peroxisomal biogenesis factor 1 (PEX1) - coding DNA reference sequence

(used for variant description)

(last modified September 9, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_000466.2 in the PEX1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008341.2, covering PEX1 transcript NM_000466.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5036
                         cgatcgatctcctccggctccgacgtcctcggcctg       c.-61

 .         .         .         .         .         .                g.5096
 ccgggtcccgggtcctttgcggcgctagggtgggcgaacccagagcgacgctccgggacg       c.-1

          .         .         .         .         .         .       g.5156
 ATGTGGGGCAGCGATCGCCTGGCGGGTGCTGGGGGAGGCGGGGCGGCAGTGACTGTGGCC       c.60
 M  W  G  S  D  R  L  A  G  A  G  G  G  G  A  A  V  T  V  A         p.20

          .         .         .         .         .         .       g.5216
 TTCACCAACGCTCGCGACTGCTTCCTCCACCTGCCGCGGCGTCTCGTGGCCCAGCTGCAT       c.120
 F  T  N  A  R  D  C  F  L  H  L  P  R  R  L  V  A  Q  L  H         p.40

           | 02        .         .         .         .         .    g.11337
 CTGCTGCAG | AATCAAGCTATAGAAGTGGTCTGGAGTCACCAGCCTGCATTCTTGAGCTGG    c.180
 L  L  Q   | N  Q  A  I  E  V  V  W  S  H  Q  P  A  F  L  S  W      p.60

          .         .         .         .         .         .       g.11397
 GTGGAAGGCAGGCATTTTAGTGATCAAGGTGAAAATGTGGCTGAAATTAACAGACAAGTT       c.240
 V  E  G  R  H  F  S  D  Q  G  E  N  V  A  E  I  N  R  Q  V         p.80

          .         .         .    | 03    .         .         .    g.14480
 GGTCAAAAACTTGGACTCTCAAATGGGGGACAG | GTATTTCTCAAGCCATGTTCCCATGTG    c.300
 G  Q  K  L  G  L  S  N  G  G  Q   | V  F  L  K  P  C  S  H  V      p.100

          .         .         .         .         .        | 04.    g.15279
 GTATCTTGTCAACAAGTTGAGGTGGAACCCCTCTCAGCAGATGATTGGGAGATACTG | GAG    c.360
 V  S  C  Q  Q  V  E  V  E  P  L  S  A  D  D  W  E  I  L   | E      p.120

          .         .         .         .         .         .       g.15339
 CTGCATGCTGTTTCCCTTGAACAACATCTTCTAGATCAAATTCGAATAGTTTTTCCAAAA       c.420
 L  H  A  V  S  L  E  Q  H  L  L  D  Q  I  R  I  V  F  P  K         p.140

          .         .         .         .         .   | 05     .    g.15497
 GCCATTTTTCCTGTTTGGGTTGATCAACAAACGTACATATTTATCCAAATTG | TTGCACTA    c.480
 A  I  F  P  V  W  V  D  Q  Q  T  Y  I  F  I  Q  I  V |   A  L      p.160

          .         .         .         .         .         .       g.15557
 ATACCAGCTGCCTCTTATGGAAGGCTGGAAACTGACACCAAACTCCTTATTCAGCCAAAG       c.540
 I  P  A  A  S  Y  G  R  L  E  T  D  T  K  L  L  I  Q  P  K         p.180

          .         .         .         .         .         .       g.15617
 ACACGCCGAGCCAAAGAGAATACATTTTCAAAAGCTGATGCTGAATATAAAAAACTTCAT       c.600
 T  R  R  A  K  E  N  T  F  S  K  A  D  A  E  Y  K  K  L  H         p.200

          .         .         .         .         .         .       g.15677
 AGTTATGGAAGAGACCAGAAAGGAATGATGAAAGAACTTCAAACCAAGCAACTTCAGTCA       c.660
 S  Y  G  R  D  Q  K  G  M  M  K  E  L  Q  T  K  Q  L  Q  S         p.220

          .         .         .         .         .         .       g.15737
 AATACTGTGGGAATCACTGAATCTAATGAAAACGAGTCAGAGATTCCAGTTGACTCATCA       c.720
 N  T  V  G  I  T  E  S  N  E  N  E  S  E  I  P  V  D  S  S         p.240

          .         .         .         .         .         .       g.15797
 TCAGTAGCAAGTTTATGGACTATGATAGGAAGCATTTTTTCCTTTCAATCTGAGAAGAAA       c.780
 S  V  A  S  L  W  T  M  I  G  S  I  F  S  F  Q  S  E  K  K         p.260

