pyridoxal (pyridoxine, vitamin B6) kinase (PDXK) - coding DNA reference sequence

(used for variant description)

(last modified March 26, 2026)


This file was created to facilitate the description of sequence variants on transcript NM_003681.4 in the PDXK gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000021.8, covering PDXK transcript NM_003681.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5018
                                           cggaactcgcgggttcgg       c.-181

 .         .         .         .         .         .                g.5078
 agccgcccgctgaggtcagaaggaggcgtctgcgctgatcgggtccgccgcgcgccagag       c.-121

 .         .         .         .         .         .                g.5138
 ccagagtcgcagccgaggggagccggggccggagcccgagcccgagccgagccggagccc       c.-61

 .         .         .         .         .         .                g.5198
 gagcgagcggcggagaccgtgcccccgcctcggccccgcgccgccgcggccaggcccggc       c.-1

          .         .         .         .         .         .       g.5258
 ATGGAGGAGGAGTGCCGGGTGCTCTCCATACAGAGCCACGTCATCCGCGGCTACGTGGGC       c.60
 M  E  E  E  C  R  V  L  S  I  Q  S  H  V  I  R  G  Y  V  G         p.20

          .         .        | 02.         .         .         .    g.20005
 AACCGGGCGGCCACGTTCCCGCTGCAG | GTTTTGGGATTTGAGATTGACGCGGTGAACTCT    c.120
 N  R  A  A  T  F  P  L  Q   | V  L  G  F  E  I  D  A  V  N  S      p.40

          .         .   | 03     .         .         .         .    g.27608
 GTCCAGTTTTCAAACCACACAG | GCTATGCCCACTGGAAGGGCCAAGTGCTGAATTCAGAT    c.180
 V  Q  F  S  N  H  T  G |   Y  A  H  W  K  G  Q  V  L  N  S  D      p.60

          .         .         .         .         .         .       g.27668
 GAGCTCCAGGAGTTGTACGAAGGCCTGAGGCTGAACAACATGAATAAATATGACTACGTG       c.240
 E  L  Q  E  L  Y  E  G  L  R  L  N  N  M  N  K  Y  D  Y  V         p.80

         | 04.         .         .         .         .         .    g.29680
 CTCACAG | GTTATACGAGGGACAAGTCGTTCCTGGCCATGGTGGTGGACATTGTGCAGGAG    c.300
 L  T  G |   Y  T  R  D  K  S  F  L  A  M  V  V  D  I  V  Q  E      p.100

          .         .         .  | 05      .         .         .    g.32011
 CTGAAGCAGCAGAACCCCAGGCTGGTGTACG | TGTGTGATCCAGTCTTGGGTGACAAGTGG    c.360
 L  K  Q  Q  N  P  R  L  V  Y  V |   C  D  P  V  L  G  D  K  W      p.120

          .         | 06         .         .         .         .    g.34940
 GACGGCGAAGGCTCGATG | TACGTCCCGGAGGACCTCCTTCCCGTCTACAAAGAAAAAGTG    c.420
 D  G  E  G  S  M   | Y  V  P  E  D  L  L  P  V  Y  K  E  K  V      p.140

          .         .         .         .     | 07   .         .    g.36419
 GTGCCGCTTGCAGACATTATCACGCCCAACCAGTTTGAGGCCGA | GTTACTGAGTGGCCGG    c.480
 V  P  L  A  D  I  I  T  P  N  Q  F  E  A  E  |  L  L  S  G  R      p.160

          .         .         . | 08       .         .         .    g.38451
 AAGATCCACAGCCAGGAGGAAGCCTTGCGG | GTGATGGACATGCTGCACTCTATGGGCCCC    c.540
 K  I  H  S  Q  E  E  A  L  R   | V  M  D  M  L  H  S  M  G  P      p.180

          .         .         .         .         .         .       g.38511
 GACACCGTGGTCATCACCAGCTCCGACCTGCCCTCCCCGCAGGGCAGCAACTACCTGATT       c.600
 D  T  V  V  I  T  S  S  D  L  P  S  P  Q  G  S  N  Y  L  I         p.200

          .         .   | 09     .         .         .         .    g.39524
 GTGCTGGGGAGTCAGAGGAGGA | GGAATCCCGCTGGCTCCGTGGTGATGGAACGCATCCGG    c.660
 V  L  G  S  Q  R  R  R |   N  P  A  G  S  V  V  M  E  R  I  R      p.220

          .         .         .         .         .         .       g.39584
 ATGGACATTCGCAAAGTGGACGCCGTCTTTGTGGGCACTGGGGACCTGTTTGCTGCCATG       c.720
 M  D  I  R  K  V  D  A  V  F  V  G  T  G  D  L  F  A  A  M         p.240

