phosphofructokinase, muscle (PFKM) - coding DNA reference sequence

(used for variant description)

(last modified February 6, 2026)


This file was created to facilitate the description of sequence variants on transcript NM_000289.5 in the PFKM gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000012.11, covering PFKM transcript NM_000289.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.18362
                                                        aggag       c.-181

 .         .         .         .         .         .                g.18422
 gaggcggagccttcttgtcagcatctgttagtggaggttgggaagcctctcctccttccc       c.-121

 .         .         .         .         .         .                g.18482
 cctccctctttgcctccacctggctcctccccatgttcgtccatcacccctccccccttt       c.-61

 .         .         .         .         .         .  | 02          g.21902
 cccaaggacaatctgcaagaaagcagcggcggaggagagctaagactaaaag | agtggatc    c.-1

          .         .         .         .         .         .       g.21962
 ATGACCCATGAAGAGCACCATGCAGCCAAAACCCTGGGGATTGGCAAAGCCATTGCTGTC       c.60
 M  T  H  E  E  H  H  A  A  K  T  L  G  I  G  K  A  I  A  V         p.20

          .         .      | 03  .         .         .         .    g.29525
 TTAACCTCTGGTGGAGATGCCCAAG | GTATGAATGCTGCTGTCAGGGCTGTGGTTCGAGTT    c.120
 L  T  S  G  G  D  A  Q  G |   M  N  A  A  V  R  A  V  V  R  V      p.40

          .         .         .          | 04        .         .    g.30464
 GGTATCTTCACCGGTGCCCGTGTCTTCTTTGTCCATGAG | GGTTATCAAGGCCTGGTGGAT    c.180
 G  I  F  T  G  A  R  V  F  F  V  H  E   | G  Y  Q  G  L  V  D      p.60

          .         .         .         .         .        | 05.    g.31998
 GGTGGAGATCACATCAAGGAAGCCACCTGGGAGAGCGTTTCGATGATGCTTCAGCTG | GGA    c.240
 G  G  D  H  I  K  E  A  T  W  E  S  V  S  M  M  L  Q  L   | G      p.80

          .         .         .         .         .         .       g.32058
 GGCACGGTGATTGGAAGTGCCCGGTGCAAGGACTTTCGGGAACGAGAAGGACGACTCCGA       c.300
 G  T  V  I  G  S  A  R  C  K  D  F  R  E  R  E  G  R  L  R         p.100

          .         .         .         .         .         .       g.32118
 GCTGCCTACAACCTGGTGAAGCGTGGGATCACCAATCTCTGTGTCATTGGGGGTGATGGC       c.360
 A  A  Y  N  L  V  K  R  G  I  T  N  L  C  V  I  G  G  D  G         p.120

          .         .         .         .         .         .       g.32178
 AGCCTCACTGGGGCTGACACCTTCCGTTCTGAGTGGAGTGACTTGTTGAGTGACCTCCAG       c.420
 S  L  T  G  A  D  T  F  R  S  E  W  S  D  L  L  S  D  L  Q         p.140

         | 06.         .         .         .         .         .    g.32495
 AAAGCAG | GTAAGATCACAGATGAGGAGGCTACGAAGTCCAGCTACCTGAACATTGTGGGC    c.480
 K  A  G |   K  I  T  D  E  E  A  T  K  S  S  Y  L  N  I  V  G      p.160

          .         .         .         .         .         .       g.32555
 CTGGTTGGGTCAATTGACAATGACTTCTGTGGCACCGATATGACCATTGGCACTGACTCT       c.540
 L  V  G  S  I  D  N  D  F  C  G  T  D  M  T  I  G  T  D  S         p.180

          .         .         .         .         .    | 07    .    g.33366
 GCCCTGCATCGGATCATGGAAATTGTAGATGCCATCACTACCACTGCCCAGAG | CCACCAG    c.600
 A  L  H  R  I  M  E  I  V  D  A  I  T  T  T  A  Q  S  |  H  Q      p.200

          .         .         .         | 08         .         .    g.33870
 AGGACATTTGTGTTAGAAGTAATGGGCCGCCACTGTGG | ATACCTGGCCCTTGTCACCTCT    c.660
 R  T  F  V  L  E  V  M  G  R  H  C  G  |  Y  L  A  L  V  T  S      p.220

          .         .         .         .         .         .       g.33930
 CTGTCCTGTGGGGCCGACTGGGTTTTTATTCCTGAATGTCCACCAGATGACGACTGGGAG       c.720
 L  S  C  G  A  D  W  V  F  I  P  E  C  P  P  D  D  D  W  E         p.240

          .         .        | 09.         .         .         .    g.34103
 GAACACCTTTGTCGCCGACTCAGCGAG | ACAAGGACCCGTGGTTCTCGTCTCAACATCATC    c.780
 E  H  L  C  R  R  L  S  E   | T  R  T  R  G  S  R  L  N  I  I      p.260

