peroxisomal biogenesis factor 12 (PEX12) - coding DNA reference sequence

(used for variant description)

(last modified September 8, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_000286.2 in the PEX12 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008447.1, covering PEX12 transcript NM_000286.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5016
                                             tagagcgcctctcttc       c.-601

 .         .         .         .         .         .                g.5076
 cgccaggcatcccagaggtcctggtggtttcatttccgggtgcggcttctgtcataaagc       c.-541

 .         .         .         .         .         .                g.5136
 ggagacctcccttcaaacgtggcgtcgtgggttgtttgcgcctcgcctggggtcagcgag       c.-481

 .         .         .         .         .         .                g.5196
 caaggacgggcgcgggcggggatactcaaagccaacagctggagtcagcccttgtgtccc       c.-421

 .         .         .         .         .         .                g.5256
 gggctcacagtggcacgactgaatcctcagagtcggctggcttttgagctctcacgattg       c.-361

 .         .         .         .         .         .                g.5316
 gggaggagggggcgtttctggttcgcagctccagaggattgcgttccttcccccatacct       c.-301

 .         .         .         .         .         .                g.5376
 gtcccccacagtcacgctctgccctgacgtgcagcatttgacaagttaccccctcgccac       c.-241

 .         .         .         .         .         .                g.5436
 atactacttccacccacgtccgagttaactttgttcttaaccttcttgagactaccctcg       c.-181

 .         .         .         .         .         .                g.5496
 gcctccaggtctttttttcccagttcatttttgcccataagattgagtttcgagtttcag       c.-121

 .         .         .         .         .         .                g.5556
 atatcatgcagaaagtttacctttaagactgagcacccatctgatactcttcctcccgaa       c.-61

 .         .         .         .         .         .                g.5616
 aaagttcatgctcacgagagagtttgtgggaaaagtgaaagccagtacacgcaggaaact       c.-1

          .         .         .         .         .         .       g.5676
 ATGGCTGAGCACGGGGCTCACTTCACAGCTGCTTCTGTGGCCGATGACCAGCCATCCATC       c.60
 M  A  E  H  G  A  H  F  T  A  A  S  V  A  D  D  Q  P  S  I         p.20

          .         .         .         .         .         .       g.5736
 TTTGAGGTGGTAGCACAGGACAGTTTAATGACAGCAGTGAGACCCGCTCTTCAGCATGTG       c.120
 F  E  V  V  A  Q  D  S  L  M  T  A  V  R  P  A  L  Q  H  V         p.40

        | 02 .         .         .         .         .         .    g.6100
 GTCAAG | GTTCTTGCAGAATCAAATCCCACCCACTATGGCTTCTTGTGGAGGTGGTTTGAT    c.180
 V  K   | V  L  A  E  S  N  P  T  H  Y  G  F  L  W  R  W  F  D      p.60

          .         .         .         .         .         .       g.6160
 GAAATCTTTACTCTGCTAGATCTTCTGCTCCAGCAACATTATCTGTCTAGAACCAGTGCC       c.240
 E  I  F  T  L  L  D  L  L  L  Q  Q  H  Y  L  S  R  T  S  A         p.80

          .         .         .         .         .         .       g.6220
 TCATTTTCTGAAAACTTTTACGGCTTAAAGAGAATTGTAATGGGGGACACTCACAAGTCT       c.300
 S  F  S  E  N  F  Y  G  L  K  R  I  V  M  G  D  T  H  K  S         p.100

          .         .         .         .         .         .       g.6280
 CAGAGATTGGCTAGTGCTGGTCTCCCAAAGCAGCAGCTTTGGAAATCTATTATGTTCCTG       c.360
 Q  R  L  A  S  A  G  L  P  K  Q  Q  L  W  K  S  I  M  F  L         p.120

          .         .         .         .         .         .       g.6340
 GTTCTTCTTCCCTATCTGAAAGTGAAGCTGGAGAAGCTGGTTTCTAGCCTGAGAGAAGAG       c.420
 V  L  L  P  Y  L  K  V  K  L  E  K  L  V  S  S  L  R  E  E         p.140

          .         .         .         .         .         .       g.6400
 GATGAATATTCTATTCATCCCCCTTCTTCCCGCTGGAAACGATTTTACAGAGCTTTCCTG       c.480
 D  E  Y  S  I  H  P  P  S  S  R  W  K  R  F  Y  R  A  F  L         p.160

          .         .         .         .         .         .       g.6460
 GCAGCCTACCCATTTGTGAACATGGCCTGGGAAGGATGGTTTCTTGTACAACAACTTCGA       c.540
 A  A  Y  P  F  V  N  M  A  W  E  G  W  F  L  V  Q  Q  L  R         p.180

          .         .         .         .         .         .       g.6520
 TACATCCTAGGAAAAGCTCAGCATCACTCACCACTGCTGAGGCTGGCTGGAGTTCAGCTA       c.600
 Y  I  L  G  K  A  Q  H  H  S  P  L  L  R  L  A  G  V  Q  L         p.200