          .         .         .          | 10        .         .    g.41622
 CTCCTGGCGTGGACACACAAGCACCCCAATAACCTCAAG | GTGGCCTGTGAGAAGACCGTG    c.780
 L  L  A  W  T  H  K  H  P  N  N  L  K   | V  A  C  E  K  T  V      p.260

          .         .         .         .       | 11 .         .    g.41868
 TCTACCTTGCACCACGTTCTGCAGAGGACCATCCAGTGTGCAAAAG | CCCAGGCCGGGGAA    c.840
 S  T  L  H  H  V  L  Q  R  T  I  Q  C  A  K  A |   Q  A  G  E      p.280

          .         .         .         .         .         .       g.41928
 GGAGTGAGGCCCAGCCCCATGCAGCTGGAGCTGCGGATGGTGCAGAGCAAAAGGGACATC       c.900
 G  V  R  P  S  P  M  Q  L  E  L  R  M  V  Q  S  K  R  D  I         p.300

          .         .         .                                     g.41967
 GAGGACCCAGAGATCGTCGTCCAGGCCACGGTGCTGTGA                            c.939
 E  D  P  E  I  V  V  Q  A  T  V  L  X                              p.312

          .         .         .         .         .         .       g.42027
 gggccccgccgcttgcccgtgacacgcagcgcgttggtgtctccgtgtttgtccctgtga       c.*60

          .         .         .         .         .         .       g.42087
 aaacatgtaacgtctgccttagagccatgaccgaaacttgatatttttttctttcatgag       c.*120

          .         .         .         .         .         .       g.42147
 tgtccggcatctgctggtcttcattgtgaaacgtgccagtcgtgctttgtgaaaaataac       c.*180

          .         .         .         .         .         .       g.42207
 aaagtggtcacagaaatttgtgatctgaaaacccggctcccttccccacaaggctcctgg       c.*240

          .         .         .         .         .         .       g.42267
 gcctccgggaagacgggcccctgtttgccatctcgggggtgttccctgtgggagggtgag       c.*300

          .         .         .         .         .         .       g.42327
 tgggtgaggccgagcctgctgcgtgtggagcctcgagtgggccctggctgccactaccgt       c.*360

          .         .         .         .         .         .       g.42387
 acagaggccgtgtcgcgctgggctgggcctgggtggcctctgtctttgcatctctgagaa       c.*420

          .         .         .         .         .         .       g.42447
 ggagtcgggtggtaacggttggggtcaggaagaattctgccaagtatctttactgtcatt       c.*480

          .         .         .         .         .         .       g.42507
 ctgaccatagcctctttgttcccgcattcgaacttttggttcttactttgctgctcgttt       c.*540

          .         .         .         .         .         .       g.42567
 agtccctggggatttcagatcttaggctgttgtttcaccgtatgggagggttgatgtgag       c.*600

          .         .         .         .         .         .       g.42627
 cttgcttggagacacacggtgcagcatcagggaccttcccaggccccagcaaattcaagt       c.*660

          .         .         .         .         .         .       g.42687
 cggtctgcagacctctcagctacccgcgggacctcttgtaacccatcggcatcttccagg       c.*720

          .         .         .         .         .         .       g.42747
 aatccgccgagtgacttgaggaagatgctaacgcagtaaggtctgtgctgggccaagagc       c.*780

          .         .         .         .         .         .       g.42807
 agctttgaagctccagagaaccaccccgtcaggttccttgtggaagctcccctcatccgt       c.*840

          .         .         .         .         .         .       g.42867
 ggtgcagcaggctgagcactgcgcgtttgccacgtgctgcccgtgacagcacattgagcc       c.*900

          .         .         .         .         .         .       g.42927
 acagcatttgtagacaggacagaggggtgcctgccccctgcccctgctggcacatttaac       c.*960

          .         .         .         .         .         .       g.42987
 ccttgtcccctgacctcagttctgtgccccaccaaatgcccaggggcaagaggccaccct       c.*1020

          .         .         .         .         .         .       g.43047
 ggaagctgccaatcttccaaggtgggtgtggggcacggtgggggcgggcagctcccaggc       c.*1080

          .         .         .         .         .         .       g.43107
 ccttgggcaggctggggtgacggcagaggccacagcaccagctctgacaagtcctatcat       c.*1140

          .         .         .         .         .         .       g.43167
 cctctgctcagcagtgacctccctggccccactttgcccagagtttggggtccccccagg       c.*1200

