phosphoglucomutase 1 (PGM1) - coding DNA reference sequence

(used for variant description)

(last modified March 20, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_002633.2 in the PGM1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016966.1, covering PGM1 transcript NM_002633.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5033
                            cctttcccctcccgccggacctgccaggaggtg       c.-181

 .         .         .         .         .         .                g.5093
 ggctggcgcggagggagggccctgtcccctgtccctttaaggaggagggccaaacgccgg       c.-121

 .         .         .         .         .         .                g.5153
 cctagagtgcggcgtagcccccacccgccgtgccctcaccccagagcagctgcagcctca       c.-61

 .         .         .         .         .         .                g.5213
 gccggccgcccctccgccagccaagtccgccgctctgacccccggcagcaagtcgccacc       c.-1

          .         .         .         .         .         .       g.5273
 ATGGTGAAGATCGTGACAGTTAAGACCCAGGCGTACCAGGACCAGAAGCCGGGCACGAGC       c.60
 M  V  K  I  V  T  V  K  T  Q  A  Y  Q  D  Q  K  P  G  T  S         p.20

          .         .         .         .         .         .       g.5333
 GGGCTGCGGAAGCGGGTGAAGGTGTTCCAGAGCAGCGCCAACTACGCGGAGAACTTCATC       c.120
 G  L  R  K  R  V  K  V  F  Q  S  S  A  N  Y  A  E  N  F  I         p.40

          .         .         .         .         .         .       g.5393
 CAGAGTATCATCTCCACCGTGGAGCCGGCGCAGCGGCAGGAGGCCACGCTGGTGGTGGGC       c.180
 Q  S  I  I  S  T  V  E  P  A  Q  R  Q  E  A  T  L  V  V  G         p.60

          .         .         .         .         .         .       g.5453
 GGGGACGGCCGGTTCTACATGAAGGAGGCCATCCAGCTCATCGCTCGCATCGCTGCCGCC       c.240
 G  D  G  R  F  Y  M  K  E  A  I  Q  L  I  A  R  I  A  A  A         p.80

        | 02 .         .         .         .         .         .    g.41203
 AACGGG | ATCGGTCGCTTGGTTATCGGACAGAATGGAATCCTCTCCACCCCTGCTGTATCC    c.300
 N  G   | I  G  R  L  V  I  G  Q  N  G  I  L  S  T  P  A  V  S      p.100

          .         .         .         .         .         .       g.41263
 TGCATCATTAGAAAAATCAAAGCCATTGGTGGGATCATTCTGACAGCCAGTCACAACCCA       c.360
 C  I  I  R  K  I  K  A  I  G  G  I  I  L  T  A  S  H  N  P         p.120

          .         .         .         .          | 03        .    g.41677
 GGGGGCCCCAATGGAGATTTTGGAATCAAATTCAATATTTCTAATGGAG | GTCCTGCTCCA    c.420
 G  G  P  N  G  D  F  G  I  K  F  N  I  S  N  G  G |   P  A  P      p.140

          .         .         .         .         .         .       g.41737
 GAAGCAATAACTGATAAAATTTTCCAAATCAGCAAGACAATTGAAGAATATGCAGTTTGC       c.480
 E  A  I  T  D  K  I  F  Q  I  S  K  T  I  E  E  Y  A  V  C         p.160

          .         .         .         .         .         .       g.41797
 CCTGACCTGAAAGTAGACCTTGGTGTTCTGGGAAAGCAGCAGTTTGACTTGGAAAATAAG       c.540
 P  D  L  K  V  D  L  G  V  L  G  K  Q  Q  F  D  L  E  N  K         p.180

          .       | 04 .         .         .         .         .    g.43425
 TTCAAACCCTTCACAG | TGGAAATTGTGGATTCGGTAGAAGCTTATGCTACAATGCTGAGA    c.600
 F  K  P  F  T  V |   E  I  V  D  S  V  E  A  Y  A  T  M  L  R      p.200

          .         .         .         .         .         .       g.43485
 AGCATCTTTGATTTCAGTGCACTGAAAGAACTACTTTCTGGGCCAAACCGACTGAAGATC       c.660
 S  I  F  D  F  S  A  L  K  E  L  L  S  G  P  N  R  L  K  I         p.220

          .         .   | 05     .         .         .         .    g.46591
 CGTATTGATGCTATGCATGGAG | TTGTGGGACCGTATGTAAAGAAGATCCTCTGTGAAGAA    c.720
 R  I  D  A  M  H  G  V |   V  G  P  Y  V  K  K  I  L  C  E  E      p.240

          .         .         .         .         .         .       g.46651
 CTCGGTGCCCCTGCGAACTCGGCAGTTAACTGCGTTCCTCTGGAGGACTTTGGAGGCCAC       c.780
 L  G  A  P  A  N  S  A  V  N  C  V  P  L  E  D  F  G  G  H         p.260

          .         .         .         .         .         .       g.46711
 CACCCTGACCCCAACCTCACCTATGCAGCTGACCTGGTGGAGACCATGAAGTCAGGAGAG       c.840
 H  P  D  P  N  L  T  Y  A  A  D  L  V  E  T  M  K  S  G  E         p.280

          .         .         .    | 06    .         .         .    g.47985
 CATGATTTTGGGGCTGCCTTTGATGGAGATGGG | GATCGAAACATGATTCTGGGCAAGCAT    c.900
 H  D  F  G  A  A  F  D  G  D  G   | D  R  N  M  I  L  G  K  H      p.300

          .         .         .         .         .         .       g.48045
 GGGTTCTTTGTGAACCCTTCAGACTCTGTGGCTGTCATTGCTGCCAACATCTTCAGCATT       c.960
 G  F  F  V  N  P  S  D  S  V  A  V  I  A  A  N  I  F  S  I         p.320