          .         .         .         .         .         .       g.15857
 CAAGAGACATCTTGGGGTTTAACTGAAATCAATGCATTCAAAAATATGCAGTCAAAGGTT       c.840
 Q  E  T  S  W  G  L  T  E  I  N  A  F  K  N  M  Q  S  K  V         p.280

          .         .         .         .         .         .       g.15917
 GTTCCTCTAGACAATATTTTCAGAGTATGCAAATCTCAACCTCCTAGTATATATAACGCG       c.900
 V  P  L  D  N  I  F  R  V  C  K  S  Q  P  P  S  I  Y  N  A         p.300

          .         .         .         .         .         .       g.15977
 TCAGCAACCTCTGTTTTTCATAAACACTGTGCCATTCATGTATTTCCATGGGACCAGGAA       c.960
 S  A  T  S  V  F  H  K  H  C  A  I  H  V  F  P  W  D  Q  E         p.320

          .         .         .         .         .         .       g.16037
 TATTTTGATGTAGAGCCCAGCTTTACTGTGACATATGGAAAGCTAGTTAAGCTACTTTCT       c.1020
 Y  F  D  V  E  P  S  F  T  V  T  Y  G  K  L  V  K  L  L  S         p.340

          .         .         .         .         .         .       g.16097
 CCAAAGCAACAGCAAAGTAAAACAAAACAAAATGTGTTATCACCTGAAAAAGAGAAGCAG       c.1080
 P  K  Q  Q  Q  S  K  T  K  Q  N  V  L  S  P  E  K  E  K  Q         p.360

          .         .         .         .         .         .       g.16157
 ATGTCAGAGCCACTAGATCAAAAAAAAATTAGGTCAGATCATAATGAAGAAGATGAGAAG       c.1140
 M  S  E  P  L  D  Q  K  K  I  R  S  D  H  N  E  E  D  E  K         p.380

          .         .         .         .         .         .       g.16217
 GCCTGTGTGCTACAAGTAGTCTGGAATGGACTTGAAGAATTGAACAATGCCATCAAATAT       c.1200
 A  C  V  L  Q  V  V  W  N  G  L  E  E  L  N  N  A  I  K  Y         p.400

          .         .         .          | 06        .         .    g.19585
 ACCAAAAATGTAGAAGTTCTCCATCTTGGGAAAGTCTGG | ATTCCAGATGACCTGAGGAAG    c.1260
 T  K  N  V  E  V  L  H  L  G  K  V  W   | I  P  D  D  L  R  K      p.420

          .         .         .         .         .         .       g.19645
 AGACTAAATATAGAAATGCATGCCGTAGTCAGGATAACTCCAGTGGAAGTTACCCCTAAA       c.1320
 R  L  N  I  E  M  H  A  V  V  R  I  T  P  V  E  V  T  P  K         p.440

          .         .         .          | 07        .         .    g.21849
 ATTCCAAGATCTCTAAAGTTACAACCTAGAGAGAATTTA | CCTAAAGACATAAGTGAAGAA    c.1380
 I  P  R  S  L  K  L  Q  P  R  E  N  L   | P  K  D  I  S  E  E      p.460

          .         .         .         .         .         .       g.21909
 GACATAAAAACTGTATTTTATTCATGGCTACAGCAGTCTACTACCACCATGCTTCCTTTG       c.1440
 D  I  K  T  V  F  Y  S  W  L  Q  Q  S  T  T  T  M  L  P  L         p.480

          .         .         .         .    | 08    .         .    g.22501
 GTAATATCAGAGGAAGAATTTATTAAGCTGGAAACTAAAGATG | GACTGAAGGAATTTTCT    c.1500
 V  I  S  E  E  E  F  I  K  L  E  T  K  D  G |   L  K  E  F  S      p.500

          .         .         .         .         .         .       g.22561
 CTGAGTATAGTTCATTCTTGGGAAAAAGAAAAAGATAAAAATATTTTTCTGTTGAGTCCC       c.1560
 L  S  I  V  H  S  W  E  K  E  K  D  K  N  I  F  L  L  S  P         p.520

          .         .        | 09.         .         .         .    g.24153
 AATTTGCTGCAGAAGACTACAATACAA | GTCCTTCTAGATCCTATGGTAAAAGAAGAAAAC    c.1620
 N  L  L  Q  K  T  T  I  Q   | V  L  L  D  P  M  V  K  E  E  N      p.540

