platelet-derived growth factor receptor, beta polypeptide (PDGFRB) - coding DNA reference sequence

(used for variant description)

(last modified January 26, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_002609.3 in the PDGFRB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_023367.1, covering PDGFRB transcript NM_002609.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5049
            ctcctgaggctgccagcagccagcagtgactgcccgccctatctgggac       c.-421

 .         .         .         .         .         .                g.5109
 ccaggatcgctctgtgagcaacttggagccagagaggagatcaacaaggaggaggagaga       c.-361

 .         .         .         .         .         .                g.5169
 gccggcccctcagccctgctgcccagcagcagcctgtgctcgccctgcccaacgcagaca       c.-301

 .         .         .         .         .         .                g.5229
 gccagacccagggcggcccctctggcggctctgctcctcccgaaggatgcttggggagtg       c.-241

 .         .         .         .         .         .                g.5289
 aggcgaagctgggccgctcctctcccctacagcagcccccttcctccatccctctgttct       c.-181

 .         .         .         .         .         .                g.5349
 cctgagccttcaggagcctgcaccagtcctgcctgtccttctactcagctgttacccact       c.-121

 .         .         .         .         .         .                g.5409
 ctgggaccagcagtctttctgataactgggagagggcagtaaggaggacttcctggaggg       c.-61

 .         .         .         .         .         .    | 02        g.23812
 ggtgactgtccagagcctggaactgtgcccacaccagaagccatcagcagcaag | gacacc    c.-1

          .         .         .         . | 03       .         .    g.25001
 ATGCGGCTTCCGGGTGCGATGCCAGCTCTGGCCCTCAAAG | GCGAGCTGCTGTTGCTGTCT    c.60
 M  R  L  P  G  A  M  P  A  L  A  L  K  G |   E  L  L  L  L  S      p.20

          .         .         .         .         .         .       g.25061
 CTCCTGTTACTTCTGGAACCACAGATCTCTCAGGGCCTGGTCGTCACACCCCCGGGGCCA       c.120
 L  L  L  L  L  E  P  Q  I  S  Q  G  L  V  V  T  P  P  G  P         p.40

          .         .         .         .         .         .       g.25121
 GAGCTTGTCCTCAATGTCTCCAGCACCTTCGTTCTGACCTGCTCGGGTTCAGCTCCGGTG       c.180
 E  L  V  L  N  V  S  S  T  F  V  L  T  C  S  G  S  A  P  V         p.60

          .         .         .         .         .         .       g.25181
 GTGTGGGAACGGATGTCCCAGGAGCCCCCACAGGAAATGGCCAAGGCCCAGGATGGCACC       c.240
 V  W  E  R  M  S  Q  E  P  P  Q  E  M  A  K  A  Q  D  G  T         p.80

          .         .         .         .         .         .       g.25241
 TTCTCCAGCGTGCTCACACTGACCAACCTCACTGGGCTAGACACGGGAGAATACTTTTGC       c.300
 F  S  S  V  L  T  L  T  N  L  T  G  L  D  T  G  E  Y  F  C         p.100

          .         .         .         .         .         .       g.25301
 ACCCACAATGACTCCCGTGGACTGGAGACCGATGAGCGGAAACGGCTCTACATCTTTGTG       c.360
 T  H  N  D  S  R  G  L  E  T  D  E  R  K  R  L  Y  I  F  V         p.120

      | 04   .         .         .         .         .         .    g.25899
 CCAG | ATCCCACCGTGGGCTTCCTCCCTAATGATGCCGAGGAACTATTCATCTTTCTCACG    c.420
 P  D |   P  T  V  G  F  L  P  N  D  A  E  E  L  F  I  F  L  T      p.140

          .         .         .         .         .         .       g.25959
 GAAATAACTGAGATCACCATTCCATGCCGAGTAACAGACCCACAGCTGGTGGTGACACTG       c.480
 E  I  T  E  I  T  I  P  C  R  V  T  D  P  Q  L  V  V  T  L         p.160

