phosphatase and actin regulator 1 (PHACTR1) - coding DNA reference sequence

(used for variant description)

(last modified November 5, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_030948.2 in the PHACTR1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering PHACTR1 transcript NM_030948.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5013
                                                aagctgttcattt       c.-361

 .         .         .         .         .         .                g.5073
 gtgcttgcgggctcagaagcgtcgcactgctttgttttgtactctaccgtgtcctgttga       c.-301

 .         .         | 02         .         .         .             g.5745
 aaggggtcaacaagtgccg | gggagggtgcagaggctgaggctggcgtcaccttccgttgc    c.-241

 .         .         .         .         .         .                g.5805
 taaggtaacgtgctctggccattttatctgataaaggaagtccagtggactgtatgcatt       c.-181

 .         .         .         .         .         .                g.5865
 attcatcactgttctaatcaaacaatcaaaatcgtttactttcaccgggaatatttagca       c.-121

 .         .         .         .         .         .                g.5925
 agatcaaagacactctggctggaacggctcttgttttaccgctgacagatagcctttgat       c.-61

 .         .    | 03    .         .         .         .             g.6940
 ttttattttttgca | gtgttccagtgttttctctcaaaactctgtgtttggaacatcaagg    c.-1

          .         .         .         .         .         .       g.7000
 ATGGATTATCCCAAAATGGATTATTTTCTGGATGTAGAGTCTGCTCACAGACTCTTGGAT       c.60
 M  D  Y  P  K  M  D  Y  F  L  D  V  E  S  A  H  R  L  L  D         p.20

          .         .         .         .    | 04    .         .    g.37856
 GTTGAGTCAGCTCAAAGATTCTTCTACAGTCAAGGAGCTCAAG | CTCGCCGGGCGACCCTG    c.120
 V  E  S  A  Q  R  F  F  Y  S  Q  G  A  Q  A |   R  R  A  T  L      p.40

          .         .         .         .         .         .       g.37916
 CTCCTGCCTCCCACATTAATGGCGGCATCCTCGGAGGATGATATAGACCGGCGGCCCATC       c.180
 L  L  P  P  T  L  M  A  A  S  S  E  D  D  I  D  R  R  P  I         p.60

          .         .         .         .         .         .       g.37976
 CGGAGAGTGCGCTCCAAGAGCGACACGCCGTACCTCGCAGAGGCCAGGATCTCCTTTAAC       c.240
 R  R  V  R  S  K  S  D  T  P  Y  L  A  E  A  R  I  S  F  N         p.80

          . | 05       .         .         .         .         .    g.341610
 CTGGGGGCAG | CTGAGGAAGTGGAGAGGCTGGCGGCGATGCGTTCTGACTCCCTCGTCCCA    c.300
 L  G  A  A |   E  E  V  E  R  L  A  A  M  R  S  D  S  L  V  P      p.100

          .         .         .         .         .         .       g.341670
 GGCACCCACACCCCACCCATCCGCAGGAGAAGTAAGTTTGCCAACCTGGGAAGGATTTTC       c.360
 G  T  H  T  P  P  I  R  R  R  S  K  F  A  N  L  G  R  I  F         p.120

          .         .         .         .         .      | 06  .    g.448404
 AAGCCTTGGAAATGGAGGAAGAAGAAAAGCGAAAAGTTCAAACACACGTCAGCAG | CCCTG    c.420
 K  P  W  K  W  R  K  K  K  S  E  K  F  K  H  T  S  A  A |   L      p.140

          .         .         .         .         .         .       g.448464
 GAAAGGAAAATATCTATGAGGCAAAGCAGAGAAGAGCTGATAAAGCGAGGAGTCCTGAAG       c.480
 E  R  K  I  S  M  R  Q  S  R  E  E  L  I  K  R  G  V  L  K         p.160

          .       | 07 .         .         .         .         .    g.470758
 GAAATCTATGATAAAG | ATGGGGAACTCTCTATATCCAATGAAGAGGACTCCCTAGAAAAT    c.540
 E  I  Y  D  K  D |   G  E  L  S  I  S  N  E  E  D  S  L  E  N      p.180