          .         .         .         .         .         .       g.43227
 tatagctataggcggcagtgcctgtccctggcctgccttgatttcagccacacccctgca       c.*1260

          .         .         .         .         .         .       g.43287
 gccctgcatcccagctctggggtgtgcagaggtttgtgtctccagggaacccacggctgg       c.*1320

          .         .         .         .         .         .       g.43347
 agagaaatagggagatgcaggaagtgggggcccatggggcccccaagaagcggactctcc       c.*1380

          .         .         .         .         .         .       g.43407
 aaggggtacccccaccccgctaccttccccacggacgggcccctcctggagcccataccc       c.*1440

          .         .         .         .         .         .       g.43467
 tcctgtgaggccattccagtgtcttctagaaagactcgcttgccaggagtgcgttctttg       c.*1500

          .         .         .         .         .         .       g.43527
 ttgaaaaatgccctgaagcgaaaagatgcaggtttatatggaacccccaccccctccccc       c.*1560

          .         .         .         .         .         .       g.43587
 actctcccactctgttcgttctgaatgtcttcacgagcgtgcatcagggcgcctggctcc       c.*1620

          .         .         .         .         .         .       g.43647
 cccacctcagccagtgagtcagacacgggtttcgcagccatgtttcctggctccgaggac       c.*1680

          .         .         .         .         .         .       g.43707
 acgggtggcaggcccgttgcagcccagagccactggtccctacagggcgccgccacacca       c.*1740

          .         .         .         .         .         .       g.43767
 gcaggaaggaggatggctgtgtccggagcctggcggggaggcggcctccccagtatgtga       c.*1800

          .         .         .         .         .         .       g.43827
 gtgcagggatctgccagaaccacctggccctctgtagggcgtttaactggaaataccctc       c.*1860

          .         .         .         .         .         .       g.43887
 actgccaagtggagactggggcgtgtgccacattgccagccaccaggaaagcttttcttt       c.*1920

          .         .         .         .         .         .       g.43947
 ttcttttttttttttttttaaacaccaagagcacgtatagcatgggggaaagaacctaaa       c.*1980

          .         .         .         .         .         .       g.44007
 tgtctctctgtcctgtgagctggtgaaaaacccagcatgagaacgcagtgtcaggtgtgg       c.*2040

          .         .         .         .         .         .       g.44067
 gactccttctgcccctgcagtgggtgttacgggcggtgtgccctggcgagcaagctttga       c.*2100

          .         .         .         .         .         .       g.44127
 ttcttggttctttgagctcgtttcagaggctgagtccccacatcagctttagttcttgga       c.*2160

          .         .         .         .         .         .       g.44187
 cttccctgtattaagcaagaattaggagaatggctgtccctgcaggcgcctcccgtaaat       c.*2220

          .         .         .         .         .         .       g.44247
 cctgagctctctggcgcaatctgaaacttctcttctgttttctttggctgtatcagccga       c.*2280

          .         .         .         .         .         .       g.44307
 accaggagaggcctgggctgcgactaaggagaaagaaatcgggggtttctgagagcagat       c.*2340

          .         .         .         .         .         .       g.44367
 ggtgcctttgtgggtgcagggcttttgtggaaattgtcagcctctacgggcagagtccgg       c.*2400

          .         .         .         .         .         .       g.44427
 catcccctccccagactgcctgctgtcaaaccacggagcagctggagcctgccctgtcca       c.*2460

          .         .         .         .         .         .       g.44487
 cggcccgtttccacccgggcatgttcgtctctcctgacttcggcagaggcccctggtggc       c.*2520

          .         .         .         .         .         .       g.44547
 cttcagtttcagtttctcatccaggaaggtaaccttgggcattggcagtgggtttcccta       c.*2580

          .         .         .         .         .         .       g.44607
 tggcttggatccagattagaattgatctttgttttcactttccatagttaataacatgca       c.*2640

          .         .         .         .         .         .       g.44667
 aaataatgagaagaatttattttaaggtgacagctatactggtccaacatcgcctgctta       c.*2700

          .         .         .         .         .         .       g.44727
 ttgtcagggtacagaagtttaatactttcttaatccagtttttcaaacttctccctgtag       c.*2760

          .         .         .         .         .         .       g.44787
 accgtaaggatgaattccacaataggatcctttttaaaatcgattttaaattgttgccta       c.*2820

          .         .         .         .         .         .       g.44847
 gtcctgccaaggttattatgtgcatctgttatttttccaatacatgtaaacagttgcagc       c.*2880

          .         .         .         .         .         .       g.44907
 atgatgctttgtttaatgtcctgttcttaagctcgttagagccagttttgaaacgtttgg       c.*2940

