phosphodiesterase 6C, cGMP-specific, cone, alpha prime (PDE6C) - coding DNA reference sequence

(used for variant description)

(last modified November 25, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_006204.3 in the PDE6C gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016752.1, covering PDE6C transcript NM_006204.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5018
                                           ctttggaagtcctatgag       c.-121

 .         .         .         .         .         .                g.5078
 ggaccatttacggtttcctcagtaatttccaccaggatgaatttccttctcatcactctg       c.-61

 .         .         .         .         .         .                g.5138
 cctcaggtagtgctctgaaggtcgtcctttctgaacaaacgcagcaaagcaagccacacc       c.-1

          .         .         .         .         .         .       g.5198
 ATGGGTGAGATCAACCAAGTTGCCGTGGAGAAATACCTGGAGGAGAACCCTCAGTTTGCC       c.60
 M  G  E  I  N  Q  V  A  V  E  K  Y  L  E  E  N  P  Q  F  A         p.20

          .         .         .         .         .         .       g.5258
 AAGGAGTACTTTGACAGGAAGTTGCGGGTGGAGGTGCTGGGAGAAATCTTCAAGAACAGC       c.120
 K  E  Y  F  D  R  K  L  R  V  E  V  L  G  E  I  F  K  N  S         p.40

          .         .         .         .         .         .       g.5318
 CAGGTGCCAGTCCAGTCCAGCATGTCCTTCTCTGAGCTGACCCAGGTGGAGGAGTCAGCC       c.180
 Q  V  P  V  Q  S  S  M  S  F  S  E  L  T  Q  V  E  E  S  A         p.60

          .         .         .         .         .         .       g.5378
 CTGTGCTTGGAGCTGCTGTGGACCGTGCAGGAGGAGGGGGGCACCCCAGAGCAGGGGGTT       c.240
 L  C  L  E  L  L  W  T  V  Q  E  E  G  G  T  P  E  Q  G  V         p.80

          .         .         .         .         .         .       g.5438
 CACAGGGCCCTGCAGAGGCTGGCCCACCTGCTCCAGGCTGACCGCTGCAGCATGTTCCTG       c.300
 H  R  A  L  Q  R  L  A  H  L  L  Q  A  D  R  C  S  M  F  L         p.100

          .         .         .         .         .         .       g.5498
 TGCCGGTCCCGGAACGGCATACCTGAGGTGGCCTCTAGGTTGCTGGATGTCACCCCCACC       c.360
 C  R  S  R  N  G  I  P  E  V  A  S  R  L  L  D  V  T  P  T         p.120

          .         .         .         .         .         .       g.5558
 TCCAAGTTTGAGGACAACCTGGTGGGCCCTGACAAAGAAGTTGTGTTTCCATTGGACATT       c.420
 S  K  F  E  D  N  L  V  G  P  D  K  E  V  V  F  P  L  D  I         p.140

          .         .         .         .         .         .       g.5618
 GGGATAGTGGGTTGGGCTGCTCACACGAAGAAAACTCATAATGTCCCAGATGTGAAAAAG       c.480
 G  I  V  G  W  A  A  H  T  K  K  T  H  N  V  P  D  V  K  K         p.160

  | 02       .         .         .         .         .         .    g.13104
  | AACAGCCATTTTTCTGACTTCATGGACAAGCAAACTGGGTATGTCACTAAGAACCTGCTG    c.540
  | N  S  H  F  S  D  F  M  D  K  Q  T  G  Y  V  T  K  N  L  L      p.180

          .         .         .         .         .         .       g.13164
 GCAACCCCGATCGTGGTGGGCAAGGAGGTTCTTGCTGTGATCATGGCAGTTAACAAAGTA       c.600
 A  T  P  I  V  V  G  K  E  V  L  A  V  I  M  A  V  N  K  V         p.200

          .         .         .    | 03    .         .         .    g.13330
 AATGCATCTGAATTTTCCAAACAGGATGAAGAG | GTCTTTTCCAAATACCTCAACTTTGTG    c.660
 N  A  S  E  F  S  K  Q  D  E  E   | V  F  S  K  Y  L  N  F  V      p.220

          .         .         .         .         .         .       g.13390
 TCTATCATCCTAAGGCTTCATCACACCAGCTACATGTACAATATTGAATCCCGAAGAAGC       c.720
 S  I  I  L  R  L  H  H  T  S  Y  M  Y  N  I  E  S  R  R  S         p.240

     | 04    .         .         .         .         .         .    g.14401
 CAG | ATCCTTATGTGGTCAGCCAATAAAGTATTTGAAGAACTCACAGATGTTGAGCGACAG    c.780
 Q   | I  L  M  W  S  A  N  K  V  F  E  E  L  T  D  V  E  R  Q      p.260

          .         .         .         .         .         .       g.14461
 TTTCACAAAGCGCTCTACACGGTTAGATCATATCTGAACTGTGAACGATACTCCATTGGA       c.840
 F  H  K  A  L  Y  T  V  R  S  Y  L  N  C  E  R  Y  S  I  G         p.280

