peroxisomal biogenesis factor 3 (PEX3) - coding DNA reference sequence

(used for variant description)

(last modified September 6, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_003630.2 in the PEX3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008459.1, covering PEX3 transcript NM_003630.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       gaacggacctgggcttgtcgga       c.-241

 .         .         .         .         .         .                g.5082
 ccagtgagcggcggcggctgcgcggcggcagcggcagaaagcgtagctgctttgctgtag       c.-181

 .         .         .         .         .         .                g.5142
 tccacgcccccttgccgctccggtgacagtctctgcggaaagtcacgtttgtgatttcgg       c.-121

 .         .         .         .         .         .                g.5202
 gagagcacagaacgggacgacggcgctcttgctgggtcatctgggccaggtgacgaagaa       c.-61

 .         .         .         .         .         .                g.5262
 acagtttcctggtgaagcagtccctcacccctagtcagcccacacccctagggcctaaag       c.-1

          .         .         .         .         .         .       g.5322
 ATGCTGAGGTCTGTATGGAATTTTCTGAAACGCCACAAAAAGAAATGCATCTTCCTGGGC       c.60
 M  L  R  S  V  W  N  F  L  K  R  H  K  K  K  C  I  F  L  G         p.20

          .    | 02    .         .         .         .         .    g.13351
 ACGGTCCTTGGAG | GAGTATATATTCTGGGGAAATATGGACAGAAGAAAATCAGAGAAATA    c.120
 T  V  L  G  G |   V  Y  I  L  G  K  Y  G  Q  K  K  I  R  E  I      p.40

          .         .         .         .         .         .       g.13411
 CAGGAAAGGGAGGCTGCAGAATACATTGCCCAAGCACGACGACAATATCATTTTGAAAGT       c.180
 Q  E  R  E  A  A  E  Y  I  A  Q  A  R  R  Q  Y  H  F  E  S         p.60

          .         .      | 03  .         .         .         .    g.17170
 AACCAGAGGACTTGCAATATGACAG | TGCTGTCCATGCTTCCAACACTGAGAGAGGCCTTA    c.240
 N  Q  R  T  C  N  M  T  V |   L  S  M  L  P  T  L  R  E  A  L      p.80

          .         .         .         .        | 04.         .    g.22354
 ATGCAGCAACTGAATTCCGAGAGCCTCACAGCTCTGCTAAAAAACAG | GCCTTCAAACAAG    c.300
 M  Q  Q  L  N  S  E  S  L  T  A  L  L  K  N  R  |  P  S  N  K      p.100

          .         .         .  | 05      .         .         .    g.25209
 CTAGAAATATGGGAGGATCTGAAGATAATAA | GTTTCACAAGAAGTACTGTGGCTGTATAC    c.360
 L  E  I  W  E  D  L  K  I  I  S |   F  T  R  S  T  V  A  V  Y      p.120

          .         .         .         .         .         .       g.25269
 AGTACCTGTATGCTGGTTGTTCTTTTGCGGGTCCAGTTAAACATAATTGGTGGATATATT       c.420
 S  T  C  M  L  V  V  L  L  R  V  Q  L  N  I  I  G  G  Y  I         p.140

          .         .         .       | 06 .         .         .    g.25626
 TACCTGGATAATGCAGCAGTTGGCAAAAATGGCACT | ACAATTCTTGCTCCCCCAGATGTC    c.480
 Y  L  D  N  A  A  V  G  K  N  G  T   | T  I  L  A  P  P  D  V      p.160

          .         .         .         .    | 07    .         .    g.25793
 CAACAGCAGTATTTATCAAGTATTCAGCACCTACTTGGAGATG | GCCTGACAGAATTGATC    c.540
 Q  Q  Q  Y  L  S  S  I  Q  H  L  L  G  D  G |   L  T  E  L  I      p.180

          .         .         .         | 08         .         .    g.26401
 ACTGTCATTAAACAAGCTGTGCAGAAGGTTTTAGGAAG | TGTTTCTCTTAAACATTCTTTG    c.600
 T  V  I  K  Q  A  V  Q  K  V  L  G  S  |  V  S  L  K  H  S  L      p.200

          .         .         .         .         .         .       g.26461
 TCCCTTTTGGACTTGGAGCAAAAACTAAAAGAAATCAGAAATCTCGTTGAGCAGCATAAG       c.660
 S  L  L  D  L  E  Q  K  L  K  E  I  R  N  L  V  E  Q  H  K         p.220

          .         .         .         .         .         .       g.26521
 TCTTCTTCTTGGATTAATAAAGATGGATCCAAACCTTTATTATGCCATTATATGATGCCA       c.720
 S  S  S  W  I  N  K  D  G  S  K  P  L  L  C  H  Y  M  M  P         p.240

          .         .        | 09.         .         .         .    g.29038
 GATGAAGAAACTCCATTAGCAGTGCAG | GCCTGTGGACTTTCTCCTCGAGACATTACCACT    c.780
 D  E  E  T  P  L  A  V  Q   | A  C  G  L  S  P  R  D  I  T  T      p.260

          .         .         .         | 10         .         .    g.33317
 ATTAAACTTCTCAATGAAACTAGAGACATGTTGGAAAG | CCCAGATTTTAGTACAGTTTTG    c.840
 I  K  L  L  N  E  T  R  D  M  L  E  S  |  P  D  F  S  T  V  L      p.280

