phosphorylase kinase, beta (PHKB) - coding DNA reference sequence

(used for variant description)

(last modified March 5, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_000293.2 in the PHKB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016598.1, covering PHKB transcript NM_000293.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5052
         attgctgacaggcggccccgggggcggtggccaaggcggcgaccggagcgcg       c.-1

          .         .         .         .         .         .       g.5112
 ATGGCGGGGGCGGCGGGACTCACGGCAGAAGTGAGCTGGAAGGTCTTGGAGCGAAGAGCT       c.60
 M  A  G  A  A  G  L  T  A  E  V  S  W  K  V  L  E  R  R  A         p.20

          .       | 02 .         .         .         .         .    g.41144
 CGGACCAAGCGCTCAG | GCTCAGTTTATGAACCTCTTAAAAGCATTAATCTTCCAAGACCT    c.120
 R  T  K  R  S  G |   S  V  Y  E  P  L  K  S  I  N  L  P  R  P      p.40

          .         .         .         .       | 03 .         .    g.43471
 GATAATGAAACTCTCTGGGATAAGTTGGACCATTATTACAGAATTG | TCAAGTCAACATTG    c.180
 D  N  E  T  L  W  D  K  L  D  H  Y  Y  R  I  V |   K  S  T  L      p.60

          .         .         .         .         .         .       g.43531
 CTGCTGTATCAAAGTCCAACTACCGGTCTCTTTCCCACTAAAACATGCGGTGGTGACCAG       c.240
 L  L  Y  Q  S  P  T  T  G  L  F  P  T  K  T  C  G  G  D  Q         p.80

          .         .         .         .         .         .       g.43591
 AAGGCCAAGATCCAGGACAGCCTATACTGCGCTGCTGGGGCCTGGGCTTTGGCTCTTGCA       c.300
 K  A  K  I  Q  D  S  L  Y  C  A  A  G  A  W  A  L  A  L  A         p.100

       | 04  .         .         .         .         .         .    g.46747
 TACAG | GCGAATTGATGATGACAAGGGAAGGACCCATGAGCTGGAGCACTCAGCTATAAAA    c.360
 Y  R  |  R  I  D  D  D  K  G  R  T  H  E  L  E  H  S  A  I  K      p.120

          .         .         .         .      | 05  .         .    g.55381
 TGCATGAGAGGAATTCTCTACTGCTATATGCGTCAGGCCGATAAG | GTCCAGCAGTTTAAG    c.420
 C  M  R  G  I  L  Y  C  Y  M  R  Q  A  D  K   | V  Q  Q  F  K      p.140

          .         .         .         .         .         .       g.55441
 CAGGATCCACGCCCAACAACATGTCTTCACTCTGTTTTCAATGTGCATACAGGAGATGAG       c.480
 Q  D  P  R  P  T  T  C  L  H  S  V  F  N  V  H  T  G  D  E         p.160

          .         .         .    | 06    .         .         .    g.59249
 TTGCTTTCCTATGAGGAATATGGTCATCTTCAG | ATAAATGCAGTGTCACTTTATCTCCTT    c.540
 L  L  S  Y  E  E  Y  G  H  L  Q   | I  N  A  V  S  L  Y  L  L      p.180

          .         .         .         .         .     | 07   .    g.91140
 TACCTTGTGGAAATGATTTCCTCAGGACTCCAGATTATCTACAACACTGATGAG | GTCTCT    c.600
 Y  L  V  E  M  I  S  S  G  L  Q  I  I  Y  N  T  D  E   | V  S      p.200

          .         .         .         .         .         .       g.91200
 TTTATTCAAAACCTTGTATTTTGTGTGGAAAGAGTTTACCGTGTGCCTGACTTTGGTGTC       c.660
 F  I  Q  N  L  V  F  C  V  E  R  V  Y  R  V  P  D  F  G  V         p.220