          .         .         .         .         .         .       g.44967
 tcttaccgtgaacggaggctggcttggcttagccacgctgatgagtaagtgagggatgtc       c.*3000

          .         .         .         .         .         .       g.45027
 tccatcttgagatcaccaggcaagagagttgcctgcaccaggtaagaggccaaagcccct       c.*3060

          .         .         .         .         .         .       g.45087
 ggggtaacagtccccaccgctacccgaggtaaaacaataaaagctatgtggttgagctca       c.*3120

          .         .         .         .         .         .       g.45147
 ggcctctcgtgcctggtgtcagagaaggcagagcccacagtaggtgcacggtgcaaggcc       c.*3180

          .         .         .         .         .         .       g.45207
 ctgggagggcactggccagggaaggtggtatagatggccctcagattgcggggccccgag       c.*3240

          .         .         .         .         .         .       g.45267
 cagctccccactctgcccgtccaccttccctggctccagcctcattctctctttagttta       c.*3300

          .         .         .         .         .         .       g.45327
 actatgcaaagagaggaggttgagagtgttctggcagctggagctcttttccttgtcctt       c.*3360

          .         .         .         .         .         .       g.45387
 cctgccctccgatggggccacctgtgtcggggcagcagtgtccatgtttatggagatcag       c.*3420

          .         .         .         .         .         .       g.45447
 aggtgtccccactgtgtggctggactgtactctgctgcccgggtagccaggagtctctcc       c.*3480

          .         .         .         .         .         .       g.45507
 ctctctcccctgccgcctgcctggtctcatgggcctccttcacacacccctccctgtgga       c.*3540

          .         .         .         .         .         .       g.45567
 tcgcctgcctgggcccagagcaggggaactggagtttgtgagtgagcagagcaggttatg       c.*3600

          .         .         .         .         .         .       g.45627
 tgcagacagggaaacgagaactttggacctggctttctgagtccaggtgagagctgtgtg       c.*3660

          .         .         .         .         .         .       g.45687
 gccccccgatgccactctgcccgccggagggatgtgcctgctgagccttttccttccacg       c.*3720

          .         .         .         .         .         .       g.45747
 ccgcctctcactgccaggccagcggcttccgctgagactcgctggagaggcggctcccgt       c.*3780

          .         .         .         .         .         .       g.45807
 gtccgtccaccgagcactcagatggatgctgatcaccagggccgagggggctcccagaag       c.*3840

          .         .         .         .         .         .       g.45867
 gaccccaggccctggggagggtggctgtgggaggccaagtccactgcccggaagtcttgt       c.*3900

          .         .         .         .         .         .       g.45927
 cagccctaagccagggaagcctggagcgtggcctggcgggtctgggtggacaccgtcccc       c.*3960

          .         .         .         .         .         .       g.45987
 actccggactcccagcacaggggaggatacctgagcctgtatggccctgtagccctgggc       c.*4020

          .         .         .         .         .         .       g.46047
 agagctgggcctgtcgtgtgttcctgcctggcaggtgcaggtgctggccatctgcaggtg       c.*4080

          .         .         .         .         .         .       g.46107
 gaaggaggtgggaatcttggattttttgtttttttttgtttttttttttttgaggtgaag       c.*4140

          .         .         .         .         .         .       g.46167
 tctcgctctgacacccaggctggcgtgcagtggtgtgatctcggctcactgcaaactccg       c.*4200

          .         .         .         .         .         .       g.46227
 cttcctgggttcaagtggttctcctgccccagcctcccaagtagctgggattacaggcat       c.*4260

          .         .         .         .         .         .       g.46287
 gcgccaccacgctcagctgatttttgtatttttagtagagatggggtttcaccatgttgg       c.*4320

          .         .         .         .         .         .       g.46347
 ccaagctggtctcaaactcctgacctcaagtgatctgcccgcctcggcctcccagagtgc       c.*4380

          .         .         .         .         .         .       g.46407
 tgggattacaggcatgagccagtgcacccggcggaatcttggaatttttatagacagcac       c.*4440

          .         .         .         .         .         .       g.46467
 ctcagtttctgactccagccgcacacctcctgcctctgccagcaggggttgccgccagac       c.*4500

          .         .         .         .         .         .       g.46527
 cagagccagggccaggtccctgcgtccatcccccccggtaggatggacgtgagccatcct       c.*4560

          .         .         .         .         .         .       g.46587
 tctaggggacttttttcagtgtgcgactcgtctctgttaggtggtaggagccagtttgtg       c.*4620