          .         .         .         .         .         .       g.34163
 ATTGTGGCTGAGGGTGCAATTGACAAGAATGGAAAACCAATCACCTCAGAAGACATCAAG       c.840
 I  V  A  E  G  A  I  D  K  N  G  K  P  I  T  S  E  D  I  K         p.280

     | 10    .         .         .         .         .         .    g.34475
 AAT | CTGGTGGTTAAGCGTCTGGGATATGACACCCGGGTTACTGTCTTGGGGCATGTGCAG    c.900
 N   | L  V  V  K  R  L  G  Y  D  T  R  V  T  V  L  G  H  V  Q      p.300

          .         .         .       | 11 .         .         .    g.36872
 AGGGGTGGGACGCCATCAGCCTTTGACAGAATTCTG | GGCAGCAGGATGGGTGTGGAAGCA    c.960
 R  G  G  T  P  S  A  F  D  R  I  L   | G  S  R  M  G  V  E  A      p.320

          .         .         .         .         .         .       g.36932
 GTGATGGCACTTTTGGAGGGGACCCCAGATACCCCAGCCTGTGTAGTGAGCCTCTCTGGT       c.1020
 V  M  A  L  L  E  G  T  P  D  T  P  A  C  V  V  S  L  S  G         p.340

          .         .         .         .   | 12     .         .    g.38430
 AACCAGGCTGTGCGCCTGCCCCTCATGGAATGTGTCCAGGTG | ACCAAAGATGTGACCAAG    c.1080
 N  Q  A  V  R  L  P  L  M  E  C  V  Q  V   | T  K  D  V  T  K      p.360

          .         .         .         .        | 13.         .    g.38989
 GCCATGGATGAGAAGAAATTTGACGAAGCCCTGAAGCTGAGAGGCCG | GAGCTTCATGAAC    c.1140
 A  M  D  E  K  K  F  D  E  A  L  K  L  R  G  R  |  S  F  M  N      p.380

          .         .         .         .         .  | 14      .    g.39858
 AACTGGGAGGTGTACAAGCTTCTAGCTCATGTCAGACCCCCGGTATCTAAG | AGTGGTTCG    c.1200
 N  W  E  V  Y  K  L  L  A  H  V  R  P  P  V  S  K   | S  G  S      p.400

          .         .         .         .         .         .       g.39918
 CACACAGTGGCTGTGATGAACGTGGGGGCTCCGGCTGCAGGCATGAATGCTGCTGTTCGC       c.1260
 H  T  V  A  V  M  N  V  G  A  P  A  A  G  M  N  A  A  V  R         p.420

          .         .         .         .         .         .       g.39978
 TCCACTGTGAGGATTGGCCTTATCCAGGGCAACCGAGTGCTCGTTGTCCATGATGGTTTC       c.1320
 S  T  V  R  I  G  L  I  Q  G  N  R  V  L  V  V  H  D  G  F         p.440

          .         .  | 15      .         .         .         .    g.40477
 GAGGGCCTGGCCAAGGGGCAG | ATAGAGGAAGCTGGCTGGAGCTATGTTGGGGGCTGGACT    c.1380
 E  G  L  A  K  G  Q   | I  E  E  A  G  W  S  Y  V  G  G  W  T      p.460

          .         .         .   | 16     .         .         .    g.40895
 GGCCAAGGTGGCTCTAAACTTGGGACTAAAAG | GACTCTACCCAAGAAGAGCTTTGAACAG    c.1440
 G  Q  G  G  S  K  L  G  T  K  R  |  T  L  P  K  K  S  F  E  Q      p.480

          .         .         .         .         .         .       g.40955
 ATCAGTGCCAATATAACTAAGTTTAACATTCAGGGCCTTGTCATCATTGGGGGCTTTGAG       c.1500
 I  S  A  N  I  T  K  F  N  I  Q  G  L  V  I  I  G  G  F  E         p.500

  | 17       .         .         .         .         .         .    g.41101
  | GCTTACACAGGGGGCCTGGAACTGATGGAGGGCAGGAAGCAGTTTGATGAGCTCTGCATC    c.1560
  | A  Y  T  G  G  L  E  L  M  E  G  R  K  Q  F  D  E  L  C  I      p.520

          .         .         .         .         .         .       g.41161
 CCATTTGTGGTCATTCCTGCTACAGTCTCCAACAATGTCCCTGGCTCAGACTTCAGCGTT       c.1620
 P  F  V  V  I  P  A  T  V  S  N  N  V  P  G  S  D  F  S  V         p.540

          .         .         .    | 18    .         .         .    g.41936
 GGGGCTGACACAGCACTCAATACTATCTGCACA | ACCTGTGACCGCATCAAGCAGTCAGCA    c.1680
 G  A  D  T  A  L  N  T  I  C  T   | T  C  D  R  I  K  Q  S  A      p.560

          .         .         .         .         .         .       g.41996
 GCTGGCACCAAGCGTCGGGTGTTTATCATTGAGACTATGGGTGGCTACTGTGGCTACCTG       c.1740
 A  G  T  K  R  R  V  F  I  I  E  T  M  G  G  Y  C  G  Y  L         p.580