          .         .     | 05   .         .         .         .    g.18023
 CTGCTGGACATGACCAAGGAGAAG | GAATTCTACGATGAATGGCCAATCAAGCTTGGAGAA    c.900
 L  L  D  M  T  K  E  K   | E  F  Y  D  E  W  P  I  K  L  G  E      p.300

          .         .         .          | 06        .         .    g.19073
 GTAGAGCCTTATAAAGGTCCAAAGACACCTGATGGCAGG | GAAGTCAACTTTTATAAAATC    c.960
 V  E  P  Y  K  G  P  K  T  P  D  G  R   | E  V  N  F  Y  K  I      p.320

          .         .         .         .     | 07   .         .    g.19233
 ATTGATTACATTTTACATGGAAAAGAAGAGATCAAAGTGATTCC | GACGCCTCCTGCAGAC    c.1020
 I  D  Y  I  L  H  G  K  E  E  I  K  V  I  P  |  T  P  P  A  D      p.340

          .         .         .         .         .  | 08      .    g.21679
 CACTGGACACTCATTAGTGGGTTGCCAACATATGTTGCTGAAAATGGATTT | ATCTGTAAC    c.1080
 H  W  T  L  I  S  G  L  P  T  Y  V  A  E  N  G  F   | I  C  N      p.360

          .         .         .          | 09        .         .    g.27191
 ATGATGAATGCCCCTGCGGATGAATACTTCACATTTCAG | AAAGGACCTGTAGACGAAACT    c.1140
 M  M  N  A  P  A  D  E  Y  F  T  F  Q   | K  G  P  V  D  E  T      p.380

          .         .         .         .         .         .       g.27251
 GGTTGGGTCATTAAGAATGTTTTGTCCCTGCCTATTGTCAACAAGAAAGAAGATATTGTG       c.1200
 G  W  V  I  K  N  V  L  S  L  P  I  V  N  K  K  E  D  I  V         p.400

          .         .         .         .         .         .       g.27311
 GGAGTGGCTACATTTTACAACAGGAAGGATGGAAAACCTTTCGATGAGCATGATGAATAC       c.1260
 G  V  A  T  F  Y  N  R  K  D  G  K  P  F  D  E  H  D  E  Y         p.420

           | 10        .         .         .         .         .    g.27960
 ATTACCGAG | ACTCTCACACAATTTCTTGGATGGTCTCTTTTAAATACTGACACCTACGAT    c.1320
 I  T  E   | T  L  T  Q  F  L  G  W  S  L  L  N  T  D  T  Y  D      p.440

          .         .         .         .         .         .       g.28020
 AAGATGAATAAGCTAGAAAACAGAAAGGACATTGCTCAGGAAATGCTCATGAACCAAACC       c.1380
 K  M  N  K  L  E  N  R  K  D  I  A  Q  E  M  L  M  N  Q  T         p.460

          .         .         .    | 11    .         .         .    g.29434
 AAAGCCACTCCTGAAGAAATTAAGTCCATTTTG | AAATTTCAAGAGAAGTTAAATGTTGAT    c.1440
 K  A  T  P  E  E  I  K  S  I  L   | K  F  Q  E  K  L  N  V  D      p.480

          .         .         .         .   | 12     .         .    g.32500
 GTAATTGACGACTGTGAAGAAAAACAACTTGTTGCAATTTTG | AAAGAGGACTTGCCAGAC    c.1500
 V  I  D  D  C  E  E  K  Q  L  V  A  I  L   | K  E  D  L  P  D      p.500

          .         .         .         .         .         .       g.32560
 CCACGCTCAGCAGAACTGTACGAATTCCGCTTCAGTGACTTCCCCCTTACAGAGCACGGA       c.1560
 P  R  S  A  E  L  Y  E  F  R  F  S  D  F  P  L  T  E  H  G         p.520

          .         .         .         .         .         .       g.32620
 TTGATTAAATGTGGAATACGACTGTTTTTTGAAATAAATGTGGTGGAGAAATTCAAAGTA       c.1620
 L  I  K  C  G  I  R  L  F  F  E  I  N  V  V  E  K  F  K  V         p.540

           | 13        .         .         .         .         .    g.32913
 CCTGTAGAG | GTTCTTACCAGATGGATGTACACTGTGAGGAAAGGGTACCGAGCTGTCACT    c.1680
 P  V  E   | V  L  T  R  W  M  Y  T  V  R  K  G  Y  R  A  V  T      p.560

          .         .         .         .         .        | 14.    g.33335
 TACCACAATTGGCGGCATGGGTTCAACGTGGGGCAGACCATGTTTACTTTGCTGATG | ACA    c.1740
 Y  H  N  W  R  H  G  F  N  V  G  Q  T  M  F  T  L  L  M   | T      p.580

          .         .         .         .         .         .       g.33395
 GGAAGATTAAAGAAGTACTACACAGATCTCGAAGCCTTTGCCATGCTTGCTGCTGCTTTC       c.1800
 G  R  L  K  K  Y  Y  T  D  L  E  A  F  A  M  L  A  A  A  F         p.600