          .         .         .         .         .         .       g.26019
 CACGAGAAGAAAGGGGACGTTGCACTGCCTGTCCCCTATGATCACCAACGTGGCTTTTCT       c.540
 H  E  K  K  G  D  V  A  L  P  V  P  Y  D  H  Q  R  G  F  S         p.180

          .         .         .         .         .         .       g.26079
 GGTATCTTTGAGGACAGAAGCTACATCTGCAAAACCACCATTGGGGACAGGGAGGTGGAT       c.600
 G  I  F  E  D  R  S  Y  I  C  K  T  T  I  G  D  R  E  V  D         p.200

          .         .         .  | 05      .         .         .    g.26880
 TCTGATGCCTACTATGTCTACAGACTCCAGG | TGTCATCCATCAACGTCTCTGTGAACGCA    c.660
 S  D  A  Y  Y  V  Y  R  L  Q  V |   S  S  I  N  V  S  V  N  A      p.220

          .         .         .         .         .         .       g.26940
 GTGCAGACTGTGGTCCGCCAGGGTGAGAACATCACCCTCATGTGCATTGTGATCGGGAAT       c.720
 V  Q  T  V  V  R  Q  G  E  N  I  T  L  M  C  I  V  I  G  N         p.240

          .         .         .          | 06        .         .    g.27120
 GAGGTGGTCAACTTCGAGTGGACATACCCCCGCAAAGAA | AGTGGGCGGCTGGTGGAGCCG    c.780
 E  V  V  N  F  E  W  T  Y  P  R  K  E   | S  G  R  L  V  E  P      p.260

          .         .         .         .         .         .       g.27180
 GTGACTGACTTCCTCTTGGATATGCCTTACCACATCCGCTCCATCCTGCACATCCCCAGT       c.840
 V  T  D  F  L  L  D  M  P  Y  H  I  R  S  I  L  H  I  P  S         p.280

          .         .         .         .         .         .       g.27240
 GCCGAGTTAGAAGACTCGGGGACCTACACCTGCAATGTGACGGAGAGTGTGAATGACCAT       c.900
 A  E  L  E  D  S  G  T  Y  T  C  N  V  T  E  S  V  N  D  H         p.300

          .         .         .     | 07   .         .         .    g.27943
 CAGGATGAAAAGGCCATCAACATCACCGTGGTTG | AGAGCGGCTACGTGCGGCTCCTGGGA    c.960
 Q  D  E  K  A  I  N  I  T  V  V  E |   S  G  Y  V  R  L  L  G      p.320

          .         .         .         .         .         .       g.28003
 GAGGTGGGCACACTACAATTTGCTGAGCTGCATCGGAGCCGGACACTGCAGGTAGTGTTC       c.1020
 E  V  G  T  L  Q  F  A  E  L  H  R  S  R  T  L  Q  V  V  F         p.340

          .         .         .         .         .         .       g.28063
 GAGGCCTACCCACCGCCCACTGTCCTGTGGTTCAAAGACAACCGCACCCTGGGCGACTCC       c.1080
 E  A  Y  P  P  P  T  V  L  W  F  K  D  N  R  T  L  G  D  S         p.360

          .         .         .         .        | 08.         .    g.28778
 AGCGCTGGCGAAATCGCCCTGTCCACGCGCAACGTGTCGGAGACCCG | GTATGTGTCAGAG    c.1140
 S  A  G  E  I  A  L  S  T  R  N  V  S  E  T  R  |  Y  V  S  E      p.380

          .         .         .         .         .         .       g.28838
 CTGACACTGGTTCGCGTGAAGGTGGCAGAGGCTGGCCACTACACCATGCGGGCCTTCCAT       c.1200
 L  T  L  V  R  V  K  V  A  E  A  G  H  Y  T  M  R  A  F  H         p.400

          .         .         .         .    | 09    .         .    g.30214
 GAGGATGCTGAGGTCCAGCTCTCCTTCCAGCTACAGATCAATG | TCCCTGTCCGAGTGCTG    c.1260
 E  D  A  E  V  Q  L  S  F  Q  L  Q  I  N  V |   P  V  R  V  L      p.420