          .         .         .         .         .         .       g.42056
 GCTACCATGGCTGGACTGGCAGCTGGGGCCGATGCTGCCTACATTTTTGAGGAGCCCTTC       c.1800
 A  T  M  A  G  L  A  A  G  A  D  A  A  Y  I  F  E  E  P  F         p.600

          .         | 19         .         .         .         .    g.42922
 ACCATTCGAGACCTGCAG | GCAAATGTTGAACATCTGGTGCAAAAGATGAAAACAACTGTG    c.1860
 T  I  R  D  L  Q   | A  N  V  E  H  L  V  Q  K  M  K  T  T  V      p.620

          .         . | 20       .         .         .         .    g.43213
 AAAAGGGGCTTGGTGTTAAG | GAATGAAAAGTGCAATGAGAACTATACCACTGACTTCATT    c.1920
 K  R  G  L  V  L  R  |  N  E  K  C  N  E  N  Y  T  T  D  F  I      p.640

          .         .         .         .         .         .       g.43273
 TTCAACCTGTACTCTGAGGAGGGGAAGGGCATCTTCGACAGCAGGAAGAATGTGCTTGGT       c.1980
 F  N  L  Y  S  E  E  G  K  G  I  F  D  S  R  K  N  V  L  G         p.660

          .   | 21     .         .         .         .         .    g.44206
 CACATGCAGCAG | GGTGGGAGCCCAACCCCATTTGATAGGAATTTTGCCACTAAGATGGGC    c.2040
 H  M  Q  Q   | G  G  S  P  T  P  F  D  R  N  F  A  T  K  M  G      p.680

          .         .         .         .         .   | 22     .    g.44345
 GCCAAGGCTATGAACTGGATGTCTGGGAAAATCAAAGAGAGTTACCGTAATG | GGCGGATC    c.2100
 A  K  A  M  N  W  M  S  G  K  I  K  E  S  Y  R  N  G |   R  I      p.700

          .         .         .         .         .         .       g.44405
 TTTGCCAATACTCCAGATTCGGGCTGTGTTCTGGGGATGCGTAAGAGGGCTCTGGTCTTC       c.2160
 F  A  N  T  P  D  S  G  C  V  L  G  M  R  K  R  A  L  V  F         p.720

          .         .         .         | 23         .         .    g.44713
 CAACCAGTGGCTGAGCTGAAGGACCAGACAGATTTTGA | GCATCGAATCCCCAAGGAACAG    c.2220
 Q  P  V  A  E  L  K  D  Q  T  D  F  E  |  H  R  I  P  K  E  Q      p.740

          .         .         .         .         .         .       g.44773
 TGGTGGCTGAAACTGAGGCCCATCCTCAAAATCCTAGCCAAGTACGAGATTGACTTGGAC       c.2280
 W  W  L  K  L  R  P  I  L  K  I  L  A  K  Y  E  I  D  L  D         p.760

          .         .         .         .         .         .       g.44833
 ACTTCAGACCATGCCCACCTGGAGCACATCACCCGGAAGCGGTCCGGGGAAGCTGCCGTC       c.2340
 T  S  D  H  A  H  L  E  H  I  T  R  K  R  S  G  E  A  A  V         p.780

                                                                    g.44836
 TAA                                                                c.2343
 X                                                                  p.780

          .         .         .         .         .         .       g.44896
 acctctctggagtgaggggaatagattacctgatcatggtcagctcacaccctaataagt       c.*60

          .         .         .         .         .         .       g.44956
 ccacatcttctcagtgttttagctgtttttttcattaggtttccttttattctgtacctt       c.*120

          .         .         .         .         .         .       g.45016
 gcagccatgaccagttctggccaggagctggaggagcaggcagtgggtgggagctccttt       c.*180

          .         .         .         .         .         .       g.45076
 taggtagaatttaacatgacttctgccccagctttatctgtcacacaaggctgggcacct       c.*240

          .         .         .         .         .         .       g.45136
 ctagtgctactgctagatatcacttactcagttagaattttcctaaaaataagctttatt       c.*300

          .         .         .         .         .         .       g.45196
 tatttctttgtgataacaaagagtcttggttcctctactacttttactacagtgacaaat       c.*360

          .         .         .         .         .         .       g.45256
 tgtaactacactaataaatgccaactggtcactgtgcttttgcttctcctgttatcatct       c.*420

          .         .         .         .         .         .       g.45316
 tcctaagtggaatgtaatactgtcagccccatgtatcagacacttgtctgatgaagcagt       c.*480

          .         .         .         .         .         .       g.45376
 aaagacgttaagggtatcacagggggtggaggaagggattatctctagtacactacttgc       c.*540

          .         .         .         .         .         .       g.45436
 tggctgtctgaaaaattgtcactgccaaactctaaaaacagttctaaatagtgactgaga       c.*600

          .         .         .         .         .         .       g.45496
 aggtttgttgctggagtcagggaataaggcagccaaatactctttgcacagttctttagt       c.*660

          .         .         .                                     g.45532
 gggaagagaaattaacaataaatatcaagcactgtg                               c.*696

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phosphofructokinase, muscle protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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