          .         .         .         .         . | 08       .    g.124006
 TGGGAAAGAGGAAGCAAATATAATAATGGCAGCACAGAGCTACATTCGAG | CTCGGTTGGT    c.720
 W  E  R  G  S  K  Y  N  N  G  S  T  E  L  H  S  S  |  S  V  G      p.240

          .         .         .         .         .     | 09   .    g.131375
 TTAGCAAAAGCAGCTCTAGAAGCAATTAATGGATTCAACCTTTTTGGCAACCAG | GGCTGT    c.780
 L  A  K  A  A  L  E  A  I  N  G  F  N  L  F  G  N  Q   | G  C      p.260

          .         .         .         .         .         .       g.131435
 TCGTGGTCAGTTATATTTGTGGATCTCGATGCTCACAATCGCAACAGGCAAACTTTGTGC       c.840
 S  W  S  V  I  F  V  D  L  D  A  H  N  R  N  R  Q  T  L  C         p.280

          .         .         . | 10       .         .         .    g.132636
 TCGCTGTTACCCAGAGAATCAAGATCACAT | AATACAGATGCTGCCCTGCTCCCCTGCATC    c.900
 S  L  L  P  R  E  S  R  S  H   | N  T  D  A  A  L  L  P  C  I      p.300

          .         .         .         .         .         .       g.132696
 AGTTATCCTGCATTTGCCCTGGATGATGAAGTTCTTTTTAGCCAGACACTTGATAAAGTG       c.960
 S  Y  P  A  F  A  L  D  D  E  V  L  F  S  Q  T  L  D  K  V         p.320

          .         .         .         .         .         .       g.132756
 GTTAGAAAATTAAAAGGAAAATATGGATTTAAACGTTTCTTGAGAGATGGGTATAGAACA       c.1020
 V  R  K  L  K  G  K  Y  G  F  K  R  F  L  R  D  G  Y  R  T         p.340

          .         .         .         .         | 11         .    g.137213
 TCATTGGAAGATCCCAACAGATGCTACTACAAGCCAGCTGAAATTAAG | CTATTTGATGGC    c.1080
 S  L  E  D  P  N  R  C  Y  Y  K  P  A  E  I  K   | L  F  D  G      p.360

          .         .         .         .       | 12 .         .    g.137852
 ATTGAATGTGAATTTCCCATATTTTTCCTTTATATGATGATTGATG | GAGTTTTTAGAGGC    c.1140
 I  E  C  E  F  P  I  F  F  L  Y  M  M  I  D  G |   V  F  R  G      p.380

          .         .         .         .         .         .       g.137912
 AATCCTAAGCAAGTACAGGAATATCAGGATCTTTTGACTCCAGTACTTCATCATACCACA       c.1200
 N  P  K  Q  V  Q  E  Y  Q  D  L  L  T  P  V  L  H  H  T  T         p.400

      | 13   .         .         .         .         .         .    g.140130
 GAAG | GATATCCTGTTGTACCAAAGTACTATTATGTGCCAGCTGACTTTGTAGAATATGAA    c.1260
 E  G |   Y  P  V  V  P  K  Y  Y  Y  V  P  A  D  F  V  E  Y  E      p.420

          .         .         .         .         .         .       g.140190
 AAAAATAACCCTGGTAGTCAAAAACGATTTCCTAGCAACTGTGGCCGTGATGGAAAACTG       c.1320
 K  N  N  P  G  S  Q  K  R  F  P  S  N  C  G  R  D  G  K  L         p.440

          .         .         .         .    | 14    .         .    g.154544
 TTTCTTTGGGGACAAGCACTTTATATCATCGCAAAACTCCTGG | CTGATGAACTTATTAGT    c.1380
 F  L  W  G  Q  A  L  Y  I  I  A  K  L  L  A |   D  E  L  I  S      p.460

          .         .         .         .         .         .       g.154604
 CCTAAAGACATTGATCCTGTCCAGCGCTATGTCCCACTAAAGGATCAACGTAACGTGAGC       c.1440
 P  K  D  I  D  P  V  Q  R  Y  V  P  L  K  D  Q  R  N  V  S         p.480