          .         .         .         .         .         .       g.30274
 GAGCTAAGTGAGAGCCACCCTGACAGTGGGGAACAGACAGTCCGCTGTCGTGGCCGGGGC       c.1320
 E  L  S  E  S  H  P  D  S  G  E  Q  T  V  R  C  R  G  R  G         p.440

          .         .         .         .        | 10.         .    g.30904
 ATGCCCCAGCCGAACATCATCTGGTCTGCCTGCAGAGACCTCAAAAG | GTGTCCACGTGAG    c.1380
 M  P  Q  P  N  I  I  W  S  A  C  R  D  L  K  R  |  C  P  R  E      p.460

          .         .         .         .         .         .       g.30964
 CTGCCGCCCACGCTGCTGGGGAACAGTTCCGAAGAGGAGAGCCAGCTGGAGACTAACGTG       c.1440
 L  P  P  T  L  L  G  N  S  S  E  E  E  S  Q  L  E  T  N  V         p.480

          .         .         .         .         .         .       g.31024
 ACGTACTGGGAGGAGGAGCAGGAGTTTGAGGTGGTGAGCACACTGCGTCTGCAGCACGTG       c.1500
 T  Y  W  E  E  E  Q  E  F  E  V  V  S  T  L  R  L  Q  H  V         p.500

          .         .         .         .         .         .       g.31084
 GATCGGCCACTGTCGGTGCGCTGCACGCTGCGCAACGCTGTGGGCCAGGACACGCAGGAG       c.1560
 D  R  P  L  S  V  R  C  T  L  R  N  A  V  G  Q  D  T  Q  E         p.520

          .          | 11        .         .         .         .    g.34286
 GTCATCGTGGTGCCACACT | CCTTGCCCTTTAAGGTGGTGGTGATCTCAGCCATCCTGGCC    c.1620
 V  I  V  V  P  H  S |   L  P  F  K  V  V  V  I  S  A  I  L  A      p.540

          .         .         .         .         .     | 12   .    g.35288
 CTGGTGGTGCTCACCATCATCTCCCTTATCATCCTCATCATGCTTTGGCAGAAG | AAGCCA    c.1680
 L  V  V  L  T  I  I  S  L  I  I  L  I  M  L  W  Q  K   | K  P      p.560

          .         .         .         .         .         .       g.35348
 CGTTACGAGATCCGATGGAAGGTGATTGAGTCTGTGAGCTCTGACGGCCATGAGTACATC       c.1740
 R  Y  E  I  R  W  K  V  I  E  S  V  S  S  D  G  H  E  Y  I         p.580

          .         .         .         .         .         .       g.35408
 TACGTGGACCCCATGCAGCTGCCCTATGACTCCACGTGGGAGCTGCCGCGGGACCAGCTT       c.1800
 Y  V  D  P  M  Q  L  P  Y  D  S  T  W  E  L  P  R  D  Q  L         p.600

         | 13.         .         .         .         .         .    g.36081
 GTGCTGG | GACGCACCCTCGGCTCTGGGGCCTTTGGGCAGGTGGTGGAGGCCACGGCTCAT    c.1860
 V  L  G |   R  T  L  G  S  G  A  F  G  Q  V  V  E  A  T  A  H      p.620

          .         .         .         .         .   | 14     .    g.36507
 GGCCTGAGCCATTCTCAGGCCACGATGAAAGTGGCCGTCAAGATGCTTAAAT | CCACAGCC    c.1920
 G  L  S  H  S  Q  A  T  M  K  V  A  V  K  M  L  K  S |   T  A      p.640

          .         .         .         .         .         .       g.36567
 CGCAGCAGTGAGAAGCAAGCCCTTATGTCGGAGCTGAAGATCATGAGTCACCTTGGGCCC       c.1980
 R  S  S  E  K  Q  A  L  M  S  E  L  K  I  M  S  H  L  G  P         p.660

          .         .         .         .    | 15    .         .    g.37675
 CACCTGAACGTGGTCAACCTGTTGGGGGCCTGCACCAAAGGAG | GACCCATCTATATCATC    c.2040
 H  L  N  V  V  N  L  L  G  A  C  T  K  G  G |   P  I  Y  I  I      p.680