          .         .         .         .         .         .       g.470818
 GGGCAGTCCCTGAGCTCCAGCCAGCTGTCTCTGCCTGCCCTGTCCGAAATGGAGCCAGTC       c.600
 G  Q  S  L  S  S  S  Q  L  S  L  P  A  L  S  E  M  E  P  V         p.200

          .         .         .         .         .         .       g.470878
 CCAATGCCCAGGGATCCCTGCTCATATGAGGTGCTCCAACCGTCAGACATCATGGATGGG       c.660
 P  M  P  R  D  P  C  S  Y  E  V  L  Q  P  S  D  I  M  D  G         p.220

      | 08   .         .         .         .         .         .    g.494066
 CCAG | ATCCTGGCGCCCCTGTGAAATTGCCTTGTCTGCCAGTGAAACTGTCGCCTCCGCTA    c.720
 P  D |   P  G  A  P  V  K  L  P  C  L  P  V  K  L  S  P  P  L      p.240

          .         .         .         .         .         .       g.494126
 CCTCCAAAGAAAGTCATGATCTGTATGCCCGTGGGGGGGCCAGACCTCTCACTGGTGTCC       c.780
 P  P  K  K  V  M  I  C  M  P  V  G  G  P  D  L  S  L  V  S         p.260

          .         .         .         .         .         .       g.494186
 TACACAGCCCAGAAGAGTGGCCAGCAGGGTGTGGCCCAGCACCACCACACTGTCCTGCCC       c.840
 Y  T  A  Q  K  S  G  Q  Q  G  V  A  Q  H  H  H  T  V  L  P         p.280

          .         .         .         .         .         .       g.494246
 TCCCAGATCCAGCACCAGCTGCAGTACGGCAGCCACGGCCAGCACCTCCCCTCCACCACC       c.900
 S  Q  I  Q  H  Q  L  Q  Y  G  S  H  G  Q  H  L  P  S  T  T         p.300

          .         .         .         .         .         .       g.494306
 GGCTCCCTCCCCATGCACCCCTCGGGCTGCAGAATGATAGACGAGCTCAACAAAACGCTG       c.960
 G  S  L  P  M  H  P  S  G  C  R  M  I  D  E  L  N  K  T  L         p.320

          .         .       | 09 .         .         .         .    g.516045
 GCCATGACCATGCAGAGGCTGGAAAG | CTCTGAGCAGCGGGTCCCCTGTTCCACTTCTTAC    c.1020
 A  M  T  M  Q  R  L  E  S  |  S  E  Q  R  V  P  C  S  T  S  Y      p.340

          .         .         .         .         .         .       g.516105
 CACAGCTCTGGGTTGCACTCGGGTGATGGGGTCACCAAAGCAGGACCTATGGGCCTTCCA       c.1080
 H  S  S  G  L  H  S  G  D  G  V  T  K  A  G  P  M  G  L  P         p.360

          .         .         .         .         .         .       g.516165
 GAAATAAGACAAGTGCCAACTGTTGTGATTGAATGTGATGACAATAAAGAAAATGTGCCT       c.1140
 E  I  R  Q  V  P  T  V  V  I  E  C  D  D  N  K  E  N  V  P         p.380

          .         .         .         .         .         .       g.516225
 CATGAGTCAGACTACGAAGACTCTTCTTGCCTGTATACAAGAGAAGAGGAGGAAGAGGAG       c.1200
 H  E  S  D  Y  E  D  S  S  C  L  Y  T  R  E  E  E  E  E  E         p.400

          .         .         .     | 10   .         .         .    g.518258
 GAGGACGAAGACGACGACAGCTCATTATACACCA | GCTCCCTGGCCATGAAGGTCTGCAGG    c.1260
 E  D  E  D  D  D  S  S  L  Y  T  S |   S  L  A  M  K  V  C  R      p.420

          .         .         .         .         .         .       g.518318
 AAGGACTCCTTAGCCATCAAACTCAGCAACAGGCCCTCCAAGCGAGAGCTGGAAGAAAAG       c.1320
 K  D  S  L  A  I  K  L  S  N  R  P  S  K  R  E  L  E  E  K         p.440

          .         .         .         .         .         .       g.518378
 AACATCCTTCCCAGGCAGACGGATGAGGAGCGGCTGGAGCTGAGGCAACAGATTGGCACC       c.1380
 N  I  L  P  R  Q  T  D  E  E  R  L  E  L  R  Q  Q  I  G  T         p.460

