platelet-derived growth factor beta polypeptide (PDGFB) - coding DNA reference sequence

(used for variant description)

(last modified November 22, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_002608.2 in the PDGFB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012111.1, covering PDGFB transcript NM_002608.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5029
                                cctgcctgcctccctgcgcacccgcagcc       c.-961

 .         .         .         .         .         .                g.5089
 tcccccgctgcctccctagggctcccctccggccgccagcgcccatttttcattccctag       c.-901

 .         .         .         .         .         .                g.5149
 atagagatactttgcgcgcacacacatacatacgcgcgcaaaaaggaaaaaaaaaaaaaa       c.-841

 .         .         .         .         .         .                g.5209
 aagcccaccctccagcctcgctgcaaagagaaaaccggagcagccgcagctcgcagctcg       c.-781

 .         .         .         .         .         .                g.5269
 cagctcgcagcccgcagcccgcagaggacgcccagagcggcgagcgggcgggcagacgga       c.-721

 .         .         .         .         .         .                g.5329
 ccgacggactcgcgccgcgtccacctgtcggccgggcccagccgagcgcgcagcgggcac       c.-661

 .         .         .         .         .         .                g.5389
 gccgcgcgcgcggagcagccgtgcccgccgcccgggccccgcgccagggcgcacacgctc       c.-601

 .         .         .         .         .         .                g.5449
 ccgcccccctacccggcccgggcgggagtttgcacctctccctgcccgggtgctcgagct       c.-541

 .         .         .         .         .         .                g.5509
 gccgttgcaaagccaactttggaaaaagttttttgggggagacttgggccttgaggtgcc       c.-481

 .         .         .         .         .         .                g.5569
 cagctccgcgctttccgattttgggggcctttccagaaaatgttgcaaaaaagctaagcc       c.-421

 .         .         .         .         .         .                g.5629
 ggcgggcagaggaaaacgcctgtagccggcgagtgaagacgaaccatcgactgccgtgtt       c.-361

 .         .         .         .         .         .                g.5689
 ccttttcctcttggaggttggagtcccctgggcgcccccacacggctagacgcctcggct       c.-301

 .         .         .         .         .         .                g.5749
 ggttcgcgacgcagccccccggccgtggatgctcactcgggctcgggatccgcccaggta       c.-241

 .         .         .         .         .         .                g.5809
 gcggcctcggacccaggtcctgcgcccaggtcctcccctgccccccagcgacggagccgg       c.-181

 .         .         .         .         .         .                g.5869
 ggccgggggcggcggcgcccgggggccatgcgggtgagccgcggctgcagaggcctgagc       c.-121

 .         .         .         .         .         .                g.5929
 gcctgatcgccgcggacccgagccgagcccacccccctccccagccccccaccctggccg       c.-61

 .         .         .         .         .         .                g.5989
 cgggggcggcgcgctcgatctacgcgtccggggccccgcggggccgggcccggagtcggc       c.-1

          .         .         .         .         .         .       g.6049
 ATGAATCGCTGCTGGGCGCTCTTCCTGTCTCTCTGCTGCTACCTGCGTCTGGTCAGCGCC       c.60
 M  N  R  C  W  A  L  F  L  S  L  C  C  Y  L  R  L  V  S  A         p.20

     | 02    .         .         .         .         .         .    g.14135
 GAG | GGGGACCCCATTCCCGAGGAGCTTTATGAGATGCTGAGTGACCACTCGATCCGCTCC    c.120
 E   | G  D  P  I  P  E  E  L  Y  E  M  L  S  D  H  S  I  R  S      p.40

          .         .         .         . | 03       .         .    g.16448
 TTTGATGATCTCCAACGCCTGCTGCACGGAGACCCCGGAG | AGGAAGATGGGGCCGAGTTG    c.180
 F  D  D  L  Q  R  L  L  H  G  D  P  G  E |   E  D  G  A  E  L      p.60

          .         .         .         .         .         .       g.16508
 GACCTGAACATGACCCGCTCCCACTCTGGAGGCGAGCTGGAGAGCTTGGCTCGTGGAAGA       c.240
 D  L  N  M  T  R  S  H  S  G  G  E  L  E  S  L  A  R  G  R         p.80

          . | 04       .         .         .         .         .    g.18175
 AGGAGCCTGG | GTTCCCTGACCATTGCTGAGCCGGCCATGATCGCCGAGTGCAAGACGCGC    c.300
 R  S  L  G |   S  L  T  I  A  E  P  A  M  I  A  E  C  K  T  R      p.100

          .         .         .         .         .         .       g.18235
 ACCGAGGTGTTCGAGATCTCCCGGCGCCTCATAGACCGCACCAACGCCAACTTCCTGGTG       c.360
 T  E  V  F  E  I  S  R  R  L  I  D  R  T  N  A  N  F  L  V         p.120

          .         .         .         .         .         .       g.18295
 TGGCCGCCCTGTGTGGAGGTGCAGCGCTGCTCCGGCTGCTGCAACAACCGCAACGTGCAG       c.420
 W  P  P  C  V  E  V  Q  R  C  S  G  C  C  N  N  R  N  V  Q         p.140

          .         .         .       | 05 .         .         .    g.19748
 TGCCGCCCCACCCAGGTGCAGCTGCGACCTGTCCAG | GTGAGAAAGATCGAGATTGTGCGG    c.480
 C  R  P  T  Q  V  Q  L  R  P  V  Q   | V  R  K  I  E  I  V  R      p.160

          .         .         .         .         .         .       g.19808
 AAGAAGCCAATCTTTAAGAAGGCCACGGTGACGCTGGAAGACCACCTGGCATGCAAGTGT       c.540
 K  K  P  I  F  K  K  A  T  V  T  L  E  D  H  L  A  C  K  C         p.180