          .         .         .         .         .         .       g.37735
 ACTGAGTACTGCCGCTACGGAGACCTGGTGGACTACCTGCACCGCAACAAACACACCTTC       c.2100
 T  E  Y  C  R  Y  G  D  L  V  D  Y  L  H  R  N  K  H  T  F         p.700

          .         .         .         .         .         .       g.37795
 CTGCAGCACCACTCCGACAAGCGCCGCCCGCCCAGCGCGGAGCTCTACAGCAATGCTCTG       c.2160
 L  Q  H  H  S  D  K  R  R  P  P  S  A  E  L  Y  S  N  A  L         p.720

          .         .    | 16    .         .         .         .    g.38856
 CCCGTTGGGCTCCCCCTGCCCAG | CCATGTGTCCTTGACCGGGGAGAGCGACGGTGGCTAC    c.2220
 P  V  G  L  P  L  P  S  |  H  V  S  L  T  G  E  S  D  G  G  Y      p.740

          .         .         .         .         .         .       g.38916
 ATGGACATGAGCAAGGACGAGTCGGTGGACTATGTGCCCATGCTGGACATGAAAGGAGAC       c.2280
 M  D  M  S  K  D  E  S  V  D  Y  V  P  M  L  D  M  K  G  D         p.760

          .         .         .         .         .         .       g.38976
 GTCAAATATGCAGACATCGAGTCCTCCAACTACATGGCCCCTTACGATAACTACGTTCCC       c.2340
 V  K  Y  A  D  I  E  S  S  N  Y  M  A  P  Y  D  N  Y  V  P         p.780

      | 17   .         .         .         .         .         .    g.39593
 TCTG | CCCCTGAGAGGACCTGCCGAGCAACTTTGATCAACGAGTCTCCAGTGCTAAGCTAC    c.2400
 S  A |   P  E  R  T  C  R  A  T  L  I  N  E  S  P  V  L  S  Y      p.800

          .         .         .         .         .         .       g.39653
 ATGGACCTCGTGGGCTTCAGCTACCAGGTGGCCAATGGCATGGAGTTTCTGGCCTCCAAG       c.2460
 M  D  L  V  G  F  S  Y  Q  V  A  N  G  M  E  F  L  A  S  K         p.820

     | 18    .         .         .         .         .         .    g.39906
 AAC | TGCGTCCACAGAGACCTGGCGGCTAGGAACGTGCTCATCTGTGAAGGCAAGCTGGTC    c.2520
 N   | C  V  H  R  D  L  A  A  R  N  V  L  I  C  E  G  K  L  V      p.840

          .         .         .         .         .         .       g.39966
 AAGATCTGTGACTTTGGCCTGGCTCGAGACATCATGCGGGACTCGAATTACATCTCCAAA       c.2580
 K  I  C  D  F  G  L  A  R  D  I  M  R  D  S  N  Y  I  S  K         p.860

        | 19 .         .         .         .         .         .    g.40790
 GGCAGC | ACCTTTTTGCCTTTAAAGTGGATGGCTCCGGAGAGCATCTTCAACAGCCTCTAC    c.2640
 G  S   | T  F  L  P  L  K  W  M  A  P  E  S  I  F  N  S  L  Y      p.880

          .         .         .         .         .         | 20    g.41295
 ACCACCCTGAGCGACGTGTGGTCCTTCGGGATCCTGCTCTGGGAGATCTTCACCTTGG | GT    c.2700
 T  T  L  S  D  V  W  S  F  G  I  L  L  W  E  I  F  T  L  G |       p.900

          .         .         .         .         .         .       g.41355
 GGCACCCCTTACCCAGAGCTGCCCATGAACGAGCAGTTCTACAATGCCATCAAACGGGGT       c.2760
 G  T  P  Y  P  E  L  P  M  N  E  Q  F  Y  N  A  I  K  R  G         p.920