          .         .         .         .        | 15.         .    g.38385
 TGCCATGATATTGACCACAGAGGCACCAATAATTTGTACCAGATGAA | ATCCACGTCTCCA    c.1860
 C  H  D  I  D  H  R  G  T  N  N  L  Y  Q  M  K  |  S  T  S  P      p.620

          .         .         .         .         .         .       g.38445
 TTAGCAAGACTTCATGGTTCTTCTATTTTGGAGAGGCACCACCTGGAGTACAGTAAGACT       c.1920
 L  A  R  L  H  G  S  S  I  L  E  R  H  H  L  E  Y  S  K  T         p.640

          .      | 16  .         .         .         .         .    g.48217
 CTGTTGCAGGATGAG | AGTTTAAACATCTTCCAGAACCTAAATAAGCGGCAGTTTGAAACA    c.1980
 L  L  Q  D  E   | S  L  N  I  F  Q  N  L  N  K  R  Q  F  E  T      p.660

          .         .         .         .         .       | 17 .    g.51317
 GTTATTCATTTGTTCGAGGTCGCAATAATAGCAACTGACCTGGCTTTATATTTCAA | GAAG    c.2040
 V  I  H  L  F  E  V  A  I  I  A  T  D  L  A  L  Y  F  K  |  K      p.680

          .         .         .         .         .         .       g.51377
 AGGACCATGTTTCAAAAAATTGTTGATGCCTGTGAACAAATGCAAACGGAAGAAGAAGCC       c.2100
 R  T  M  F  Q  K  I  V  D  A  C  E  Q  M  Q  T  E  E  E  A         p.700

          .         .         .         .     | 18   .         .    g.51532
 ATCAAATATGTAACTGTTGATCCAACCAAGAAAGAGATTATCAT | GGCAATGATGATGACG    c.2160
 I  K  Y  V  T  V  D  P  T  K  K  E  I  I  M  |  A  M  M  M  T      p.720

          .         .         .         .         | 19         .    g.54483
 GCATGTGACTTGTCTGCTATTACCAAGCCCTGGGAGGTGCAAAGTCAG | GTAGCACTTATG    c.2220
 A  C  D  L  S  A  I  T  K  P  W  E  V  Q  S  Q   | V  A  L  M      p.740

          .         .         .         .         .         .       g.54543
 GTTGCAAATGAATTTTGGGAACAAGGAGATCTGGAGAGAACAGTGTTGCAGCAACAACCC       c.2280
 V  A  N  E  F  W  E  Q  G  D  L  E  R  T  V  L  Q  Q  Q  P         p.760

     | 20    .         .         .         .         .         .    g.55029
 ATT | CCTATGATGGACAGAAACAAAAGAGATGAATTACCTAAACTTCAAGTTGGATTTATT    c.2340
 I   | P  M  M  D  R  N  K  R  D  E  L  P  K  L  Q  V  G  F  I      p.780

          .         .        | 21.         .         .         .    g.55473
 GATTTTGTTTGTACTTTTGTATATAAG | GAGTTCTCACGGTTTCACAAAGAAATCACACCT    c.2400
 D  F  V  C  T  F  V  Y  K   | E  F  S  R  F  H  K  E  I  T  P      p.800

          .         .         .         .         .         .       g.55533
 ATGCTGAGTGGTCTTCAGAATAACAGAGTAGAATGGAAATCACTAGCTGATGAGTATGAT       c.2460
 M  L  S  G  L  Q  N  N  R  V  E  W  K  S  L  A  D  E  Y  D         p.820

          .         .         .         .         .         | 22    g.57774
 GCAAAGATGAAGGTCATTGAAGAGGAGGCAAAAAAGCAAGAAGGAGGAGCCGAAAAAG | CT    c.2520
 A  K  M  K  V  I  E  E  E  A  K  K  Q  E  G  G  A  E  K  A |       p.840

          .         .         .         .         .                 g.57831
 GCTGAAGATTCAGGAGGTGGTGATGACAAAAAGTCCAAAACATGTTTAATGTTGTAA          c.2577
 A  E  D  S  G  G  G  D  D  K  K  S  K  T  C  L  M  L  X            p.858

          .         .         .         .         .         .       g.57891
 tattatctaactggtctaaacttcaaatatcattttacctttgaagaaaaccagaaaaca       c.*60

          .         .         .         .         .         .       g.57951
 ttcaaaagaacttcaacaaatcatcacgtaacaggatcttcagaaaaactaccctgtgac       c.*120

          .         .         .         .         .         .       g.58011
 tatgaagaaaatatatattgctagcccaaaaatcccaggggcaaaataaagttcaacaaa       c.*180

          .         .         .         .         .         .       g.58071
 agtgcaaaatatgacaaaaataggtacatttttggtgccaatttattttaaattaaaaaa       c.*240

          .                                                         g.58086
 tatgcaatcctgaaa                                                    c.*255

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phosphodiesterase 6C, cGMP-specific, cone, alpha prime protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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