          .         .         .         .         . | 10       .    g.26415
 AGTGAGGAAATTGACTTTATTCTTCCTTTTTTAAAGCTGAGCTCTTTGGG | AGGAGTGAAT    c.1680
 S  E  E  I  D  F  I  L  P  F  L  K  L  S  S  L  G  |  G  V  N      p.560

          .         .         .         .         .         .       g.26475
 TCCTTAGGCGTATCCTCCTTGGAGCACATCACTCACAGCCTCCTGGGACGCCCTTTGTCT       c.1740
 S  L  G  V  S  S  L  E  H  I  T  H  S  L  L  G  R  P  L  S         p.580

          .         .         .         .         .         .       g.26535
 CGGCAGCTGATGTCTCTTGTTGCAGGACTTAGGAATGGAGCTCTTTTACTCACAGGAGGA       c.1800
 R  Q  L  M  S  L  V  A  G  L  R  N  G  A  L  L  L  T  G  G         p.600

     | 11    .         .         .         .         .         .    g.27244
 AAG | GGAAGTGGAAAATCAACTTTAGCCAAAGCAATCTGTAAAGAAGCATTTGACAAACTG    c.1860
 K   | G  S  G  K  S  T  L  A  K  A  I  C  K  E  A  F  D  K  L      p.620

          .         .         .         . | 12       .         .    g.28649
 GATGCCCATGTGGAGAGAGTTGACTGTAAAGCTTTACGAG | GAAAAAGGCTTGAAAACATA    c.1920
 D  A  H  V  E  R  V  D  C  K  A  L  R  G |   K  R  L  E  N  I      p.640

          .         .         .         .         .         .       g.28709
 CAAAAAACCCTAGAGGTGGCTTTCTCAGAGGCAGTGTGGATGCAGCCATCTGTTGTCCTG       c.1980
 Q  K  T  L  E  V  A  F  S  E  A  V  W  M  Q  P  S  V  V  L         p.660

          .         .         .         .         .         .       g.28769
 CTGGATGACCTTGACCTCATTGCTGGACTGCCTGCTGTCCCGGAACATGAGCACAGTCCT       c.2040
 L  D  D  L  D  L  I  A  G  L  P  A  V  P  E  H  E  H  S  P         p.680

          .         .         .  | 13      .         .         .    g.30365
 GATGCGGTGCAGAGCCAGCGGCTTGCTCATG | CTTTGAATGATATGATAAAAGAGTTTATC    c.2100
 D  A  V  Q  S  Q  R  L  A  H  A |   L  N  D  M  I  K  E  F  I      p.700

          .         .         .         .         .         .       g.30425
 TCCATGGGAAGTTTGGTTGCACTGATTGCCACAAGTCAGTCTCAGCAATCTCTACATCCT       c.2160
 S  M  G  S  L  V  A  L  I  A  T  S  Q  S  Q  Q  S  L  H  P         p.720

          .         .         .         .         .         .       g.30485
 TTACTTGTTTCTGCTCAAGGAGTTCACATATTTCAGTGCGTCCAACACATTCAGCCTCCT       c.2220
 L  L  V  S  A  Q  G  V  H  I  F  Q  C  V  Q  H  I  Q  P  P         p.740

        | 14 .         .         .         .         .         .    g.31506
 AATCAG | GAACAAAGATGTGAAATTCTGTGTAATGTAATAAAAAATAAATTGGACTGTGAT    c.2280
 N  Q   | E  Q  R  C  E  I  L  C  N  V  I  K  N  K  L  D  C  D      p.760

          .         .         .         .         .         .       g.31566
 ATAAACAAGTTCACCGATCTTGACCTGCAGCATGTAGCTAAAGAAACTGGCGGGTTTGTG       c.2340
 I  N  K  F  T  D  L  D  L  Q  H  V  A  K  E  T  G  G  F  V         p.780

          .         .         .         .         .         .       g.31626
 GCTAGAGATTTTACAGTACTTGTGGATCGAGCCATACATTCTCGACTCTCTCGTCAGAGT       c.2400
 A  R  D  F  T  V  L  V  D  R  A  I  H  S  R  L  S  R  Q  S         p.800