          .         | 15         .         .         .         .    g.184778
 ATGAGGTTTTCCAATCAG | GGCCCACTGGAAAATGACTTGGTAGTTCATGTGGCACTTATA    c.1500
 M  R  F  S  N  Q   | G  P  L  E  N  D  L  V  V  H  V  A  L  I      p.500

          .     | 16   .         .         .         .         .    g.185346
 GCAGAAAGCCAAAG | ACTTCAAGTTTTTCTGAACACATATGGTATTCAAACTCAAACTCCT    c.1560
 A  E  S  Q  R  |  L  Q  V  F  L  N  T  Y  G  I  Q  T  Q  T  P      p.520

          .         .         .         .         | 17         .    g.192246
 CAACAAGTAGAACCCATTCAGATATGGCCTCAGCAGGAGCTTGTGAAA | GCTTATTTGCAG    c.1620
 Q  Q  V  E  P  I  Q  I  W  P  Q  Q  E  L  V  K   | A  Y  L  Q      p.540

          .         .         .         .         .         .       g.192306
 CTGGGTATCAATGAAAAGTTAGGACTCTCTGGAAGGCCAGACAGGCCCATTGGCTGCCTC       c.1680
 L  G  I  N  E  K  L  G  L  S  G  R  P  D  R  P  I  G  C  L         p.560

          .   | 18     .         .         .         .         .    g.192849
 GGGACATCAAAG | ATTTATCGCATTCTAGGAAAGACTGTGGTTTGTTACCCGATTATTTTC    c.1740
 G  T  S  K   | I  Y  R  I  L  G  K  T  V  V  C  Y  P  I  I  F      p.580

          .         .         .         .         .        | 19.    g.194248
 GACCTAAGTGATTTCTACATGTCTCAGGATGTTTTCCTGCTGATAGATGACATAAAG | AAT    c.1800
 D  L  S  D  F  Y  M  S  Q  D  V  F  L  L  I  D  D  I  K   | N      p.600

          .         .         .         .         .         .       g.194308
 GCGCTGCAGTTCATTAAACAATATTGGAAAATGCATGGACGTCCACTTTTCCTTGTTCTC       c.1860
 A  L  Q  F  I  K  Q  Y  W  K  M  H  G  R  P  L  F  L  V  L         p.620

          .         . | 20       .         .         .         .    g.194572
 ATCCGGGAAGACAATATAAG | AGGTAGCCGGTTCAACCCCATATTAGATATGCTGGCAGCC    c.1920
 I  R  E  D  N  I  R  |  G  S  R  F  N  P  I  L  D  M  L  A  A      p.640

          .         .         .         .         .  | 21      .    g.204216
 CTTAAAAAAGGAATAATTGGAGGAGTCAAAGTTCATGTGGATCGTCTACAG | ACACTAATA    c.1980
 L  K  K  G  I  I  G  G  V  K  V  H  V  D  R  L  Q   | T  L  I      p.660

          .         .         .         .         .    | 22    .    g.204365
 TCTGGAGCTGTGGTAGAACAACTTGATTTCCTACGAATCAGTGACACAGAAGA | GCTTCCA    c.2040
 S  G  A  V  V  E  Q  L  D  F  L  R  I  S  D  T  E  E  |  L  P      p.680

          .         .         .         .         .         .       g.204425
 GAATTTAAGAGTTTTGAGGAACTAGAACCTCCCAAACATTCAAAAGTCAAACGGCAAAGC       c.2100
 E  F  K  S  F  E  E  L  E  P  P  K  H  S  K  V  K  R  Q  S         p.700

          .         .         .         .         .         .       g.204485
 AGCACCCCTAGTGCTCCTGAACTGGGACAGCAGCCGGATGTCAACATTAGTGAATGGAAG       c.2160
 S  T  P  S  A  P  E  L  G  Q  Q  P  D  V  N  I  S  E  W  K         p.720

