pyruvate dehydrogenase complex, component X (PDHX) - coding DNA reference sequence

(used for variant description)

(last modified December 7, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_003477.2 in the PDHX gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_013368.1, covering PDHX transcript NM_003477.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5046
               aaacgcccggcccgctaccctgcgcccagctccagccgccgggtcc       c.-481

 .         .         .         .         .         .                g.5106
 cgcctgggcctctcctcctgggaataccgggcaccggtggccccgcccctacctgcgcgc       c.-421

 .         .         .         .         .         .                g.5166
 cgcatctccgggaacaacagtctccctcccgagcatcacagccagacatggcccagacca       c.-361

 .         .         .         .         .         .                g.5226
 gggacccgcgcggcctccaatctccgcacggctttgcgcgcggcgcttagcctgggatac       c.-301

 .         .         .         .         .         .                g.5286
 ggcagcgaggccgcaaatgcaatcaggcggcgctgagggcagcccgggggcggggcgaac       c.-241

 .         .         .         .         .         .                g.5346
 ggggcgggggccggggtctggtaaggccccgccggctgagatatccagcggcgcacctga       c.-181

 .         .         .         .         .         .                g.5406
 cttcccgggaggcaaggccaacgtggttggaggcggggctgggttggggggcgggggttc       c.-121

 .         .         .         .         .         .                g.5466
 aagtctgagagacctaaaggcaccgctagcgtctgggggcgtggccaaccatgcgggagg       c.-61

 .         .         .         .         .         .                g.5526
 cggggccttgatgctggacatcaggctgtgctgcgggcagccagtgagaaggccgtcaag       c.-1

          .         .         .         .         .         .       g.5586
 ATGGCGGCCTCCTGGAGGCTGGGCTGTGATCCGCGGCTGCTGCGTTATCTTGTGGGCTTC       c.60
 M  A  A  S  W  R  L  G  C  D  P  R  L  L  R  Y  L  V  G  F         p.20

          .         .         .         .         .         .       g.5646
 CCCGGCCGCCGAAGCGTAGGGCTGGTGAAGGGGGCTCTTGGGTGGTCTGTAAGCCGCGGA       c.120
 P  G  R  R  S  V  G  L  V  K  G  A  L  G  W  S  V  S  R  G         p.40

          .         .         .         . | 02       .         .    g.20294
 GCTAATTGGAGATGGTTTCACAGCACGCAGTGGCTTCGGG | GTGATCCCATTAAGATACTA    c.180
 A  N  W  R  W  F  H  S  T  Q  W  L  R  G |   D  P  I  K  I  L      p.60

          .         .         .         .         .         .       g.20354
 ATGCCATCACTGTCTCCTACAATGGAAGAAGGAAACATTGTGAAATGGCTGAAAAAGGAA       c.240
 M  P  S  L  S  P  T  M  E  E  G  N  I  V  K  W  L  K  K  E         p.80

   | 03      .         .         .         .         .         .    g.36435
 G | GTGAAGCGGTGAGTGCTGGAGATGCATTATGTGAAATTGAGACTGACAAAGCTGTGGTT    c.300
 G |   E  A  V  S  A  G  D  A  L  C  E  I  E  T  D  K  A  V  V      p.100

          .         .         .         .   | 04     .         .    g.46272
 ACCTTAGATGCAAGTGATGATGGAATCTTGGCCAAAATCGTG | GTTGAAGAAGGAAGTAAA    c.360
 T  L  D  A  S  D  D  G  I  L  A  K  I  V   | V  E  E  G  S  K      p.120

          .         .         .         .         .         .       g.46332
 AATATACGGCTAGGTTCACTAATTGGTTTGATAGTAGAAGAAGGAGAAGATTGGAAACAT       c.420
 N  I  R  L  G  S  L  I  G  L  I  V  E  E  G  E  D  W  K  H         p.140

          .         .         .         .         .         .       g.46392
 GTTGAAATTCCCAAAGACGTAGGTCCTCCACCACCAGTTTCAAAACCTTCAGAGCCTCGC       c.480
 V  E  I  P  K  D  V  G  P  P  P  P  V  S  K  P  S  E  P  R         p.160

