phosphate regulating endopeptidase homolog, X-linked (PHEX) - coding DNA reference sequence

(used for variant description)

(last modified August 13, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_000444.4 in the PHEX gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007563.1, covering PHEX transcript NM_000444.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5023
                                      ccaatattttggtttttataatt       c.-181

 .         .         .         .         .         .                g.5083
 ttcatttgtgaagaattatttgagaaagggtggcgaggggagatttcctgacggcagttt       c.-121

 .         .         .         .         .         .                g.5143
 cttaagctgtccattagtagaagagcaagaaagccttggatgtcaacgcctcgctcttga       c.-61

 .         .         .         .         .         .                g.5203
 gaccagccaccaaaccacgaaaagtgactttcttctcgtgtgctctctacggcccttctg       c.-1

          .         .         .         .         .         .       g.5263
 ATGGAAGCAGAAACAGGGAGCAGCGTGGAGACTGGAAAGAAGGCCAACAGAGGCACTCGA       c.60
 M  E  A  E  T  G  S  S  V  E  T  G  K  K  A  N  R  G  T  R         p.20

          .         .         .         .         .         | 02    g.10668
 ATTGCCCTGGTCGTGTTTGTCGGTGGCACCCTAGTTCTGGGCACGATCCTCTTTCTAG | TG    c.120
 I  A  L  V  V  F  V  G  G  T  L  V  L  G  T  I  L  F  L  V |       p.40

          .         .         .         .         .         .       g.10728
 AGTCAAGGTCTCTTAAGTCTCCAAGCTAAACAGGAGTACTGCCTGAAGCCAGAATGCATC       c.180
 S  Q  G  L  L  S  L  Q  A  K  Q  E  Y  C  L  K  P  E  C  I         p.60

         | 03.         .         .         .         .         .    g.19300
 GAAGCGG | CTGCTGCCATCTTAAGTAAAGTAAATCTGTCTGTGGATCCTTGTGATAATTTC    c.240
 E  A  A |   A  A  I  L  S  K  V  N  L  S  V  D  P  C  D  N  F      p.80

          .         .         .         .         .         .       g.19360
 TTCCGGTTCGCTTGTGATGGCTGGATAAGCAATAATCCAATTCCCGAAGATATGCCAAGC       c.300
 F  R  F  A  C  D  G  W  I  S  N  N  P  I  P  E  D  M  P  S         p.100

          .         .         .         .          | 04        .    g.48596
 TATGGGGTTTATCCTTGGCTGAGACATAATGTTGACCTCAAGTTGAAGG | AACTTTTGGAG    c.360
 Y  G  V  Y  P  W  L  R  H  N  V  D  L  K  L  K  E |   L  L  E      p.120

          .         .         .         .         .         .       g.48656
 AAATCAATCAGTAGAAGGCGGGACACCGAAGCCATACAGAAAGCCAAAATCCTTTATTCA       c.420
 K  S  I  S  R  R  R  D  T  E  A  I  Q  K  A  K  I  L  Y  S         p.140

          .       | 05 .         .         .         .         .    g.49717
 TCCTGCATGAATGAGA | AAGCGATTGAAAAAGCAGATGCCAAGCCACTGCTACACATCCTA    c.480
 S  C  M  N  E  K |   A  I  E  K  A  D  A  K  P  L  L  H  I  L      p.160

          .         .         .         .         .         .       g.49777
 CGGCATTCACCTTTCCGCTGGCCCGTGCTTGAATCTAATATTGGCCCTGAAGGGGTTTGG       c.540
 R  H  S  P  F  R  W  P  V  L  E  S  N  I  G  P  E  G  V  W         p.180

          .         .         .         .         .         .       g.49837
 TCAGAGAGAAAGTTCAGCCTTCTGCAGACACTTGCAACGTTTCGTGGTCAATACAGCAAT       c.600
 S  E  R  K  F  S  L  L  Q  T  L  A  T  F  R  G  Q  Y  S  N         p.200

          .         .         .         .         .         .       g.49897
 TCTGTGTTCATCCGTTTGTATGTGTCCCCTGATGACAAAGCATCCAATGAACATATCTTG       c.660
 S  V  F  I  R  L  Y  V  S  P  D  D  K  A  S  N  E  H  I  L         p.220

     | 06    .         .         .         .         .         .    g.62683
 AAG | CTGGACCAAGCAACACTCTCCCTGGCCGTGAGGGAAGACTACCTTGATAACAGTACA    c.720
 K   | L  D  Q  A  T  L  S  L  A  V  R  E  D  Y  L  D  N  S  T      p.240

