peroxisomal biogenesis factor 5 (PEX5) - coding DNA reference sequence

(used for variant description)

(last modified September 7, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_000319.4 in the PEX5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008448.1, covering PEX5 transcript NM_000319.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.6215
                                             agagctggcggtcacc       c.-1

          .         .         .         .         .         .       g.6275
 ATGGCAATGCGGGAGCTGGTGGAGGCCGAATGCGGGGGTGCCAACCCGCTCATGAAGCTC       c.60
 M  A  M  R  E  L  V  E  A  E  C  G  G  A  N  P  L  M  K  L         p.20

          .         .         .         .         .         .       g.6335
 GCCGGGCACTTCACCCAGGACAAGGCCCTTCGGCAGGAGGGATTGAGGCCTGGCCCCTGG       c.120
 A  G  H  F  T  Q  D  K  A  L  R  Q  E  G  L  R  P  G  P  W         p.40

          .         .        | 02.         .         .         .    g.6758
 CCCCCCGGAGCCCCGGCCTCTGAGGCA | GCCTCCAAGCCTTTGGGAGTAGCTTCTGAAGAT    c.180
 P  P  G  A  P  A  S  E  A   | A  S  K  P  L  G  V  A  S  E  D      p.60

     | 03    .         .         .         .         .         .    g.7120
 GAG | TTGGTGGCTGAATTCCTGCAGGACCAGAATGCACCCCTTGTGTCCCGTGCCCCTCAG    c.240
 E   | L  V  A  E  F  L  Q  D  Q  N  A  P  L  V  S  R  A  P  Q      p.80

          .         .         .         .         .         .       g.7180
 ACCTTCAAGATGGATGACCTCCTGGCTGAGATGCAGCAGATTGAGCAGTCAAACTTCCGC       c.300
 T  F  K  M  D  D  L  L  A  E  M  Q  Q  I  E  Q  S  N  F  R         p.100

          .       | 04 .         .         .         .         .    g.7450
 CAGGCTCCCCAGAGAG | CCCCTGGTGTGGCAGACTTGGCCTTGTCTGAGAACTGGGCCCAG    c.360
 Q  A  P  Q  R  A |   P  G  V  A  D  L  A  L  S  E  N  W  A  Q      p.120

          .         .         .         .         .         .       g.7510
 GAGTTTCTTGCAGCTGGAGATGCTGTGGATGTAACTCAGGATTATAATGAGACTGACTGG       c.420
 E  F  L  A  A  G  D  A  V  D  V  T  Q  D  Y  N  E  T  D  W         p.140

          .         .         | 05         .         .         .    g.14880
 TCCCAAGAATTCATCTCTGAAGTTACAG | ACCCCTTGTCTGTGTCCCCTGCCCGCTGGGCT    c.480
 S  Q  E  F  I  S  E  V  T  D |   P  L  S  V  S  P  A  R  W  A      p.160

          .         .         .         .         .         .       g.14940
 GAGGAATATTTGGAGCAATCAGAGGAGAAGCTGTGGCTGGGAGAACCTGAGGGAACAGCC       c.540
 E  E  Y  L  E  Q  S  E  E  K  L  W  L  G  E  P  E  G  T  A         p.180

          .  | 06      .         .         .         .         .    g.17637
 ACCGATCGCTG | GTATGATGAATATCATCCTGAGGAGGATCTGCAGCACACGGCCAGTGAC    c.600
 T  D  R  W  |  Y  D  E  Y  H  P  E  E  D  L  Q  H  T  A  S  D      p.200

          .         .         .         .   | 07     .         .    g.18096
 TTTGTGGCCAAAGTGGATGACCCCAAATTGGCTAATTCTGAG | TTCCTGAAATTCGTGCGG    c.660
 F  V  A  K  V  D  D  P  K  L  A  N  S  E   | F  L  K  F  V  R      p.220

          .         .         .         .         .         .       g.18156
 CAGATTGGCGAAGGGCAGGTGTCCCTGGAGTCCGGTGCAGGGTCGGGCCGAGCTCAGGCA       c.720
 Q  I  G  E  G  Q  V  S  L  E  S  G  A  G  S  G  R  A  Q  A         p.240

          .         .         .    | 08    .         .         .    g.18476
 GAACAGTGGGCAGCAGAGTTTATACAGCAGCAG | GGTACATCAGATGCCTGGGTTGACCAG    c.780
 E  Q  W  A  A  E  F  I  Q  Q  Q   | G  T  S  D  A  W  V  D  Q      p.260