          .         .         .         .         .         .       g.48105
 CCGTATTTCCAGCAGACTGGGGTCCGCGGCTTTGCACGGAGCATGCCCACGAGTGGTGCT       c.1020
 P  Y  F  Q  Q  T  G  V  R  G  F  A  R  S  M  P  T  S  G  A         p.340

          | 07         .         .         .         .         .    g.50461
 CTGGACCG | GGTGGCTAGTGCTACAAAGATTGCTTTGTATGAGACCCCAACTGGCTGGAAG    c.1080
 L  D  R  |  V  A  S  A  T  K  I  A  L  Y  E  T  P  T  G  W  K      p.360

          .         .         .         .         .         .       g.50521
 TTTTTTGGGAATTTGATGGACGCGAGCAAACTGTCCCTTTGTGGGGAGGAGAGCTTCGGG       c.1140
 F  F  G  N  L  M  D  A  S  K  L  S  L  C  G  E  E  S  F  G         p.380

      | 08   .         .         .         .         .         .    g.60297
 ACCG | GTTCTGACCACATCCGTGAGAAAGATGGACTGTGGGCTGTCCTTGCCTGGCTCTCC    c.1200
 T  G |   S  D  H  I  R  E  K  D  G  L  W  A  V  L  A  W  L  S      p.400

          .         .         .         .         .         .       g.60357
 ATCCTAGCCACCCGCAAGCAGAGTGTGGAGGACATTCTCAAAGATCATTGGCAAAAGTAT       c.1260
 I  L  A  T  R  K  Q  S  V  E  D  I  L  K  D  H  W  Q  K  Y         p.420

          .         . | 09       .         .         .         .    g.63433
 GGCCGGAATTTCTTCACCAG | GTATGATTACGAGGAGGTGGAAGCTGAGGGCGCAAACAAA    c.1320
 G  R  N  F  F  T  R  |  Y  D  Y  E  E  V  E  A  E  G  A  N  K      p.440

          .         .         .         .         .         .       g.63493
 ATGATGAAGGACTTGGAGGCCCTGATGTTTGATCGCTCCTTTGTGGGGAAGCAGTTCTCA       c.1380
 M  M  K  D  L  E  A  L  M  F  D  R  S  F  V  G  K  Q  F  S         p.460

          .         .         .         .         .         .       g.63553
 GCAAATGACAAAGTTTACACTGTGGAGAAGGCCGATAACTTTGAATACAGCGACCCAGTG       c.1440
 A  N  D  K  V  Y  T  V  E  K  A  D  N  F  E  Y  S  D  P  V         p.480

          .         .     | 10   .         .         .         .    g.66092
 GATGGAAGCATTTCAAGAAATCAG | GGCTTGCGCCTCATTTTCACAGATGGTTCTCGAATC    c.1500
 D  G  S  I  S  R  N  Q   | G  L  R  L  I  F  T  D  G  S  R  I      p.500

          .         .         .         .         .         .       g.66152
 GTCTTCCGACTGAGCGGCACTGGGAGTGCCGGGGCCACCATTCGGCTGTACATCGATAGC       c.1560
 V  F  R  L  S  G  T  G  S  A  G  A  T  I  R  L  Y  I  D  S         p.520

          .         .         .          | 11        .         .    g.71331
 TATGAGAAGGACGTTGCCAAGATTAACCAGGACCCCCAG | GTCATGTTGGCCCCCCTTATT    c.1620
 Y  E  K  D  V  A  K  I  N  Q  D  P  Q   | V  M  L  A  P  L  I      p.540

          .         .         .         .         .         .       g.71391
 TCCATTGCTCTGAAAGTGTCCCAGCTGCAGGAGAGGACGGGACGCACTGCACCCACTGTC       c.1680
 S  I  A  L  K  V  S  Q  L  Q  E  R  T  G  R  T  A  P  T  V         p.560

                                                                    g.71400
 ATCACCTAA                                                          c.1689
 I  T  X                                                            p.562

          .         .         .         .         .         .       g.71460
 gaagacaggcctgatgtggtacgtccctccacccccggacccatccaagtcatctgattg       c.*60

          .         .         .         .         .         .       g.71520
 aagagcatgacagaaacaaaatgtattcaccaagcattttaggatttgactttttcacta       c.*120

          .         .         .         .         .         .       g.71580
 accagttgacgagcagtgcatttacaaggcactgccaaacaagatgcccttgggagctgt       c.*180

          .         .         .         .         .         .       g.71640
 gagggaaagaggacctgcgggcttagatcaatctcaattccttttcatgccctcctgcat       c.*240

          .         .         .         .         .         .       g.71700
 tgctgctgcgtgggtatttgtctccttagccatcaggtacagtttacactacaatgtaag       c.*300

          .         .         .         .         .         .       g.71760
 ctataggtggagcatcagcagtgagtgaggccattcttcatccttaggatgtggcaatga       c.*360

          .         .         .         .         .         .       g.71820
 aatgatggtgcaagttcctttctcttttgtgaatctttccccccatttcctgtttacatg       c.*420

          .         .         .         .         .         .       g.71880
 taacccaacaaaatgcaatttctagtgccttctgtccaatcagttctttcctctgagtga       c.*480

          .         .         .         .         .         .       g.71940
 gacgtacttggctacagatttctgccttgttttgcgacattgtcccattcacacagatat       c.*540

          .         .         .                                     g.71970
 tttgggataataaaggaaaataagctacaa                                     c.*570

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phosphoglucomutase 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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