PHD finger protein 6 (PHF6) - coding DNA reference sequence

(used for variant description)

(last modified November 11, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001015877.1 in the PHF6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008886.1, covering PHF6 transcript NM_001015877.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5022
                                       aagggcgctccgcgagcccgtc       c.-181

 .         .         .         .         .         .                g.5082
 tctcctcgaatgaaaggaaacaacctccggcgacagagccccgctctcaggcactgctgg       c.-121

 .         .         .         .         .         .                g.5142
 agaaccgagaccgacttctttctctttaccctcattggcgcttctctcctgcagtccgcc       c.-61

 .         .    | 02    .         .         .         .             g.9306
 tctgggccctgccg | catttcttgagacttaaagtggcattctaaaggcaatttaaaaatc    c.-1

          .         .         .         .         .         .       g.9366
 ATGTCAAGCTCAGTTGAACAGAAAAAAGGGCCTACAAGACAGCGCAAATGTGGCTTTTGT       c.60
 M  S  S  S  V  E  Q  K  K  G  P  T  R  Q  R  K  C  G  F  C         p.20

          .         .         .         .         .         .       g.9426
 AAGTCAAATAGAGACAAGGAATGTGGACAGTTACTAATATCTGAAAACCAGAAGGTGGCA       c.120
 K  S  N  R  D  K  E  C  G  Q  L  L  I  S  E  N  Q  K  V  A         p.40

          .         | 03         .         .         .         .    g.9735
 GCGCACCATAAGTGCATG | CTCTTTTCATCTGCTTTGGTATCATCACACTCTGATAATGAA    c.180
 A  H  H  K  C  M   | L  F  S  S  A  L  V  S  S  H  S  D  N  E      p.60

          .         .         .         .         .         .       g.9795
 AGTCTTGGTGGATTTTCTATTGAAGATGTCCAAAAGGAAATTAAAAGAGGCACGAAGCTG       c.240
 S  L  G  G  F  S  I  E  D  V  Q  K  E  I  K  R  G  T  K  L         p.80

  | 04       .         .         .         .         .         .    g.25249
  | ATGTGTTCTTTGTGCCATTGTCCTGGAGCAACAATTGGTTGTGATGTGAAAACATGTCAC    c.300
  | M  C  S  L  C  H  C  P  G  A  T  I  G  C  D  V  K  T  C  H      p.100

          .         .         .         .         .         .       g.25309
 AGGACATACCACTACCACTGTGCATTGCATGATAAAGCTCAAATACGAGAGAAACCTTCA       c.360
 R  T  Y  H  Y  H  C  A  L  H  D  K  A  Q  I  R  E  K  P  S         p.120

          .     | 05   .         .         .         .         | 06 g.45181
 CAAGGAATTTACAT | GGTCTATTGCCGAAAACACAAGAAAACTGCACATAACTCCGAAG | CT c.420
 Q  G  I  Y  M  |  V  Y  C  R  K  H  K  K  T  A  H  N  S  E  A |    p.140

          .         .         .         .         .         .       g.45241
 GATTTAGAAGAAAGTTTTAATGAACATGAACTGGAGCCCTCATCACCTAAAAGTAAAAAG       c.480
 D  L  E  E  S  F  N  E  H  E  L  E  P  S  S  P  K  S  K  K         p.160

          .         .         .         .         .         .       g.45301
 AAAAGTCGCAAAGGAAGGCCAAGAAAAACTAATTTTAAAGGGCTGTCAGAAGATACCAGG       c.540
 K  S  R  K  G  R  P  R  K  T  N  F  K  G  L  S  E  D  T  R         p.180

          .         .         .         .      | 07  .         .    g.45526
 TCCACATCCTCCCATGGAACAGATGAAATGGAAAGTAGTTCCTAT | AGAGATAGGTCTCCA    c.600
 S  T  S  S  H  G  T  D  E  M  E  S  S  S  Y   | R  D  R  S  P      p.200

          .         .         .         .         .         .       g.45586
 CACAGAAGCAGCCCTAGTGACACCAGGCCTAAATGTGGATTTTGCCATGTAGGGGAGGAA       c.660
 H  R  S  S  P  S  D  T  R  P  K  C  G  F  C  H  V  G  E  E         p.220

          .         .         .         .         .         .       g.45646
 GAAAATGAAGCACGAGGAAAACTGCATATATTTAATGCCAAGAAGGCAGCTGCCCATTAT       c.720
 E  N  E  A  R  G  K  L  H  I  F  N  A  K  K  A  A  A  H  Y         p.240

           | 08        .         .         .         .         .    g.46755
 AAGTGCATG | TTGTTTTCTTCTGGCACAGTCCAGCTCACAACAACATCAAGAGCAGAATTT    c.780
 K  C  M   | L  F  S  S  G  T  V  Q  L  T  T  T  S  R  A  E  F      p.260