          .       | 15 .         .         .         .         .    g.31902
 ATATCCACCAGAGAAA | AATTAGTTTTAACAACATTGGACTTCCAAAAGGCTCTCCGCGGA    c.2460
 I  S  T  R  E  K |   L  V  L  T  T  L  D  F  Q  K  A  L  R  G      p.820

          .         .         .         .         .         .       g.31962
 TTTCTTCCTGCGTCTTTGCGAAGTGTCAACCTGCATAAACCTAGAGACCTGGGTTGGGAC       c.2520
 F  L  P  A  S  L  R  S  V  N  L  H  K  P  R  D  L  G  W  D         p.840

          .         .         .         .         .         .       g.32022
 AAGATTGGTGGGTTACATGAAGTTAGGCAGATACTCATGGATACTATCCAGTTACCTGCC       c.2580
 K  I  G  G  L  H  E  V  R  Q  I  L  M  D  T  I  Q  L  P  A         p.860

     | 16    .         .         .         .         .         .    g.33750
 AAG | TATCCAGAATTATTTGCAAACTTGCCCATACGACAAAGAACAGGAATACTGTTGTAT    c.2640
 K   | Y  P  E  L  F  A  N  L  P  I  R  Q  R  T  G  I  L  L  Y      p.880

          .         .         .         .         .         .       g.33810
 GGTCCGCCTGGAACAGGAAAAACCTTACTAGCTGGGGTAATTGCACGAGAGAGTAGAATG       c.2700
 G  P  P  G  T  G  K  T  L  L  A  G  V  I  A  R  E  S  R  M         p.900

          .         | 17         .         .         .         .    g.36796
 AATTTTATAAGTGTCAAG | GGGCCAGAGTTACTCAGCAAATACATTGGAGCAAGTGAACAA    c.2760
 N  F  I  S  V  K   | G  P  E  L  L  S  K  Y  I  G  A  S  E  Q      p.920

          .         .    | 18    .         .         .         .    g.38939
 GCTGTTCGGGATATTTTTATTAG | AGCACAGGCTGCAAAGCCCTGCATTCTTTTCTTTGAT    c.2820
 A  V  R  D  I  F  I  R  |  A  Q  A  A  K  P  C  I  L  F  F  D      p.940

          .         .         .         .         .         .       g.38999
 GAATTTGAATCCATTGCTCCTCGGCGGGGTCATGATAATACAGGAGTTACAGACCGAGTA       c.2880
 E  F  E  S  I  A  P  R  R  G  H  D  N  T  G  V  T  D  R  V         p.960

          .         .         .         .       | 19 .         .    g.39149
 GTTAACCAGTTGCTGACTCAGTTGGATGGAGTAGAAGGCTTACAGG | GTGTTTATGTATTG    c.2940
 V  N  Q  L  L  T  Q  L  D  G  V  E  G  L  Q  G |   V  Y  V  L      p.980

          .         .         .         .         .         .       g.39209
 GCTGCTACTAGTCGCCCTGACTTGATTGACCCTGCCCTGCTTAGGCCTGGTCGACTAGAT       c.3000
 A  A  T  S  R  P  D  L  I  D  P  A  L  L  R  P  G  R  L  D         p.1000

          .         .         . | 20       .         .         .    g.40432
 AAATGTGTATACTGTCCTCCTCCTGATCAG | GTGTCACGTCTTGAAATTTTAAATGTCCTC    c.3060
 K  C  V  Y  C  P  P  P  D  Q   | V  S  R  L  E  I  L  N  V  L      p.1020

          .         .         .         .         .         .       g.40492
 AGTGACTCTCTACCTCTGGCAGATGATGTTGACCTTCAGCATGTAGCATCAGTAACTGAC       c.3120
 S  D  S  L  P  L  A  D  D  V  D  L  Q  H  V  A  S  V  T  D         p.1040

          .         .         .         .         .         .       g.40552
 TCCTTTACTGGAGCTGATCTGAAAGCTTTACTTTACAATGCCCAATTGGAGGCCTTACAT       c.3180
 S  F  T  G  A  D  L  K  A  L  L  Y  N  A  Q  L  E  A  L  H         p.1060

          .         .        | 21.         .         .         .    g.42062
 GGAATGCTGCTCTCGAGTGGACTCCAG | GATGGAAGTTCCAGCTCTGATAGTGACCTAAGT    c.3240
 G  M  L  L  S  S  G  L  Q   | D  G  S  S  S  S  D  S  D  L  S      p.1080