          .         .         .       | 23 .         .         .    g.205444
 GACAAACCCACCCACGAAATTCTTCAAAAACTGAAT | GATTGCAGTTGTCTGGCTAGCCAA    c.2220
 D  K  P  T  H  E  I  L  Q  K  L  N   | D  C  S  C  L  A  S  Q      p.740

          .         .         .         .         .         | 24    g.207380
 GCCATCCTGCTGGGTATACTGCTCAAAAGAGAAGGCCCCAACTTCATCACAAAGGAAG | GT    c.2280
 A  I  L  L  G  I  L  L  K  R  E  G  P  N  F  I  T  K  E  G |       p.760

          .         .         .         .         .       | 25 .    g.208590
 ACCGTTTCTGATCACATTGAGAGAGTCTATAGAAGAGCTGGCAGCCAAAAACTTTG | GTTG    c.2340
 T  V  S  D  H  I  E  R  V  Y  R  R  A  G  S  Q  K  L  W  |  L      p.780

          .         .         .         .         .         .       g.208650
 GCGGTGCGCTACGGGGCTGCATTTACCCAGAAATTTTCTTCCTCTATAGCCCCACACATT       c.2400
 A  V  R  Y  G  A  A  F  T  Q  K  F  S  S  S  I  A  P  H  I         p.800

          .         .        | 26.         .         .         .    g.212949
 ACTACTTTTCTGGTACATGGGAAACAG | GTAACTCTGGGTGCCTTTGGGCATGAAGAAGAA    c.2460
 T  T  F  L  V  H  G  K  Q   | V  T  L  G  A  F  G  H  E  E  E      p.820

          .         .         .         .         .         .       g.213009
 GTTATCTCTAATCCTTTGTCTCCAAGAGTGATTCAAAACATCATCTATTATAAGTGTAAC       c.2520
 V  I  S  N  P  L  S  P  R  V  I  Q  N  I  I  Y  Y  K  C  N         p.840

          .         .         .         .         .         .       g.213069
 ACCCATGATGAGAGGGAAGCGGTCATTCAGCAAGAACTGGTCATCCATATTGGCTGGATC       c.2580
 T  H  D  E  R  E  A  V  I  Q  Q  E  L  V  I  H  I  G  W  I         p.860

          .         .         .         .         . | 27       .    g.232752
 ATCTCCAATAACCCTGAGTTATTCAGTGGCATGCTGAAAATACGAATCGG | GTGGATCATC    c.2640
 I  S  N  N  P  E  L  F  S  G  M  L  K  I  R  I  G  |  W  I  I      p.880

          .         .         .         .         .         .       g.232812
 CATGCCATGGAGTATGAACTTCAGATCCGTGGCGGAGACAAGCCAGCCTTGGACTTGTAT       c.2700
 H  A  M  E  Y  E  L  Q  I  R  G  G  D  K  P  A  L  D  L  Y         p.900

          .         .         .         .         .         .       g.232872
 CAGCTGTCACCTAGTGAAGTTAAACAGCTTCTGCTGGATATTCTGCAGCCTCAACAGAAT       c.2760
 Q  L  S  P  S  E  V  K  Q  L  L  L  D  I  L  Q  P  Q  Q  N         p.920

       | 28  .         .         .         .         .         .    g.237134
 GGAAG | ATGTTGGCTGAACAGGCGTCAGATCGATGGGTCTTTGAATAGAACTCCCACCGGG    c.2820
 G  R  |  C  W  L  N  R  R  Q  I  D  G  S  L  N  R  T  P  T  G      p.940

          .         .         .         .         .         .       g.237194
 TTCTATGACCGAGTGTGGCAGATTCTGGAGCGCACGCCCAATGGGATCATTGTTGCTGGG       c.2880
 F  Y  D  R  V  W  Q  I  L  E  R  T  P  N  G  I  I  V  A  G         p.960

