peroxisomal biogenesis factor 6 (PEX6) - coding DNA reference sequence

(used for variant description)

(last modified September 25, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_000287.3 in the PEX6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008370.1, covering PEX6 transcript NM_000287.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5033
                            ggaagcggaagcggccctcgcgcacactagtcg       c.-61

 .         .         .         .         .         .                g.5093
 tctggctctctggctccggaagctgcgctccttcaccctcctcgttggtgtcctgtcacc       c.-1

          .         .         .         .         .         .       g.5153
 ATGGCGCTGGCTGTCTTGCGGGTCCTGGAGCCCTTTCCGACCGAGACACCCCCGTTGGCA       c.60
 M  A  L  A  V  L  R  V  L  E  P  F  P  T  E  T  P  P  L  A         p.20

          .         .         .         .         .         .       g.5213
 GTGCTGCTGCCACCCGGGGGCCCGTGGCCGGCGGCGGAGCTGGGCCTGGTGCTGGCCCTG       c.120
 V  L  L  P  P  G  G  P  W  P  A  A  E  L  G  L  V  L  A  L         p.40

          .         .         .         .         .         .       g.5273
 AGGCCTGCAGGGGAGAGCCCGGCAGGGCCGGCGCTGCTGGTGGCAGCCCTGGAGGGGCCG       c.180
 R  P  A  G  E  S  P  A  G  P  A  L  L  V  A  A  L  E  G  P         p.60

          .         .         .         .         .         .       g.5333
 GACGCGGGCACCGAAGAGCAGGGTCCCGGGCCGCCGCAGCTACTGGTTAGCCGCGCGCTG       c.240
 D  A  G  T  E  E  Q  G  P  G  P  P  Q  L  L  V  S  R  A  L         p.80

          .         .         .         .         .         .       g.5393
 CTGCGGCTCCTGGCACTGGGCTCCGGGGCCTGGGTGCGGGCGCGGGCGGTGCGGCGGCCC       c.300
 L  R  L  L  A  L  G  S  G  A  W  V  R  A  R  A  V  R  R  P         p.100

          .         .         .         .         .         .       g.5453
 CCGGCGCTAGGTTGGGCACTGCTTGGCACCTCGCTGGGGCCTGGGCTCGGACCGCGAGTC       c.360
 P  A  L  G  W  A  L  L  G  T  S  L  G  P  G  L  G  P  R  V         p.120

          .         .         .         .         .         .       g.5513
 GGGCCGCTGCTGGTGAGGCGCGGAGAGACCCTCCCAGTGCCCGGACCGCGGGTGCTGGAG       c.420
 G  P  L  L  V  R  R  G  E  T  L  P  V  P  G  P  R  V  L  E         p.140

          .         .         .         .         .         .       g.5573
 ACGCGGCCGGCGTTGCAAGGGCTGCTGGGCCCAGGGACTCGGCTGGCTGTGACTGAGCTC       c.480
 T  R  P  A  L  Q  G  L  L  G  P  G  T  R  L  A  V  T  E  L         p.160

          .         .         .         .         .         .       g.5633
 CGCGGGCGGGCCAGACTGTGTCCAGAGTCTGGGGACAGCAGTCGGCCCCCACCCCCGCCC       c.540
 R  G  R  A  R  L  C  P  E  S  G  D  S  S  R  P  P  P  P  P         p.180

          .         .         .         .         .         .       g.5693
 GTGGTGTCCTCCTTTGCGGTTTCTGGCACAGTGCGGCGACTCCAGGGAGTTCTGGGAGGG       c.600
 V  V  S  S  F  A  V  S  G  T  V  R  R  L  Q  G  V  L  G  G         p.200

          .         .         .         .         .         .       g.5753
 ACTGGAGATTCACTAGGGGTGAGCCGGAGCTGTCTCCGTGGCCTTGGCCTCTTCCAGGGC       c.660
 T  G  D  S  L  G  V  S  R  S  C  L  R  G  L  G  L  F  Q  G         p.220

          .         .         .         .         .         .       g.5813
 GAATGGGTGTGGGTGGCCCAGGCCAGAGAGTCATCGAACACTTCACAGCCGCACTTGGCT       c.720
 E  W  V  W  V  A  Q  A  R  E  S  S  N  T  S  Q  P  H  L  A         p.240