          .         .         .         .         .         .       g.19868
 GAGACAGTGGCAGCTGCACGGCCTGTGACCCGAAGCCCGGGGGGTTCCCAGGAGCAGCGA       c.600
 E  T  V  A  A  A  R  P  V  T  R  S  P  G  G  S  Q  E  Q  R         p.200

   | 06      .         .         .         .         .         .    g.24164
 G | CCAAAACGCCCCAAACTCGGGTGACCATTCGGACGGTGCGAGTCCGCCGGCCCCCCAAG    c.660
 A |   K  T  P  Q  T  R  V  T  I  R  T  V  R  V  R  R  P  P  K      p.220

          .         .         .         .         .         .       g.24224
 GGCAAGCACCGGAAATTCAAGCACACGCATGACAAGACGGCACTGAAGGAGACCCTTGGA       c.720
 G  K  H  R  K  F  K  H  T  H  D  K  T  A  L  K  E  T  L  G         p.240

                                                                g.24230
 GCCTAG |                                                          c.727
 A  X                                                            p.241

          .         .         | 07         .         .         .    g.24671
 gggcatcggcaggagagtgtgtgggcag | ggttatttaatatggtatttgctgtattgccc    c.*60

          .         .         .         .         .         .       g.24731
 ccatggggtccttggagtgataatattgtttccctcgtccgtctgtctcgatgcctgatt       c.*120

          .         .         .         .         .         .       g.24791
 cggacggccaatggtgcttcccccacccctccacgtgtccgtccacccttccatcagcgg       c.*180

          .         .         .         .         .         .       g.24851
 gtctcctcccagcggcctccggcgtcttgcccagcagctcaagaagaaaaagaaggactg       c.*240

          .         .         .         .         .         .       g.24911
 aactccatcgccatcttcttcccttaactccaagaacttgggataagagtgtgagagaga       c.*300

          .         .         .         .         .         .       g.24971
 ctgatggggtcgctctttgggggaaacgggctccttcccctgcacctggcctgggccaca       c.*360

          .         .         .         .         .         .       g.25031
 cctgagcgctgtggactgtcctgaggagccctgaggacctctcagcatagcctgcctgat       c.*420

          .         .         .         .         .         .       g.25091
 ccctgaacccctggccagctctgaggggaggcacctccaggcaggccaggctgcctcgga       c.*480

          .         .         .         .         .         .       g.25151
 ctccatggctaagaccacagacgggcacacagactggagaaaacccctcccacggtgccc       c.*540

          .         .         .         .         .         .       g.25211
 aaacaccagtcacctcgtctccctggtgcctctgtgcacagtggcttcttttcgttttcg       c.*600

          .         .         .         .         .         .       g.25271
 ttttgaagacgtggactcctcttggtgggtgtggccagcacaccaagtggctgggtgccc       c.*660

          .         .         .         .         .         .       g.25331
 tctcaggtgggttagagatggagtttgctgttgaggtggctgtagatggtgacctgggta       c.*720

          .         .         .         .         .         .       g.25391
 tcccctgcctcctgccaccccttcctccccacactccactctgattcacctcttcctctg       c.*780

          .         .         .         .         .         .       g.25451
 gttcctttcatctctctacctccaccctgcattttcctcttgtcctggcccttcagtctg       c.*840

          .         .         .         .         .         .       g.25511
 ctccaccaaggggctcttgaaccccttattaaggccccagatgatcccagtcactcctct       c.*900

          .         .         .         .         .         .       g.25571
 ctagggcagaagactagaggccagggcagcaagggacctgctcatcatattccaacccag       c.*960

          .         .         .         .         .         .       g.25631
 ccacgactgccatgtaaggttgtgcagggtgtgtactgcacaaggacattgtatgcaggg       c.*1020

          .         .         .         .         .         .       g.25691
 agcactgttcacatcatagataaagctgatttgtatatttattatgacaatttctggcag       c.*1080

          .         .         .         .         .         .       g.25751
 atgtaggtaaagaggaaaaggatccttttcctaattcacacaaagactccttgtggactg       c.*1140

          .         .         .         .         .         .       g.25811
 gctgtgcccctgatgcagcctgtggcttggagtggccaaataggagggagactgtggtag       c.*1200

          .         .         .         .         .         .       g.25871
 gggcagggaggcaacactgctgtccacatgacctccatttcccaaagtcctctgctccag       c.*1260

          .         .         .         .         .         .       g.25931
 caactgcccttccaggtgggtgtgggacacctgggagaaggtctccaagggagggtgcag       c.*1320

          .         .         .         .         .         .       g.25991
 ccctcttgcccgcacccctccctgcttgcacacttccccatctttgatccttctgagctc       c.*1380

          .         .         .         .         .         .       g.26051
 cacctctggtggctcctcctaggaaaccagctcgtgggctgggaatgggggagagaaggg       c.*1440

          .         .         .         .         .         .       g.26111
 aaaagatccccaagaccccctggggtgggatctgagctcccacctcccttcccacctact       c.*1500

          .         .         .         .         .         .       g.26171
 gcactttcccccttcccgccttccaaaacctgcttccttcagtttgtaaagtcggtgatt       c.*1560

          .         .         .         .         .         .       g.26231
 atatttttgggggctttccttttattttttaaatgtaaaatttatttatattccgtattt       c.*1620

          .         .         .         .                           g.26273
 aaagttgtaaaaaaaaataaccacaaaacaaaaccaaatgaa                         c.*1662

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Platelet-derived growth factor beta polypeptide protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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