          .      | 29  .         .         .         .         .    g.240127
 AAGCATTTGCCTCAG | CAACCAACCCTGTCAGATATGACCATGTATGAGATGAATTTCTCT    c.2940
 K  H  L  P  Q   | Q  P  T  L  S  D  M  T  M  Y  E  M  N  F  S      p.980

          .         .         .         .         .         .       g.240187
 CTCCTTGTTGAAGACACGTTGGGAAATATTGACCAGCCACAGTACAGACAGATCGTTGTA       c.3000
 L  L  V  E  D  T  L  G  N  I  D  Q  P  Q  Y  R  Q  I  V  V         p.1000

     | 30    .         .         .         .         .         .    g.242206
 GAG | TTACTTATGGTTGTATCCATTGTACTGGAAAGAAACCCCGAGCTAGAATTTCAAGAC    c.3060
 E   | L  L  M  V  V  S  I  V  L  E  R  N  P  E  L  E  F  Q  D      p.1020

          .         .         .         .         .         .       g.242266
 AAAGTAGATCTAGACAGACTGGTCAAAGAAGCATTTAATGAATTTCAAAAAGATCAGAGT       c.3120
 K  V  D  L  D  R  L  V  K  E  A  F  N  E  F  Q  K  D  Q  S         p.1040

          .         .     | 31   .         .         .         .    g.242966
 CGGCTAAAGGAAATTGAAAAACAA | GATGACATGACTTCCTTTTACAACACTCCTCCCCTG    c.3180
 R  L  K  E  I  E  K  Q   | D  D  M  T  S  F  Y  N  T  P  P  L      p.1060

          .         .         .         .         .         .       g.243026
 GGAAAAAGAGGAACATGCAGCTATTTGACAAAGGCGGTGATGAATCTGCTGCTGGAAGGA       c.3240
 G  K  R  G  T  C  S  Y  L  T  K  A  V  M  N  L  L  L  E  G         p.1080

          .         .         .         .                           g.243068
 GAAGTCAAGCCAAACAATGATGACCCGTGTCTGATTAGCTAG                         c.3282
 E  V  K  P  N  N  D  D  P  C  L  I  S  X                           p.1093

          .         .         .         .         .         .       g.243128
 tggggaaggtgtaggaagctctgttgagacacatgttctgaagtgtgttgtgtttcatgt       c.*60

          .         .         .         .         .         .       g.243188
 tcaagcttaatcaaggcagccattaatatacgaactgagcatgctggggaggtgaatgcc       c.*120

          .         .         .         .         .         .       g.243248
 acatccttggcggggttatggacctcttgcatgtcatagccaatctaacggtaatggtaa       c.*180

          .         .         .         .         .         .       g.243308
 atgcttttaatcaagcaggaaaaagttctcatgattatgccaactataatagtaatcctc       c.*240

          .         .         .         .         .         .       g.243368
 actgagtgataaaaatagtttatgaattgaaaatttgccgctgcatgttgtatgatcaaa       c.*300

          .         .         .         .         .         .       g.243428
 tagttcatcaaaatgaatctttgctctttggactgaattcttaccatactgccattaaaa       c.*360

          .         .         .         .         .         .       g.243488
 taaatttgccaactagtaatgcatactggaaatcaaaagatactgaaagaatggtgaact       c.*420

          .         .         .         .         .         .       g.243548
 tctcttagtggtattgtcatgctaaaagatgttaatatacatcataaaagcaaagtcagc       c.*480

          .         .         .         .         .         .       g.243608
 cagctgatattttggttctcaaaaactgcattattaataatattttagtatacagagcta       c.*540

          .         .         .         .         .         .       g.243668
 ttctacagtttttacattgtaaacatgactgtggttttgtatttgctaaatataggggtt       c.*600

          .         .         .         .         .         .       g.243728
 ggactaaaatataataaatctgtaccttatcaaacattttctttgagctcctgctaaaaa       c.*660

          .         .         .         .         .         .       g.243788
 taggacatgtctatgattgttcaaaaatatgttaaatttaggctcagcacagtagctcac       c.*720