          .         .         .         .         .         .       g.42122
 CTGTCTTCAATGGTCTTTCTTAACCATAGCAGTGGCTCTGACGATTCAGCTGGAGATGGA       c.3300
 L  S  S  M  V  F  L  N  H  S  S  G  S  D  D  S  A  G  D  G         p.1100

          .         .         .         .         .         .       g.42182
 GAATGTGGCTTAGATCAGTCCCTTGTTTCTTTAGAGATGTCCGAGATCCTTCCAGATGAA       c.3360
 E  C  G  L  D  Q  S  L  V  S  L  E  M  S  E  I  L  P  D  E         p.1120

          .         .         .         .         .         .       g.42242
 TCAAAATTCAATATGTACCGGCTCTACTTTGGAAGCTCTTATGAATCAGAACTTGGAAAT       c.3420
 S  K  F  N  M  Y  R  L  Y  F  G  S  S  Y  E  S  E  L  G  N         p.1140

          .         | 22         .         .         .         .    g.43662
 GGAACCTCTTCTGATTTG | AGCTCACAATGTCTCTCTGCACCAAGCTCCATGACTCAGGAT    c.3480
 G  T  S  S  D  L   | S  S  Q  C  L  S  A  P  S  S  M  T  Q  D      p.1160

          .         .         .         .         .         .       g.43722
 TTGCCTGGAGTTCCTGGGAAAGACCAGTTGTTTTCACAGCCTCCAGTGTTAAGGACAGCT       c.3540
 L  P  G  V  P  G  K  D  Q  L  F  S  Q  P  P  V  L  R  T  A         p.1180

          .         .         .         .         .         .       g.43782
 TCACAAGAGGGTTGCCAAGAACTTACACAAGAACAAAGAGATCAACTGAGGGCAGATATC       c.3600
 S  Q  E  G  C  Q  E  L  T  Q  E  Q  R  D  Q  L  R  A  D  I         p.1200

          .         .         .       | 23 .         .         .    g.44132
 AGTATTATCAAAGGCAGATACCGGAGCCAAAGTGGA | GAGGACGAATCCATGAACCAACCA    c.3660
 S  I  I  K  G  R  Y  R  S  Q  S  G   | E  D  E  S  M  N  Q  P      p.1220

          .         .         .         .         .         .       g.44192
 GGACCAATCAAAACCAGACTGGCTATTAGTCAGTCACATTTAATGACTGCACTTGGTCAC       c.3720
 G  P  I  K  T  R  L  A  I  S  Q  S  H  L  M  T  A  L  G  H         p.1240

          .         .         .         .        | 24.         .    g.46003
 ACAAGACCATCCATTAGTGAAGATGACTGGAAGAATTTTGCTGAGCT | ATATGAAAGCTTT    c.3780
 T  R  P  S  I  S  E  D  D  W  K  N  F  A  E  L  |  Y  E  S  F      p.1260

          .         .         .         .         .         .       g.46063
 CAAAATCCAAAGAGGAGAAAAAATCAAAGTGGAACAATGTTTCGACCTGGACAGAAAGTA       c.3840
 Q  N  P  K  R  R  K  N  Q  S  G  T  M  F  R  P  G  Q  K  V         p.1280

          .                                                         g.46075
 ACTTTAGCATAA                                                       c.3852
 T  L  A  X                                                         p.1283

          .         .         .         .         .         .       g.46135
 aatatacttctttttgatttggttctgttaagttttttgatggcttttccatatgttgta       c.*60

          .         .         .         .         .         .       g.46195
 acaggaaaaaaatggtgtctatgaatttcttcttaatttaacaaatttggttaatttata       c.*120

          .         .         .         .         .         .       g.46255
 aaatcacagattggtaaatgctataattatgtaatgatcaggattgagattaatactgta       c.*180

          .         .         .         .         .         .       g.46315
 gtataaattgggacattataacagattccatattttatttcctaaaatctaaattcagtc       c.*240

          .         .         .         .         .         .       g.46375
 tttaatgaaataatattagccaaatggtggaactaatttatttcttttgaggaaaagata       c.*300

          .         .         .         .         .         .       g.46435
 ataaagaatgtaattaaatttaaatttcttggaattcccagttgtatattcatcaccttt       c.*360

          .         .         .         .         .         .       g.46495
 gtagcatttgacaaattttatgcttagcagcttcttcactgttttgaaataaaatatcct       c.*420

          .                                                         g.46509
 attacctactgata                                                     c.*434

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Peroxisomal biogenesis factor 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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