          .         .         .         .         .         .       g.33377
 AATACCTGTTTAAACCGAGGTTTTAGTAGACTTCTAGACAATATGGCTGAGTTCTTTCGA       c.900
 N  T  C  L  N  R  G  F  S  R  L  L  D  N  M  A  E  F  F  R         p.300

          .         .         .         .  | 11      .         .    g.39390
 CCTACTGAACAGGACCTGCAACATGGTAACTCTATGAATAG | TCTTTCCAGTGTCAGCCTG    c.960
 P  T  E  Q  D  L  Q  H  G  N  S  M  N  S  |  L  S  S  V  S  L      p.320

          .         .         .         .         .         .       g.39450
 CCTTTAGCTAAGATAATTCCAATAGTAAACGGACAGATCCATTCAGTTTGCAGTGAAACA       c.1020
 P  L  A  K  I  I  P  I  V  N  G  Q  I  H  S  V  C  S  E  T         p.340

          .         | 12         .         .         .         .    g.43404
 CCTAGTCATTTTGTTCAG | GATCTGTTGACAATGGAGCAAGTGAAAGACTTTGCTGCTAAT    c.1080
 P  S  H  F  V  Q   | D  L  L  T  M  E  Q  V  K  D  F  A  A  N      p.360

          .         .         .         .                           g.43446
 GTGTATGAAGCTTTTAGTACCCCTCAGCAACTGGAGAAATGA                         c.1122
 V  Y  E  A  F  S  T  P  Q  Q  L  E  K  X                           p.373

          .         .         .         .         .         .       g.43506
 tttttccttcaagaaaaactacagtgggattcatttactttttaaaatacactgggtaaa       c.*60

          .         .         .         .         .         .       g.43566
 tcacctatacttagagtaacagtttgttatcaaaatgcctgataaaatatattcttaata       c.*120

          .         .         .         .         .         .       g.43626
 aaagtcttcatttcataatgaaatcaatttatttggcatcttaatatatttttttagatt       c.*180

          .         .         .         .         .         .       g.43686
 catcaacagaccagtttttgtgggcatatatatatacacgtgcaaatatcagaattgtta       c.*240

          .         .         .         .         .         .       g.43746
 ataatttgttacacatggacatttgttccaaactgactaaaaatcaatatagatatttta       c.*300

          .         .         .         .         .         .       g.43806
 tatacatatatatatataaaaatacaaaattcagtgtactttaccatattaatactgagg       c.*360

          .         .         .         .         .         .       g.43866
 aaaaatctgttggagacataggtctaggatgtgtgaagtttggaaaaatatgctatttaa       c.*420

          .         .         .         .         .         .       g.43926
 ttataatgttccctagactgctgtaaacagaagtgaatcagacttttctccagctacctt       c.*480

          .         .         .         .         .         .       g.43986
 tcaaaataataaattatttgtctcaaatataccttgatggaggacttttttattcttatg       c.*540

          .         .         .         .         .         .       g.44046
 gaaatagtgaattccaacaactatgatgaactatgttctttgctatttcttcactatatt       c.*600

          .         .         .         .         .         .       g.44106
 ttttaaggttttattaaaaagccttagaaagttacatattggtttagaggctaaaattgt       c.*660

          .         .         .         .         .         .       g.44166
 gttgatgctgtttactcacctaattacatagttttaatcatttgtacataattttaaaaa       c.*720

          .         .         .         .         .         .       g.44226
 cttactttgtattgattttgaatacagtgaaaatcttattgcaataaactattttagtaa       c.*780

          .         .         .         .         .         .       g.44286
 aatattattttgttgagttaatatttttcagctattaatttacttatcccatagcatttt       c.*840

          .         .         .         .         .         .       g.44346
 tgttattatttcggaagagagagcatgctagtttaagtttcattttaattggtcgtgtac       c.*900

          .         .         .         .         .         .       g.44406
 ttggtgcttttttgttgttgttaacttgttcatttagtaaaaagcaaatagctttacttt       c.*960

          .         .         .         .         .         .       g.44466
 ctgaaaaagaaataattcattatctctagtaatacatctgtaattcttcatttagaaggg       c.*1020

          .         .         .         .         .         .       g.44526
 taattagggcaaaagtaaataaatcattatatatcattagtatgttgacatatattttca       c.*1080

          .         .         .         .         .         .       g.44586
 gtaacattgttttatgttcctccagcgtaacatgtagctgaacagtagaaggtagaaaat       c.*1140

          .         .         .         .         .         .       g.44646
 aaattatgacatctcttctaaggcctggctaggcctgaagctcactgccagggagtttgt       c.*1200

          .         .         .         .         .         .       g.44706
 gtctagaatgtttttaaaaataggtagtggagccatagccctcaccatagacacctctga       c.*1260

          .         .         .         .         .         .       g.44766
 gcccactggcattgtctctgagcagaagatggctgtgccactcacatatgctaatcttgg       c.*1320

          .         .         .         .         .         .       g.44826
 caaatctgccaagcatgtcttcaccaagggatatggatttggcttaataaaacctgattt       c.*1380

          .                                                         g.44836
 gaaaacaaaa                                                         c.*1390

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Peroxisomal biogenesis factor 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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