          .  | 11      .         .         .         .         .    g.561104
 AAGCTCACCAG | GCGGCTGAGCCAGAGGCCAACTGCAGAGGAACTGGAACAGAGGAACATT    c.1440
 K  L  T  R  |  R  L  S  Q  R  P  T  A  E  E  L  E  Q  R  N  I      p.480

         | 12.         .         .         .         .         .    g.566516
 TTGAAAC | CTCGGAATGAACAAGAGGAACAGGAGGAGAAGAGAGAGATCAAGAGGAGGCTA    c.1500
 L  K  P |   R  N  E  Q  E  E  Q  E  E  K  R  E  I  K  R  R  L      p.500

           | 13        .         .         .         .         .    g.571668
 ACCCGAAAG | CTCAGTCAAAGGCCCACGGTGGAAGAGCTTCGGGAAAGAAAGATCCTCATC    c.1560
 T  R  K   | L  S  Q  R  P  T  V  E  E  L  R  E  R  K  I  L  I      p.520

          .         .         .         .         .         .       g.571728
 CGCTTCAGTGACTACGTGGAGGTGGCTGACGCTCAGGACTATGACCGCAGGGCAGATAAG       c.1620
 R  F  S  D  Y  V  E  V  A  D  A  Q  D  Y  D  R  R  A  D  K         p.540

          .         .         . | 14       .         .         .    g.574371
 CCGTGGACCCGCCTCACCGCTGCAGACAAA | GCTGCCATCCGAAAGGAGCTCAATGAATTC    c.1680
 P  W  T  R  L  T  A  A  D  K   | A  A  I  R  K  E  L  N  E  F      p.560

          .         .         .         .        | 15.         .    g.575271
 AAAAGCACTGAGATGGAAGTTCATGAATTGAGTAGACACTTAACAAG | GTTTCACCGACCT    c.1740
 K  S  T  E  M  E  V  H  E  L  S  R  H  L  T  R  |  F  H  R  P      p.580

                                                                    g.575274
 TAA                                                                c.1743
 X                                                                  p.580

          .         .         .         .         .         .       g.575334
 cagtcgaattcctcttgagtgctatgctgtcttcaaaacataaatttataagaaccataa       c.*60

          .         .         .         .         .         .       g.575394
 gtgctggtatttattcacttccccattacgatgtaaatcttctgaactgcctttttttta       c.*120

          .         .         .         .         .         .       g.575454
 aaaagaagaaaaatcaaggaaacacaatcaggattttatgtgtgaaaacgcaaaagtgat       c.*180

          .         .         .         .         .         .       g.575514
 ggctcggcggtccgagctgctggtcccacttctgacaccaaaatgcatcccaacccccgg       c.*240

          .         .         .         .         .         .       g.575574
 cagtgccaagggcaccagcagggccctgactgaagactgtctggcaggtggaacggtcct       c.*300

          .         .         .         .         .         .       g.575634
 tgtcctctccagccaggcccagcaggcactaccttcatgaagtctccagcaaacctcttc       c.*360

          .         .         .         .         .         .       g.575694
 ctcacaagtgtctgtcatctgagtccaaagaaagctgaaggggtgggtttgttttggggg       c.*420

          .         .         .         .         .         .       g.575754
 tactgtgcaaagctaatgatctggttggacttctacacttggccaaatgtactggctcca       c.*480

          .         .         .         .         .         .       g.575814
 gacatgacatttggtttgggggccctttgaagttgatgccaagaaggagtgaacacttct       c.*540

          .         .         .         .         .         .       g.575874
 cagttgcccctggcttttccctcctttcagccaccacccacacaatgaacaaaagggaag       c.*600

          .         .         .         .         .         .       g.575934
 ggcccatttctgggggagtctggctgcctcttggctacgaaggctggcactgagcaccca       c.*660

          .         .         .         .         .         .       g.575994
 tcctgctccctctgcctgagctgagctgcctttcaggaagctctggtttagaaggggaaa       c.*720

          .         .         .         .                           g.576039
 gatgtcatatgctcagttcaaataatcaacccaactgtgtccaga                      c.*765

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phosphatase and actin regulator 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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