          .         .         .         .         .         .       g.46452
 CCCTCACCAGAACCACAGATTTCCATCCCTGTCAAGAAGGAACACATACCCGGGACACTA       c.540
 P  S  P  E  P  Q  I  S  I  P  V  K  K  E  H  I  P  G  T  L         p.180

    | 05     .         .         .         .         .         .    g.49348
 CG | GTTCCGTTTAAGTCCAGCTGCCCGCAATATTCTGGAAAAACACTCACTGGATGCTAGC    c.600
 R  |  F  R  L  S  P  A  A  R  N  I  L  E  K  H  S  L  D  A  S      p.200

          .         .         .         .  | 06      .         .    g.55529
 CAGGGCACAGCCACTGGCCCTCGGGGGATATTCACTAAAGA | GGATGCTCTCAAACTTGTC    c.660
 Q  G  T  A  T  G  P  R  G  I  F  T  K  E  |  D  A  L  K  L  V      p.220

          .         .         .         .         .         .       g.55589
 CAGTTGAAACAAACGGGCAAGATTACCGAGTCCAGACCAACTCCAGCCCCCACAGCCACT       c.720
 Q  L  K  Q  T  G  K  I  T  E  S  R  P  T  P  A  P  T  A  T         p.240

          .         .         .         .         .         .       g.55649
 CCCACAGCACCTTCGCCCCTACAGGCCACAGCTGGACCATCTTATCCCCGGCCTGTGATC       c.780
 P  T  A  P  S  P  L  Q  A  T  A  G  P  S  Y  P  R  P  V  I         p.260

          .         .         .       | 07 .         .         .    g.59033
 CCACCAGTATCAACTCCTGGACAACCCAATGCAGTG | GGCACATTCACTGAAATCCCCGCC    c.840
 P  P  V  S  T  P  G  Q  P  N  A  V   | G  T  F  T  E  I  P  A      p.280

          .         .         .         .         .         .       g.59093
 AGCAATATTCGAAGAGTTATTGCCAAGAGATTAACTGAATCTAAAAGTACTGTACCTCAT       c.900
 S  N  I  R  R  V  I  A  K  R  L  T  E  S  K  S  T  V  P  H         p.300

          .         .         .         .         .         .       g.59153
 GCATATGCTACTGCTGACTGTGACCTTGGAGCTGTTTTAAAAGTTAGGCAAGATCTGGTC       c.960
 A  Y  A  T  A  D  C  D  L  G  A  V  L  K  V  R  Q  D  L  V         p.320

      | 08   .         .         .         .         .         .    g.67050
 AAAG | ATGACATTAAAGTATCAGTAAATGATTTTATCATCAAGGCAGCAGCTGTTACCCTT    c.1020
 K  D |   D  I  K  V  S  V  N  D  F  I  I  K  A  A  A  V  T  L      p.340

     | 09    .         .         .         .         .         .    g.73497
 AAA | CAAATGCCAGATGTTAATGTAAGCTGGGATGGAGAGGGCCCAAAGCAACTGCCATTT    c.1080
 K   | Q  M  P  D  V  N  V  S  W  D  G  E  G  P  K  Q  L  P  F      p.360

          .         .         .         .         .         .       g.73557
 ATTGACATTTCAGTGGCTGTGGCAACAGATAAAGGCTTACTTACTCCAATCATAAAAGAT       c.1140
 I  D  I  S  V  A  V  A  T  D  K  G  L  L  T  P  I  I  K  D         p.380

          .         .         .         .   | 10     .         .    g.81203
 GCTGCTGCTAAAGGTATCCAGGAAATTGCTGACTCTGTAAAG | GCTCTATCAAAGAAAGCA    c.1200
 A  A  A  K  G  I  Q  E  I  A  D  S  V  K   | A  L  S  K  K  A      p.400

          .         .         .         .        | 11.         .    g.83797
 AGAGATGGAAAATTGTTGCCTGAAGAATACCAAGGAGGATCTTTTAG | TATTTCCAACTTG    c.1260
 R  D  G  K  L  L  P  E  E  Y  Q  G  G  S  F  S  |  I  S  N  L      p.420