          .         .         .         .         .         .       g.18536
 TTCACAAGACCAGTAAACACATCTGCCCTTGATATGGAGTTTGAACGAGCCAAGTCAGCT       c.840
 F  T  R  P  V  N  T  S  A  L  D  M  E  F  E  R  A  K  S  A         p.280

        | 09 .         .         .         .         .         .    g.19347
 ATAGAG | TTGCAGGCAGAGTTGGAGGAGATGGCAAAACGGGATGCTGAGGCCCACCCCTGG    c.900
 I  E   | L  Q  A  E  L  E  E  M  A  K  R  D  A  E  A  H  P  W      p.300

          .         .         .         .   | 10     .         .    g.23514
 CTTTCTGACTATGATGACCTTACGTCAGCTACCTATGATAAG | GGGTACCAGTTTGAGGAG    c.960
 L  S  D  Y  D  D  L  T  S  A  T  Y  D  K   | G  Y  Q  F  E  E      p.320

          .         .         .         .         .         .       g.23574
 GAGAACCCCTTGCGTGATCACCCTCAGCCTTTTGAAGAAGGGCTGCGGCGCCTTCAGGAG       c.1020
 E  N  P  L  R  D  H  P  Q  P  F  E  E  G  L  R  R  L  Q  E         p.340

          .         .         .         .         .         .       g.23634
 GGGGACCTGCCAAATGCTGTGCTGCTTTTTGAGGCAGCTGTGCAGCAGGATCCTAAGCAC       c.1080
 G  D  L  P  N  A  V  L  L  F  E  A  A  V  Q  Q  D  P  K  H         p.360

        | 11 .         .         .         .         .         .    g.23901
 ATGGAA | GCTTGGCAGTATCTGGGTACCACCCAGGCAGAGAATGAACAAGAACTATTAGCC    c.1140
 M  E   | A  W  Q  Y  L  G  T  T  Q  A  E  N  E  Q  E  L  L  A      p.380

          .        | 12.         .         .         .         .    g.24337
 ATCAGTGCATTGCGGAG | GTGTCTGGAGCTAAAGCCAGATAACCAGACAGCACTGATGGCG    c.1200
 I  S  A  L  R  R  |  C  L  E  L  K  P  D  N  Q  T  A  L  M  A      p.400

          .         .         .         .         .         .       g.24397
 CTGGCTGTGAGCTTCACCAACGAGTCCCTGCAGCGACAGGCCTGTGAAACCCTACGAGAC       c.1260
 L  A  V  S  F  T  N  E  S  L  Q  R  Q  A  C  E  T  L  R  D         p.420

          .         .         .         .         .         .       g.24457
 TGGCTGCGGTACACACCAGCCTATGCCCATCTGGTGACACCTGCTGAAGAAGGGGCTGGT       c.1320
 W  L  R  Y  T  P  A  Y  A  H  L  V  T  P  A  E  E  G  A  G         p.440

          .         .         .         .         . | 13       .    g.24852
 GGGGCAGGACTGGGCCCCAGCAAGCGTATCCTGGGATCTCTCTTGTCTGA | CTCCCTGTTT    c.1380
 G  A  G  L  G  P  S  K  R  I  L  G  S  L  L  S  D  |  S  L  F      p.460

          .         .         .         .         .         .       g.24912
 CTTGAAGTGAAAGAGCTCTTCCTGGCAGCTGTGCGGCTGGACCCTACCTCCATTGACCCT       c.1440
 L  E  V  K  E  L  F  L  A  A  V  R  L  D  P  T  S  I  D  P         p.480

          .         .         .         .         .         .       g.24972
 GATGTGCAGTGTGGCTTGGGAGTCCTTTTCAACCTGAGTGGGGAGTATGACAAGGCCGTG       c.1500
 D  V  Q  C  G  L  G  V  L  F  N  L  S  G  E  Y  D  K  A  V         p.500

          .         .         .       | 14 .         .         .    g.25544
 GACTGCTTCACAGCTGCCCTCAGCGTTCGTCCCAAT | GACTATTTGCTGTGGAATAAGCTA    c.1560
 D  C  F  T  A  A  L  S  V  R  P  N   | D  Y  L  L  W  N  K  L      p.520

          .         .         .         .         .         .       g.25604
 GGCGCCACCCTGGCCAATGGAAACCAGAGTGAAGAAGCAGTAGCTGCGTACCGCCGGGCC       c.1620
 G  A  T  L  A  N  G  N  Q  S  E  E  A  V  A  A  Y  R  R  A         p.540

          .         .         .         .         .         .       g.25664
 CTCGAGCTCCAGCCTGGCTATATCCGGTCCCGCTATAACCTGGGCATCAGCTGCATCAAC       c.1680
 L  E  L  Q  P  G  Y  I  R  S  R  Y  N  L  G  I  S  C  I  N         p.560