          .         .         .         .         .         .       g.6580
 GGTCGACTGACAGTTCAGGATATACAAGCTCTGGAGCACAAACCAGCTAAGGCCAGCATG       c.660
 G  R  L  T  V  Q  D  I  Q  A  L  E  H  K  P  A  K  A  S  M         p.220

          .         . | 03       .         .         .         .    g.7496
 ATGCAGCAACCAGCCAGGAG | TGTTAGTGAGAAGATAAACTCAGCTCTGAAGAAAGCTGTT    c.720
 M  Q  Q  P  A  R  S  |  V  S  E  K  I  N  S  A  L  K  K  A  V      p.240

          .         .         .         .         .         .       g.7556
 GGGGGTGTTGCCTTATCCCTGTCTACTGGCCTTTCTGTGGGTGTATTCTTCTTGCAGTTC       c.780
 G  G  V  A  L  S  L  S  T  G  L  S  V  G  V  F  F  L  Q  F         p.260

          .         .         .         .         .         .       g.7616
 CTTGACTGGTGGTACTCATCTGAAAATCAAGAAACCATCAAGTCATTGACTGCCCTGCCT       c.840
 L  D  W  W  Y  S  S  E  N  Q  E  T  I  K  S  L  T  A  L  P         p.280

          .         .         .         .         .         .       g.7676
 ACTCCACCACCACCTGTACACCTAGACTATAACTCTGATTCTCCCCTCTTACCCAAAATG       c.900
 T  P  P  P  P  V  H  L  D  Y  N  S  D  S  P  L  L  P  K  M         p.300

          .         .         .         .         .         .       g.7736
 AAGACTGTGTGCCCACTGTGTCGTAAAACCCGGGTGAATGATACTGTTCTTGCCACCTCT       c.960
 K  T  V  C  P  L  C  R  K  T  R  V  N  D  T  V  L  A  T  S         p.320

          .         .         .         .         .         .       g.7796
 GGCTATGTGTTTTGTTACCGCTGTGTGTTTCATTATGTGAGGAGTCACCAAGCTTGTCCC       c.1020
 G  Y  V  F  C  Y  R  C  V  F  H  Y  V  R  S  H  Q  A  C  P         p.340

          .         .         .         .         .         .       g.7856
 ATCACAGGTTATCCAACAGAAGTACAACATCTGATTAAACTCTACTCCCCTGAGAACTGA       c.1080
 I  T  G  Y  P  T  E  V  Q  H  L  I  K  L  Y  S  P  E  N  X         p.359

          .         .         .         .         .         .       g.7916
 aagggaatcatgtcttatcctcacaacaaaagtattgcgctgtaatgtcacagagctggt       c.*60

          .         .         .         .         .         .       g.7976
 ttcagcatggtattgagttgacacttctcagcctcaattcataactatatgaactttaaa       c.*120

          .         .         .         .         .         .       g.8036
 tgattatatggatttctttaaaaggatatgcccatttgatcctaaccttttagcctgctc       c.*180

          .         .         .         .         .         .       g.8096
 tctagaaccctacttacagttgaccaagctgcttaaagtagaaggatcaggactggcagg       c.*240

          .         .         .         .         .         .       g.8156
 ggatatgagggccagtgtagagattaaacagaataatgagtacacaagtttttgcctatc       c.*300

          .         .         .         .         .         .       g.8216
 cctttccttaaaatataagaaataaaggagctcttacgaaaaacccaggttagaccgcat       c.*360

          .         .         .         .         .         .       g.8276
 aaaaaataaagtgaacagtgaggtggtagcaagacttctttttagaaaagaaagcattta       c.*420

          .         .         .         .         .         .       g.8336
 cctgcctgtctgtaaggtggaaatttcatcagtttgcaaacgataagaaatgcagacttg       c.*480

          .         .         .         .         .         .       g.8396
 ctcttgatagaaatgcttagaaacactctgggggggaaaaaagctccttccatatactgt       c.*540

          .         .         .         .         .         .       g.8456
 gagacatttgttaagtgacatctattgtttatcagcttttaaggataaaaaaggtatttt       c.*600

          .         .         .         .         .         .       g.8516
 aaaagttggatatttaggatatttgaggatattcctttatgagctctccatatccttctt       c.*660

          .         .         .         .         .         .       g.8576
 gagaaactggttaaaaaaggaataggggttgagtgttacagagagtagtctgaagattcc       c.*720

          .         .         .         .         .         .       g.8636
 tgtgtaaaagcaaagctaacaagcaatgaagacatgaagcaaaatactaatctaattgtg       c.*780

          .         .         .         .         .         .       g.8696
 taaagaaaggatattttaataagttctttctgcttgctgctaagagtttgctaaagtgtc       c.*840

          .         .         .         .         .         .       g.8756
 atgaattattctggttattactaaagtttctatgaaacacttaagtagattttaagaata       c.*900

          .         .         .         .         .         .       g.8816
 aatgtttctggaaaagaactatgttatgattttgtagaaatgtaaagattacttgaggtg       c.*960

          .         .                                               g.8843
 tttaaaataaatttttcattcagacta                                        c.*987

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Peroxisomal biogenesis factor 12 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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