          .   | 07     .         .         .         .         .    g.66228
 GAAGCCAAGTCT | TATCGGGATGCCCTTTACAAGTTCATGGTGGATACTGCCGTGCTTTTA    c.780
 E  A  K  S   | Y  R  D  A  L  Y  K  F  M  V  D  T  A  V  L  L      p.260

          .         .         .         .         .         .       g.66288
 GGAGCTAACAGTTCCAGAGCAGAGCATGACATGAAGTCAGTGCTCAGATTGGAAATTAAG       c.840
 G  A  N  S  S  R  A  E  H  D  M  K  S  V  L  R  L  E  I  K         p.280

           | 08        .         .         .         .         .    g.69203
 ATAGCTGAG | ATAATGATTCCACATGAAAACCGAACCAGCGAGGCCATGTACAACAAAATG    c.900
 I  A  E   | I  M  I  P  H  E  N  R  T  S  E  A  M  Y  N  K  M      p.300

          .         .         .    | 09    .         .         .    g.71230
 AACATTTCTGAACTGAGTGCTATGATTCCCCAG | TTCGACTGGCTGGGCTACATCAAGAAG    c.960
 N  I  S  E  L  S  A  M  I  P  Q   | F  D  W  L  G  Y  I  K  K      p.320

          .         .         .         .         .         .       g.71290
 GTCATTGACACCAGACTCTACCCCCATCTGAAAGACATCAGCCCCTCCGAGAATGTGGTG       c.1020
 V  I  D  T  R  L  Y  P  H  L  K  D  I  S  P  S  E  N  V  V         p.340

          .         .         .         .         .          | 10    g.83665
 GTCCGCGTCCCGCAGTACTTTAAAGATTTGTTTAGGATATTAGGGTCTGAGAGAAAGAA | G    c.1080
 V  R  V  P  Q  Y  F  K  D  L  F  R  I  L  G  S  E  R  K  K  |      p.360

          .         .         .         .         .         .       g.83725
 ACCATTGCCAACTATTTGGTGTGGAGAATGGTTTATTCCAGAATTCCAAACCTTAGCAGG       c.1140
 T  I  A  N  Y  L  V  W  R  M  V  Y  S  R  I  P  N  L  S  R         p.380

          .         .         .    | 11    .         .         .    g.86682
 CGCTTTCAGTATAGATGGCTGGAATTCTCAAGG | GTAATCCAGGGGACCACAACTTTGCTG    c.1200
 R  F  Q  Y  R  W  L  E  F  S  R   | V  I  Q  G  T  T  T  L  L      p.400

          .         .         .         .         .         .       g.86742
 CCTCAATGGGACAAATGTGTAAACTTTATTGAAAGTGCCCTCCCTTATGTTGTTGGAAAG       c.1260
 P  Q  W  D  K  C  V  N  F  I  E  S  A  L  P  Y  V  V  G  K         p.420

          .         .         .         .   | 12     .         .    g.105737
 ATGTTTGTAGATGTGTACTTCCAGGAAGATAAGAAGGAAATG | ATGGAGGAATTGGTTGAG    c.1320
 M  F  V  D  V  Y  F  Q  E  D  K  K  E  M   | M  E  E  L  V  E      p.440

          .         .         .         .         .         .       g.105797
 GGCGTTCGCTGGGCCTTTATTGACATGCTAGAGAAAGAAAATGAGTGGATGGATGCAGGA       c.1380
 G  V  R  W  A  F  I  D  M  L  E  K  E  N  E  W  M  D  A  G         p.460

          .         .     | 13   .         .         .         .    g.140544
 ACGAAAAGGAAAGCCAAAGAAAAG | GCGAGAGCTGTTTTGGCAAAAGTTGGCTATCCAGAG    c.1440
 T  K  R  K  A  K  E  K   | A  R  A  V  L  A  K  V  G  Y  P  E      p.480

          .         .         .         .   | 14     .         .    g.150487
 TTTATAATGAATGATACTCATGTTAATGAAGACCTCAAAGCT | ATCAAGTTTTCAGAAGCC    c.1500
 F  I  M  N  D  T  H  V  N  E  D  L  K  A   | I  K  F  S  E  A      p.500

          .         .         .         .         .         .       g.150547
 GACTACTTTGGCAACGTCCTACAAACTCGCAAGTATTTAGCACAGTCTGATTTCTTCTGG       c.1560
 D  Y  F  G  N  V  L  Q  T  R  K  Y  L  A  Q  S  D  F  F  W         p.520

          .         .       | 15 .         .         .         .    g.162674
 CTAAGAAAAGCCGTTCCAAAAACAGA | GTGGTTTACAAATCCGACGACTGTCAATGCCTTC    c.1620
 L  R  K  A  V  P  K  T  E  |  W  F  T  N  P  T  T  V  N  A  F      p.540