          .         .         .         .         .         .       g.5873
 AGGGTGCAGGTCCTAGAACCTCGCTGGGACCTCTCTGATAGACTGGGACCCGGCTCTGGA       c.780
 R  V  Q  V  L  E  P  R  W  D  L  S  D  R  L  G  P  G  S  G         p.260

          .         .         .         .         .         .       g.5933
 CCGCTGGGAGAGCCCCTCGCTGACGGACTGGCGCTTGTCCCTGCCACTTTGGCTTTTAAT       c.840
 P  L  G  E  P  L  A  D  G  L  A  L  V  P  A  T  L  A  F  N         p.280

          .         .         .         .   | 02     .         .    g.9223
 CTTGGCTGTGACCCCCTGGAAATGGGAGAGCTCAGAATTCAG | AGGTACTTGGAAGGCTCC    c.900
 L  G  C  D  P  L  E  M  G  E  L  R  I  Q   | R  Y  L  E  G  S      p.300

          .         .         .         .         .         .       g.9283
 ATCGCCCCTGAAGACAAAGGAAGCTGCTCATTGCTGCCTGGGCCTCCATTTGCCAGAGAG       c.960
 I  A  P  E  D  K  G  S  C  S  L  L  P  G  P  P  F  A  R  E         p.320

          .         .         .         .         .         .       g.9343
 TTACACATCGAAATTGTGTCTTCTCCCCACTACAGCACTAATGGAAATTATGACGGTGTT       c.1020
 L  H  I  E  I  V  S  S  P  H  Y  S  T  N  G  N  Y  D  G  V         p.340

          .         .       | 03 .         .         .         .    g.10191
 CTTTACCGGCACTTTCAGATACCCAG | GGTAGTCCAGGAAGGGGATGTTCTATGTGTGCCA    c.1080
 L  Y  R  H  F  Q  I  P  R  |  V  V  Q  E  G  D  V  L  C  V  P      p.360

          .         .         .         .         . | 04       .    g.14266
 ACAATTGGGCAAGTAGAGATCCTGGAAGGAAGTCCAGAGAAACTGCCCAG | GTGGCGGGAA    c.1140
 T  I  G  Q  V  E  I  L  E  G  S  P  E  K  L  P  R  |  W  R  E      p.380

          .         .         .         .         .         .       g.14326
 ATGTTTTTTAAAGTGAAGAAAACAGTTGGGGAAGCTCCAGATGGACCAGCCAGTGCCTAC       c.1200
 M  F  F  K  V  K  K  T  V  G  E  A  P  D  G  P  A  S  A  Y         p.400

          .         .         .    | 05    .         .         .    g.14469
 TTGGCCGACACCACCCATACCTCCTTGTACATG | GTGGGTTCTACCCTGAGCCCTGTTCCA    c.1260
 L  A  D  T  T  H  T  S  L  Y  M   | V  G  S  T  L  S  P  V  P      p.420

          .         .         .         .         .         .       g.14529
 TGGCTCCCTTCAGAGGAATCCACTCTCTGGAGCAGTTTGTCTCCTCCAGGCCTGGAGGCC       c.1320
 W  L  P  S  E  E  S  T  L  W  S  S  L  S  P  P  G  L  E  A         p.440

          .         .         .         .        | 06.         .    g.15271
 TTGGTGTCTGAACTCTGTGCTGTCCTGAAGCCTCGCCTCCAGCCAGG | GGGTGCCCTGCTG    c.1380
 L  V  S  E  L  C  A  V  L  K  P  R  L  Q  P  G  |  G  A  L  L      p.460

          .         .         .         .         .         .       g.15331
 ACAGGAACTAGCAGTGTCCTTCTACGGGGCCCCCCAGGCTGTGGGAAGACCACAGTAGTT       c.1440
 T  G  T  S  S  V  L  L  R  G  P  P  G  C  G  K  T  T  V  V         p.480

          .         .         .          | 07        .         .    g.15766
 GCTGCTGCCTGTAGTCACCTTGGGCTCCACTTACTGAAG | GTGCCCTGCTCCAGCCTCTGT    c.1500
 A  A  A  C  S  H  L  G  L  H  L  L  K   | V  P  C  S  S  L  C      p.500

          .         .         .         .         .         .       g.15826
 GCAGAAAGTAGTGGGGCTGTGGAGACAAAACTGCAGGCCATCTTCTCCCGGGCCCGCCGT       c.1560
 A  E  S  S  G  A  V  E  T  K  L  Q  A  I  F  S  R  A  R  R         p.520