          .         .         .         .         .         .       g.83857
 GGGATGTTTGGCATCGACGAATTTACTGCAGTGATTAACCCTCCTCAGGCCTGCATTTTG       c.1320
 G  M  F  G  I  D  E  F  T  A  V  I  N  P  P  Q  A  C  I  L         p.440

          .         .         .         .         .         .       g.83917
 GCGGTTGGGAGGTTCCGACCTGTGCTGAAGCTCACTGAGGATGAAGAGGGAAATGCCAAA       c.1380
 A  V  G  R  F  R  P  V  L  K  L  T  E  D  E  E  G  N  A  K         p.460

          .         .         .         .         .         .       g.83977
 CTGCAGCAGCGCCAGCTCATAACAGTCACAATGTCAAGTGACAGTCGAGTGGTTGATGAC       c.1440
 L  Q  Q  R  Q  L  I  T  V  T  M  S  S  D  S  R  V  V  D  D         p.480

          .         .         .         .         .         .       g.84037
 GAACTGGCAACCAGGTTTCTTAAAAGTTTTAAAGCAAACCTAGAGAATCCTATCCGACTT       c.1500
 E  L  A  T  R  F  L  K  S  F  K  A  N  L  E  N  P  I  R  L         p.500

                                                                    g.84043
 GCCTAG                                                             c.1506
 A  X                                                               p.501

          .         .         .         .         .         .       g.84103
 tcctcaaagataagaagttggtgttcagcttagttgattcagtagttgttaccaagaaac       c.*60

          .         .         .         .         .         .       g.84163
 atatgttataggaaaacaacttggtatttaagtatgaagtggatgaaatgtttatttatt       c.*120

          .         .         .         .         .         .       g.84223
 taaggtgaaagcatttgacccagggtgtcttcatcttcaatttgggtttaatgttataga       c.*180

          .         .         .         .         .         .       g.84283
 aataaatgatgataaactctaactaataaaggaaagagaatatttggttactcagatcca       c.*240

          .         .         .         .         .         .       g.84343
 tttttaacctctggtgctgtataaagggaatattaaactagatgtaaatcaaagtatatg       c.*300

          .         .         .         .         .         .       g.84403
 tttggctcatttgagcattttggaatatttgagaatgtatgatacatgtaaaattaaaaa       c.*360

          .         .         .         .         .         .       g.84463
 aactattagaactgtaccataattatgttgaaggtagaagtgatcttcaaagagatggcc       c.*420

          .         .         .         .         .         .       g.84523
 attaacttagcagtgggacctcacttttacaagcactgctctagatatacttgaagaatt       c.*480

          .         .         .         .         .         .       g.84583
 taataggtacagaagtttattctggataataaataaataaggatcacactgtattagggg       c.*540

          .         .         .         .         .         .       g.84643
 ttatggcaacattattgaattttttatgtacataaagccatatgtttagggtggtttcta       c.*600

          .         .         .         .         .         .       g.84703
 tctgtcttgtttttcacttatataacactgtgaacttctaaagcaagaggataaaagaag       c.*660

          .         .         .         .         .         .       g.84763
 catgaatgaaaagaatgacatttcaaaaaaatggttcaatgaaaaactatagctaaaata       c.*720

          .         .         .         .         .         .       g.84823
 tgtaaacctttctaggtaaaccgcttgccttcatcttgagtcggaatatatttaaataaa       c.*780

          .         .         .         .         .         .       g.84883
 ttgtgttatctcttgccaaacattttgttagtgtttatttaaaaacaaaatgttgtttct       c.*840

          .         .         .         .         .         .       g.84943
 taatgcatttaaatcagttttgtattgtgcagtaaaatgtgagaaaatataaacatttct       c.*900

          .         .         .         .         .                 g.84999
 attgtattttaaatgttaaaacacaaaagttcaataaaccttgaagttgattagta           c.*956

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Pyruvate dehydrogenase complex, component X protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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