          .         .         .         .         .     | 09   .    g.48863
 GGAGACTTTGATATTAAAACTGTACTTCAGGAGATTAAACGAGGAAAAAGAATG | AAATGT    c.840
 G  D  F  D  I  K  T  V  L  Q  E  I  K  R  G  K  R  M   | K  C      p.280

          .         .         .         .         .         .       g.48923
 ACACTTTGCAGTCAGCCTGGTGCTACTATTGGATGTGAAATAAAAGCCTGTGTTAAGACT       c.900
 T  L  C  S  Q  P  G  A  T  I  G  C  E  I  K  A  C  V  K  T         p.300

          .         .         .         .         .         .       g.48983
 TACCATTACCACTGTGGAGTACAAGACAAAGCTAAATACATTGAAAATATGTCACGAGGA       c.960
 Y  H  Y  H  C  G  V  Q  D  K  A  K  Y  I  E  N  M  S  R  G         p.320

          | 10         .         .         .         .         .    g.56941
 ATTTACAA | ACTATACTGTAAAAATCATAGTGGAAATGATGAGAGAGATGAAGAAGATGAG    c.1020
 I  Y  K  |  L  Y  C  K  N  H  S  G  N  D  E  R  D  E  E  D  E      p.340

          .         .         .         .         .         .       g.57001
 GAACGAGAGAGTAAAAGCCGAGGAAAAGTAGAAATTGATCAGCAACAACTAACTCAGCAG       c.1080
 E  R  E  S  K  S  R  G  K  V  E  I  D  Q  Q  Q  L  T  Q  Q         p.360

          .                                                     g.57019
 CAACTTAATGGAAACTAG |                                              c.1099
 Q  L  N  G  N  X                                                p.365

  | 11       .         .         .         .         .         .    g.57409
  | gttcatgggacagagttagaaaactgggaatgaataagacatccataactactattcttt    c.*60

          .         .         .         .         .         .       g.57469
 tttcactgttttctaaaatcaaaaagggtttgtaactttttactgcccaactcttagatc       c.*120

          .         .         .         .         .         .       g.57529
 cttcattgaactgcctaaaaatgtcttgtttgttttatgagccctcactagaaggctgag       c.*180

          .         .         .         .         .         .       g.57589
 tttgacatgttgatattacgtagctatagtttgcagtttctgggaagcaattgaaacact       c.*240

          .         .         .         .         .         .       g.57649
 attaaccctgtgtatagtgtcaacagttaaagcagacgaaacgaagtaagctatatttct       c.*300

          .         .         .         .         .         .       g.57709
 ggactgaacaaagctctgctgtttagagcatttaagtttgtttagtggatccatactcaa       c.*360

          .         .         .         .         .         .       g.57769
 aggaaagcataagcaaattttcctttacaatgcaaacatgccactggtggcagcacatgg       c.*420

          .         .         .         .         .         .       g.57829
 taatttgtggatttttttttcatactcaagtaatggaggctagaaatgaagagaaccttc       c.*480

          .         .         .         .         .         .       g.57889
 tttttctcttgactttgacagcacatgctaaaaatctcttccaagaagtatgctaaagct       c.*540

          .         .         .         .         .         .       g.57949
 tttcatttggttcctgttaaagttgttctcactgaccagcatggactcaggcaactggta       c.*600

          .         .         .         .         .         .       g.58009
 atgataagctatgagctccagtgcttttgccaaaattctcttgacagcacacctcctctc       c.*660

          .         .         .         .         .         .       g.58069
 tttccatgttatacaaaggacttctggcaaaatgattgagtccttcaagtttaaactaac       c.*720

          .         .         .         .         .         .       g.58129
 atttggcaacagcaaattaaacgtttttaagatgtaaagaaagggttaccgcttgctaag       c.*780

          .         .         .         .         .         .       g.58189
 gacttcagacaccatgtccgaaacctgttcctctcaagtgccctgttgtgtggaacactt       c.*840

          .         .         .         .         .         .       g.58249
 cacatattggcgcacagtacgtaaggaggtctcatgtgctgtaggagtaaaaaagtcttt       c.*900

          .         .         .         .         .         .       g.58309
 gcataaaacagtatttatttttacttttgtgaccactattttagaaactttatttaatat       c.*960

          .         .         .         .         .         .       g.58369
 tttaatgttttcagtcattgctttggttatctataaaataggcttttgtgccctactttt       c.*1020

          .         .         .         .         .         .       g.58429
 cttcttgtagggcttggtggtgttttatcgattgtcagaattgtttttgaaagcctaaga       c.*1080

          .         .         .         .         .         .       g.58489
 acccagctttttagaaaggattttcacactggcatttctaggtagtgatattttcttcca       c.*1140

          .         .         .         .         .         .       g.58549
 cttacctgctgaagcacatttatgcatttctttatggcaaaaccaaataactttagttgt       c.*1200

          .         .         .         .         .         .       g.58609
 ggtctgcctgatactaccatagcacctcagtaccaaggggagggattttgactagttgaa       c.*1260