          .         .         .         | 21         .         .    g.42029
 TACCGCATGGCCCAGCCTGCCCATGCCTCCGACGAGAT | CTATGAGATCATGCAGAAGTGC    c.2820
 Y  R  M  A  Q  P  A  H  A  S  D  E  I  |  Y  E  I  M  Q  K  C      p.940

          .         .         .         .         .         .       g.42089
 TGGGAAGAGAAGTTTGAGATTCGGCCCCCCTTCTCCCAGCTGGTGCTGCTTCTCGAGAGA       c.2880
 W  E  E  K  F  E  I  R  P  P  F  S  Q  L  V  L  L  L  E  R         p.960

          .         .     | 22   .         .         .         .    g.43045
 CTGTTGGGCGAAGGTTACAAAAAG | AAGTACCAGCAGGTGGATGAGGAGTTTCTGAGGAGT    c.2940
 L  L  G  E  G  Y  K  K   | K  Y  Q  Q  V  D  E  E  F  L  R  S      p.980

          .         .         .         .         .         .       g.43105
 GACCACCCAGCCATCCTTCGGTCCCAGGCCCGCTTGCCTGGGTTCCATGGCCTCCGATCT       c.3000
 D  H  P  A  I  L  R  S  Q  A  R  L  P  G  F  H  G  L  R  S         p.1000

          .         .         .         .         .         .       g.43165
 CCCCTGGACACCAGCTCCGTCCTCTATACTGCCGTGCAGCCCAATGAGGGTGACAACGAC       c.3060
 P  L  D  T  S  S  V  L  Y  T  A  V  Q  P  N  E  G  D  N  D         p.1020

          .         .         .         .         .         .       g.43225
 TATATCATCCCCCTGCCTGACCCCAAACCCGAGGTTGCTGACGAGGGCCCACTGGAGGGT       c.3120
 Y  I  I  P  L  P  D  P  K  P  E  V  A  D  E  G  P  L  E  G         p.1040

          .        | 23.         .         .         .         .    g.44956
 TCCCCCAGCCTAGCCAG | CTCCACCCTGAATGAAGTCAACACCTCCTCAACCATCTCCTGT    c.3180
 S  P  S  L  A  S  |  S  T  L  N  E  V  N  T  S  S  T  I  S  C      p.1060

          .         .         .         .         .         .       g.45016
 GACAGCCCCCTGGAGCCCCAGGACGAACCAGAGCCAGAGCCCCAGCTTGAGCTCCAGGTG       c.3240
 D  S  P  L  E  P  Q  D  E  P  E  P  E  P  Q  L  E  L  Q  V         p.1080

          .         .         .         .         .         .       g.45076
 GAGCCGGAGCCAGAGCTGGAACAGTTGCCGGATTCGGGGTGCCCTGCGCCTCGGGCGGAA       c.3300
 E  P  E  P  E  L  E  Q  L  P  D  S  G  C  P  A  P  R  A  E         p.1100

          .         .                                               g.45097
 GCAGAGGATAGCTTCCTGTAG                                              c.3321
 A  E  D  S  F  L  X                                                p.1106

          .         .         .         .         .         .       g.45157
 ggggctggcccctaccctgccctgcctgaagctccccccctgccagcacccagcatctcc       c.*60

          .         .         .         .         .         .       g.45217
 tggcctggcctgaccgggcttcctgtcagccaggctgcccttatcagctgtccccttctg       c.*120

          .         .         .         .         .         .       g.45277
 gaagctttctgctcctgacgtgttgtgccccaaaccctggggctggcttaggaggcaaga       c.*180

          .         .         .         .         .         .       g.45337
 aaactgcaggggccgtgaccagccctctgcctccagggaggccaactgactctgagccag       c.*240

          .         .         .         .         .         .       g.45397
 ggttcccccagggaactcagttttcccatatgtaagatgggaaagttaggcttgatgacc       c.*300

          .         .         .         .         .         .       g.45457
 cagaatctaggattctctccctggctgacaggtggggagaccgaatccctccctgggaag       c.*360

          .         .         .         .         .         .       g.45517
 attcttggagttactgaggtggtaaattaacttttttctgttcagccagctacccctcaa       c.*420