          .         .         .         .         .         .       g.243848
 acctgaaatcttagcacttcgggaggctgaggcaggtggatcacttgaggttaggagttc       c.*780

          .         .         .         .         .         .       g.243908
 aagaccagcccagccaacatggtgaaaaccctgtctctactaaaaatacaaaaattagcc       c.*840

          .         .         .         .         .         .       g.243968
 aggcatgatggtgcatgcctttaaacccagctactgaggaggctgaggcatgagaattgc       c.*900

          .         .         .         .         .         .       g.244028
 ttgaaccaggagacggaggttgcagtgagctgaaatcctgccactgcacaccagcctggg       c.*960

          .         .         .         .         .         .       g.244088
 tgacagagcgagactccatctcaaaaaaaaaaaaaaaaaagaaaaagaaaaaaatatgtt       c.*1020

          .         .         .         .         .         .       g.244148
 aaatttaaggactgttaacctacgttctactagtaaaaacaacattaagggtcattaaat       c.*1080

          .         .         .         .         .         .       g.244208
 tttatttctgaattaatgaacatatctggacattttttgttcctaggttcacaagattga       c.*1140

          .         .         .         .         .         .       g.244268
 gcttcaaactcccgagtgttttcatttaattgatttagaggtagaatggaagagaatctg       c.*1200

          .         .         .         .         .         .       g.244328
 tggtacctaccattatacacatttagttgcccagtttacttaaactttaatgaaagtaga       c.*1260

          .         .         .         .         .         .       g.244388
 aagtagattaaacatttaaattttatttctttcctaaatagaaaaaaaaaaggcccatga       c.*1320

          .         .         .         .         .         .       g.244448
 gtttgagcccttgccccaaagagagttgtttttctgatcaatcttactggagtttcacct       c.*1380

          .         .         .         .         .         .       g.244508
 gagaagatagatttgtcacataaaaaatgcagcttatttgtagtgttttgaaaggatgta       c.*1440

          .         .         .         .         .         .       g.244568
 agaaaggatgagtggcttcagtattgagtcaatcgatatcaaatgaatggatgtgtgagc       c.*1500

          .         .         .         .         .         .       g.244628
 acatggaaaaatctgctgtcagtcacatttctcataacattgaggtacagtgccgagatc       c.*1560

          .         .         .         .         .         .       g.244688
 ttgcataagaaattgtatggatattagttggcaaaattgaaatgaatgagacacagttgg       c.*1620

          .         .         .         .         .         .       g.244748
 gccctaaagaactaaggagggggattgacaaagaatagaattaaactacttgactcaata       c.*1680

          .         .         .         .         .         .       g.244808
 tgttaagagagtttatgaaaagatagtcgtgaagggtgaagctaatttgtaaaactaatg       c.*1740

          .         .         .         .         .         .       g.244868
 cctgaaaaaaacgtaagcatgaagtccatggagagggaattgagagctgacacttcataa       c.*1800

          .         .         .         .         .         .       g.244928
 ctggagaaactggaaattaaagaaagggaaacaaaagacttaaaatttttgtttgccgaa       c.*1860

          .         .         .         .         .         .       g.244988
 atttttacgaaagtaaactgtgttgtagttttaagaatttttttaaaaaatctgattagc       c.*1920

          .         .         .         .         .         .       g.245048
 tgagcaaagttaccagaaaactgctatcctagttgaaatcaaacattacttgcaaatgtg       c.*1980

          .         .         .         .         .         .       g.245108
 ttttctgagtgttagcttcctgcttaaatgttacatatgcaaaattctgaagttttcctg       c.*2040

          .         .         .         .         .         .       g.245168
 tgctactcctgaaagcattcagaatctgtgacacgtattgacttcatgctttgagattca       c.*2100

          .         .         .         .         .                 g.245225
 aaatttattgttctgaaagttatatttagaatcagtaaatcttgatattcaccttta          c.*2157

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Phosphorylase kinase, beta protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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