          .         .         .         .         .         .       g.46647
 tggcctgtgccacgctccacagtgcgtggctgggctctgtgtgtggcctgtgtcccctgt       c.*4680

          .         .         .         .         .         .       g.46707
 ccctgcaggacccagcaggcatcgtggcgtgacagctgtgtccaagccactgcccgggca       c.*4740

          .         .         .         .         .         .       g.46767
 tcccatcacccaccagggtgcacggtctctcctgctgggggctttctgtcgcatgtgtgt       c.*4800

          .         .         .         .         .         .       g.46827
 ctcctgtcgactctgcagtttgttctcagagcagaatgtttcctgttctcagtgcacaaa       c.*4860

          .         .         .         .         .         .       g.46887
 gacactggttttcaatcggcgtctaaaaccacgttcctgcctttcattgcaacacggtgt       c.*4920

          .         .         .         .         .         .       g.46947
 gttcatttgtttaaaacagtttaatgagtaagtttagatgactggtcaatatcttaaaaa       c.*4980

          .         .         .         .         .         .       g.47007
 tgtatattagtaagaagttcttcctggaatttttctttcgattctggcagaataaacagg       c.*5040

          .         .         .         .         .         .       g.47067
 tgtttttagttttcccactgtctgagccaagcaggaccctgtcccagagcaagagatgtc       c.*5100

          .         .         .         .         .         .       g.47127
 cccttccatctctgacccttgcctgggacaagctttgatggggggccccagcttcaaggc       c.*5160

          .         .         .         .         .         .       g.47187
 tgtggtgggaacagcacccccaaatgccagcctctcctttcttcccatccaccagtatac       c.*5220

          .         .         .         .         .         .       g.47247
 tgcggggccatttctggtctttgtccaacaggaaacccatttctggtgggatatgccttc       c.*5280

          .         .         .         .         .         .       g.47307
 cagtgccacagggccactcaccccatgcatctctgtcctgcccgtcagtgctgggacgga       c.*5340

          .         .         .         .         .         .       g.47367
 cagcaagggcaagcccagtgtctggcggataggtgggtgggaacagagaggggagaatgc       c.*5400

          .         .         .         .         .         .       g.47427
 cgtcctaagcttctgcttggggatcccccacacgacctgggtactgcctgggaaacctgt       c.*5460

          .         .         .         .         .         .       g.47487
 cctaagtaaaactatggacctcgcctcgcccaccggcctgcgaagccagcatctccgtga       c.*5520

          .         .         .         .         .         .       g.47547
 aggtggatggaagcgcctttgtcctcattttgagctgcaagctgggtcagcggctctgaa       c.*5580

          .         .         .         .         .         .       g.47607
 gccctcgagtgactttctaacccaagacccagcccctggcaggaggagggtgggtgcagg       c.*5640

          .         .         .         .         .         .       g.47667
 gctggtgggacaaaaagaggcctcagcaggcctggaagacccttccagtacatcccacag       c.*5700

          .         .         .         .         .         .       g.47727
 cgtgtcgagcagctgggagaacctgtgtcaagctcgagccgtcataggtccccatgaggt       c.*5760

          .         .         .         .         .         .       g.47787
 gtctgaagccccttcttggtgatgggaggcagaggtgctgacgttctggagcatggacgt       c.*5820

          .         .         .         .         .         .       g.47847
 gagtcctcagctggctccgcgtgggcccttggagggtgccaggtgtgtggtgaccttctg       c.*5880

          .         .         .         .         .         .       g.47907
 gatgcctttaacttcatggctgcgtcattcctgatttagaactttaaccggagcttcatc       c.*5940

          .         .         .         .         .         .       g.47967
 tagtgattgcaaaactggaccaatgggaggacggcggcgcagcccgctccctccgtggaa       c.*6000

          .         .         .         .         .         .       g.48027
 tggagctcagctcttcggaggcatcaaagcacctgtcgcctccgtggtccccctgctgag       c.*6060

          .         .         .         .         .         .       g.48087
 ggagtgcggcctctgcaaggttcgggggtggcttcgtttgcctggagtggccggccctgc       c.*6120

          .         .         .         .         .         .       g.48147
 ttgtgccatgtggatgtttgtgagcctcggtcctacagcactgtgtaggctgcatctgtt       c.*6180

          .         .         .         .         .         .       g.48207
 tcgtgctggtcctgttgacttgtatgatatccacaaataaatattttcatggcggtcgtg       c.*6240

                                                                    g.48211
 ttga                                                               c.*6244

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Pyridoxal (pyridoxine, vitamin B6) kinase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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