          .     | 15   .         .         .         .         .    g.25905
 CTCGGGGCTCACCG | GGAGGCTGTGGAGCACTTTCTGGAGGCCCTGAACATGCAGAGGAAA    c.1740
 L  G  A  H  R  |  E  A  V  E  H  F  L  E  A  L  N  M  Q  R  K      p.580

          .         .         .         .         .         .       g.25965
 AGCCGGGGCCCCCGGGGTGAAGGAGGTGCCATGTCGGAGAACATCTGGAGCACCCTGCGT       c.1800
 S  R  G  P  R  G  E  G  G  A  M  S  E  N  I  W  S  T  L  R         p.600

          .         .         .         .         .         .       g.26025
 TTGGCATTGTCTATGTTAGGCCAGAGCGATGCCTATGGGGCAGCCGACGCGCGGGATCTG       c.1860
 L  A  L  S  M  L  G  Q  S  D  A  Y  G  A  A  D  A  R  D  L         p.620

          .         .         .                                     g.26061
 TCCACCCTCCTAACTATGTTTGGCCTGCCCCAGTGA                               c.1896
 S  T  L  L  T  M  F  G  L  P  Q  X                                 p.631

          .         .         .         .         .         .       g.26121
 cagtgggacgggctgccctgtgagtgtccacctggagggatccccgctttggatgtgatt       c.*60

          .         .         .         .         .         .       g.26181
 ccctctccccaaatgggcctaccaagggggcgggctgatgaccataagcggtacggcctt       c.*120

          .         .         .         .         .         .       g.26241
 tcaggagctgcctcaacgtaggggtgggtagtctgtgttctagttcctacataattgtag       c.*180

          .         .         .         .         .         .       g.26301
 gaaaatgagctgtgtcatctctgagtcccttggtaattcaagggctgtacatccagctac       c.*240

          .         .         .         .         .         .       g.26361
 agatctctctgctcatcatgccctttcttggtgctgctttttgggtaggaccccacgatt       c.*300

          .         .         .         .         .         .       g.26421
 tagggtaactgttatcatcagctgccatttctgatagggtctaccacatctgtaatgtct       c.*360

          .         .         .         .         .         .       g.26481
 gtcctttcccccacttttactgggaattgatagtccagcttccttgggcagtgtaagtag       c.*420

          .         .         .         .         .         .       g.26541
 gaggttcatctgctgtgcgcctctaatgtctgtctggatgggatgtgttaggagttggcc       c.*480

          .         .         .         .         .         .       g.26601
 tgttgggttgaattgttgatttggctgagcagagctgagttttggtaggagtgctcatgg       c.*540

          .         .         .         .         .         .       g.26661
 ttctgtcattcttggacctctcctggctgagctctgattccctgtgagcacgatgctgat       c.*600

          .         .         .         .         .         .       g.26721
 gcaatagtcctgtgtcatcactgcagcggtcctcaggagctgccagggccaattgctaca       c.*660

          .         .         .         .         .         .       g.26781
 gagtgtctgggtgtgtggcataggaggaaggtttgcttgtgaaatgaggctgggtgggag       c.*720

          .         .         .         .         .         .       g.26841
 cggggagggactagatcagaagagatcaagggctctattcaggaacgttggtgggaggac       c.*780

          .         .         .         .         .         .       g.26901
 agagcaagtgggaagggggtatggtgagtgcggcaatccctcatcctcttagaagcacct       c.*840

          .         .         .         .         .         .       g.26961
 gtgaatgggaattgagccaactgttatagaaaattggttcagaaagtgcaatcttgccag       c.*900

          .         .         .         .         .         .       g.27021
 atttctagcaaataggttcagtgttaccataagcctttgctgtacttcttgaaatgtttc       c.*960

          .         .         .         .         .         .       g.27081
 taggggagagcattggaaaatccccttcccccatctagatcgaaggaagatgagggagca       c.*1020

          .         .         .         .         .         .       g.27141
 gcttggattcttctcagttgtcccctgcatggggagatacactaacccccagaaatgact       c.*1080

          .         .         .         .         .         .       g.27201
 gctaagcctcttgccttgtctttagtagctaatgatcagagagattttttttttaaacta       c.*1140

          .         .         .         .         .         .       g.27261
 ccatggtcccaggattccatcctgaaatttatttttctttgtatgaatatgtgtaaatga       c.*1200

          .         .         .         .         .         .       g.27321
 tttaaaaataaaactgtaaaatatttgtacgaagaataaatggaactgatgtgggtatga       c.*1260

 

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Peroxisomal biogenesis factor 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 24
©2004-2020 Leiden University Medical Center