          .         .      | 16  .         .         .         .    g.185135
 TACAGTGCATCCACCAACCAGATCC | GATTTCCAGCAGGAGAGCTCCAGAAGCCTTTCTTT    c.1680
 Y  S  A  S  T  N  Q  I  R |   F  P  A  G  E  L  Q  K  P  F  F      p.560

          .         . | 17       .         .         .         .    g.191272
 TGGGGAACAGAATATCCTCG | ATCTCTGAGTTATGGTGCTATAGGAGTAATTGTCGGACAT    c.1740
 W  G  T  E  Y  P  R  |  S  L  S  Y  G  A  I  G  V  I  V  G  H      p.580

          .         .         | 18         .         .         .    g.193841
 GAATTTACACATGGATTTGATAATAATG | GTAGAAAATATGATAAAAATGGAAACCTGGAT    c.1800
 E  F  T  H  G  F  D  N  N  G |   R  K  Y  D  K  N  G  N  L  D      p.600

          .         .         .         .         .         .       g.193901
 CCTTGGTGGTCTACTGAATCAGAAGAAAAGTTTAAGGAAAAAACAAAATGCATGATTAAC       c.1860
 P  W  W  S  T  E  S  E  E  K  F  K  E  K  T  K  C  M  I  N         p.620

          .         .         .          | 19        .         .    g.198660
 CAGTATAGCAACTATTATTGGAAGAAAGCTGGCTTAAAT | GTCAAGGGGAAGAGGACCCTG    c.1920
 Q  Y  S  N  Y  Y  W  K  K  A  G  L  N   | V  K  G  K  R  T  L      p.640

          .         .         .         .      | 20  .         .    g.199718
 GGAGAAAATATTGCTGATAATGGAGGCCTGCGGGAAGCTTTTAGG | GCTTACAGGAAATGG    c.1980
 G  E  N  I  A  D  N  G  G  L  R  E  A  F  R   | A  Y  R  K  W      p.660

          .         .         .         .         .         .       g.199778
 ATAAATGACAGAAGGCAGGGACTTGAGGAGCCTCTTCTACCAGGCATCACATTCACCAAC       c.2040
 I  N  D  R  R  Q  G  L  E  E  P  L  L  P  G  I  T  F  T  N         p.680

          .         .         . | 21       .         .         .    g.217559
 AACCAGCTCTTCTTCCTGAGTTATGCTCAT | GTGAGGTGCAATTCCTACAGACCAGAAGCT    c.2100
 N  Q  L  F  F  L  S  Y  A  H   | V  R  C  N  S  Y  R  P  E  A      p.700

          .         .         .         .        | 22.         .    g.220060
 GCCCGAGAACAAGTCCAAATTGGTGCTCACAGTCCCCCTCAGTTTAG | GGTCAATGGTGCA    c.2160
 A  R  E  Q  V  Q  I  G  A  H  S  P  P  Q  F  R  |  V  N  G  A      p.720

          .         .         .         .         .         .       g.220120
 ATTAGTAACTTTGAAGAATTCCAGAAAGCTTTTAACTGTCCACCCAATTCCACGATGAAC       c.2220
 I  S  N  F  E  E  F  Q  K  A  F  N  C  P  P  N  S  T  M  N         p.740

          .         .         .                                     g.220150
 AGAGGCATGGACTCCTGCCGACTCTGGTAG                                     c.2250
 R  G  M  D  S  C  R  L  W  X                                       p.749

          .         .         .         .         .         .       g.220210
 ctgggacgctggtttatggcatcctgagacagttgcacagtgccagcggaggctgcactg       c.*60

          .         .         .         .         .         .       g.220270
 agccttcatcgcccattgctttaggcctggagactttcatttttagtgcattttcattat       c.*120

          .         .         .         .         .         .       g.220330
 ttgggtaggtgacctgcttggatctagacagcatctgttcaaagttgtagggcttataaa       c.*180

          .         .         .         .         .         .       g.220390
 gtggaatataagaatgaactaagtatgtttctttagaaaatcaaaccaacaaaaataaat       c.*240

          .         .         .         .         .         .       g.220450
 ccctaggctacttttgttaaaatgctatctgctaaattgttgctattgtccattttaggg       c.*300

          .         .         .         .         .         .       g.220510
 tgttggccacagttatgtggtacatagcatttcaatctatagctttgtgggaagcctaaa       c.*360

          .         .         .         .                           g.220558
 ttgatgtatcctttaaaagttcaatctattaaacttgtagcctctcaa                   c.*408

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phosphate regulating endopeptidase homolog, X-linked protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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