          .         .         .         .         .         .       g.45577
 ggaatcatagctctctcctcgcacttttatccacccaggagctagggaagagaccctagc       c.*480

          .         .         .         .         .         .       g.45637
 ctccctggctgctggctgagctagggcctagccttgagcagtgttgcctcatccagaaga       c.*540

          .         .         .         .         .         .       g.45697
 aagccagtctcctccctatgatgccagtccctgcgttccctggcccgagctggtctgggg       c.*600

          .         .         .         .         .         .       g.45757
 ccattaggcagcctaattaatgctggaggctgagccaagtacaggacacccccagcctgc       c.*660

          .         .         .         .         .         .       g.45817
 agcccttgcccagggcacttggagcacacgcagccatagcaagtgcctgtgtccctgtcc       c.*720

          .         .         .         .         .         .       g.45877
 ttcaggcccatcagtcctggggctttttctttatcaccctcagtcttaatccatccacca       c.*780

          .         .         .         .         .         .       g.45937
 gagtctagaaggccagacgggccccgcatctgtgatgagaatgtaaatgtgccagtgtgg       c.*840

          .         .         .         .         .         .       g.45997
 agtggccacgtgtgtgtgccagtatatggccctggctctgcattggacctgctatgaggc       c.*900

          .         .         .         .         .         .       g.46057
 tttggaggaatccctcaccctctctgggcctcagtttccccttcaaaaaatgaataagtc       c.*960

          .         .         .         .         .         .       g.46117
 ggacttattaactctgagtgccttgccagcactaacattctagagtattccaggtggttg       c.*1020

          .         .         .         .         .         .       g.46177
 cacatttgtccagatgaagcaaggccatataccctaaacttccatcctgggggtcagctg       c.*1080

          .         .         .         .         .         .       g.46237
 ggctcctgggagattccagatcacacatcacactctggggactcaggaaccatgcccctt       c.*1140

          .         .         .         .         .         .       g.46297
 ccccaggcccccagcaagtctcaagaacacagctgcacaggccttgacttagagtgacag       c.*1200

          .         .         .         .         .         .       g.46357
 ccggtgtcctggaaagcccccagcagctgccccagggacatgggaagaccacgggacctc       c.*1260

          .         .         .         .         .         .       g.46417
 tttcactacccacgatgacctccgggggtatcctgggcaaaagggacaaagagggcaaat       c.*1320

          .         .         .         .         .         .       g.46477
 gagatcacctcctgcagcccaccactccagcacctgtgccgaggtctgcgtcgaagacag       c.*1380

          .         .         .         .         .         .       g.46537
 aatggacagtgaggacagttatgtcttgtaaaagacaagaagcttcagatgggtacccca       c.*1440

          .         .         .         .         .         .       g.46597
 agaaggatgtgagaggtgggcgctttggaggtttgcccctcacccaccagctgccccatc       c.*1500

          .         .         .         .         .         .       g.46657
 cctgaggcagcgctccatgggggtatggttttgtcactgcccagacctagcagtgacatc       c.*1560

          .         .         .         .         .         .       g.46717
 tcattgtccccagcccagtgggcattggaggtgccaggggagtcagggttgtagccaaga       c.*1620

          .         .         .         .         .         .       g.46777
 cgcccccgcacggggagggttgggaagggggtgcaggaagctcaacccctctgggcacca       c.*1680

          .         .         .         .         .         .       g.46837
 accctgcattgcaggttggcaccttacttccctgggatccccagagttggtccaaggagg       c.*1740

          .         .         .         .         .         .       g.46897
 gagagtgggttctcaatacggtaccaaagatataatcacctaggtttacaaatattttta       c.*1800

          .         .         .         .         .         .       g.46957
 ggactcacgttaactcacatttatacagcagaaatgctattttgtatgctgttaagtttt       c.*1860

          .         .         .         .         .         .       g.47017
 tctatctgtgtacttttttttaagggaaagattttaatattaaacctggtgcttctcact       c.*1920

                                                                    g.47021
 caca                                                               c.*1924

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Platelet-derived growth factor receptor, beta polypeptide protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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