          .         .         .         .         .         .       g.15886
 TGCCGGCCTGCAGTCCTGTTGCTCACAGCTGTGGACCTTCTGGGCCGGGACCGTGATGGG       c.1620
 C  R  P  A  V  L  L  L  T  A  V  D  L  L  G  R  D  R  D  G         p.540

          .         .         .         .         .         .       g.15946
 CTGGGTGAGGATGCCCGTGTGATGGCTGTGCTGCGTCACCTCCTCCTCAATGAGGACCCC       c.1680
 L  G  E  D  A  R  V  M  A  V  L  R  H  L  L  L  N  E  D  P         p.560

          | 08         .         .         .         .         .    g.16732
 CTCAACAG | CTGCCCTCCCCTCATGGTTGTGGCCACCACAAGCCGGGCCCAGGACCTGCCT    c.1740
 L  N  S  |  C  P  P  L  M  V  V  A  T  T  S  R  A  Q  D  L  P      p.580

          .         .         .         .         .         .       g.16792
 GCTGATGTGCAGACAGCATTTCCTCATGAGCTCGAGGTGCCTGCTCTGTCAGAGGGGCAG       c.1800
 A  D  V  Q  T  A  F  P  H  E  L  E  V  P  A  L  S  E  G  Q         p.600

          .         .         .         .         .         .       g.16852
 CGGCTCAGCATCCTGCGGGCCCTCACTGCCCACCTTCCCCTGGGCCAGGAGGTGAACTTG       c.1860
 R  L  S  I  L  R  A  L  T  A  H  L  P  L  G  Q  E  V  N  L         p.620

          .         .     | 09   .         .         .         .    g.17421
 GCACAGCTAGCACGGCGGTGTGCA | GGCTTTGTGGTAGGGGATCTCTATGCCCTTCTGACC    c.1920
 A  Q  L  A  R  R  C  A   | G  F  V  V  G  D  L  Y  A  L  L  T      p.640

          .         .         .         .  | 10      .         .    g.17605
 CACAGCAGCCGGGCAGCCTGCACCAGGATCAAGAACTCAGG | TTTGGCAGGTGGCTTGACT    c.1980
 H  S  S  R  A  A  C  T  R  I  K  N  S  G  |  L  A  G  G  L  T      p.660

          .         .         .         .         .         .       g.17665
 GAGGAGGATGAGGGGGAGCTGTGTGCTGCCGGCTTTCCTCTCCTGGCTGAGGACTTTGGG       c.2040
 E  E  D  E  G  E  L  C  A  A  G  F  P  L  L  A  E  D  F  G         p.680

          .         .         .         .         .     | 11   .    g.17802
 CAGGCACTGGAGCAACTGCAGACAGCTCACTCCCAGGCCGTTGGAGCCCCCAAG | ATCCCC    c.2100
 Q  A  L  E  Q  L  Q  T  A  H  S  Q  A  V  G  A  P  K   | I  P      p.700

          .         .         .         .         .         .       g.17862
 TCAGTGTCCTGGCATGATGTGGGTGGGCTGCAGGAGGTGAAGAAGGAGATCCTGGAGACC       c.2160
 S  V  S  W  H  D  V  G  G  L  Q  E  V  K  K  E  I  L  E  T         p.720

          .         .         .         .         .         .       g.17922
 ATTCAGCTCCCCCTGGAGCACCCTGAGCTACTGAGCCTGGGCCTGAGACGCTCAGGCCTT       c.2220
 I  Q  L  P  L  E  H  P  E  L  L  S  L  G  L  R  R  S  G  L         p.740

          .         .         .         .         .         .       g.17982
 CTGCTCCATGGGCCCCCTGGCACCGGCAAGACCCTTCTGGCCAAGGCAGTAGCCACTGAG       c.2280
 L  L  H  G  P  P  G  T  G  K  T  L  L  A  K  A  V  A  T  E         p.760

          .         . | 12       .         .         .         .    g.18178
 TGCAGCCTTACCTTCCTCAG | CGTGAAGGGGCCAGAGCTCATTAACATGTATGTGGGCCAA    c.2340
 C  S  L  T  F  L  S  |  V  K  G  P  E  L  I  N  M  Y  V  G  Q      p.780

          .         .   | 13     .         .         .         .    g.18492
 AGTGAGGAGAATGTGCGGGAAG | TGTTTGCCAGGGCCAGGGCTGCAGCTCCATGCATTATC    c.2400
 S  E  E  N  V  R  E  V |   F  A  R  A  R  A  A  A  P  C  I  I      p.800

