaatccccacatacccatca       c.*600

          .         .         .         .         .         .       g.89559
 cccagattccaatatcaagattttgctacatgcatttcgtctgtcctttttacattttct       c.*660

          .         .         .         .         .         .       g.89619
 tttcaattttttttcttacctgaagtgtttaaaggcaaatcctggccaggcgtggtggct       c.*720

          .         .         .         .         .         .       g.89679
 cacacctgtaatcccagcacttcaggaggctgaggtgggcagactgcatgagcccaggag       c.*780

          .         .         .         .         .         .       g.89739
 tctgagaccaacctgagcaaaatggcaaaaccctgtctctacaaaaaatacaaaaattag       c.*840

          .         .         .         .         .         .       g.89799
 cactcacctgtagtctcagctacctgggaggcagaggtgagaggatctcttgaacccagg       c.*900

          .         .         .         .         .         .       g.89859
 aggcggaagttgcagtgagctgagatcatgctactgcactccagcttgggcgaccgagcg       c.*960

          .         .         .         .         .         .       g.89919
 agactctgactcaaacaaaagcaaaagaaaaggcaaatcccaaacatatcatttcacacc       c.*1020

          .         .         .         .         .         .       g.89979
 tctactatctcatctttaaagaaataagtatgttttctaacataaccacatcactggccc       c.*1080

          .         .         .         .         .         .       g.90039
 atgcaaccaatgcctgcctaatacccagctgtgatctatgctttgatgggctgcacagac       c.*1140

          .         .         .         .         .         .       g.90099
 cccaagcttcagcaaaggacttgggaccccaccagctttgagtgctgttgacagaccctt       c.*1200

          .         .         .         .         .         .       g.90159
 agtatcaaccccatcaggtgttactgcagccttccccagggtggcctacacccaatgact       c.*1260

          .         .         .         .         .         .       g.90219
 gatccatgccaggtggagaggcctggccatcttggctgagcatgggataactgtgcaggg       c.*1320

          .         .         .         .         .         .       g.90279
 ctgttccagctccacgactcctcgtggggtccactaaggctgtcgctgggctcacatccc       c.*1380

          .         .         .         .         .         .       g.90339
 aactcgacttctccctctgcccactcctatttccttcccttccccaagcatcggtcccca       c.*1440

          .         .         .         .         .         .       g.90399
 gggcactgcttaataagcatcctgcagactaagtccattttagagtctgctttctgggac       c.*1500

          .         .         .         .         .         .       g.90459
 acccaacttgtgatgccagcccttaatcaaccttccttcattctcatgaacgttttcaat       c.*1560

          .         .         .         .         .         .       g.90519
 ggttggcttgcctgaatctgatccaaacaaattcacatattgaatttagttgtttctttt       c.*1620

          .         .         .         .         .         .       g.90579
 tgttggtttttagaaaaaagaagatgtactttttattcttggatttttcattgatttcac       c.*1680

          .         .         .         .         .         .       g.90639
 agagtataaattaagtcagattattctcaattccagaacttctgtttcttaaattagcag       c.*1740

          .         .         .         .         .         .       g.90699
 gcattctgttggtttaaaaagatagatgttggccgggcgcggtggctcacgcctgtaatt       c.*1800

          .         .         .         .         .         .       g.90759
 ccagcactttgggaggccaaggtgggtggatcacctgaggtcaggagttcaagaccagcc       c.*1860

          .         .         .         .         .         .       g.90819
 tggccaacatggtgaaaccccatctctactaaaaatacaaaaattagctgggtgtggtgg       c.*1920

          .         .         .         .         .         .       g.90879
 tgtgcacctgtaatcccagctactcaggaggctgaggcaggagaatcgcttgaacctggg       c.*1980

          .         .         .         .         .         .       g.90939
 aggcgaaggttgcagtgagctgagatcatgccactgcactccagcctgggcaacaagagc       c.*2040

          .         .         .         .         .         .       g.90999
 aagactccgtctcaaaaaaaaaaaaaagaaaaaaaaaagatgtggcagatagaatttctc       c.*2100

          .         .         .         .         .         .       g.91059
 tctttctctatctttcatgacgaggtctcactctgtcgcccaggctggagtgcagtggta       c.*2160

          .         .         .         .         .         .       g.91119
 tgaccatagctcactggagccccagctgcccgggctcaagcaatcctccatctcagctta       c.*2220

          .         .         .         .         .         .       g.91179
 ccaagcagcggtgaccacaggcatgcaccaccatgcccagctaattttttaaaacctatc       c.*2280

          .         .         .         .         .         .       g.91239
 tttgtagacatggggtctcattctgttgcccaggctggcctcaaactcctgacttcaagc       c.*2340

          .         .         .         .         .         .       g.91299
 aatcctcctgcctcagcctcccaaagtgttgggattacaggcgtgagccactgcacctgg       c.*2400

          .         .         .         .         .         .       g.91359
 ccaggacttatttcttttaaaccgaatctaagtatgttctggcaagtatgcaatacctag       c.*2460

          .         .         .         .         .         .       g.91419
 cggaatgcactggcctgatcagcattcataccatagtaactgatgttgaaaacagcacaa       c.*2520

          .         .         .         .         .         .       g.91479
 ataaaccagaagttgaaaatggcaataacatgctaaaaatttgcaagtcaatttgttaca       c.*2580

          .         .         .         .         .         .       g.91539
 cttgtccaaatcttgattttttttccttctctatcgttccccccccaccaccagctttat       c.*2640

          .         .         .         .         .         .       g.91599
 ggaggtataattagcaaataaaaagtatacatatttaaggtatacactgtgatgttttga       c.*2700

          .         .         .         .         .         .       g.91659
 tatacattgtgaaatggttaccataattaagctaattaatatatccatcacctcacatag       c.*2760

          .         .         .         .         .         .       g.91719
 ccatggttaagtttctgaagtctcttttaatctacaaagtactccttccttttttccatt       c.*2820

          .         .         .         .         .         .       g.91779
 gtcatcaccttgcagaaacagagtcagttttcccacattctgtatttatctgtttgtttc       c.*2880

          .         .         .         .         .                 g.91838
 tttgtggccgcatgtaacacattcctctgtctcattctaataaatggacattagctcta        c.*2939

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phosphodiesterase 6A, cGMP-specific, rod, alpha protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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