          .         .         .         .         .         .       g.58669
 ttattaagccaccacaataaagcagatttttaaataagaaataataatgttaacttgact       c.*1320

          .         .         .         .         .         .       g.58729
 gtacattgagatattctgcagctgatagagcagcattttaaaaatgtaacaggtggaaaa       c.*1380

          .         .         .         .         .         .       g.58789
 ttacactgtgcttaatgactgatttttttttaaactgcgagtcccttaagatcacgtttg       c.*1440

          .         .         .         .         .         .       g.58849
 tcaagtgtgtattcacacatttacttaaatcaagggactcaatgcttgcttttattttaa       c.*1500

          .         .         .         .         .         .       g.58909
 ccatcttttactatttttagaaggaaactagctttagtagtgggttgccctgtatgtttt       c.*1560

          .         .         .         .         .         .       g.58969
 ctctttttgctcttaatatgccattgggtttttgtgtgtatgtgattttcaaaattcatg       c.*1620

          .         .         .         .         .         .       g.59029
 acttgaagtgcaaggacagatctagatgtttgtttaccaagctatgtgacttctcccaaa       c.*1680

          .         .         .         .         .         .       g.59089
 ggatctgtactttctttccttacaacagcttgaaaatcattattttaaaatccttaaatc       c.*1740

          .         .         .         .         .         .       g.59149
 actgtgtctagatcattttttacattgtgtgccatagacttacccatgggacaacagagc       c.*1800

          .         .         .         .         .         .       g.59209
 tccttcatttttggacaactactgtaatcattttttttttaggaaaaatggaaggtgccg       c.*1860

          .         .         .         .         .         .       g.59269
 ggggtaatcatggccagtcaataattatataaaggagttcaaatactatagctgtcagtt       c.*1920

          .         .         .         .         .         .       g.59329
 gatgaatttgttatgtagtaaaatgtatgactttgtatgggtttcttcagccctttttct       c.*1980

          .         .         .         .         .         .       g.59389
 gccactagcaaccagaatagcactttaccttttggttggctagataagtggctgactacc       c.*2040

          .         .         .         .         .         .       g.59449
 tgtttttctcactgtggtgtgattggctaaacaatctcgcattaaaaattcaaatgtaaa       c.*2100

          .         .         .         .         .         .       g.59509
 ttgaattcacatgaaaaatcatgtttggttgtaaacctccaatgttttgattctctaatc       c.*2160

          .         .         .         .         .         .       g.59569
 atgttttcgtcacatgctgagtaaaagtgccttacaatgtaaaaattgtacagtacttat       c.*2220

          .         .         .         .         .         .       g.59629
 gttcccaagtagcatcatcatcttctgggtagtaattacattgtggtattaatatttaga       c.*2280

          .         .         .         .         .         .       g.59689
 aaaatggacctcagcagtgtatttactgtacatctcttaagtccttaactgtagttttaa       c.*2340

          .         .         .         .         .         .       g.59749
 taagcatgacattatttgataagtatataacatttacatcatttcaaaaaatactgccgt       c.*2400

          .         .         .         .         .         .       g.59809
 tactgtcttttatgcatattttagcctgaaattttgaagcgtcttttttctttctttttt       c.*2460

          .         .         .         .         .         .       g.59869
 ctttttttgttttgttttttgttattgatattaaacagtgtaatctttgcaagcgtatat       c.*2520

          .         .         .         .         .         .       g.59929
 tgaagattattctggagcatttattgccttaccagaaatgttagtaggaaatgttcttta       c.*2580

          .         .         .         .         .         .       g.59989
 gagtagaaagatagacttgagtttctatacttttaagaagagctctttgttcctggggga       c.*2640

          .         .         .         .         .         .       g.60049
 ggggggcagggggtgaattttactttcatctcaagttattaaaaacccacaactgaagta       c.*2700

          .         .         .         .         .         .       g.60109
 aattttatttcaagaatcagcagttttagaatttcagatagtacttgctcagaagtacat       c.*2760

          .         .         .         .         .         .       g.60169
 gctactcaagatattaagagataacaagatctgtagatctgctattgaatcagaatctgt       c.*2820

          .         .         .         .         .         .       g.60229
 gtacttgaacaaatgtgtgaatctcaaatatctcaaagcaaaagaaaaagtgttctagag       c.*2880

          .         .         .         .         .         .       g.60289
 tgttgttgcttttttaaaaaaagcgctgaagttagaccaaggtatacagttttgttctaa       c.*2940

          .         .         .         .         .         .       g.60349
 cagacatttaggttaattgtaaagataaggaatgcattatgggtcaaaaatcaaacattc       c.*3000

          .         .         .         .         .         .       g.60409
 ctctcatgttatgtatattttgttcctgttatattggctttattttcaaaattgtagttt       c.*3060

          .         .         .         .         .         .       g.60469
 gtagtattagtttccttttattggtattcttgcatatactattcattcaataaatgactt       c.*3120

          .                                                         g.60481
 atgactttcata                                                       c.*3132

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The PHD finger protein 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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