          .         .         .         .         .         .       g.18552
 TTCTTTGATGAACTGGACTCTTTGGCCCCAAGCCGGGGGCGAAGTGGAGATTCTGGAGGA       c.2460
 F  F  D  E  L  D  S  L  A  P  S  R  G  R  S  G  D  S  G  G         p.820

          .  | 14      .         .         .         .         .    g.18924
 GTGATGGACAG | GGTGGTGTCTCAGCTCCTTGCCGAGCTAGATGGGCTGCACAGCACTCAG    c.2520
 V  M  D  R  |  V  V  S  Q  L  L  A  E  L  D  G  L  H  S  T  Q      p.840

          .         .         .         .         .         .       g.18984
 GATGTGTTTGTGATTGGAGCCACCAACAGACCAGATCTCCTGGACCCTGCCCTTCTGCGG       c.2580
 D  V  F  V  I  G  A  T  N  R  P  D  L  L  D  P  A  L  L  R         p.860

          | 15         .         .         .         .         .    g.19143
 CCTGGCAG | ATTTGACAAGCTGGTGTTTGTGGGGGCAAATGAGGACCGGGCCTCCCAGCTA    c.2640
 P  G  R  |  F  D  K  L  V  F  V  G  A  N  E  D  R  A  S  Q  L      p.880

          .         .       | 16 .         .         .         .    g.19348
 CGCGTTCTAAGTGCCATCACACGCAA | ATTCAAGCTAGAGCCATCTGTGAGCCTGGTAAAC    c.2700
 R  V  L  S  A  I  T  R  K  |  F  K  L  E  P  S  V  S  L  V  N      p.900

          .         .         .         .         .         .       g.19408
 GTGCTAGATTGCTGCCCTCCCCAGCTGACGGGCGCGGACCTCTACTCTCTCTGCTCTGAT       c.2760
 V  L  D  C  C  P  P  Q  L  T  G  A  D  L  Y  S  L  C  S  D         p.920

          .         .         .         .       | 17 .         .    g.19786
 GCTATGACAGCTGCCCTCAAACGCAGGGTTCATGACCTGGAGGAAG | GGCTGGAGCCAGGT    c.2820
 A  M  T  A  A  L  K  R  R  V  H  D  L  E  E  G |   L  E  P  G      p.940

          .         .         .         .         .         .       g.19846
 AGCTCAGCACTGATGCTCACCATGGAGGACTTGCTGCAGGCTGCCGCCCGGCTGCAACCC       c.2880
 S  S  A  L  M  L  T  M  E  D  L  L  Q  A  A  A  R  L  Q  P         p.960

          .         .         .         .         .         .       g.19906
 TCAGTCAGTGAGCAGGAGCTGCTCCGGTACAAGCGCATCCAGCGCAAGTTTGCTGCCTGC       c.2940
 S  V  S  E  Q  E  L  L  R  Y  K  R  I  Q  R  K  F  A  A  C         p.980

                                                                    g.19909
 TAG                                                                c.2943
 X                                                                  p.980

          .         .         .         .         .         .       g.19969
 gagccccccagggtctgggaccccgctcagcatggctgcaggtaccttgatagcccacag       c.*60

          .         .         .         .         .         .       g.20029
 agagatctgggaaggaagggctcctcctcaggctgctgccaacccacctggaggccacct       c.*120

          .         .         .         .         .         .       g.20089
 ccctccaggagatcccagggtgcaaagtggcattgagacagcagcaacagctcaagagat       c.*180

          .         .         .         .         .         .       g.20149
 atctcctgcctacttgcccctccttccaggccggctctaagagaaaggcccatctactca       c.*240

          .         .         .         .         .         .       g.20209
 ggaagagggccagggccttgggttctggggattgggccctgagagggctagttctgtggc       c.*300

          .         .         .         .         .         .       g.20269
 tgaaaataaagcatgtcccgccccctactggtgttgtggcatgaaaggttggagtgagaa       c.*360

          .         .         .         .         .         .       g.20329
 agagcagggttgtgggaggagtaagccctgggagagggtgggggggtgggcagcatggga       c.*420

          .         .         .         .                           g.20371
 gcctgatccttctgacataaataaacacaatgcatgcaggaa                         c.*462

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Peroxisomal biogenesis factor 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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